EA004632B1 - Ингибиторы агрегации амилоидных белков, их применение (варианты), композиция на их основе и способ визуализации амилоидных отложений - Google Patents
Ингибиторы агрегации амилоидных белков, их применение (варианты), композиция на их основе и способ визуализации амилоидных отложений Download PDFInfo
- Publication number
- EA004632B1 EA004632B1 EA200101135A EA200101135A EA004632B1 EA 004632 B1 EA004632 B1 EA 004632B1 EA 200101135 A EA200101135 A EA 200101135A EA 200101135 A EA200101135 A EA 200101135A EA 004632 B1 EA004632 B1 EA 004632B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- phenylamino
- ethyl
- benzoic acid
- phenyl
- acid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
- C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/62—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino groups and at least two carboxyl groups bound to carbon atoms of the same six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13855099P | 1999-06-10 | 1999-06-10 | |
PCT/US2000/015071 WO2000076489A2 (fr) | 1999-06-10 | 2000-05-31 | Procede d'inhibition de l'agregation de proteines amyloides et de formation d'images de depots amyloides |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200101135A1 EA200101135A1 (ru) | 2002-06-27 |
EA004632B1 true EA004632B1 (ru) | 2004-06-24 |
Family
ID=22482537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200101135A EA004632B1 (ru) | 1999-06-10 | 2000-05-31 | Ингибиторы агрегации амилоидных белков, их применение (варианты), композиция на их основе и способ визуализации амилоидных отложений |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP1225886A2 (fr) |
JP (1) | JP2003504310A (fr) |
KR (1) | KR20020008224A (fr) |
CN (1) | CN1378446A (fr) |
AP (1) | AP2002002387A0 (fr) |
AU (1) | AU775157B2 (fr) |
BG (1) | BG106293A (fr) |
BR (1) | BR0011728A (fr) |
CA (1) | CA2375551A1 (fr) |
CR (1) | CR6528A (fr) |
DZ (1) | DZ3252A1 (fr) |
EA (1) | EA004632B1 (fr) |
EE (1) | EE200100673A (fr) |
GE (1) | GEP20053423B (fr) |
HK (1) | HK1048258A1 (fr) |
HR (1) | HRP20020026A2 (fr) |
HU (1) | HUP0202508A3 (fr) |
IL (1) | IL146971A0 (fr) |
IS (1) | IS6193A (fr) |
MA (1) | MA26805A1 (fr) |
MX (1) | MXPA01012318A (fr) |
NO (1) | NO20015995L (fr) |
NZ (1) | NZ515621A (fr) |
OA (1) | OA11963A (fr) |
PL (1) | PL352430A1 (fr) |
SK (1) | SK17632001A3 (fr) |
TR (1) | TR200103551T2 (fr) |
WO (1) | WO2000076489A2 (fr) |
YU (1) | YU86701A (fr) |
ZA (1) | ZA200109794B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1266884A4 (fr) * | 2000-03-22 | 2003-04-23 | Bf Res Inst Inc | Sonde de diagnostic par image, a base d'azobenzene substitue ou d'un analogue de celui-ci, pour les maladies imputables a l'accumulation d'amyloide et composition pour le diagnostic par image le contenant |
CA2357450A1 (fr) * | 2000-09-29 | 2002-03-29 | Warner-Lambert Company | Analogues de phenoxazine pouvant etre utilises comme inhibiteurs d'agregation de substances amyloides et traitement de la maladie d'alzheimer et des troubles relatifs a l'amyloidose |
GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
ES2319596B1 (es) * | 2006-12-22 | 2010-02-08 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
ES2327372B1 (es) * | 2007-04-23 | 2010-08-24 | Laboratorios Almirall S.A. | Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico. |
EP2121633A2 (fr) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Dérivés de pipérazine pour le traitement de la maladie d'alzheimer et des conditions apparentées |
US20080253967A1 (en) * | 2007-04-13 | 2008-10-16 | Kung Hank F | Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques |
UY31272A1 (es) | 2007-08-10 | 2009-01-30 | Almirall Lab | Nuevos derivados de ácido azabifenilaminobenzoico |
EP2135610A1 (fr) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combinaison comportant des inhibiteurs DHODH et de la méthotrexate |
EP2320897B1 (fr) * | 2008-08-29 | 2014-01-15 | Treventis Corporation | Procédés de traitement d'une maladie amyloïde utilisant des analogues de 1-(4-nitrophényl)pipérazine |
EP2239256A1 (fr) | 2009-03-13 | 2010-10-13 | Almirall, S.A. | Sel de sodium de l'acide 5-cyclopropyl-2-{[2-(2,6-difluorophényl)pyrimidin-5-yl]amino}benzoïque en tant qu'inhibiteurs de la DHOD |
EP2228367A1 (fr) * | 2009-03-13 | 2010-09-15 | Almirall, S.A. | Sels adjuvants d'amines contenant des groupes hydroxyle et/ou carbonyle avec des dérivés d'acides aminonicotiques en tant qu'inhibiteurs de la DHODH |
EP2314577A1 (fr) | 2009-10-16 | 2011-04-27 | Almirall, S.A. | Procédé de fabrication de l'acide 2-[(3,5-difluoro-3'-méthoxy-1,1'-biphényl-4-yl)amino]nicotinique |
EP2536405A1 (fr) * | 2010-02-16 | 2012-12-26 | Universita Degli Studi di Siena | Inhibiteurs non peptidiques des protéines 14-3-3 et leur utilisation |
WO2012071186A1 (fr) * | 2010-11-24 | 2012-05-31 | Allergan, Inc. | Modulateurs de récepteurs de la s1p |
JP7046968B2 (ja) * | 2017-03-02 | 2022-04-04 | 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ | 2-(置換フェニルヘテロ)芳香族カルボン酸系fto阻害剤、その製造方法およびその使用 |
WO2019031472A1 (fr) * | 2017-08-07 | 2019-02-14 | 国立大学法人広島大学 | NOUVEAU COMPOSÉ À BASE D'ACIDE ANTHRANILIQUE, ET INHIBITEUR DE Pin1, AGENT THÉRAPEUTIQUE CONTRE LES MALADIES INFLAMMATOIRES AINSI QU'AGENT THÉRAPEUTIQUE CONTRE LE CANCER METTANT EN ŒUVRE CELUI-CI |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
US5739169A (en) * | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
HUP0201586A2 (en) * | 1999-06-10 | 2002-08-28 | Warner Lambert Co | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives |
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2000
- 2000-05-31 AP APAP/P/2002/002387A patent/AP2002002387A0/en unknown
- 2000-05-31 IL IL14697100A patent/IL146971A0/xx unknown
- 2000-05-31 JP JP2001502823A patent/JP2003504310A/ja active Pending
- 2000-05-31 OA OA1200100327A patent/OA11963A/en unknown
- 2000-05-31 PL PL00352430A patent/PL352430A1/xx not_active Application Discontinuation
- 2000-05-31 NZ NZ515621A patent/NZ515621A/en unknown
- 2000-05-31 CN CN00808672A patent/CN1378446A/zh active Pending
- 2000-05-31 SK SK1763-2001A patent/SK17632001A3/sk unknown
- 2000-05-31 BR BR0011728-5A patent/BR0011728A/pt not_active IP Right Cessation
- 2000-05-31 HU HU0202508A patent/HUP0202508A3/hu unknown
- 2000-05-31 GE GE4687A patent/GEP20053423B/en unknown
- 2000-05-31 EA EA200101135A patent/EA004632B1/ru not_active IP Right Cessation
- 2000-05-31 YU YU86701A patent/YU86701A/sh unknown
- 2000-05-31 CA CA002375551A patent/CA2375551A1/fr not_active Abandoned
- 2000-05-31 KR KR1020017015879A patent/KR20020008224A/ko not_active Application Discontinuation
- 2000-05-31 AU AU54553/00A patent/AU775157B2/en not_active Ceased
- 2000-05-31 EE EEP200100673A patent/EE200100673A/xx unknown
- 2000-05-31 MX MXPA01012318A patent/MXPA01012318A/es not_active Application Discontinuation
- 2000-05-31 WO PCT/US2000/015071 patent/WO2000076489A2/fr not_active Application Discontinuation
- 2000-05-31 DZ DZ003252A patent/DZ3252A1/fr active
- 2000-05-31 EP EP00939471A patent/EP1225886A2/fr not_active Withdrawn
- 2000-05-31 TR TR2001/03551T patent/TR200103551T2/xx unknown
-
2001
- 2001-11-28 ZA ZA200109794A patent/ZA200109794B/en unknown
- 2001-12-07 IS IS6193A patent/IS6193A/is unknown
- 2001-12-07 CR CR6528A patent/CR6528A/es not_active Application Discontinuation
- 2001-12-07 NO NO20015995A patent/NO20015995L/no not_active Application Discontinuation
-
2002
- 2002-01-02 MA MA26463A patent/MA26805A1/fr unknown
- 2002-01-09 BG BG106293A patent/BG106293A/xx unknown
- 2002-01-10 HR HR20020026A patent/HRP20020026A2/hr not_active Application Discontinuation
-
2003
- 2003-01-16 HK HK03100404.7A patent/HK1048258A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2375551A1 (fr) | 2000-12-21 |
TR200103551T2 (tr) | 2002-12-23 |
HRP20020026A2 (en) | 2003-08-31 |
CR6528A (es) | 2004-02-23 |
ZA200109794B (en) | 2003-07-01 |
SK17632001A3 (sk) | 2003-03-04 |
DZ3252A1 (fr) | 2000-12-21 |
KR20020008224A (ko) | 2002-01-29 |
WO2000076489A2 (fr) | 2000-12-21 |
WO2000076489A3 (fr) | 2002-05-30 |
GEP20053423B (en) | 2005-01-25 |
EA200101135A1 (ru) | 2002-06-27 |
EP1225886A2 (fr) | 2002-07-31 |
CN1378446A (zh) | 2002-11-06 |
AP2002002387A0 (en) | 2002-03-31 |
HUP0202508A2 (hu) | 2002-12-28 |
BR0011728A (pt) | 2002-02-26 |
EE200100673A (et) | 2003-02-17 |
IS6193A (is) | 2001-12-07 |
JP2003504310A (ja) | 2003-02-04 |
IL146971A0 (en) | 2002-08-14 |
BG106293A (en) | 2002-06-28 |
YU86701A (sh) | 2004-09-03 |
PL352430A1 (en) | 2003-08-25 |
NZ515621A (en) | 2004-05-28 |
NO20015995D0 (no) | 2001-12-07 |
HK1048258A1 (zh) | 2003-03-28 |
AU5455300A (en) | 2001-01-02 |
MA26805A1 (fr) | 2004-12-20 |
AU775157B2 (en) | 2004-07-22 |
OA11963A (en) | 2006-04-17 |
MXPA01012318A (es) | 2002-07-22 |
HUP0202508A3 (en) | 2003-03-28 |
NO20015995L (no) | 2002-02-04 |
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