DK434187A - Injektionspraeparat omfattende i phospholipidpartikler indkapslede antifungale polyen-antibiotika - Google Patents
Injektionspraeparat omfattende i phospholipidpartikler indkapslede antifungale polyen-antibiotikaInfo
- Publication number
- DK434187A DK434187A DK434187A DK434187A DK434187A DK 434187 A DK434187 A DK 434187A DK 434187 A DK434187 A DK 434187A DK 434187 A DK434187 A DK 434187A DK 434187 A DK434187 A DK 434187A
- Authority
- DK
- Denmark
- Prior art keywords
- antifungal
- antibiotics
- polyen
- vesicles
- injection preparation
- Prior art date
Links
- 230000000843 anti-fungal effect Effects 0.000 title abstract 4
- 229940121375 antifungal agent Drugs 0.000 title abstract 4
- 239000002245 particle Substances 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 150000003904 phospholipids Chemical class 0.000 title abstract 2
- 238000002347 injection Methods 0.000 title 1
- 239000007924 injection Substances 0.000 title 1
- 206010017533 Fungal infection Diseases 0.000 abstract 2
- 208000031888 Mycoses Diseases 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000004291 polyenes Chemical class 0.000 abstract 2
- 230000009885 systemic effect Effects 0.000 abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960000988 nystatin Drugs 0.000 abstract 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89906486A | 1986-08-21 | 1986-08-21 | |
| US89906486 | 1986-08-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK434187D0 DK434187D0 (da) | 1987-08-20 |
| DK434187A true DK434187A (da) | 1988-02-22 |
| DK168982B1 DK168982B1 (da) | 1994-07-25 |
Family
ID=25410437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK434187A DK168982B1 (da) | 1986-08-21 | 1987-08-20 | Fremgangsmåde til dannelse af små vesikler, der omfatter et phospholipid og indkapsler et antifungalt polyen-antibiotikum, og præparat dannet ved denne fremgangsmåde til anvendelse ved en fremgangsmåde til behandling af systemiske fungale infektioner |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5874104A (da) |
| EP (1) | EP0260811B1 (da) |
| JP (1) | JPH0615475B2 (da) |
| KR (1) | KR950013747B1 (da) |
| AT (1) | ATE66597T1 (da) |
| AU (1) | AU606880B2 (da) |
| CA (1) | CA1292184C (da) |
| DE (1) | DE3772498D1 (da) |
| DK (1) | DK168982B1 (da) |
| ES (1) | ES2051740T3 (da) |
| GR (1) | GR3002852T3 (da) |
| HK (1) | HK115393A (da) |
| IE (1) | IE60901B1 (da) |
| NO (1) | NO174833C (da) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620028B2 (fr) * | 1986-12-05 | 1994-02-25 | Ire Celltarg Sa | Procede de preparation de microcristaux comportant a titre de substance active, notamment de l'amphotericine b, microcristaux obtenus et composition pharmaceutique en comprenant |
| CA1338736C (fr) * | 1986-12-05 | 1996-11-26 | Roger Baurain | Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation |
| US4812312A (en) * | 1987-03-03 | 1989-03-14 | Board Of Regents Of The University Of Texas System | Liposome-incorporated nystatin |
| CA1338702C (en) * | 1987-03-05 | 1996-11-12 | Lawrence D. Mayer | High drug:lipid formulations of liposomal- antineoplastic agents |
| US6406713B1 (en) | 1987-03-05 | 2002-06-18 | The Liposome Company, Inc. | Methods of preparing low-toxicity drug-lipid complexes |
| US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
| US4999199A (en) * | 1988-11-10 | 1991-03-12 | Board Of Regents, The University Of Texas System | Pharmaceutical formulations: liposomes incorporating aromatic polyene antibiotics |
| JP2653245B2 (ja) * | 1989-11-27 | 1997-09-17 | 日本新薬株式会社 | 脂肪乳剤 |
| JPH06509058A (ja) * | 1991-01-14 | 1994-10-13 | ボード、オブ、リージェンツ、ザ、ユニバーシティー、オブ、テキサス、システム | リポソームニスタチン及びアンホテリシンｂの抗ｈｉｖ活性 |
| WO1993007884A1 (en) * | 1991-10-25 | 1993-04-29 | Senju Pharmaceutical Co., Ltd. | External preparation for treating hemorrhoidal diseases |
| JP2915296B2 (ja) * | 1993-08-30 | 1999-07-05 | 宇野 潤 | 抗真菌製剤 |
| GB9519654D0 (en) * | 1995-09-27 | 1995-11-29 | Nycomed Imaging As | Stabilised phospholipid compositions |
| KR100505772B1 (ko) | 1996-01-25 | 2005-10-25 | 쉐링 악티엔게젤샤프트 | 개선된정맥투여용농축주사액및주입액 |
| GB9721901D0 (en) * | 1997-10-16 | 1997-12-17 | Univ Manchester | Particles |
| AU1350099A (en) * | 1997-12-01 | 1999-06-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Formulations for topical treatment of skin infections |
| IT1301807B1 (it) * | 1998-06-25 | 2000-07-07 | Tiberio Bruzzese | Formulazioni farmaceutiche iniettabili di derivati della partricina. |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| US6413537B1 (en) | 2000-03-10 | 2002-07-02 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
| JP4786041B2 (ja) * | 2001-03-02 | 2011-10-05 | 丸善製薬株式会社 | 渋味、収斂味を低減する方法および渋味、収斂味低減ハス胚芽抽出物製剤 |
| US7651689B2 (en) * | 2002-11-15 | 2010-01-26 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of applying ionization radiation for therapy of infections |
| US7855279B2 (en) * | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
| US20090099031A1 (en) * | 2005-09-27 | 2009-04-16 | Stemmer Willem P | Genetic package and uses thereof |
| JP2009509535A (ja) * | 2005-09-27 | 2009-03-12 | アムニクス， インコーポレイテッド | タンパク様薬剤およびその使用 |
| EP1956906A4 (en) | 2005-11-09 | 2009-12-30 | Combinatorx Inc | METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES |
| EP1981525B1 (en) | 2005-12-30 | 2015-01-21 | Zensun (Shanghai) Science and Technology Limited | Extended release of neuregulin for improved cardiac function |
| AU2008287340A1 (en) * | 2007-08-15 | 2009-02-19 | Amunix, Inc. | Compositions and methods for modifying properties of biologically active polypeptides |
| RU2547441C2 (ru) | 2008-03-06 | 2015-04-10 | Анакор Фармасьютикалз, Инк. | Борсодержащие малые молекулы в качестве противовоспалительных агентов |
| CN102348715B (zh) | 2009-02-03 | 2017-12-08 | 阿穆尼克斯运营公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| NZ596778A (en) | 2009-06-08 | 2013-11-29 | Amunix Operating Inc | Glucose-regulating polypeptides and methods of making and using same |
| CN106916229A (zh) | 2009-06-08 | 2017-07-04 | 阿穆尼克斯运营公司 | 生长激素多肽及其制备和使用方法 |
| CA3027255C (en) | 2009-07-10 | 2022-06-21 | The General Hospital Corporation | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| AU2010290077C1 (en) | 2009-08-24 | 2015-12-03 | Bioverativ Therapeutics Inc. | Coagulation factor IX compositions and methods of making and using same |
| RU2481100C2 (ru) * | 2009-10-16 | 2013-05-10 | Лайфкеа Инновейшнз Пвт. Лтд. | Новая лекарственная форма для лечения грибковой инфекции |
| BR112012009801A8 (pt) | 2009-10-30 | 2016-08-30 | Cns Therapeutics Inc | Polipeptídeo neurturina e variante de neurturina |
| ES2677352T3 (es) | 2009-12-18 | 2018-08-01 | Achelios Therapeutics, Inc. | Métodos y composiciones para tratar y prevenir las cefaleas autonómicas trigeminales, la migraña y las afecciones vasculares |
| WO2011094450A1 (en) | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
| EP2668961A4 (en) * | 2010-11-19 | 2016-07-06 | Univ Sapporo Medical | PHARMACEUTICAL COMBINATION PREPARATION |
| RS63870B1 (sr) | 2012-02-15 | 2023-01-31 | Bioverativ Therapeutics Inc | Sastavi faktora viii i postupci za pravljenje i upotrebu istih |
| NZ628014A (en) | 2012-02-15 | 2016-09-30 | Biogen Ma Inc | Recombinant factor viii proteins |
| WO2013184938A2 (en) | 2012-06-08 | 2013-12-12 | Alkermes. Inc. | Fusion polypeptides comprising mucin-domain polypeptide linkers |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| CN107124869B (zh) | 2014-03-25 | 2022-04-01 | 美国政府陆军部 | 包含含有单磷酰脂质a（mpla）的脂质体组合物和皂苷的无毒佐剂制剂 |
| US20170266106A1 (en) | 2014-12-01 | 2017-09-21 | Achelios Therapeutics, Inc. | Methods and compositions for treating migraine and conditions associated with pain |
| JP6833811B2 (ja) | 2015-08-03 | 2021-02-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 荷電イオンチャネル遮断薬及び使用方法 |
| TWI741992B (zh) | 2015-08-03 | 2021-10-11 | 美商百歐維拉提夫治療公司 | 因子ｉｘ融合蛋白以及其製備及使用方法 |
| KR20180077180A (ko) | 2015-11-06 | 2018-07-06 | 아쥬반스 테크놀로지스 인코포레이티드 | 트리테르펜 사포닌 유사체 |
| CN110023321A (zh) | 2016-08-17 | 2019-07-16 | 索尔斯蒂斯生物有限公司 | 多核苷酸构建体 |
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| SG11202001826YA (en) | 2017-10-16 | 2020-03-30 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| JP2021523878A (ja) | 2018-05-18 | 2021-09-09 | バイオベラティブ セラピューティクス インコーポレイテッド | 血友病ａを処置する方法 |
| CA3129089A1 (en) | 2019-03-11 | 2020-09-17 | Bridget Mccarthy Cole | Ester substituted ion channel blockers and methods for use |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| AU2020237474A1 (en) | 2019-03-11 | 2021-09-30 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11377422B2 (en) | 2019-03-11 | 2022-07-05 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US20220307013A1 (en) | 2019-08-30 | 2022-09-29 | The Regents Of The University Of California | Gene fragment overexpression screening methodologies, and uses thereof |
| KR20220123381A (ko) | 2019-11-06 | 2022-09-06 | 녹시온 테라퓨틱스 인코포레이티드 | 하전된 이온 채널 차단제 및 사용 방법 |
| US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| EP4118070A4 (en) | 2020-03-11 | 2024-04-10 | Nocion Therapeutics, Inc. | CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE |
| WO2023175454A1 (en) | 2022-03-14 | 2023-09-21 | Pfizer Inc. | Methods for producing an adjuvant |
| WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4310505A (en) * | 1979-11-08 | 1982-01-12 | California Institute Of Technology | Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances |
| US4497791A (en) * | 1983-02-10 | 1985-02-05 | Vestar Research Incorporated | Method for labeling phagocytic cells |
| GB2135647A (en) * | 1983-02-15 | 1984-09-05 | Squibb & Sons Inc | Method of preparing liposomes and products produced thereby |
| PT78628B (en) * | 1984-05-02 | 1986-06-18 | Liposome Co Inc | Pharmaceutical composition with reduced toxicity |
| US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| CA1298548C (en) * | 1984-10-22 | 1992-04-07 | Cary Arnet Presant | Method of delivering micellular particles encapsulating imaging and chemotherapeutic agents to tumors in a body |
| US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
| US4766046A (en) * | 1985-09-27 | 1988-08-23 | Liposome Technology, Inc. | Stabilized liposome/amphotericin composition and method |
| US4812312A (en) * | 1987-03-03 | 1989-03-14 | Board Of Regents Of The University Of Texas System | Liposome-incorporated nystatin |
-
1987
- 1987-08-11 IE IE214887A patent/IE60901B1/en not_active IP Right Cessation
- 1987-08-14 EP EP87307221A patent/EP0260811B1/en not_active Expired - Lifetime
- 1987-08-14 AT AT87307221T patent/ATE66597T1/de not_active IP Right Cessation
- 1987-08-14 ES ES87307221T patent/ES2051740T3/es not_active Expired - Lifetime
- 1987-08-14 DE DE8787307221T patent/DE3772498D1/de not_active Expired - Lifetime
- 1987-08-18 AU AU77160/87A patent/AU606880B2/en not_active Expired
- 1987-08-19 NO NO873492A patent/NO174833C/no not_active IP Right Cessation
- 1987-08-19 CA CA000544830A patent/CA1292184C/en not_active Expired - Lifetime
- 1987-08-20 DK DK434187A patent/DK168982B1/da not_active IP Right Cessation
- 1987-08-20 KR KR1019870009101A patent/KR950013747B1/ko not_active IP Right Cessation
- 1987-08-21 JP JP62208049A patent/JPH0615475B2/ja not_active Expired - Fee Related
-
1991
- 1991-10-08 GR GR91401494T patent/GR3002852T3/el unknown
-
1993
- 1993-10-28 HK HK1153/93A patent/HK115393A/xx not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/467,864 patent/US5874104A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO873492D0 (no) | 1987-08-19 |
| NO873492L (no) | 1988-02-22 |
| KR950013747B1 (ko) | 1995-11-15 |
| EP0260811A3 (en) | 1988-07-20 |
| EP0260811A2 (en) | 1988-03-23 |
| KR880002531A (ko) | 1988-05-09 |
| ATE66597T1 (de) | 1991-09-15 |
| DK434187D0 (da) | 1987-08-20 |
| ES2051740T3 (es) | 1994-07-01 |
| DE3772498D1 (de) | 1991-10-02 |
| NO174833B (no) | 1994-04-11 |
| AU606880B2 (en) | 1991-02-21 |
| EP0260811B1 (en) | 1991-08-28 |
| US5874104A (en) | 1999-02-23 |
| CA1292184C (en) | 1991-11-19 |
| JPH0615475B2 (ja) | 1994-03-02 |
| GR3002852T3 (en) | 1993-01-25 |
| HK115393A (en) | 1993-11-05 |
| JPS6366123A (ja) | 1988-03-24 |
| NO174833C (no) | 1994-07-20 |
| AU7716087A (en) | 1988-02-25 |
| IE872148L (en) | 1988-02-21 |
| DK168982B1 (da) | 1994-07-25 |
| IE60901B1 (en) | 1994-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |