DK416589A - Rekombinantdyresomatotropiner, fremgangsmaade til inhibering af deres aggregering og farmaceutika indeholdende dem - Google Patents
Rekombinantdyresomatotropiner, fremgangsmaade til inhibering af deres aggregering og farmaceutika indeholdende demInfo
- Publication number
- DK416589A DK416589A DK416589A DK416589A DK416589A DK 416589 A DK416589 A DK 416589A DK 416589 A DK416589 A DK 416589A DK 416589 A DK416589 A DK 416589A DK 416589 A DK416589 A DK 416589A
- Authority
- DK
- Denmark
- Prior art keywords
- somatotropines
- aggregation
- inhibiting
- procedure
- recombinant animal
- Prior art date
Links
- 238000004220 aggregation Methods 0.000 title 1
- 230000002776 aggregation Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23606088A | 1988-08-24 | 1988-08-24 | |
US37269989A | 1989-07-03 | 1989-07-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK416589D0 DK416589D0 (da) | 1989-08-23 |
DK416589A true DK416589A (da) | 1990-02-25 |
Family
ID=26929421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK416589A DK416589A (da) | 1988-08-24 | 1989-08-23 | Rekombinantdyresomatotropiner, fremgangsmaade til inhibering af deres aggregering og farmaceutika indeholdende dem |
Country Status (18)
Country | Link |
---|---|
US (1) | US5891840A (el) |
EP (1) | EP0355460B1 (el) |
JP (1) | JP2894355B2 (el) |
AR (1) | AR245138A1 (el) |
AT (1) | ATE198353T1 (el) |
AU (1) | AU630105B2 (el) |
DE (1) | DE68929273T2 (el) |
DK (1) | DK416589A (el) |
ES (1) | ES2154627T3 (el) |
FI (1) | FI104908B (el) |
GR (1) | GR3035608T3 (el) |
HU (1) | HU217095B (el) |
IE (1) | IE892706A1 (el) |
IL (1) | IL91156A (el) |
NO (1) | NO893387L (el) |
NZ (1) | NZ230342A (el) |
PT (1) | PT91512B (el) |
YU (1) | YU163289A (el) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988006186A2 (en) * | 1987-02-19 | 1988-08-25 | The Upjohn Company | cDNAs ENCODING SOMATOTROPIN, EXPRESSION VECTORS AND HOSTS |
US5089473A (en) * | 1988-08-29 | 1992-02-18 | Monsanto Company | Somatotropin variants and their use |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5951972A (en) * | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
ES2113354T3 (es) * | 1990-05-04 | 1998-05-01 | American Cyanamid Co | Estabilizacion de somatotropinas y otras proteinas por modificacion de residuos de cisteina. |
US6894023B1 (en) | 1990-07-13 | 2005-05-17 | Novo Nordisk A/S | Growth hormone crystals and a process for production of these GH-crystals |
DK168790D0 (el) * | 1990-07-13 | 1990-07-13 | Novo Nordisk As | |
US5780599A (en) * | 1990-07-13 | 1998-07-14 | Novo Nordisk A/S | Growth hormone crystals and a process for production of growth hormone crystals |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
US5310882A (en) * | 1990-11-30 | 1994-05-10 | American Cyanamid Company | Somatotropins with alterations in the α-helix 3 region |
NZ240718A (en) * | 1990-11-30 | 1996-10-28 | Bio Technology General Corp | Somatotropin analogues carrying mutations in the alpha-helix-1 region |
GB9100381D0 (en) * | 1991-01-09 | 1991-02-20 | Erba Carlo Spa | Human bfgf derivatives,their analogs and process for their production |
FR2671554A1 (fr) * | 1991-01-11 | 1992-07-17 | Clonatec Sa | Peptides synthetiques derivant de l'antigene hbc du virus de l'hepatite b, leurs applications a la detection d'une infection par ce virus et a la vaccination contre l'hepatite b. |
AU654563B2 (en) * | 1991-07-24 | 1994-11-10 | Imperial Chemical Industries Plc | Proteins |
ZA936811B (en) * | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US7270809B2 (en) | 1997-07-14 | 2007-09-18 | Bolder Biotechnology, Inc. | Cysteine variants of alpha interferon-2 |
US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
US7306931B2 (en) | 2000-05-16 | 2007-12-11 | Bolder Biotechnology, Inc. | Method for refolding proteins containing free cysteine residues |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
US7060442B2 (en) | 2000-10-30 | 2006-06-13 | Regents Of The University Of Michigan | Modulators on Nod2 signaling |
EP1539960B1 (en) * | 2002-09-09 | 2010-04-28 | Hanall Pharmaceutical Co., Ltd. | Protease-resistant modified interferon alpha polypeptides |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
US8329866B2 (en) | 2005-10-03 | 2012-12-11 | Bolder Biotechnology, Inc. | Long acting VEGF inhibitors and methods of use |
EP2471550A1 (en) * | 2005-10-07 | 2012-07-04 | Health Protection Agency | Proteins with improved solubility and methods for producing and using same |
US8617531B2 (en) | 2006-12-14 | 2013-12-31 | Bolder Biotechnology, Inc. | Methods of making proteins and peptides containing a single free cysteine |
CN102112157B (zh) * | 2008-08-06 | 2013-05-29 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内效能的缀合蛋白 |
CN102292349B (zh) * | 2009-01-22 | 2016-04-13 | 诺沃—诺迪斯克保健股份有限公司 | 稳定的生长激素化合物 |
US8841249B2 (en) | 2009-08-06 | 2014-09-23 | Novo Nordisk A/S | Growth hormones with prolonged in-vivo efficacy |
NZ600361A (en) * | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
TWI508737B (zh) | 2010-01-22 | 2015-11-21 | 諾佛 儂迪克股份有限公司 | 具有延長的活體內功效的生長激素 |
US9211342B2 (en) | 2010-01-22 | 2015-12-15 | Novo Nordisk Healthcare Ag | Stable growth hormone compounds resistant to proteolytic degradation |
DK2890394T3 (da) * | 2012-08-31 | 2019-07-15 | Glaxosmithkline Biologicals Sa | Stabiliserede proteiner til immunisering mod Staphylococcus aureus |
WO2014166836A1 (en) | 2013-04-05 | 2014-10-16 | Novo Nordisk A/S | Growth hormone compound formulation |
KR20180003677A (ko) * | 2016-06-30 | 2018-01-10 | 주식회사 크레아플래닛 | 인간 성장호르몬 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
US4774091A (en) * | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US4761289A (en) * | 1986-10-10 | 1988-08-02 | International Minerals & Chemical Corp. | Sustained release implant and method for preparing same |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
JPH04502762A (ja) * | 1989-01-19 | 1992-05-21 | ジ・アップジョン・カンパニー | ソマトトロピン・アナログ |
EP0456642A1 (en) * | 1989-01-31 | 1991-11-21 | The Upjohn Company | Somatotropin analogs |
US5849694A (en) * | 1990-07-16 | 1998-12-15 | Synenki; Richard M. | Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof |
-
1989
- 1989-07-27 DE DE68929273T patent/DE68929273T2/de not_active Expired - Fee Related
- 1989-07-27 EP EP89113852A patent/EP0355460B1/en not_active Expired - Lifetime
- 1989-07-27 ES ES89113852T patent/ES2154627T3/es not_active Expired - Lifetime
- 1989-07-27 AT AT89113852T patent/ATE198353T1/de not_active IP Right Cessation
- 1989-07-30 IL IL9115689A patent/IL91156A/en not_active IP Right Cessation
- 1989-08-17 NZ NZ230342A patent/NZ230342A/en unknown
- 1989-08-22 PT PT91512A patent/PT91512B/pt not_active IP Right Cessation
- 1989-08-23 IE IE270689A patent/IE892706A1/en unknown
- 1989-08-23 NO NO89893387A patent/NO893387L/no unknown
- 1989-08-23 FI FI893963A patent/FI104908B/fi not_active IP Right Cessation
- 1989-08-23 AR AR89314728A patent/AR245138A1/es active
- 1989-08-23 YU YU01632/89A patent/YU163289A/xx unknown
- 1989-08-23 HU HU894322A patent/HU217095B/hu not_active IP Right Cessation
- 1989-08-23 JP JP1217185A patent/JP2894355B2/ja not_active Expired - Lifetime
- 1989-08-23 DK DK416589A patent/DK416589A/da not_active Application Discontinuation
- 1989-08-24 AU AU40202/89A patent/AU630105B2/en not_active Ceased
-
1995
- 1995-05-09 US US08/437,578 patent/US5891840A/en not_active Expired - Fee Related
-
2001
- 2001-03-20 GR GR20010400454T patent/GR3035608T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0355460A3 (en) | 1991-04-03 |
AU630105B2 (en) | 1992-10-22 |
DE68929273D1 (de) | 2001-02-01 |
NO893387D0 (no) | 1989-08-23 |
HUT51331A (en) | 1990-04-28 |
FI104908B (fi) | 2000-04-28 |
ES2154627T3 (es) | 2001-04-16 |
EP0355460B1 (en) | 2000-12-27 |
IL91156A (en) | 1995-05-26 |
IL91156A0 (en) | 1990-03-19 |
NZ230342A (en) | 1992-08-26 |
AR245138A1 (es) | 1993-12-30 |
EP0355460A2 (en) | 1990-02-28 |
IE892706A1 (en) | 1991-01-16 |
FI893963A (fi) | 1990-02-25 |
HU217095B (hu) | 1999-11-29 |
DK416589D0 (da) | 1989-08-23 |
PT91512B (pt) | 1995-05-31 |
JP2894355B2 (ja) | 1999-05-24 |
YU163289A (en) | 1992-05-28 |
DE68929273T2 (de) | 2001-07-05 |
PT91512A (pt) | 1990-03-08 |
JPH034797A (ja) | 1991-01-10 |
NO893387L (no) | 1990-02-26 |
IE892706L (en) | 1990-02-24 |
ATE198353T1 (de) | 2001-01-15 |
FI893963A0 (fi) | 1989-08-23 |
GR3035608T3 (en) | 2001-06-29 |
US5891840A (en) | 1999-04-06 |
AU4020289A (en) | 1990-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A0 | Application filed | ||
AHB | Application shelved due to non-payment |