DK42588A - Protein med prokoagulantaktivitet af human faktor viii:c-typen, dets fremstilling og anvendelse samt cdna, som koder det - Google Patents

Protein med prokoagulantaktivitet af human faktor viii:c-typen, dets fremstilling og anvendelse samt cdna, som koder det

Info

Publication number
DK42588A
DK42588A DK042588A DK42588A DK42588A DK 42588 A DK42588 A DK 42588A DK 042588 A DK042588 A DK 042588A DK 42588 A DK42588 A DK 42588A DK 42588 A DK42588 A DK 42588A
Authority
DK
Denmark
Prior art keywords
type
factor viii
human factor
procoagulant activity
activity protein
Prior art date
Application number
DK042588A
Other languages
Danish (da)
English (en)
Other versions
DK42588D0 (da
Inventor
Randal J Kaufman
Debra D Pittman
John J Toole Jr
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of DK42588A publication Critical patent/DK42588A/da
Publication of DK42588D0 publication Critical patent/DK42588D0/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/10—Factor VIII, AHF; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK042588A 1986-05-29 1988-01-28 Protein med prokoagulantaktivitet af human faktor viii:c-typen, dets fremstilling og anvendelse samt cdna, som koder det DK42588D0 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86841086A 1986-05-29 1986-05-29
US93276786A 1986-11-18 1986-11-18
US06/939,658 US5451521A (en) 1986-05-29 1986-12-09 Procoagulant proteins
PCT/US1987/001299 WO1987007144A1 (en) 1986-05-29 1987-05-29 Novel procoagulant proteins

Publications (2)

Publication Number Publication Date
DK42588A true DK42588A (da) 1988-01-28
DK42588D0 DK42588D0 (da) 1988-01-28

Family

ID=27420451

Family Applications (1)

Application Number Title Priority Date Filing Date
DK042588A DK42588D0 (da) 1986-05-29 1988-01-28 Protein med prokoagulantaktivitet af human faktor viii:c-typen, dets fremstilling og anvendelse samt cdna, som koder det

Country Status (8)

Country Link
US (1) US5451521A (ja)
EP (1) EP0270618A4 (ja)
JP (1) JPS63503357A (ja)
KR (1) KR880701105A (ja)
AU (1) AU609043B2 (ja)
CA (1) CA1341229C (ja)
DK (1) DK42588D0 (ja)
WO (1) WO1987007144A1 (ja)

Families Citing this family (57)

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KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5422260A (en) * 1986-05-29 1995-06-06 Genetics Institute, Inc. -Legal Affairs Human factor VIII:c muteins
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
EP0690126B1 (en) * 1987-06-12 2001-11-28 Baxter Aktiengesellschaft Novel proteins with factor VIII activitiy: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
US6346513B1 (en) 1987-06-12 2002-02-12 Baxter Trading Gmbh Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
IL86693A (en) 1987-06-12 1994-06-24 Stichting Centraal Lab Proteins that have the activity IIIV of the blood, a process for their preparation that uses cells are produced through genetic engineering and pharmaceutical preparations that contain them
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
FR2619314B1 (fr) * 1987-08-11 1990-06-15 Transgene Sa Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
SE459586B (sv) * 1987-09-14 1989-07-17 Mta Szegedi Biolog Koezponti Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
US5879907A (en) * 1987-09-14 1999-03-09 Skandigen Ab Artificial gene coding for authentic human serum albumin, use thereof and method
SE468050C (sv) * 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Rekombinant derivat av human faktor VIII
US5661008A (en) * 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
US6376463B1 (en) * 1992-04-07 2002-04-23 Emory University Modified factor VIII
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
ES2252732T3 (es) 1992-05-26 2006-05-16 Immunex Corporation Nueva citoquina que une cd30.
US5563045A (en) 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
DK128093D0 (da) * 1993-11-12 1993-11-12 Novo Nordisk As Hidtil ukendte forbindelser
AU697205B2 (en) * 1994-04-22 1998-10-01 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Method and means for detecting and treating disorders in the blood coagulation cascade
AU6486196A (en) * 1995-07-11 1997-02-10 Chiron Corporation Novel factor viii:c polypeptide analogs with altered protease sites
AU6456096A (en) * 1995-07-11 1997-02-10 Chiron Corporation Lysine 1689 factor viii:c polypeptide analogs
EP1754718B1 (en) * 1996-04-24 2011-03-23 The Regents Of The University Of Michigan Inactivation resistant factor VIII
US20040092442A1 (en) * 1996-04-24 2004-05-13 University Of Michigan Inactivation resistant factor VIII
US8183344B2 (en) * 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
ES2182501T3 (es) 1998-03-12 2003-03-01 Inst Genetics Llc Metodos mejorados para producir proteinas del factor viii.
US7820796B2 (en) 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
US6200560B1 (en) * 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
WO2000028021A1 (de) 1998-11-10 2000-05-18 Baxter Aktiengesellschaft Ein faktor viii-polypeptid mit faktor viii:c-aktivität
AU5471501A (en) * 2000-03-22 2001-10-03 Octagene Gmbh Production of recombinant blood clotting factors in human cell lines
ATE386538T1 (de) * 2001-02-05 2008-03-15 Novo Nordisk Healthcare Ag Kombinierte verwendung von faktor vii polypeptiden und faktor viii polypeptiden
US7041635B2 (en) 2003-01-28 2006-05-09 In2Gen Co., Ltd. Factor VIII polypeptide
SI2292780T1 (sl) 2003-09-30 2017-12-29 The Trustees Of The University Of Pennsylvania Genotipske skupine, zaporedja, vektorji, ki vsebujejo le-te z adenovirusi povezanega virusa (aav) in njihova uporaba
WO2006027111A1 (en) * 2004-09-06 2006-03-16 Zlb Behring Gmbh Modified coagulation factor viii with enhanced stability
KR101654011B1 (ko) 2004-11-12 2016-09-05 바이엘 헬스케어 엘엘씨 Ｆｖｉｉｉ의 부위 지향 변형
EP1707634A1 (en) 2005-03-29 2006-10-04 Octapharma AG Method for isolation of recombinantly produced proteins
EP1871801A2 (en) * 2005-04-01 2008-01-02 Novo Nordisk Health Care AG Blood coagulation fviii analogues
ES2525143T3 (es) 2005-04-07 2014-12-18 The Trustees Of The University Of Pennsylvania Cápsides de AAVrh.64 modificado, composiciones que las contienen y usos de las mismas
AU2006233638A1 (en) * 2005-04-14 2006-10-19 Csl Behring Gmbh Modified coagulation Factor VIII with enhanced stability and its derivates
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
US20090203077A1 (en) * 2006-06-30 2009-08-13 The Regents Of The University Of Michigan Method of producing factor viii proteins by recombinant methods
EP2035572A4 (en) * 2006-06-30 2010-01-06 Univ Michigan PROCESS FOR THE PREPARATION OF FACTOR VIII PROTEINS BY RECOMBINATION PROCEDURES
KR20100113478A (ko) * 2007-11-01 2010-10-21 유니버시티 오브 로체스터 증가된 안정성을 갖는 재조합 인자 ⅴⅰⅰⅰ
ES2717902T5 (es) 2009-10-02 2022-11-29 Childrens Hospital Philadelphia Composiciones y procedimientos para mejorar la función del factor VIII de coagulación
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins
MX342858B (es) 2010-03-29 2016-10-13 The Trustees Of The Univ Of Pennsylvania * Sistema de ablacion transgenica inducida farmacologicamente.
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
CN103502458B (zh) 2011-02-17 2016-11-16 宾夕法尼亚大学托管会 用于改变组织特异性和改善aav9-介导的基因转移的组合物和方法
CA2850579A1 (en) 2011-10-18 2013-04-25 Carsten Horn Method for improving the stability of purified factor viii after reconstitution
EP3404105A1 (en) 2012-07-06 2018-11-21 Bioverativ Therapeutics Inc. Cell line expressing single chain factor viii polypeptides and uses thereof
ES2680942T3 (es) * 2013-03-15 2018-09-11 Bayer Healthcare Llc Variante de polipéptidos del factor VIII y procedimientos para su producción y utilización
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN108093639B (zh) 2015-04-16 2022-07-19 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
US20170205149A1 (en) * 2016-01-15 2017-07-20 Hamilton Sundstrand Corporation Heat exchanger channels
KR20230042754A (ko) 2020-08-07 2023-03-29 아미쿠스 세라퓨틱스, 인코포레이티드 소포 표적화 단백질 및 이의 용도

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
AU5772886A (en) * 1985-04-12 1986-11-05 Genetics Institute Inc. Novel procoagulant proteins
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
JP2525022B2 (ja) * 1986-01-03 1996-08-14 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド ▲ＶＩＩＩ▼：ｃ因子型タンパク質の改良生産方法

Also Published As

Publication number Publication date
EP0270618A4 (en) 1989-02-16
KR880701105A (ko) 1988-07-25
AU609043B2 (en) 1991-04-26
US5451521A (en) 1995-09-19
CA1341229C (en) 2001-05-15
EP0270618A1 (en) 1988-06-15
WO1987007144A1 (en) 1987-12-03
AU7486887A (en) 1987-12-22
JPS63503357A (ja) 1988-12-08
DK42588D0 (da) 1988-01-28

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment