DK561881A - Farmaceutiske phenolether-forbindelser og mellemprodukter for disse samt fremgangsmaade til deres fremstilling - Google Patents
Farmaceutiske phenolether-forbindelser og mellemprodukter for disse samt fremgangsmaade til deres fremstillingInfo
- Publication number
- DK561881A DK561881A DK561881A DK561881A DK561881A DK 561881 A DK561881 A DK 561881A DK 561881 A DK561881 A DK 561881A DK 561881 A DK561881 A DK 561881A DK 561881 A DK561881 A DK 561881A
- Authority
- DK
- Denmark
- Prior art keywords
- phenolether
- intermediates
- pharmaceutical
- procedures
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/74—Unsaturated compounds containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/30—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8040512 | 1980-12-18 | ||
| GB8040512 | 1980-12-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK561881A true DK561881A (da) | 1982-06-19 |
| DK160866B DK160866B (da) | 1991-04-29 |
| DK160866C DK160866C (da) | 1991-10-14 |
Family
ID=10518062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK561881A DK160866C (da) | 1980-12-18 | 1981-12-17 | Analogifremgangsmaade til fremstilling af phenoletherforbindelser |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4535183A (da) |
| EP (1) | EP0054924B1 (da) |
| JP (1) | JPS57145844A (da) |
| DE (1) | DE3175083D1 (da) |
| DK (1) | DK160866C (da) |
| FI (1) | FI72510C (da) |
| GB (1) | GB2090830B (da) |
| GR (1) | GR76950B (da) |
| HU (1) | HU190371B (da) |
| IL (1) | IL64573A (da) |
| IT (1) | IT1193786B (da) |
| OA (1) | OA06998A (da) |
| ZA (1) | ZA818741B (da) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8318889D0 (en) * | 1983-07-13 | 1983-08-17 | Lilly Industries Ltd | Pharmaceutical compounds |
| US4887995A (en) * | 1985-01-22 | 1989-12-19 | University Of Pittsburgh | Method of treating sickle cell anemia |
| US4731381A (en) * | 1986-04-04 | 1988-03-15 | Merck & Co., Inc. | Method of treating a person for sickle cell anemia |
| IL98405A0 (en) * | 1990-06-11 | 1992-07-15 | Fmc Corp | Pharmaceutical compositions containing enzyme inhibiting agents |
| TW209866B (da) * | 1991-03-20 | 1993-07-21 | Hoechst Ag | |
| US5872151A (en) * | 1992-10-01 | 1999-02-16 | Glaxo Wellcome Inc. | Immunopotentiatory agents and physiologically acceptable salts thereof |
| SG48993A1 (en) * | 1992-10-01 | 1998-05-18 | Wellcome Found | Immunopotentiatory agent and physiologically acceptable salts thereof |
| US5958980A (en) * | 1993-08-26 | 1999-09-28 | Glaxo Wellcome, Inc. | Immunopotentiatory agent and physiologically acceptable salts thereof |
| US6068834A (en) * | 1994-03-04 | 2000-05-30 | The Procter & Gamble Company | Skin lightening compositions |
| BR9610207A (pt) * | 1995-08-28 | 1999-02-02 | American Home Prod | Acidos fenóxi acéticos como inibidores da aldose redutase e agentes anti-hiperglicêmicos |
| JP4316688B2 (ja) * | 1996-07-15 | 2009-08-19 | 日産化学工業株式会社 | 置換ビナフチル化合物及びその製造法 |
| AU7550398A (en) * | 1997-06-05 | 1998-12-21 | Takeda Chemical Industries Ltd. | Heterocyclic compounds, their production and use |
| AU2001245823A1 (en) * | 2000-03-17 | 2001-10-03 | Corixa Corporation | Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors |
| JP4688315B2 (ja) * | 2001-02-28 | 2011-05-25 | メルシャン株式会社 | ４−デメトキシダウノマイシノンの製造 |
| US8198328B2 (en) * | 2004-01-21 | 2012-06-12 | New York University | Treatment of cancer using benzoic acid derivatives |
| SI2797416T1 (sl) * | 2011-12-28 | 2017-12-29 | Global Blood Therapeutics, Inc. | Substituirane spojine benzaldehida in metode njihove uporabe pri povečanju oksigenacije tkiva |
| US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| EP2968299B1 (en) | 2013-03-15 | 2021-01-20 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| AP2015008721A0 (en) * | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) * | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| CN105209469A (zh) * | 2013-03-15 | 2015-12-30 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| US9604999B2 (en) * | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) * | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| BR112015021982B1 (pt) | 2013-03-15 | 2022-12-13 | Global Blood Therapeutics, Inc | Compostos e seus usos para a modulação de hemoglobina |
| JP6355711B2 (ja) * | 2013-03-15 | 2018-07-11 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヘモグロビンの修飾のための化合物及びその使用 |
| EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| CN114181195A (zh) | 2014-02-07 | 2022-03-15 | 全球血液疗法股份有限公司 | 一种化合物的结晶多晶型物 |
| WO2016043849A2 (en) * | 2014-07-24 | 2016-03-24 | Global Blood Therapeutics, Inc. | Compounds for treating acute respiratory distress syndrome or a negative effect thereof |
| JP6769982B2 (ja) | 2015-03-06 | 2020-10-14 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | Ｒａｓ変異と関連するがんの治療方法 |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| ES2910035T3 (es) | 2015-07-13 | 2022-05-11 | Beyondspring Pharmaceuticals Inc | Composiciones de plinabulina |
| SG11201804647TA (en) | 2015-12-04 | 2018-06-28 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| CA3013467A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| CN109475524A (zh) | 2016-06-06 | 2019-03-15 | 万春药业公司 | 用于减少中性粒细胞减少症的组合物和方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| US11633393B2 (en) | 2017-01-06 | 2023-04-25 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| US11400086B2 (en) | 2017-02-01 | 2022-08-02 | Beyondspring Pharmaceuticals, Inc. | Method of reducing chemotherapy-induced neutropenia |
| JP7350015B2 (ja) | 2018-01-24 | 2023-09-25 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | プリナブリンの投与による血小板減少症を軽減するための組成物および方法 |
| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| WO2020106642A1 (en) | 2018-11-19 | 2020-05-28 | Global Blood Therapeutics, Inc. | 2-formyl-3-hydroxyphenyloxymethyl compounds capable of modulating hemoglobin |
| CN112778155B (zh) * | 2019-11-11 | 2023-08-11 | 大连万春布林医药有限公司 | 妥卡雷琐衍生物及其用途 |
| CN115636742B (zh) * | 2022-11-11 | 2024-04-09 | 江西亚太科技发展有限公司 | 一种重结晶的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR71054E (fr) * | 1957-02-19 | 1959-10-08 | Rhone Poulenc Sa | Nouveaux dérivés phénoxycarboxyliques |
| FR1186520A (fr) * | 1957-11-18 | 1959-08-26 | Rhone Poulenc Sa | Nouvelles compositions phytohormonales |
| CH543472A (fr) * | 1969-01-31 | 1973-10-31 | Orchimed Sa | Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques |
| JPS5851972B2 (ja) * | 1976-05-14 | 1983-11-19 | 昭和化学工業株式会社 | １，４−ビス−スチリルベンゼン誘導体およびその製法 |
| IL60422A (en) * | 1979-06-29 | 1984-06-29 | Wellcome Found | Formylhydroxyphenoxy pentanoic and methylbenzoic acids and derivatives thereof,their preparation and pharmaceutical compositions containing them |
-
1981
- 1981-12-17 IT IT49937/81A patent/IT1193786B/it active
- 1981-12-17 FI FI814058A patent/FI72510C/fi not_active IP Right Cessation
- 1981-12-17 GR GR66822A patent/GR76950B/el unknown
- 1981-12-17 HU HU813807A patent/HU190371B/hu unknown
- 1981-12-17 ZA ZA818741A patent/ZA818741B/xx unknown
- 1981-12-17 DE DE8181110553T patent/DE3175083D1/de not_active Expired
- 1981-12-17 JP JP56204493A patent/JPS57145844A/ja active Granted
- 1981-12-17 DK DK561881A patent/DK160866C/da not_active IP Right Cessation
- 1981-12-17 EP EP81110553A patent/EP0054924B1/en not_active Expired
- 1981-12-17 GB GB8138086A patent/GB2090830B/en not_active Expired
- 1981-12-17 IL IL64573A patent/IL64573A/xx not_active IP Right Cessation
- 1981-12-18 US US06/332,246 patent/US4535183A/en not_active Expired - Lifetime
-
1982
- 1982-01-16 OA OA57595A patent/OA06998A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU190371B (en) | 1986-08-28 |
| JPS57145844A (en) | 1982-09-09 |
| IL64573A0 (en) | 1982-03-31 |
| GR76950B (da) | 1984-09-04 |
| EP0054924A3 (en) | 1982-09-22 |
| IT1193786B (it) | 1988-08-24 |
| US4535183A (en) | 1985-08-13 |
| FI72510B (fi) | 1987-02-27 |
| EP0054924A2 (en) | 1982-06-30 |
| GB2090830A (en) | 1982-07-21 |
| IL64573A (en) | 1985-04-30 |
| GB2090830B (en) | 1984-09-26 |
| IT8149937A0 (it) | 1981-12-17 |
| ZA818741B (en) | 1983-07-27 |
| DK160866B (da) | 1991-04-29 |
| DK160866C (da) | 1991-10-14 |
| EP0054924B1 (en) | 1986-08-06 |
| OA06998A (fr) | 1983-08-31 |
| FI814058L (fi) | 1982-06-19 |
| JPH0249294B2 (da) | 1990-10-29 |
| FI72510C (fi) | 1987-06-08 |
| DE3175083D1 (en) | 1986-09-11 |
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