US7053070B2
(en)
*
|
2000-01-25 |
2006-05-30 |
Warner-Lambert Company |
Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
|
US7235551B2
(en)
|
2000-03-02 |
2007-06-26 |
Smithkline Beecham Corporation |
1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
|
CZ20031125A3
(cs)
|
2000-10-23 |
2003-10-15 |
Smithkline Beecham Corporation |
Nové sloučeniny
|
ATE305303T1
(de)
*
|
2001-02-12 |
2005-10-15 |
Hoffmann La Roche |
6-substituierte pyridopyrimidine
|
EP1364950A4
(de)
*
|
2001-02-26 |
2005-03-09 |
Tanabe Seiyaku Co |
Pyridopyrimidin- und naphthyridinderivate
|
US20030105115A1
(en)
*
|
2001-06-21 |
2003-06-05 |
Metcalf Chester A. |
Novel pyridopyrimidines and uses thereof
|
US20030100572A1
(en)
*
|
2001-06-21 |
2003-05-29 |
Ariad Pharmaceuticals,Inc. |
Novel pyridopyrimidones and uses thereof
|
CN101001857B
(zh)
*
|
2002-01-22 |
2011-06-22 |
沃尼尔·朗伯有限责任公司 |
2-(吡啶-2-基氨基)-吡啶并[2,3-d]嘧啶-7-酮
|
PL373339A1
(en)
|
2002-04-19 |
2005-08-22 |
Smithkline Beecham Corporation |
Novel compounds
|
AU2003250701A1
(en)
|
2002-07-31 |
2004-02-16 |
Wayne R. Danter |
Protein tyrosine kinase inhibitors
|
AU2003273675A1
(en)
|
2002-10-09 |
2004-05-04 |
Wayne R. Danter |
Protein tyrosine kinase inhibitors
|
DE602004021558D1
(de)
*
|
2003-01-17 |
2009-07-30 |
Warner Lambert Co |
2-aminopyridin-substituierteheterocyclen als inhibitoren der zellulären proliferation
|
US6861422B2
(en)
|
2003-02-26 |
2005-03-01 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
|
US8362017B2
(en)
|
2003-08-29 |
2013-01-29 |
Exelixis, Inc. |
C-kit modulators and methods of use
|
ATE356124T1
(de)
|
2003-11-13 |
2007-03-15 |
Hoffmann La Roche |
Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7- one
|
DE102004029784A1
(de)
|
2004-06-21 |
2006-01-05 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
|
DE102004033670A1
(de)
|
2004-07-09 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
|
FR2873118B1
(fr)
|
2004-07-15 |
2007-11-23 |
Sanofi Synthelabo |
Derives de pyrido-pyrimidine, leur application en therapeutique
|
US20060035903A1
(en)
|
2004-08-14 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Storage stable perfusion solution for dihydropteridinones
|
US7759485B2
(en)
|
2004-08-14 |
2010-07-20 |
Boehringer Ingelheim International Gmbh |
Process for the manufacture of dihydropteridinones
|
US7728134B2
(en)
|
2004-08-14 |
2010-06-01 |
Boehringer Ingelheim International Gmbh |
Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
|
US20060074088A1
(en)
|
2004-08-14 |
2006-04-06 |
Boehringer Ingelheim International Gmbh |
Dihydropteridinones for the treatment of cancer diseases
|
US20060058311A1
(en)
|
2004-08-14 |
2006-03-16 |
Boehringer Ingelheim International Gmbh |
Combinations for the treatment of diseases involving cell proliferation
|
EP1630163A1
(de)
|
2004-08-25 |
2006-03-01 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
|
WO2006021547A1
(de)
*
|
2004-08-26 |
2006-03-02 |
Boehringer Ingelheim International Gmbh |
Pteridinone als plk (polo like kinase) inhibitoren
|
DE102004058337A1
(de)
|
2004-12-02 |
2006-06-14 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
|
WO2006076706A1
(en)
|
2005-01-14 |
2006-07-20 |
Millennium Pharmaceuticals, Inc. |
Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
|
AR053346A1
(es)
|
2005-03-25 |
2007-05-02 |
Glaxo Group Ltd |
Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
|
EA200702073A1
(ru)
|
2005-03-25 |
2008-12-30 |
Глэксо Груп Лимитед |
Способ получения пиридо[2,3-d]пиримидин-7-оновых и 3,4-дигидропиримидо[4,5-d]пиримидин-2(1н)-оновых производных
|
UY29439A1
(es)
|
2005-03-25 |
2006-10-02 |
Glaxo Group Ltd |
Nuevos compuestos
|
JP2008535822A
(ja)
|
2005-03-25 |
2008-09-04 |
グラクソ グループ リミテッド |
新規化合物
|
US7737155B2
(en)
*
|
2005-05-17 |
2010-06-15 |
Schering Corporation |
Nitrogen-containing heterocyclic compounds and methods of use thereof
|
FR2887882B1
(fr)
*
|
2005-07-01 |
2007-09-07 |
Sanofi Aventis Sa |
Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
|
TW200800983A
(en)
|
2005-09-14 |
2008-01-01 |
Janssen Pharmaceutica Nv |
5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
|
US7642270B2
(en)
|
2005-09-14 |
2010-01-05 |
Janssen Pharmaceutica N.V. |
5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
|
WO2007044813A1
(en)
*
|
2005-10-07 |
2007-04-19 |
Exelixis, Inc. |
PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα
|
WO2007044698A1
(en)
*
|
2005-10-07 |
2007-04-19 |
Exelixis, Inc. |
PYRIDOPYRIMIDINONE INHIBITORS OF PI3Kα
|
FR2896246B1
(fr)
|
2006-01-13 |
2008-08-15 |
Sanofi Aventis Sa |
Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
|
US7439358B2
(en)
|
2006-02-08 |
2008-10-21 |
Boehringer Ingelheim International Gmbh |
Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
|
MX2009002927A
(es)
|
2006-09-15 |
2009-03-31 |
Pfizer Prod Inc |
Compuestos de pirido (2,3-d)pirimidinona y su uso como inhibidores de la enzima fosfoinositido 3.
|
JP2010506902A
(ja)
*
|
2006-10-16 |
2010-03-04 |
ジーピーシー・バイオテック・インコーポレーテッド |
ピリド[2,3−d]ピリミジン類およびキナーゼ阻害剤としてのそれらの使用
|
EP1914234A1
(de)
*
|
2006-10-16 |
2008-04-23 |
GPC Biotech Inc. |
Pyrido[2,3-d]pyrimidinen und ihre Verwendung als kinase Inhibitoren
|
WO2008055013A2
(en)
*
|
2006-10-31 |
2008-05-08 |
Janssen Pharmaceutica N.V. |
5-oxo-5,8 - dihydro - pyrido - pyrimidines as inhibitors of c-fms kinase
|
FR2910813B1
(fr)
|
2006-12-28 |
2009-02-06 |
Sanofi Aventis Sa |
Nouvelle utilisation therapeutique pour le traitement des leucemies
|
UA101611C2
(ru)
*
|
2007-04-03 |
2013-04-25 |
Аррей Байофарма Инк. |
СОЕДИНЕНИЯ ИМИДАЗО[1,2-а]ПИРИДИНА КАК ИНГИБИТОРЫ ТИРОЗИНКИНАЗЫ РЕЦЕПТОРОВ
|
EP2168966B1
(de)
|
2007-06-15 |
2016-09-28 |
Msd K.K. |
Bicycloanilinderivat
|
CA2695406A1
(en)
|
2007-08-03 |
2009-02-12 |
Boehringer Ingelheim International Gmbh |
Crystalline form of a dihydropteridione derivative
|
KR20100095020A
(ko)
|
2007-12-19 |
2010-08-27 |
암젠 인크 |
세포 주기 억제제로서의 융합된 피리딘, 피리미딘 및 트리아진 화합물
|
EP2225226B1
(de)
|
2007-12-26 |
2016-08-17 |
Critical Outcome Technologies, Inc. |
Verbindungen und ihre verwending in einem verfahren zur behandlung von krebs
|
EP2100894A1
(de)
*
|
2008-03-12 |
2009-09-16 |
4Sc Ag |
Pyridopyrimidinone verwendbar als Plk1 (polo-like kinase) Hemmen
|
ATE531372T1
(de)
*
|
2008-04-07 |
2011-11-15 |
Amgen Inc |
Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren
|
EP2112150B1
(de)
|
2008-04-22 |
2013-10-16 |
Forma Therapeutics, Inc. |
Verbesserte Raf-Inhibitoren
|
CA2730890C
(en)
|
2008-07-17 |
2018-05-15 |
Critical Outcome Technologies Inc. |
Thiosemicarbazone inhibitor compounds and cancer treatment methods
|
AR073524A1
(es)
|
2008-09-30 |
2010-11-10 |
Exelixis Inc |
Piridopirimidinonas inhibidores de pi3k a y m tor
|
TW201100441A
(en)
|
2009-06-01 |
2011-01-01 |
Osi Pharm Inc |
Amino pyrimidine anticancer compounds
|
JP2013507395A
(ja)
*
|
2009-10-09 |
2013-03-04 |
アフラクシス・インコーポレイテッド |
Cns障害治療用の8−エチル−6−(アリール)ピリド[2,3−d]ピリミジン−7(8h)−オン
|
CA2784749C
(en)
*
|
2009-12-18 |
2017-12-12 |
E. Premkumar Reddy |
Substituted pyrido[2,3-d]pyrimidin-7(8h)-ones and therapeutic uses thereof
|
US8901137B2
(en)
|
2010-02-09 |
2014-12-02 |
Exelixis, Inc. |
Methods of treating cancer using pyridopyrimidinone inhibitors of PI3K and mTOR in combination with autophagy inhibitors
|
EP2552915B1
(de)
|
2010-04-01 |
2017-07-19 |
Critical Outcome Technologies Inc. |
Verbindungen zur behandlung von hiv
|
EA022527B1
(ru)
*
|
2010-08-05 |
2016-01-29 |
Темпл Юниверсити - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн |
2-ЗАМЕЩЕННЫЕ-8-АЛКИЛ-7-ОКСО-7,8-ДИГИДРОПИРИДО[2,3-d]ПИРИМИДИН-6-КАРБОНИТРИЛЫ И ИХ ПРИМЕНЕНИЕ
|
US8546566B2
(en)
|
2010-10-12 |
2013-10-01 |
Boehringer Ingelheim International Gmbh |
Process for manufacturing dihydropteridinones and intermediates thereof
|
US9358233B2
(en)
|
2010-11-29 |
2016-06-07 |
Boehringer Ingelheim International Gmbh |
Method for treating acute myeloid leukemia
|
JP6000273B2
(ja)
|
2010-11-29 |
2016-09-28 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
大環状キナーゼ阻害剤
|
PT2688887E
(pt)
|
2011-03-23 |
2015-07-06 |
Amgen Inc |
Inibidores duais tricíclicos fusionados de cdk 4/6 e flt3
|
US9370535B2
(en)
|
2011-05-17 |
2016-06-21 |
Boehringer Ingelheim International Gmbh |
Method for treatment of advanced solid tumors
|
AU2012255860C1
(en)
*
|
2011-05-17 |
2015-12-10 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
EP2817308B1
(de)
*
|
2012-02-23 |
2016-09-07 |
AbbVie Inc. |
Pyridopyrimidinon-derivate verwendbar als kinase inhibitoren
|
PL2958916T3
(pl)
*
|
2013-02-21 |
2019-01-31 |
Pfizer Inc. |
Stałe postacie selektywnego inhibitora CDK4/6
|
WO2015011236A1
(en)
|
2013-07-26 |
2015-01-29 |
Boehringer Ingelheim International Gmbh |
Treatment of myelodysplastic syndrome
|
EP3172214B1
(de)
|
2014-07-26 |
2020-05-13 |
Sunshine Lake Pharma Co., Ltd. |
2-amino-pyrido[2,3-d]pyrimidin-7(8h)-on-derivate als cdk-inhibitoren und verwendungen davon
|
US9867831B2
(en)
|
2014-10-01 |
2018-01-16 |
Boehringer Ingelheim International Gmbh |
Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
|
US10449195B2
(en)
|
2016-03-29 |
2019-10-22 |
Shenzhen Pharmacin Co., Ltd. |
Pharmaceutical formulation of palbociclib and a preparation method thereof
|
TWI646094B
(zh)
*
|
2016-06-01 |
2019-01-01 |
大陸商貝達藥業股份有限公司 |
Crystal form of inhibitory protein kinase active compound and application thereof
|
JP6563623B1
(ja)
|
2016-08-15 |
2019-08-21 |
ファイザー・インク |
ピリドピリミジノンcdk2/4/6阻害剤
|
EP3589634A4
(de)
*
|
2017-03-03 |
2020-08-12 |
Auckland Uniservices Limited |
Fgfr-kinase-inhibitoren und pharmazeutische verwendungen
|
AU2019220746A1
(en)
|
2018-02-15 |
2020-08-27 |
Nuvation Bio Inc. |
Heterocyclic compounds as kinase inhibitors
|
US20220024916A1
(en)
*
|
2018-12-07 |
2022-01-27 |
Hangzhou Innogate Pharma Co., Ltd. |
Heterocyclic comipound as cdk-hdac dual pathway inhibitor
|
CN112759589B
(zh)
*
|
2019-11-01 |
2022-04-08 |
暨南大学 |
嘧啶并吡啶酮类化合物及其应用
|
WO2021108803A1
(en)
|
2019-11-26 |
2021-06-03 |
Theravance Biopharma R&D Ip, Llc |
Fused pyrimidine pyridinone compounds as jak inhibitors
|
AU2022234998A1
(en)
*
|
2021-03-08 |
2023-10-12 |
Jinan University |
Pyridopyrimidine compounds and applications thereof
|
WO2024056091A1
(zh)
*
|
2022-09-16 |
2024-03-21 |
华东师范大学 |
作为rsk抑制剂的吡啶酮并嘧啶衍生物及其应用
|
WO2024099403A1
(zh)
*
|
2022-11-10 |
2024-05-16 |
北京普祺医药科技股份有限公司 |
一种具有软药性质的硫醚类化合物、药物组合物及其用途
|