DK414482A - Fremgangsmaade til fremstilling af substituerede 4,5-dihydro-6-(substitueret)phenyl-3(2h)-pyridazinoner og 6-(substitueret)phenyl-3(2h)-pyridazinoner - Google Patents

Fremgangsmaade til fremstilling af substituerede 4,5-dihydro-6-(substitueret)phenyl-3(2h)-pyridazinoner og 6-(substitueret)phenyl-3(2h)-pyridazinoner Download PDF

Info

Publication number
DK414482A
DK414482A DK414482A DK414482A DK414482A DK 414482 A DK414482 A DK 414482A DK 414482 A DK414482 A DK 414482A DK 414482 A DK414482 A DK 414482A DK 414482 A DK414482 A DK 414482A
Authority
DK
Denmark
Prior art keywords
substituted
phenyl
pyridazinones
compounds
dihydro
Prior art date
Application number
DK414482A
Other languages
English (en)
Inventor
Ila Sircar
James Arthur Bristol
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/302,181 external-priority patent/US4353905A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK414482A publication Critical patent/DK414482A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D521/00Heterocyclic compounds containing unspecified hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK414482A 1981-09-17 1982-09-16 Fremgangsmaade til fremstilling af substituerede 4,5-dihydro-6-(substitueret)phenyl-3(2h)-pyridazinoner og 6-(substitueret)phenyl-3(2h)-pyridazinoner DK414482A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/302,181 US4353905A (en) 1981-09-17 1981-09-17 Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
US40248882A 1982-07-27 1982-07-27
US40797382A 1982-08-13 1982-08-13

Publications (1)

Publication Number Publication Date
DK414482A true DK414482A (da) 1983-03-18

Family

ID=27404868

Family Applications (1)

Application Number Title Priority Date Filing Date
DK414482A DK414482A (da) 1981-09-17 1982-09-16 Fremgangsmaade til fremstilling af substituerede 4,5-dihydro-6-(substitueret)phenyl-3(2h)-pyridazinoner og 6-(substitueret)phenyl-3(2h)-pyridazinoner

Country Status (17)

Country Link
EP (1) EP0075436B1 (da)
KR (1) KR880001623B1 (da)
AT (1) ATE18909T1 (da)
AU (1) AU563448B2 (da)
CA (1) CA1190548A (da)
DD (1) DD208615A5 (da)
DE (1) DE3270274D1 (da)
DK (1) DK414482A (da)
ES (1) ES8400414A1 (da)
FI (1) FI76084C (da)
GR (1) GR76999B (da)
HU (1) HU190412B (da)
IE (1) IE54101B1 (da)
IL (1) IL66815A (da)
NO (1) NO159595C (da)
NZ (1) NZ201929A (da)
PH (1) PH19332A (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3212304A1 (de) * 1982-04-02 1983-10-06 Nattermann A & Cie Imidazolylphenyl-tetrahydropyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3241102A1 (de) * 1982-11-06 1984-05-10 A. Nattermann & Cie GmbH, 5000 Köln Imidazolylalkylthienyl-tetrahydropyridazine und verfahren zu ihrer herstellung
GB8310435D0 (en) * 1983-04-18 1983-05-25 Fujisawa Pharmaceutical Co Triazine derivatives
DE3321012A1 (de) * 1983-06-10 1984-12-13 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-(thien-2-yl)-3(2h)-pyridazinone und 6-(thien-2-yl)-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
US4599332A (en) * 1983-12-07 1986-07-08 Warner-Lambert Company 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)-pyridazinones and related compounds
DE3401911A1 (de) * 1984-01-20 1985-08-01 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-vinyl-3(2h)-pyridazinone und 6-vinyl-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
DE3407509A1 (de) * 1984-03-01 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln Neue arzneimittelkombination zur behandlung von bluthochdruck und thromboembolischen erkrankungen
US4584299A (en) * 1984-05-21 1986-04-22 Warner-Lambert Company Method of treating heart failure and medicaments therefor
DE3425632A1 (de) * 1984-07-12 1986-01-16 Basf Ag, 6700 Ludwigshafen (pyrrol-1-yl)-phenyl-dihydropyridazinone, ihre herstellung und verwendung
JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー 4,5‐ジヒドロ‐4,4‐ジアルキル‐6‐(置換)フエニル‐3(2h)‐ピリダジノン類
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
IL79280A (en) * 1985-07-05 1990-07-12 Smith Kline French Lab 4-(6-oxo-dihydro or tetrahydropyridazin-3-yl)benzene derivatives,their preparation and pharmaceutical compositions containing them
US4826835A (en) * 1985-10-23 1989-05-02 Rorer Pharmaceutical Corporation Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure
US4783463A (en) * 1985-10-23 1988-11-08 Rorer Pharmaceutical Corporation Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure
DE3600275A1 (de) * 1986-01-08 1987-07-09 Basf Ag Substituierte pyrrol-1-ylphenyldihydropyridazinone, ihre herstellung und verwendung
DE3626865A1 (de) * 1986-08-08 1988-02-11 Boehringer Mannheim Gmbh Neue pyridazinon-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4888169A (en) * 1986-10-14 1989-12-19 Norden Laboratories, Inc. Bordetella Bronchiseptica vaccine
US4970210A (en) * 1987-07-17 1990-11-13 Abbott Laboratories Triazinone lipoxygenase compounds
ATE110071T1 (de) * 1988-01-23 1994-09-15 Kyowa Hakko Kogyo Kk Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
DE3804490A1 (de) * 1988-02-12 1989-08-24 Heumann Pharma Gmbh & Co Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3826855A1 (de) * 1988-08-06 1990-02-15 Cassella Ag 4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung
DE3913597A1 (de) * 1989-04-25 1990-11-08 Heumann Pharma Gmbh & Co Diazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
US7309701B2 (en) 2002-11-19 2007-12-18 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
US7462613B2 (en) 2002-11-19 2008-12-09 Sanofi-Aventis Deutschland Gmbh Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EP1604988A1 (en) 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals
EP1598348A1 (en) 2004-05-18 2005-11-23 Aventis Pharma Deutschland GmbH Novel pyridazinone derivatives as inhibitors of CDK2
TWI375669B (en) 2006-03-17 2012-11-01 Sumitomo Chemical Co Pyridazinone compound and use thereof
SI2069312T1 (sl) 2006-07-25 2013-03-29 Cephalon, Inc. Derivati piridizinona
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
WO2015021358A2 (en) 2013-08-09 2015-02-12 Dominique Charmot Compounds and methods for inhibiting phosphate transport
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス, インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1383906A (en) * 1971-02-22 1974-02-12 Bdh Pharmaceuticals Ltd Pyridazinones
BE790106A (fr) * 1971-10-14 1973-04-13 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
DE3130251A1 (de) * 1981-07-31 1983-02-17 A. Nattermann & Cie GmbH, 5000 Köln 6-(4-((omega)-(1-imidazolyl)-alkyl)-phenyl)-3-oxo -2,3,4,5-tetrahydro-pyridazine und deren saeureadditionssalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
FI76084B (fi) 1988-05-31
NO823128L (no) 1983-03-18
IE822250L (en) 1983-03-17
FI823184A0 (fi) 1982-09-15
ES515743A0 (es) 1983-10-16
DD208615A5 (de) 1984-04-04
FI76084C (fi) 1988-09-09
ATE18909T1 (de) 1986-04-15
NO159595B (no) 1988-10-10
KR840001570A (ko) 1984-05-07
ES8400414A1 (es) 1983-10-16
AU563448B2 (en) 1987-07-09
EP0075436B1 (en) 1986-04-02
FI823184L (fi) 1983-03-18
PH19332A (en) 1986-03-20
GR76999B (da) 1984-09-04
KR880001623B1 (ko) 1988-09-02
DE3270274D1 (en) 1986-05-07
CA1190548A (en) 1985-07-16
EP0075436A1 (en) 1983-03-30
IL66815A0 (en) 1982-12-31
IL66815A (en) 1986-02-28
AU8840982A (en) 1983-03-24
IE54101B1 (en) 1989-06-21
HU190412B (en) 1986-09-29
NZ201929A (en) 1985-11-08
NO159595C (no) 1989-01-18

Similar Documents

Publication Publication Date Title
DK414482A (da) Fremgangsmaade til fremstilling af substituerede 4,5-dihydro-6-(substitueret)phenyl-3(2h)-pyridazinoner og 6-(substitueret)phenyl-3(2h)-pyridazinoner
YU1900A (sh) Derivati ariloksiarilsulfonilamino hidroksaminske kiseline
NO914230L (no) Imidazoler, fremgangsmaate for deres fremstilling og anvendelse
DK129282A (da) Fremgangsmaade til fremstilling af indolylethylderivater
MY101042A (en) Pyridazinone derivatives,process for preparation thereof, and insecticidal compotions
ES530809A0 (es) Un procedimiento para preparar derivados de piridazinona
SE8005946L (sv) 6-pyridazinoner och komposition anvendbar sasom cardiotonikum
DE3572816D1 (de) Pyridazinone inotropic agents
AU529482B2 (en) N-pyrrolyl-pyridazineamines
ES8602772A1 (es) Un procedimiento de preparar un derivado de 4,5-dihidro-6-(2-(4-(1h-imidazol-1-il)-fenil)-alquilenil o alquilen-3(2h)-piridazinona.
US3898230A (en) Sydnone imine compounds
ES8801802A1 (es) Procedimiento para preparar piridazinonas alquil-substituidas
SE8102660L (sv) 6-(pyridinyl)-4-substituerade-3-(2h)-pyridazinoner, anvendbara som kardiotoniska medel, och framstellning derav
EP0186484A3 (en) 4,5-dihydro-4,4-dialkyl-6-)substituted) phenyl-3-(2h)-pyridazinones useful as cardiotonic agents
ES8203880A1 (es) Un procedimiento para preparar una 4,5-dihidro-2-r-4-r -6-py-3(2h)-piridazinona

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment