EP1017687A4 - Verfahren zur herstellung von 3-aryloxy-4-aryl-furan-2-one als inhibitoren von cox-2 - Google Patents

Verfahren zur herstellung von 3-aryloxy-4-aryl-furan-2-one als inhibitoren von cox-2

Info

Publication number
EP1017687A4
EP1017687A4 EP98947177A EP98947177A EP1017687A4 EP 1017687 A4 EP1017687 A4 EP 1017687A4 EP 98947177 A EP98947177 A EP 98947177A EP 98947177 A EP98947177 A EP 98947177A EP 1017687 A4 EP1017687 A4 EP 1017687A4
Authority
EP
European Patent Office
Prior art keywords
cox
aryloxy
inhibitors
making
ones useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98947177A
Other languages
English (en)
French (fr)
Other versions
EP1017687A1 (de
Inventor
Cheng Y Chen
Robert D Larsen
Lushi Tan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815805.8A external-priority patent/GB9815805D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1017687A1 publication Critical patent/EP1017687A1/de
Publication of EP1017687A4 publication Critical patent/EP1017687A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
EP98947177A 1997-09-24 1998-09-21 Verfahren zur herstellung von 3-aryloxy-4-aryl-furan-2-one als inhibitoren von cox-2 Withdrawn EP1017687A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6069497P 1997-09-24 1997-09-24
US60694P 1997-09-24
GB9815805 1998-07-21
GBGB9815805.8A GB9815805D0 (en) 1998-07-21 1998-07-21 Chemical process
PCT/US1998/019642 WO1999015513A1 (en) 1997-09-24 1998-09-21 Process of making 3-aryloxy, 4-aryl furan-2-ones useful as inhibitors of cox-2

Publications (2)

Publication Number Publication Date
EP1017687A1 EP1017687A1 (de) 2000-07-12
EP1017687A4 true EP1017687A4 (de) 2001-10-31

Family

ID=26314074

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98947177A Withdrawn EP1017687A4 (de) 1997-09-24 1998-09-21 Verfahren zur herstellung von 3-aryloxy-4-aryl-furan-2-one als inhibitoren von cox-2

Country Status (7)

Country Link
EP (1) EP1017687A4 (de)
JP (1) JP3516658B2 (de)
CN (1) CN1271352A (de)
AU (1) AU2247599A (de)
EA (1) EA002690B1 (de)
SK (1) SK4202000A3 (de)
WO (1) WO1999015513A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064669A1 (en) 2000-03-03 2001-09-07 Pfizer Products Inc. Pyrazole ether derivatives as anti-inflammatory/analgesic agents
DK1303265T3 (da) 2000-07-20 2007-11-12 Lauras As Anvendelse af COX-2-inhibitorer, som immunostimulerende midler ved behandling af HIV eller AIDS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
WO1997014691A1 (en) * 1995-10-13 1997-04-24 Merck Frosst Canada Inc. (methylsulfonyl)phenyl-2-(5h)-furanones as cox-2 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
US5789413A (en) * 1996-02-01 1998-08-04 Merck Frosst Canada, Inc. Alkylated styrenes as prodrugs to COX-2 inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
WO1997014691A1 (en) * 1995-10-13 1997-04-24 Merck Frosst Canada Inc. (methylsulfonyl)phenyl-2-(5h)-furanones as cox-2 inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9915513A1 *
TAN L ET AL: "An Efficient Asymmetric Synthesis of A Potent COX-2 Inhibitor L-784,512", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 23, 4 June 1998 (1998-06-04), pages 3961 - 3964, XP004118785, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
CN1271352A (zh) 2000-10-25
AU2247599A (en) 1999-04-12
JP2001517661A (ja) 2001-10-09
EA002690B1 (ru) 2002-08-29
WO1999015513A1 (en) 1999-04-01
JP3516658B2 (ja) 2004-04-05
SK4202000A3 (en) 2000-10-09
EA200000350A1 (ru) 2000-10-30
EP1017687A1 (de) 2000-07-12

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