DK465986A - Fremgangsmaade til foroegelse af produktionen af t-pa (vaevsplasminogenaktivator) og scu-pa (enkeltkaede-urokinase-plasminogenaktivator) - Google Patents

Fremgangsmaade til foroegelse af produktionen af t-pa (vaevsplasminogenaktivator) og scu-pa (enkeltkaede-urokinase-plasminogenaktivator) Download PDF

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Publication number
DK465986A
DK465986A DK465986A DK465986A DK465986A DK 465986 A DK465986 A DK 465986A DK 465986 A DK465986 A DK 465986A DK 465986 A DK465986 A DK 465986A DK 465986 A DK465986 A DK 465986A
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Denmark
Prior art keywords
plasminogen activator
scu
single chain
procedure
chain urokinase
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Application number
DK465986A
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Danish (da)
English (en)
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DK465986D0 (da
Inventor
Ruth Rappaport
Original Assignee
American Home Prod
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Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of DK465986D0 publication Critical patent/DK465986D0/da
Publication of DK465986A publication Critical patent/DK465986A/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Control Of Eletrric Generators (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
DK465986A 1985-10-01 1986-09-30 Fremgangsmaade til foroegelse af produktionen af t-pa (vaevsplasminogenaktivator) og scu-pa (enkeltkaede-urokinase-plasminogenaktivator) DK465986A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78265885A 1985-10-01 1985-10-01
US07/907,004 US4889808A (en) 1985-10-01 1986-09-17 Method of enchancing t-PA and SCU-PA production

Publications (2)

Publication Number Publication Date
DK465986D0 DK465986D0 (da) 1986-09-30
DK465986A true DK465986A (da) 1987-04-02

Family

ID=27120027

Family Applications (1)

Application Number Title Priority Date Filing Date
DK465986A DK465986A (da) 1985-10-01 1986-09-30 Fremgangsmaade til foroegelse af produktionen af t-pa (vaevsplasminogenaktivator) og scu-pa (enkeltkaede-urokinase-plasminogenaktivator)

Country Status (11)

Country Link
US (1) US4889808A (fr)
EP (1) EP0219270B1 (fr)
KR (1) KR870004133A (fr)
AT (1) ATE73844T1 (fr)
AU (1) AU603552B2 (fr)
DE (1) DE3684403D1 (fr)
DK (1) DK465986A (fr)
ES (1) ES2046170T3 (fr)
GB (1) GB2181741B (fr)
GR (1) GR3004775T3 (fr)
HU (1) HU201800B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61221128A (ja) * 1985-03-26 1986-10-01 Snow Brand Milk Prod Co Ltd プラスミノ−ゲン活性化因子に対するモノクロ−ナル抗体とその調製方法及び該モノクロ−ナル抗体の使用方法
US5206223A (en) * 1986-06-26 1993-04-27 Yeda Research And Development Co. Ltd. Method for inhibiting heparanase activity
CA1322163C (fr) * 1986-07-03 1993-09-14 Kenneth A. Thomas, Jr. Production d'activateurs du plasminogene
GB8723082D0 (en) * 1987-10-01 1987-11-04 Porton Prod Ltd Enzyme production
US4957863A (en) * 1988-01-26 1990-09-18 Monsanto Company Method of increasing yield of t-PA in cell culture
WO1989009257A1 (fr) * 1988-03-22 1989-10-05 Invitron Corporation Procede d'augmentation de la production d'activateur de plasminogene tissulaire
US5210037A (en) * 1988-03-22 1993-05-11 Centocor Incorporated Method to enhance TPA production
US5830685A (en) * 1990-02-09 1998-11-03 Genentech, Inc. Method of producing proteins using mammalian lung cell lines
US5500409A (en) * 1990-10-01 1996-03-19 Thomas Jefferson University Method for inhibiting collagen synthesis by keloid fibroblasts
SK120193A3 (en) * 1991-05-02 1994-07-06 Yeda Res & Dev Pharmaceutical composition for the prevention and/or treatment of pathological processes
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US6750207B1 (en) 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5464815A (en) * 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
US7037332B2 (en) * 2000-03-15 2006-05-02 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US4520107A (en) * 1982-09-28 1985-05-28 Polydex Chemicals Ltd. Tissue culture and cell growth-promoting material and its method of manufacture
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
US4757005A (en) * 1984-04-19 1988-07-12 Miles Inc. Method and cell line for obtaining plasminogen activators
US4661453A (en) * 1984-06-19 1987-04-28 American Biogenetic Sciences, Inc. Production of tissue plasminogen activator factor
EP0186084B1 (fr) * 1984-12-24 1991-09-04 Merck & Co. Inc. Facteur de croissance dérivé du cerveau
CA1322163C (fr) * 1986-07-03 1993-09-14 Kenneth A. Thomas, Jr. Production d'activateurs du plasminogene
JP2666348B2 (ja) * 1988-04-21 1997-10-22 ソニー株式会社 再生装置

Also Published As

Publication number Publication date
ATE73844T1 (de) 1992-04-15
DE3684403D1 (de) 1992-04-23
KR870004133A (ko) 1987-05-07
ES2046170T3 (es) 1994-02-01
GB8623615D0 (en) 1986-11-05
EP0219270A2 (fr) 1987-04-22
AU6341386A (en) 1987-04-02
US4889808A (en) 1989-12-26
GB2181741A (en) 1987-04-29
EP0219270B1 (fr) 1992-03-18
HU201800B (en) 1990-12-28
HUT42524A (en) 1987-07-28
DK465986D0 (da) 1986-09-30
GB2181741B (en) 1989-10-18
GR3004775T3 (fr) 1993-04-28
EP0219270A3 (en) 1989-04-05
AU603552B2 (en) 1990-11-22

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