EP1017687A4 - Verfahren zur herstellung von 3-aryloxy-4-aryl-furan-2-one als inhibitoren von cox-2 - Google Patents
Verfahren zur herstellung von 3-aryloxy-4-aryl-furan-2-one als inhibitoren von cox-2Info
- Publication number
- EP1017687A4 EP1017687A4 EP98947177A EP98947177A EP1017687A4 EP 1017687 A4 EP1017687 A4 EP 1017687A4 EP 98947177 A EP98947177 A EP 98947177A EP 98947177 A EP98947177 A EP 98947177A EP 1017687 A4 EP1017687 A4 EP 1017687A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cox
- aryloxy
- inhibitors
- making
- ones useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6069497P | 1997-09-24 | 1997-09-24 | |
US60694P | 1997-09-24 | ||
GBGB9815805.8A GB9815805D0 (en) | 1998-07-21 | 1998-07-21 | Chemical process |
GB9815805 | 1998-07-21 | ||
PCT/US1998/019642 WO1999015513A1 (en) | 1997-09-24 | 1998-09-21 | Process of making 3-aryloxy, 4-aryl furan-2-ones useful as inhibitors of cox-2 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1017687A1 EP1017687A1 (de) | 2000-07-12 |
EP1017687A4 true EP1017687A4 (de) | 2001-10-31 |
Family
ID=26314074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98947177A Withdrawn EP1017687A4 (de) | 1997-09-24 | 1998-09-21 | Verfahren zur herstellung von 3-aryloxy-4-aryl-furan-2-one als inhibitoren von cox-2 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1017687A4 (de) |
JP (1) | JP3516658B2 (de) |
CN (1) | CN1271352A (de) |
AU (1) | AU2247599A (de) |
EA (1) | EA002690B1 (de) |
SK (1) | SK4202000A3 (de) |
WO (1) | WO1999015513A1 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3217501A (en) | 2000-03-03 | 2001-09-12 | Pfizer Prod Inc | Pyrazole ether derivatives as anti-inflammatory/analgesic agents |
CN100488500C (zh) | 2000-07-20 | 2009-05-20 | 劳拉斯有限公司 | Cox-2抑制剂预防免疫缺陷的用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5352832A (en) * | 1992-12-18 | 1994-10-04 | Schering Corporation | Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates |
WO1997014691A1 (en) * | 1995-10-13 | 1997-04-24 | Merck Frosst Canada Inc. | (methylsulfonyl)phenyl-2-(5h)-furanones as cox-2 inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
US5789413A (en) * | 1996-02-01 | 1998-08-04 | Merck Frosst Canada, Inc. | Alkylated styrenes as prodrugs to COX-2 inhibitors |
-
1998
- 1998-09-21 AU AU22475/99A patent/AU2247599A/en not_active Abandoned
- 1998-09-21 SK SK420-2000A patent/SK4202000A3/sk unknown
- 1998-09-21 EA EA200000350A patent/EA002690B1/ru not_active IP Right Cessation
- 1998-09-21 CN CN98809463A patent/CN1271352A/zh active Pending
- 1998-09-21 EP EP98947177A patent/EP1017687A4/de not_active Withdrawn
- 1998-09-21 WO PCT/US1998/019642 patent/WO1999015513A1/en not_active Application Discontinuation
- 1998-09-21 JP JP2000512820A patent/JP3516658B2/ja not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5352832A (en) * | 1992-12-18 | 1994-10-04 | Schering Corporation | Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates |
WO1997014691A1 (en) * | 1995-10-13 | 1997-04-24 | Merck Frosst Canada Inc. | (methylsulfonyl)phenyl-2-(5h)-furanones as cox-2 inhibitors |
Non-Patent Citations (2)
Title |
---|
See also references of WO9915513A1 * |
TAN L ET AL: "An Efficient Asymmetric Synthesis of A Potent COX-2 Inhibitor L-784,512", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 23, 4 June 1998 (1998-06-04), pages 3961 - 3964, XP004118785, ISSN: 0040-4039 * |
Also Published As
Publication number | Publication date |
---|---|
EP1017687A1 (de) | 2000-07-12 |
CN1271352A (zh) | 2000-10-25 |
AU2247599A (en) | 1999-04-12 |
EA002690B1 (ru) | 2002-08-29 |
JP2001517661A (ja) | 2001-10-09 |
EA200000350A1 (ru) | 2000-10-30 |
WO1999015513A1 (en) | 1999-04-01 |
JP3516658B2 (ja) | 2004-04-05 |
SK4202000A3 (en) | 2000-10-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000425 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
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AX | Request for extension of the european patent |
Free format text: RO PAYMENT 20000425 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20010917 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07D 307/02 A, 7C 07D 405/00 B, 7C 07D 307/60 B |
|
17Q | First examination report despatched |
Effective date: 20020513 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20050208 |