DK567678A - Fremgangsmaade til fremstilling af 13-halogen- og13-deoxyderivater af c-076 macrolider - Google Patents

Fremgangsmaade til fremstilling af 13-halogen- og13-deoxyderivater af c-076 macrolider

Info

Publication number
DK567678A
DK567678A DK567678A DK567678A DK567678A DK 567678 A DK567678 A DK 567678A DK 567678 A DK567678 A DK 567678A DK 567678 A DK567678 A DK 567678A DK 567678 A DK567678 A DK 567678A
Authority
DK
Denmark
Prior art keywords
deoxyde
halogene
macrolides
derivatives
procedure
Prior art date
Application number
DK567678A
Other languages
English (en)
Other versions
DK152129C (da
DK152129B (da
Inventor
J C Chcbala
M H Fisher
H H Mrozik
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27127647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK567678(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US05/861,810 external-priority patent/US4171314A/en
Priority claimed from US05/861,919 external-priority patent/US4173571A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK567678A publication Critical patent/DK567678A/da
Publication of DK152129B publication Critical patent/DK152129B/da
Application granted granted Critical
Publication of DK152129C publication Critical patent/DK152129C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
DK567678A 1977-12-19 1978-12-18 Analogifremgangsmaade til fremstilling af 13-deoxyderivater af c-076 aglyconforbindelser og c-076 aglyconforbindelser til brug som udgangsmaterialer derved DK152129C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US05/861,810 US4171314A (en) 1977-12-19 1977-12-19 13-Halo and 13-deoxy C-076 compounds
US05/861,919 US4173571A (en) 1977-12-19 1977-12-19 13-Halo and 13-deoxy derivatives of C-076 compounds
US86191977 1977-12-19
US86181077 1977-12-19

Publications (3)

Publication Number Publication Date
DK567678A true DK567678A (da) 1979-07-13
DK152129B DK152129B (da) 1988-02-01
DK152129C DK152129C (da) 1988-08-08

Family

ID=27127647

Family Applications (1)

Application Number Title Priority Date Filing Date
DK567678A DK152129C (da) 1977-12-19 1978-12-18 Analogifremgangsmaade til fremstilling af 13-deoxyderivater af c-076 aglyconforbindelser og c-076 aglyconforbindelser til brug som udgangsmaterialer derved

Country Status (14)

Country Link
EP (1) EP0002615B2 (da)
JP (1) JPS54145699A (da)
AU (1) AU527532B2 (da)
CA (1) CA1114370A (da)
DE (1) DE2862331D1 (da)
DK (1) DK152129C (da)
ES (1) ES476148A1 (da)
HU (1) HU181458B (da)
IL (1) IL56149A (da)
IT (1) IT1102350B (da)
PH (1) PH16612A (da)
PL (1) PL123050B1 (da)
YU (1) YU39431B (da)
ZA (1) ZA787081B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
JPS60126289A (ja) * 1983-11-14 1985-07-05 Sankyo Co Ltd ミルベマイシン類の５−カ−ボネ−ト誘導体
FR2570390B1 (fr) * 1984-09-14 1987-11-27 Glaxo Group Ltd Nouveaux composes antibiotiques et procede de preparation
EP0180539A1 (de) * 1984-09-18 1986-05-07 Ciba-Geigy Ag 13-Halo- und 13-Hydroximilbemycine
HUT39739A (en) * 1984-12-04 1986-10-29 Ciba Geigy Ag Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
GB2168345B (en) * 1984-12-14 1988-05-25 Ciba Geigy Ag Pesticidal 13b-substituted milbemycin derivatives
US4587247A (en) * 1985-02-25 1986-05-06 Merck & Co., Inc. Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
US4666937A (en) * 1985-03-04 1987-05-19 Merck & Co., Inc. Avermectin bioconversion products
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
US4778809A (en) * 1985-08-23 1988-10-18 Ciba-Geigy Corporation 5-esters of milbemycins for controlling parasitic pests
IE67373B1 (en) * 1985-09-13 1996-03-20 American Cyanamid Co Macrolide antibiotics and their preparation
JPH0678342B2 (ja) * 1986-01-07 1994-10-05 三共株式会社 新規マクロライド化合物
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
ATE82017T1 (de) * 1986-09-12 1992-11-15 American Cyanamid Co 23-deoxy-derivate von ll-f28249-verbindungen.
US4849446A (en) * 1986-09-12 1989-07-18 American Cyanamid Company 23-imino derivatives of 23-keto compounds
US4886828A (en) * 1986-09-12 1989-12-12 American Cyanamid Company Δ22 -derivatives of LL-F28249 compounds
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
EP0260537A1 (en) * 1986-09-12 1988-03-23 American Cyanamid Company 13-Deoxy-23-oxo(keto) and 23-imino derivatives of 13-deoxy C-076-aglycone compounds
US5019589A (en) * 1986-09-12 1991-05-28 American Cyanamid Company Δ23 -LL-F28249 compounds
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ATE87926T1 (de) * 1987-11-09 1993-04-15 Pfizer Ethylierte avermectine.
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
US4895837A (en) * 1988-01-29 1990-01-23 Merck & Co., Inc. Avermectin derivatives
GB8815967D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Antiparasitic agents
CA1339481C (en) * 1988-10-18 1997-09-30 Shieh-Shung Tom Chen Anthelmintic bioconversion products
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914624A (da) * 1972-06-08 1974-02-08
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4093629A (en) * 1977-04-11 1978-06-06 Merck & Co., Inc. Derivatives of antibiotic substance milbemycin and processes therefor

Also Published As

Publication number Publication date
EP0002615A2 (en) 1979-06-27
AU527532B2 (en) 1983-03-10
DK152129C (da) 1988-08-08
DE2862331D1 (en) 1983-11-10
DK152129B (da) 1988-02-01
PL211838A1 (da) 1980-03-10
EP0002615B2 (en) 1990-01-17
HU181458B (en) 1983-07-28
JPS54145699A (en) 1979-11-14
PL123050B1 (en) 1982-09-30
JPH0341158B2 (da) 1991-06-21
CA1114370A (en) 1981-12-15
EP0002615B1 (en) 1983-10-05
AU4238978A (en) 1979-06-28
PH16612A (en) 1983-11-28
IL56149A (en) 1989-09-28
IL56149A0 (en) 1979-03-12
EP0002615A3 (en) 1979-07-11
IT1102350B (it) 1985-10-07
YU39431B (en) 1984-12-31
YU287578A (en) 1982-10-31
ES476148A1 (es) 1979-11-16
ZA787081B (en) 1980-08-27
IT7831028A0 (it) 1978-12-19

Similar Documents

Publication Publication Date Title
DK567678A (da) Fremgangsmaade til fremstilling af 13-halogen- og13-deoxyderivater af c-076 macrolider
DK140878A (da) Fremgangsmaade til fremstilling af acetamidderivater
DK63178A (da) Fremgangsmaade til fremstilling af pyrrodinderivater
DK434478A (da) Derivater af c-076 macrolider
DK148751C (da) Fremgangsmaade til fremstilling af cyclosporinderivater
DK536178A (da) Fremgangsmaade til fremstilling af stilbenderivater
DK481678A (da) Fremgangsmaade til fremstilling af imidazolidinderivater
DK180878A (da) Fremgangsmaade til fremstilling af imidazoaziner og imidazodiaziner
DK445078A (da) Fremgangsmaade til fremstilling af 4,5-dihydro-2-alkoxycarbonylamino-5-carbocyklisk arylimidazoler og derivater deraf
DK312878A (da) Fremgangsmaade til fremstilling af indolderivater
DK30578A (da) Fremgangsmaade til fremstilling af aminoalkoxyphenylderivater
DK50778A (da) Fremgangsmaade til fremstilling af oxadiazolopyrimidinderivater
DK309678A (da) Fremgangsmaade til fremstilling af tetralinderivater
DK267078A (da) Fremgangsmaade til fremstilling af n1-glucofuranosid-6-yl-n3-n3-nitrosourinstoffer og derivater deraf
DK458977A (da) Fremgangsmaade til fremstilling af maytansinol og derivater deraf
DK300978A (da) Fremgangsmaade til fremstilling af indolderivater
DK50878A (da) Fremgangsmaade til fremstilling af oxadiazolopyrimidinderivater
DK155285C (da) Fremgangsmaade til fremstilling af thienopyridinderivater
DK574978A (da) Fremgangsmaade til fremstilling af polyfluorhydroxyisopropylderivater af cicycliske og tricycliske carbostyriler
DK246878A (da) Fremgangsmaade til fremstilling af acylderivater
NL7801350A (nl) Azetidinon derivaten en de bereidingswijze daarvan.
DK261278A (da) Fremgangsmaade til fremstilling af 24-dehydrovitamin d-3-derivater
DK61778A (da) Fremgangsmaade til fremstilling af everninominderivater
DK214678A (da) Fremgangsmaade til fremstilling af benzazepinderivater
DK417778A (da) Fremgangsmaade til fremstilling af thienobenzazepinderivater

Legal Events

Date Code Title Description
PBP Patent lapsed