EA002690B1 - Способ получения 3-арилокси, 4-арилфуран-2-онов, полезных в качестве ингибиторов циклооксигеназы-2 - Google Patents

Способ получения 3-арилокси, 4-арилфуран-2-онов, полезных в качестве ингибиторов циклооксигеназы-2 Download PDF

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Publication number
EA002690B1
EA002690B1 EA200000350A EA200000350A EA002690B1 EA 002690 B1 EA002690 B1 EA 002690B1 EA 200000350 A EA200000350 A EA 200000350A EA 200000350 A EA200000350 A EA 200000350A EA 002690 B1 EA002690 B1 EA 002690B1
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EA
Eurasian Patent Office
Prior art keywords
formula
compound
group
reacting
belongs
Prior art date
Application number
EA200000350A
Other languages
English (en)
Russian (ru)
Other versions
EA200000350A1 (ru
Inventor
Ченг Й. Чен
Роберт Д. Ларсен
Луши Тан
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815805.8A external-priority patent/GB9815805D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200000350A1 publication Critical patent/EA200000350A1/ru
Publication of EA002690B1 publication Critical patent/EA002690B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA200000350A 1997-09-24 1998-09-21 Способ получения 3-арилокси, 4-арилфуран-2-онов, полезных в качестве ингибиторов циклооксигеназы-2 EA002690B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6069497P 1997-09-24 1997-09-24
GBGB9815805.8A GB9815805D0 (en) 1998-07-21 1998-07-21 Chemical process
PCT/US1998/019642 WO1999015513A1 (en) 1997-09-24 1998-09-21 Process of making 3-aryloxy, 4-aryl furan-2-ones useful as inhibitors of cox-2

Publications (2)

Publication Number Publication Date
EA200000350A1 EA200000350A1 (ru) 2000-10-30
EA002690B1 true EA002690B1 (ru) 2002-08-29

Family

ID=26314074

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000350A EA002690B1 (ru) 1997-09-24 1998-09-21 Способ получения 3-арилокси, 4-арилфуран-2-онов, полезных в качестве ингибиторов циклооксигеназы-2

Country Status (7)

Country Link
EP (1) EP1017687A4 (de)
JP (1) JP3516658B2 (de)
CN (1) CN1271352A (de)
AU (1) AU2247599A (de)
EA (1) EA002690B1 (de)
SK (1) SK4202000A3 (de)
WO (1) WO1999015513A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0108908A (pt) 2000-03-03 2002-12-24 Pfizer Prod Inc Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos
ES2290157T3 (es) 2000-07-20 2008-02-16 Lauras As Uso de inhibidores de cox-2 como inmunoestimulantes en el tratamiento de vih o sida.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
UA57002C2 (uk) * 1995-10-13 2003-06-16 Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування
US5789413A (en) * 1996-02-01 1998-08-04 Merck Frosst Canada, Inc. Alkylated styrenes as prodrugs to COX-2 inhibitors

Also Published As

Publication number Publication date
WO1999015513A1 (en) 1999-04-01
SK4202000A3 (en) 2000-10-09
AU2247599A (en) 1999-04-12
EP1017687A4 (de) 2001-10-31
JP3516658B2 (ja) 2004-04-05
CN1271352A (zh) 2000-10-25
EA200000350A1 (ru) 2000-10-30
JP2001517661A (ja) 2001-10-09
EP1017687A1 (de) 2000-07-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU