DK564585A - Immobiliseret antistofsystem og fremgangsmaade til dets fremstilling - Google Patents
Immobiliseret antistofsystem og fremgangsmaade til dets fremstilling Download PDFInfo
- Publication number
- DK564585A DK564585A DK564585A DK564585A DK564585A DK 564585 A DK564585 A DK 564585A DK 564585 A DK564585 A DK 564585A DK 564585 A DK564585 A DK 564585A DK 564585 A DK564585 A DK 564585A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- manufacturing
- immobilized antibody
- antibody system
- immobilized
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3244—Non-macromolecular compounds
- B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
- B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
- Y10S530/814—Cellulose or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/861—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgG3, IgG4, IgA, or IgY
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/862—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgE or IgD
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/678,953 US4560504A (en) | 1984-12-06 | 1984-12-06 | Carboxyl anchored immobilized antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
DK564585D0 DK564585D0 (da) | 1985-12-05 |
DK564585A true DK564585A (da) | 1986-06-07 |
Family
ID=24725011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK564585A DK564585A (da) | 1984-12-06 | 1985-12-05 | Immobiliseret antistofsystem og fremgangsmaade til dets fremstilling |
Country Status (7)
Country | Link |
---|---|
US (1) | US4560504A (da) |
EP (1) | EP0184454A3 (da) |
JP (1) | JPS61181966A (da) |
CA (1) | CA1243968A (da) |
DK (1) | DK564585A (da) |
ES (1) | ES8704270A1 (da) |
IN (1) | IN163720B (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4693985A (en) * | 1984-08-21 | 1987-09-15 | Pall Corporation | Methods of concentrating ligands and active membranes used therefor |
EP0256344B1 (de) * | 1986-08-18 | 1992-04-22 | Wolfgang G.K. Dr. Müller-Lierheim | Kontaktlinse |
US4841024A (en) * | 1986-09-15 | 1989-06-20 | Becton Dickinson And Company | Purification of antibodies |
US4812414A (en) * | 1987-09-18 | 1989-03-14 | Eastman Kodak Company | Immunoreactive reagent particles having tracer, receptor molecules and protein of pI less than 6 |
US4886836A (en) * | 1987-06-03 | 1989-12-12 | Pall Corporation | Activated medium with low non-specific protein adsorption |
JPS6439555A (en) * | 1987-08-05 | 1989-02-09 | Teijin Ltd | Simple device for stabilized immune detection and immune detection |
DE3740471A1 (de) * | 1987-11-28 | 1989-06-08 | Boehringer Mannheim Gmbh | Testtraeger zur analyse einer probenfluessigkeit und verfahren zu seiner herstellung |
US5205929A (en) * | 1988-02-03 | 1993-04-27 | Regents Of The University Of Minnesota | High stability porous zirconium oxide spherules |
EP0524663A1 (en) * | 1988-02-03 | 1993-01-27 | The Regents Of The University Of Minnesota | High stability porous zirconium oxide spherules and support comprising same |
US5322678A (en) * | 1988-02-17 | 1994-06-21 | Neorx Corporation | Alteration of pharmacokinetics of proteins by charge modification |
JP2761881B2 (ja) * | 1988-03-10 | 1998-06-04 | チッソ株式会社 | 抗体を固定化したアフイニテイクロマトグラフイ用担体 |
WO1991000109A1 (en) * | 1989-07-05 | 1991-01-10 | Kukita, Takeshi | Carrier having antibody immobilized thereto, process for its production and its use |
US5266500A (en) * | 1989-08-03 | 1993-11-30 | Eastman Kodak Company | Attachment of compounds to polymeric particles using dication ethers and a kit containing same |
US5271833A (en) * | 1990-03-22 | 1993-12-21 | Regents Of The University Of Minnesota | Polymer-coated carbon-clad inorganic oxide particles |
US5108597A (en) * | 1990-03-22 | 1992-04-28 | Regents Of The University Of Minnesota | Carbon-clad zirconium oxide particles |
US5254262A (en) * | 1990-03-22 | 1993-10-19 | Regents Of The University Of Minnesota | Carbon-clad zirconium oxide particles |
US5308641A (en) * | 1993-01-19 | 1994-05-03 | Medtronic, Inc. | Biocompatibility of solid surfaces |
DE4341524C2 (de) * | 1993-12-06 | 1997-01-16 | Gluesenkamp Karl Heinz Dr | Verfahren zur Immobilisierung von Biomolekülen und Affinitätsliganden an polymere Träger |
GB2287707B (en) * | 1994-03-25 | 1998-02-25 | Erba Carlo Spa | Intermediates for biologically active products |
EP0804734B1 (en) * | 1994-05-13 | 2005-05-04 | Miltenyi Biotec GmbH | Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood |
AU2001249437A1 (en) * | 2000-03-24 | 2001-10-08 | Lyles, Mark B | Diagnostic devices containing porous material |
US20110123819A1 (en) * | 2007-12-21 | 2011-05-26 | Ge Healthcare Bio-Sciences Ab | Method for sterilization of chemically activated solid support materials |
JP5629306B2 (ja) * | 2010-02-26 | 2014-11-19 | 興和株式会社 | 生物由来の生理活性物質の測定方法及び測定用試薬キット |
TWI546122B (zh) * | 2011-02-25 | 2016-08-21 | 東麗股份有限公司 | 血液成分吸附用載體及血液成分吸附管柱 |
WO2020261221A1 (en) * | 2019-06-26 | 2020-12-30 | Waters Technologies Corporation | Coatings with immobilized affinity ligands and enzymes and use thereof in liquid chromatography assays |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5011448A (da) * | 1973-06-04 | 1975-02-05 | ||
SE405897B (sv) * | 1974-09-27 | 1979-01-08 | Pharmacia Ab | Sett att utnyttja s k hydrofoba bindningar vid immunkemiska bestemningsmetoder |
US3951748A (en) * | 1974-11-11 | 1976-04-20 | Medical Products, Inc. | Sensitized matrix for detection of disease |
CA1083508A (fr) * | 1975-11-13 | 1980-08-12 | Jacques Grange | Supports porteurs de chaines laterales, procedes d'obtention de ces supports, procedes de fixation de composes organiques comportant un residu glucidique sur lesdits supports, produits et reactifs resultant de ladite fixation chimique |
JPS52115046A (en) * | 1976-03-22 | 1977-09-27 | Mitsubishi Electric Corp | Elevator group control system |
US4141857A (en) * | 1976-04-30 | 1979-02-27 | Uop Inc. | Support matrices for immobilized enzymes |
JPS52129238A (en) * | 1977-03-07 | 1977-10-29 | Canon Inc | Driving unit of printer |
US4140662A (en) * | 1977-03-25 | 1979-02-20 | Ortho Diagnostics, Inc. | Attachment of proteins to inert particles |
GB2013211B (en) * | 1978-01-26 | 1982-06-30 | Technicon Instr | Immunoassays using f(ab')2 fragments |
JPS608745B2 (ja) * | 1978-02-14 | 1985-03-05 | 三洋化成工業株式会社 | 免疫活性物質−つや消しガラス複合体,その製造法及び該複合体を含有してなる測定試薬 |
JPS54147913A (en) * | 1978-05-12 | 1979-11-19 | Unitika Ltd | Preparation of immunoadsorbent |
JPS54158994A (en) * | 1978-06-06 | 1979-12-15 | Shinotesuto Kenkiyuushiyo Kk | Method and reagent for measuring antigen substance |
US4260678A (en) * | 1979-02-23 | 1981-04-07 | Corning Glass Works | Determining creatine kinase isoenzmes via immobilized antibody-isoenzyme complexes |
US4381291A (en) * | 1979-02-23 | 1983-04-26 | Ab Fortia | Measurement of free ligands |
FR2455743A1 (fr) * | 1979-05-02 | 1980-11-28 | Goella Laboratoires | Procede et dispositif pour le dosage des lipoproteines seriques |
US4347312A (en) * | 1980-03-20 | 1982-08-31 | Research Triangle Institute | Detection of antibiotics in milk |
US4581337A (en) * | 1983-07-07 | 1986-04-08 | E. I. Du Pont De Nemours And Company | Polyether polyamines as linking agents for particle reagents useful in immunoassays |
JPS576362A (en) * | 1980-06-12 | 1982-01-13 | Unitika Ltd | Production of immune adsorptive body |
US4284553A (en) * | 1980-06-20 | 1981-08-18 | North Carolina State University At Raleigh | Reversible method for covalent immobilization of biochemicals |
JPS5744854A (en) * | 1980-08-29 | 1982-03-13 | Nippi:Kk | Reagent for serological measurement |
US4357311A (en) * | 1980-10-03 | 1982-11-02 | Warner-Lambert Company | Substrate for immunoassay and means of preparing same |
JPS5853757A (ja) * | 1981-09-25 | 1983-03-30 | Denki Kagaku Kogyo Kk | 免疫アフイニテイクロマトグラフイ−用吸着体及びその製法 |
US4361509A (en) * | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
SE8200442L (sv) * | 1982-01-27 | 1983-07-28 | Forsvarets Forsknings | Forfarande vid detektion av organiska molekyler, sasom biomolekyler |
JPS5921319A (ja) * | 1982-07-24 | 1984-02-03 | 株式会社スズテック | 床土を育苗箱に供給する装置 |
JPS5942452A (ja) * | 1982-09-02 | 1984-03-09 | Sekisui Chem Co Ltd | 免疫化学的測定試薬用担体の製造方法 |
-
1984
- 1984-12-06 US US06/678,953 patent/US4560504A/en not_active Expired - Fee Related
-
1985
- 1985-12-02 CA CA000496648A patent/CA1243968A/en not_active Expired
- 1985-12-05 IN IN1027/DEL/85A patent/IN163720B/en unknown
- 1985-12-05 DK DK564585A patent/DK564585A/da not_active Application Discontinuation
- 1985-12-05 ES ES549633A patent/ES8704270A1/es not_active Expired
- 1985-12-05 EP EP85308861A patent/EP0184454A3/en not_active Withdrawn
- 1985-12-06 JP JP60274847A patent/JPS61181966A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0184454A2 (en) | 1986-06-11 |
DK564585D0 (da) | 1985-12-05 |
ES549633A0 (es) | 1987-03-16 |
IN163720B (da) | 1988-10-29 |
CA1243968A (en) | 1988-11-01 |
JPS61181966A (ja) | 1986-08-14 |
EP0184454A3 (en) | 1987-09-30 |
ES8704270A1 (es) | 1987-03-16 |
US4560504A (en) | 1985-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |