DK651088A - Konjugater af laegemidler og monoklonale antistoffer - Google Patents
Konjugater af laegemidler og monoklonale antistofferInfo
- Publication number
- DK651088A DK651088A DK651088A DK651088A DK651088A DK 651088 A DK651088 A DK 651088A DK 651088 A DK651088 A DK 651088A DK 651088 A DK651088 A DK 651088A DK 651088 A DK651088 A DK 651088A
- Authority
- DK
- Denmark
- Prior art keywords
- medicinals
- conjugates
- monoclonal antibodies
- drug
- conjugate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/124,313 US4952394A (en) | 1987-11-23 | 1987-11-23 | Drug-monoclonal antibody conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
DK651088D0 DK651088D0 (da) | 1988-11-22 |
DK651088A true DK651088A (da) | 1989-05-24 |
Family
ID=22414122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK651088A DK651088A (da) | 1987-11-23 | 1988-11-22 | Konjugater af laegemidler og monoklonale antistoffer |
Country Status (16)
Country | Link |
---|---|
US (1) | US4952394A (fr) |
EP (1) | EP0317957B1 (fr) |
JP (1) | JPH02111731A (fr) |
KR (1) | KR910005887B1 (fr) |
AT (1) | ATE81986T1 (fr) |
AU (1) | AU617380B2 (fr) |
CA (1) | CA1303524C (fr) |
DE (1) | DE3875700T2 (fr) |
DK (1) | DK651088A (fr) |
FI (1) | FI885361A (fr) |
GR (1) | GR3006211T3 (fr) |
IL (1) | IL88428A0 (fr) |
NO (1) | NO169958C (fr) |
NZ (1) | NZ226955A (fr) |
PT (1) | PT89062B (fr) |
ZA (1) | ZA886811B (fr) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5149782A (en) * | 1988-08-19 | 1992-09-22 | Tanox Biosystems, Inc. | Molecular conjugates containing cell membrane-blending agents |
US5171563A (en) * | 1988-09-30 | 1992-12-15 | Neorx Corporation | Cleavable linkers for the reduction of non-target organ retention of immunoconjugates |
US5155210A (en) * | 1990-09-11 | 1992-10-13 | Brunswick Corporation | Methods of conjugating actinomycin d |
ATE152917T1 (de) * | 1990-09-28 | 1997-05-15 | Neorx Corp | Polymere träger zur freisetzung kovalent gebundener wirkstoffe |
US5776458A (en) * | 1990-12-05 | 1998-07-07 | Pharmacia & Upjohn S.P.A. | Anthracycline-conjugates |
FR2676058B1 (fr) * | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
AU701529B2 (en) * | 1994-04-05 | 1999-01-28 | Purdue Research Foundation | NADH oxidase as a target in diagnosis and therapy |
US20030119724A1 (en) * | 1995-11-22 | 2003-06-26 | Ts`O Paul O.P. | Ligands to enhance cellular uptake of biomolecules |
JP2001503396A (ja) * | 1996-10-11 | 2001-03-13 | アルザ コーポレイション | 治療用リポソーム組成物および方法 |
US6207805B1 (en) | 1997-07-18 | 2001-03-27 | University Of Iowa Research Foundation | Prostate cell surface antigen-specific antibodies |
US7157418B1 (en) | 1998-07-22 | 2007-01-02 | Osprey Pharmaceuticals, Ltd. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
US6299860B1 (en) * | 1998-10-15 | 2001-10-09 | Fluoro Probe, Inc. | Method for viewing diseased tissue located within a body cavity |
US6652836B2 (en) | 1998-10-15 | 2003-11-25 | Fluoroprobe, Inc. | Method for viewing tumor tissue located within a body cavity |
US7238368B2 (en) | 1999-04-23 | 2007-07-03 | Alza Corporation | Releasable linkage and compositions containing same |
IL146055A0 (en) | 1999-04-23 | 2002-07-25 | Alza Corp | Conjugate having a cleavable linkage for use in a liposome |
AU770390B2 (en) * | 1999-04-23 | 2004-02-19 | Alza Corporation | Releasable linkage and compositions containing same |
US7112337B2 (en) | 1999-04-23 | 2006-09-26 | Alza Corporation | Liposome composition for delivery of nucleic acid |
US7303760B2 (en) * | 1999-04-23 | 2007-12-04 | Alza Corporation | Method for treating multi-drug resistant tumors |
CN1110322C (zh) * | 1999-07-21 | 2003-06-04 | 中国医学科学院医药生物技术研究所 | 单克隆抗体Fab'-平阳霉素偶联物及其抗肿瘤作用 |
WO2001062968A2 (fr) * | 2000-02-25 | 2001-08-30 | General Atomics | Enzymes de liaison nucleique mutantes et leur application dans le diagnostic, la detection et la purification |
WO2001071352A2 (fr) * | 2000-03-17 | 2001-09-27 | The Salk Institute For Biological Studies | Compositions associees a la formation de complexes et leurs procedes d'utilisation |
US6610504B1 (en) | 2000-04-10 | 2003-08-26 | General Atomics | Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase |
CA2408921A1 (fr) * | 2000-05-10 | 2001-11-15 | Bristol-Myers Squibb Company | Polypeptides a base de 5'-monophosphate deshydrogenase inosine modifiee et leurs utilisations |
KR20030074637A (ko) | 2000-12-01 | 2003-09-19 | 셀 웍스 인크. | 글리코실화/갈락토실화된 펩티드, 이관능기적 링커 , 및뉴클레오티드성 단량성/중합체의 접합체, 및 관련 조성물및 사용 방법 |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
US7589180B2 (en) | 2001-05-11 | 2009-09-15 | Abbott Laboratories Inc. | Specific binding proteins and uses thereof |
MXPA03011094A (es) * | 2001-05-31 | 2004-12-06 | Medarex Inc | Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello. |
US7053188B2 (en) | 2002-02-22 | 2006-05-30 | Purdue Research Foundation | Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase |
US7384760B2 (en) * | 2004-04-30 | 2008-06-10 | General Atomics | Methods for assaying inhibitors of S-adenosylhomocysteine (SAH) hydrolase and S-adenosylmethionine (SAM)-dependent methyltransferase |
RU2402548C2 (ru) * | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
AU2005244980B2 (en) * | 2004-05-19 | 2011-09-15 | E. R. Squibb & Sons, L.L.C. | Chemical linkers and conjugates thereof |
US7541330B2 (en) * | 2004-06-15 | 2009-06-02 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
EP1789091B1 (fr) * | 2004-08-26 | 2010-08-25 | Piramal Life Sciences Limited | Promedicaments contenant de nouveaux liens bio-clivables |
ES2386366T3 (es) * | 2005-02-18 | 2012-08-17 | Medarex, Inc. | Anticuerpo monoclonal humano contra el antígeno de membrana específico de la próstata (PSMA) |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
JP5290756B2 (ja) * | 2005-09-26 | 2013-09-18 | メダレックス インコーポレイテッド | 抗体−薬剤コンジュゲート及びその使用 |
US7847105B2 (en) | 2005-10-26 | 2010-12-07 | Medarex, Inc. | Methods and compounds for preparing CC-1065 analogs |
WO2007059404A2 (fr) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Composes et conjugues cytotoxiques |
TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
KR20090122439A (ko) * | 2007-02-21 | 2009-11-30 | 메다렉스, 인코포레이티드 | 단일 아미노산을 갖는 화학적 링커 및 이의 접합체 |
JP5618549B2 (ja) | 2007-03-15 | 2014-11-05 | ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド | Egfr抗体及びsrc阻害剤を用いる治療方法及び関連製剤 |
EP3486653A1 (fr) | 2007-05-24 | 2019-05-22 | The United States Government as represented by The Department of Veterans Affairs | Utilisation du transporter l'ent2 pour traitement de la maladie du muscle scelettique |
JP5532486B2 (ja) | 2007-08-14 | 2014-06-25 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Egf受容体を標的とするモノクローナル抗体175ならびにその誘導体および用途 |
EP3492488A1 (fr) | 2007-08-22 | 2019-06-05 | The Regents of The University of California | Polypeptides de liaison activables et procédés d'identification et utilisation de ceux-ci |
AU2008302345A1 (en) * | 2007-09-19 | 2009-03-26 | Oncofluor, Inc. | Method for imaging and treating organs and tissues |
TR201903610T4 (tr) | 2008-05-27 | 2019-03-21 | Genzyme Corp | Alfa-melanosit uyarici hormonlarin peptid analoglari. |
JP2012511032A (ja) | 2008-12-05 | 2012-05-17 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | SPARC結合ScFv |
EP3543256A1 (fr) | 2009-01-12 | 2019-09-25 | Cytomx Therapeutics Inc. | Compositions d anticorps modifiées et leurs procédés de production et d'utilisation |
US9238878B2 (en) | 2009-02-17 | 2016-01-19 | Redwood Bioscience, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
CA2753294A1 (fr) | 2009-02-23 | 2010-08-26 | Cytomx Therapeutics, Inc. | Proproteines et leurs procedes d'utilisation |
AU2010253863B2 (en) | 2009-05-28 | 2016-01-28 | The United States Government As Represented By The Department Of Veterans Affairs | Amino acid sequences which enhance peptide conjugate solubility |
US8871744B2 (en) | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
GB201012410D0 (en) | 2010-07-23 | 2010-09-08 | Medical Res Council | Intracellular immunity |
CN103415621A (zh) | 2011-01-14 | 2013-11-27 | 雷德伍德生物科技股份有限公司 | 醛标记免疫球蛋白多肽及其使用方法 |
GB201202268D0 (en) | 2012-02-09 | 2012-03-28 | Medical Res Council | Intracellular immunity |
AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
ES2960619T3 (es) | 2014-02-28 | 2024-03-05 | Hangzhou Dac Biotech Co Ltd | Enlazadores cargados y sus usos para la conjugación |
CN107001477A (zh) | 2014-11-05 | 2017-08-01 | 南洋理工大学 | 经稳定化且自主的抗体vh结构域 |
NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
JP2019515677A (ja) | 2016-04-26 | 2019-06-13 | アール.ピー.シェーラー テクノロジーズ エルエルシー | 抗体複合体ならびにそれを作製および使用する方法 |
CN109803687B (zh) | 2016-06-15 | 2022-11-15 | 耶鲁大学 | 纳米载体向肿瘤的抗体介导的自催化靶向递送 |
US20190330317A1 (en) | 2016-06-15 | 2019-10-31 | Yale University | Anti-guanosine antibody as a molecular delivery vehicle |
US20210308277A1 (en) | 2016-11-14 | 2021-10-07 | Hangzhou Dac Biotech Co., Ltd. | Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers |
WO2019152806A1 (fr) | 2018-02-01 | 2019-08-08 | Yale University | Compositions et procédés permettant d'améliorer la translocation nucléaire |
EP4182475A2 (fr) | 2020-07-17 | 2023-05-24 | Onena Medicines S.L. | Anticorps dirigés contre des protéines lefty |
EP4079327A1 (fr) * | 2021-04-22 | 2022-10-26 | Centaurus Polytherapeutics | Charges utiles pour conjugués de médicaments et leur utilisation pour le traitement du cancer |
EP4377338A2 (fr) | 2021-07-27 | 2024-06-05 | Novab, Inc. | Anticorps anti-vlrb génétiquement modifiés présentant des fonctions effectrices immunitaires |
WO2023056450A1 (fr) | 2021-09-30 | 2023-04-06 | Yale University | Compositions et méthodes pour le traitement de la polykystose rénale autosomique dominante et d'autres maladies ayant une activité de mtor régulée à la hausse |
WO2024050524A1 (fr) | 2022-09-01 | 2024-03-07 | University Of Georgia Research Foundation, Inc. | Compositions et procédés de direction de l'apolipoprotéine l1 en vue d'induire la mort de cellules de mammifère |
WO2024064752A2 (fr) | 2022-09-20 | 2024-03-28 | Yale University | Compositions d'adhésifs humides dérivés d'adhésines de biofilm vibrio cholerae et procédés associés |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4003792A (en) * | 1967-07-01 | 1977-01-18 | Miles Laboratories, Inc. | Conjugates of acid polysaccharides and complex organic substances |
WO1983000150A1 (fr) * | 1981-07-02 | 1983-01-20 | Walton, Alan, G. | Complexe medicamenteux de glycosaminoglycan |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
JPH0651643B2 (ja) * | 1983-01-19 | 1994-07-06 | 帝人株式会社 | 殺細胞性修飾免疫グロブリン及びその製造方法 |
US4625014A (en) * | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
DE3684887D1 (de) * | 1985-11-29 | 1992-05-21 | Biomatrix Inc | Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung. |
GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
-
1987
- 1987-11-23 US US07/124,313 patent/US4952394A/en not_active Expired - Fee Related
-
1988
- 1988-09-13 ZA ZA886811A patent/ZA886811B/xx unknown
- 1988-11-10 CA CA000582744A patent/CA1303524C/fr not_active Expired - Fee Related
- 1988-11-14 NZ NZ226955A patent/NZ226955A/en unknown
- 1988-11-18 FI FI885361A patent/FI885361A/fi not_active IP Right Cessation
- 1988-11-21 IL IL88428A patent/IL88428A0/xx unknown
- 1988-11-22 JP JP63295890A patent/JPH02111731A/ja active Pending
- 1988-11-22 NO NO885199A patent/NO169958C/no unknown
- 1988-11-22 EP EP88119419A patent/EP0317957B1/fr not_active Expired - Lifetime
- 1988-11-22 AT AT88119419T patent/ATE81986T1/de not_active IP Right Cessation
- 1988-11-22 DE DE8888119419T patent/DE3875700T2/de not_active Expired - Fee Related
- 1988-11-22 KR KR1019880015383A patent/KR910005887B1/ko not_active IP Right Cessation
- 1988-11-22 DK DK651088A patent/DK651088A/da not_active Application Discontinuation
- 1988-11-23 AU AU25824/88A patent/AU617380B2/en not_active Ceased
- 1988-11-23 PT PT89062A patent/PT89062B/pt active IP Right Grant
-
1992
- 1992-11-12 GR GR920402021T patent/GR3006211T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO169958C (no) | 1992-08-26 |
CA1303524C (fr) | 1992-06-16 |
NO885199D0 (no) | 1988-11-22 |
EP0317957A2 (fr) | 1989-05-31 |
JPH02111731A (ja) | 1990-04-24 |
PT89062B (pt) | 1993-07-30 |
AU2582488A (en) | 1989-05-25 |
AU617380B2 (en) | 1991-11-28 |
ATE81986T1 (de) | 1992-11-15 |
EP0317957B1 (fr) | 1992-11-04 |
ZA886811B (en) | 1989-07-26 |
KR890007724A (ko) | 1989-07-05 |
DE3875700T2 (de) | 1993-03-18 |
NO169958B (no) | 1992-05-18 |
GR3006211T3 (fr) | 1993-06-21 |
NO885199L (no) | 1989-05-24 |
EP0317957A3 (en) | 1989-07-05 |
DK651088D0 (da) | 1988-11-22 |
DE3875700D1 (de) | 1992-12-10 |
NZ226955A (en) | 1991-11-26 |
IL88428A0 (en) | 1989-06-30 |
PT89062A (pt) | 1989-11-30 |
KR910005887B1 (ko) | 1991-08-06 |
US4952394A (en) | 1990-08-28 |
FI885361A0 (fi) | 1988-11-18 |
FI885361A (fi) | 1989-05-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |