ATE152917T1 - Polymere träger zur freisetzung kovalent gebundener wirkstoffe - Google Patents
Polymere träger zur freisetzung kovalent gebundener wirkstoffeInfo
- Publication number
- ATE152917T1 ATE152917T1 AT91918218T AT91918218T ATE152917T1 AT E152917 T1 ATE152917 T1 AT E152917T1 AT 91918218 T AT91918218 T AT 91918218T AT 91918218 T AT91918218 T AT 91918218T AT E152917 T1 ATE152917 T1 AT E152917T1
- Authority
- AT
- Austria
- Prior art keywords
- polymeric carrier
- alpha
- side chains
- amino acids
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59008690A | 1990-09-28 | 1990-09-28 | |
US76512691A | 1991-09-25 | 1991-09-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE152917T1 true ATE152917T1 (de) | 1997-05-15 |
Family
ID=27080742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91918218T ATE152917T1 (de) | 1990-09-28 | 1991-09-27 | Polymere träger zur freisetzung kovalent gebundener wirkstoffe |
Country Status (6)
Country | Link |
---|---|
US (1) | US5549883A (de) |
EP (1) | EP0510132B1 (de) |
AT (1) | ATE152917T1 (de) |
AU (1) | AU8730691A (de) |
DE (1) | DE69126124T2 (de) |
WO (1) | WO1992005802A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2094785A1 (en) * | 1992-05-08 | 1993-11-09 | Jean Gariepy | Metal chelating peptide |
US6203775B1 (en) * | 1993-03-19 | 2001-03-20 | The General Hospital Corporation | Chelating polymers for labeling of proteins |
US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
WO1994025071A1 (en) * | 1993-05-05 | 1994-11-10 | Keith Rose | Polyoxime compounds and their preparation |
US6001364A (en) | 1993-05-05 | 1999-12-14 | Gryphon Sciences | Hetero-polyoxime compounds and their preparation by parallel assembly |
PT697891E (pt) | 1993-05-05 | 2000-09-29 | Keith Rose | Compostos de polioximas e sua preparacao |
US6413935B1 (en) * | 1993-09-14 | 2002-07-02 | Epimmune Inc. | Induction of immune response against desired determinants |
DE69612093T2 (de) * | 1995-06-07 | 2001-10-31 | Martin Sevoian | Auf antigen verarbeitende zellen zielgerichtete konjugate ein polyaminosäure rückgrat und ein nicht-steroidales antiphlogistikum enthaltend |
AU4335299A (en) * | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Bradykinin antagonists |
US6897305B2 (en) | 1998-06-08 | 2005-05-24 | Theravance, Inc. | Calcium channel drugs and uses |
AU4543899A (en) * | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
US6713651B1 (en) | 1999-06-07 | 2004-03-30 | Theravance, Inc. | β2-adrenergic receptor agonists |
AU4426499A (en) * | 1998-06-08 | 1999-12-30 | Theravance, Inc. | Novel potassium channel drugs and their uses |
CA2318806A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding agents that modulate the 5-ht transporter |
WO1999064046A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multivalent agonists, partial agonists, inverse agonists and antagonists of the 5-ht3 receptors |
WO1999064036A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Novel therapeutic agents for macromolecular structures |
US6362371B1 (en) | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
EP1085845A2 (de) * | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Mehrfachbindende inhibitoren von cyclooxygenase-2 |
WO1999064044A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Novel therapeutic agents that modulate 5-ht receptors |
SG80041A1 (en) * | 1998-06-08 | 2001-04-17 | Advanced Medicine Inc | Muscarinic receptor antagonists |
EP1085863A1 (de) * | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Neue medikamente zur behandlung von störungen, die durch kalziumkanäle hervorgerufen sind und ihre verwendung |
AU4543699A (en) | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Multibinding inhibitors of hmg-coa reductase |
US7101909B2 (en) | 1998-10-12 | 2006-09-05 | Theravance, Inc. | Calcium channel drugs and uses |
US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
US6593497B1 (en) | 1999-06-02 | 2003-07-15 | Theravance, Inc. | β2-adrenergic receptor agonists |
US6683115B2 (en) | 1999-06-02 | 2004-01-27 | Theravance, Inc. | β2-adrenergic receptor agonists |
US6479498B1 (en) | 1999-06-04 | 2002-11-12 | Theravance, Inc. | Sodium channel drugs and uses |
UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
US20100029911A1 (en) * | 2004-11-24 | 2010-02-04 | Aplagen Gmbh | Method For Solid-Phase Peptide Synthesis And Purification |
WO2009003188A2 (en) * | 2007-06-27 | 2008-12-31 | Cedars-Sinai Medical Center | N-terminal specific chemical labeling for proteomics applications |
US20230277682A1 (en) * | 2022-01-14 | 2023-09-07 | Regeneron Pharmaceuticals, Inc. | Verrucarin a derivatives and antibody drug conjugates thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541436A (en) * | 1976-02-02 | 1979-02-28 | Searle & Co | Immunological materials |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
US4587046A (en) * | 1982-05-18 | 1986-05-06 | The Regents Of The University Of California | Drug-carrier conjugates |
US4485093A (en) * | 1982-08-13 | 1984-11-27 | Runge Richard G | Immunotoxin conjugate which comprises arsanilic acid, useful for treating malignant tumors, particularly pancreatic cancer |
JPS59116232A (ja) * | 1982-12-24 | 1984-07-05 | Teijin Ltd | 細胞毒性複合体及びその製造法 |
JPS60243121A (ja) * | 1984-05-17 | 1985-12-03 | Sumitomo Chem Co Ltd | 細胞毒性物質を結合した反応性高分子 |
ATE66469T1 (de) * | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
US4744981A (en) * | 1985-10-17 | 1988-05-17 | Neorx Corporation | Trichothecene antibody conjugates |
US4699784A (en) * | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
US4732974A (en) * | 1986-03-05 | 1988-03-22 | Mallinckrodt, Inc. | Metal ion labeling of carrier molecules |
US4950469A (en) * | 1986-05-30 | 1990-08-21 | La Jolla Pharmaceutical Company | D-GL conjugate therapy |
US4997913A (en) * | 1986-06-30 | 1991-03-05 | Oncogen | pH-sensitive immunoconjugates and methods for their use in tumor therapy |
IN165717B (de) * | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
US4894226A (en) * | 1986-11-14 | 1990-01-16 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polyproline conjugation |
DE3889956T2 (de) * | 1987-03-26 | 1994-12-22 | Neorx Corp | Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie. |
US4952394A (en) * | 1987-11-23 | 1990-08-28 | Bristol-Myers Company | Drug-monoclonal antibody conjugates |
US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
US5094848A (en) * | 1989-06-30 | 1992-03-10 | Neorx Corporation | Cleavable diphosphate and amidated diphosphate linkers |
US5162505A (en) * | 1989-09-19 | 1992-11-10 | Centocor | Proteins modified with positively charged carriers and compositions prepared therefrom |
-
1991
- 1991-09-27 WO PCT/US1991/007143 patent/WO1992005802A1/en active IP Right Grant
- 1991-09-27 AT AT91918218T patent/ATE152917T1/de not_active IP Right Cessation
- 1991-09-27 EP EP91918218A patent/EP0510132B1/de not_active Expired - Lifetime
- 1991-09-27 AU AU87306/91A patent/AU8730691A/en not_active Abandoned
- 1991-09-27 DE DE69126124T patent/DE69126124T2/de not_active Expired - Fee Related
-
1993
- 1993-06-03 US US08/071,357 patent/US5549883A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0510132A4 (en) | 1993-02-24 |
DE69126124D1 (de) | 1997-06-19 |
EP0510132B1 (de) | 1997-05-14 |
WO1992005802A1 (en) | 1992-04-16 |
EP0510132A1 (de) | 1992-10-28 |
AU8730691A (en) | 1992-04-28 |
US5549883A (en) | 1996-08-27 |
DE69126124T2 (de) | 1997-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE152917T1 (de) | Polymere träger zur freisetzung kovalent gebundener wirkstoffe | |
DE69128791D1 (de) | Modifizierte antikörper mit kontrollierter clearance-zeit | |
FI955319A0 (fi) | 2-pyridyylimetyleenipolyatsamakrosyklofosfonihappoja, niiden komplekseja ja johdannaisia käytettäväksi vasta-aineina | |
NO20010021L (no) | Trifunksjonelt reagens for konjugering til et biomolekyl | |
ATE243230T1 (de) | Gelierte magnetisch markierte molekularsysteme als nmr-bilderzeugungsmittel | |
FI955336A (fi) | Varjoaineina käytettäviä trisyklopolyatsamakrosyklofosfonihappoja, niiden komplekseja ja johdannaisia | |
ES2187676T3 (es) | Conjugados de un polipeptido y un polimero biocompatible. | |
KR920000332A (ko) | 방광암세포 치료법 | |
EP0579802A4 (en) | Bicycle-polyazamacrocyclocarboxylic acid complexes, conjugates, preparation and use as contrast agents | |
IL104060A0 (en) | Bicyclopolyazamacrocyclophosphonic acids,their complexes and conjugates,for use as contrast agents,and processes for their preparation | |
ATE168695T1 (de) | Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisierten tumorspezifischen enzym- konjugaten | |
DE3862017D1 (de) | Pharmazeutische zubereitung zur behandlung von tinea pedis. | |
DE3568583D1 (en) | A carrier with an immobilised, biologically active substance, a method for its preparation, and the use thereof | |
JPS6413025A (en) | Antitumoral and manufacture | |
DE69228869D1 (de) | Stabilisierte antikörperfragmente | |
FR2622444B1 (fr) | Application de dinitro-trinitrophenyle et de ses derives ou d'anticorps anti-nitrophenyles a la modification de l'interaction entre des cellules sensibles d'un hote et un agent pathogene | |
WO2002053091A3 (fr) | Association medicamenteuse d'une biguanine (metformine) et d'arginine | |
ES2109136A1 (es) | Polimeros biodegradables de esqueleto carbonado de acetales de centeno y alcoholes, procedimiento para su obtencion y composicion y utilizacion correspondientes. | |
FR2183679A1 (en) | Modified immunoserumglobulin prepns - for intravenous injection-selective redn with dithiothreitol and alkylation-free from | |
NZ335081A (en) | Conjugates containing a cytotoxic drug attached via a bond or linker to an oligopeptide comprising at least one cyclic amino acid having a hydrophilic group useful in the treatment of prostate cancer | |
MY141501A (en) | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents and processes for their preparation | |
MY109649A (en) | Bicyclopol yazamacrocyclocarboxylic acid complexes, and conjugates, processes for their prepration, and use as contrast agents | |
KOEPKE | THE ROLE OF BRAIN DOPAMINE AND NOREPINEPHRINE IN THE ACQUISITION OF A CONDITIONED FLAVOR AVERSION IN THE DEVELOPING RAT (6-HYDROXYDOPAMINE, IMPULSIVITY, ATTENTION DEFICIT DISORDER) | |
SU731750A1 (ru) | Аффинный адсорбент для удаления из крови билирубина и других токсичных продуктов и способ его получения | |
GR900100554A (en) | Compositions and in situ methods for forming films on body tissue |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |