DK3882249T3 - Deutererede derivater af ruxolitinib - Google Patents
Deutererede derivater af ruxolitinibInfo
- Publication number
- DK3882249T3 DK3882249T3 DK21156398.6T DK21156398T DK3882249T3 DK 3882249 T3 DK3882249 T3 DK 3882249T3 DK 21156398 T DK21156398 T DK 21156398T DK 3882249 T3 DK3882249 T3 DK 3882249T3
- Authority
- DK
- Denmark
- Prior art keywords
- deuterized
- ruxolitinib
- derivatives
- deuterized derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660428P | 2012-06-15 | 2012-06-15 | |
| US201261678795P | 2012-08-02 | 2012-08-02 | |
| EP18188152.5A EP3450434B1 (en) | 2012-06-15 | 2013-06-14 | Deuterated derivatives of ruxolitinib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3882249T3 true DK3882249T3 (da) | 2025-08-25 |
Family
ID=48699982
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK21156398.6T DK3882249T3 (da) | 2012-06-15 | 2013-06-14 | Deutererede derivater af ruxolitinib |
| DK18188152.5T DK3450434T3 (da) | 2012-06-15 | 2013-06-14 | Deutererede derivater af ruxolitinib |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18188152.5T DK3450434T3 (da) | 2012-06-15 | 2013-06-14 | Deutererede derivater af ruxolitinib |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US20150197525A1 (Sortimente) |
| EP (4) | EP3450434B1 (Sortimente) |
| AU (3) | AU2013274030B2 (Sortimente) |
| BR (1) | BR122023027277A2 (Sortimente) |
| CA (1) | CA2876306C (Sortimente) |
| DK (2) | DK3882249T3 (Sortimente) |
| EA (1) | EA201492287A1 (Sortimente) |
| ES (2) | ES3037872T3 (Sortimente) |
| FI (1) | FI3882249T3 (Sortimente) |
| HR (1) | HRP20250965T1 (Sortimente) |
| IN (1) | IN2014DN10670A (Sortimente) |
| LT (1) | LT3882249T (Sortimente) |
| MX (2) | MX360495B (Sortimente) |
| PL (2) | PL3450434T3 (Sortimente) |
| PT (1) | PT3882249T (Sortimente) |
| RS (1) | RS67061B1 (Sortimente) |
| SI (1) | SI3882249T1 (Sortimente) |
| SM (1) | SMT202500302T1 (Sortimente) |
| WO (1) | WO2013188783A1 (Sortimente) |
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| SI2455382T1 (sl) | 2005-12-13 | 2017-03-31 | Incyte Holdings Corporation | S heteroarilom substituirani pirolo(2,3b)piridini in pirolo(2,3-b)pirimidini kot zaviralci janus kinaze |
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| WO2012177606A1 (en) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| FI3882249T3 (fi) | 2012-06-15 | 2025-08-11 | Sun Pharmaceutical Ind Inc | Ruksolitinibin deuteroidut johdannaiset |
| ES2880814T3 (es) | 2012-11-15 | 2021-11-25 | Incyte Holdings Corp | Formas de dosificación de liberación sostenida de ruxolitinib |
| TWI789516B (zh) | 2013-08-07 | 2023-01-11 | 美商英塞特公司 | Jak1抑制劑之持續釋放劑型 |
| EP3148545B1 (en) | 2014-05-28 | 2023-03-15 | Onco Tracker, Inc. | Anti-cancer effects of jak2 inhibitors in combination with thalidomide derivatives and glucocorticoids |
| WO2016196961A1 (en) | 2015-06-03 | 2016-12-08 | Uwm Research Foundation, Inc. | Ligands selective to alpha 6 subunit-containing gabaa receptors ans their methods of use |
| DK3411031T3 (da) | 2016-02-04 | 2024-10-21 | Cindome Pharma Inc | Deutererede domperidonpræparater og fremgangsmåder til terapi af lidelser |
| MA44019A (fr) * | 2016-02-12 | 2018-12-19 | Vertex Pharmaceuticals Europe Ltd | Modulateurs de cftr modifiés par deutérium |
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| WO2020210125A1 (en) | 2019-04-10 | 2020-10-15 | University Of Notre Dame Du Lac | Deuterated antimicrobial compounds |
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| WO2021072098A1 (en) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| CA3157499A1 (en) | 2019-10-10 | 2021-04-15 | Incyte Corporation | Biomarkers for graft-versus-host disease |
| WO2021076124A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Use of jak1 inhibitors for the treatment of cutaneous lupus erythematosus and lichen planus (lp) |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| CN112791078B (zh) | 2019-11-13 | 2022-12-06 | 润佳（苏州）医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途 |
| JP7717065B2 (ja) | 2019-11-22 | 2025-08-01 | インサイト コーポレーション | Ａｌｋ２阻害剤及びｊａｋ２阻害剤を含む併用療法 |
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| ES2467665T5 (es) * | 2007-06-13 | 2022-11-03 | Incyte Holdings Corp | Sales del inhibidor de cinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo |
| JP2011510079A (ja) | 2008-01-22 | 2011-03-31 | コンサート ファーマシューティカルズ インコーポレイテッド | ゲフィチニブ誘導体 |
| JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| FI3882249T3 (fi) | 2012-06-15 | 2025-08-11 | Sun Pharmaceutical Ind Inc | Ruksolitinibin deuteroidut johdannaiset |
| ES2880814T3 (es) * | 2012-11-15 | 2021-11-25 | Incyte Holdings Corp | Formas de dosificación de liberación sostenida de ruxolitinib |
-
2013
- 2013-06-14 FI FIEP21156398.6T patent/FI3882249T3/fi active
- 2013-06-14 ES ES21156398T patent/ES3037872T3/es active Active
- 2013-06-14 EP EP18188152.5A patent/EP3450434B1/en active Active
- 2013-06-14 SI SI201332107T patent/SI3882249T1/sl unknown
- 2013-06-14 EP EP25175288.7A patent/EP4606434A3/en active Pending
- 2013-06-14 HR HRP20250965TT patent/HRP20250965T1/hr unknown
- 2013-06-14 WO PCT/US2013/045919 patent/WO2013188783A1/en not_active Ceased
- 2013-06-14 PL PL18188152T patent/PL3450434T3/pl unknown
- 2013-06-14 EP EP13732046.1A patent/EP2861600A1/en not_active Withdrawn
- 2013-06-14 MX MX2014015185A patent/MX360495B/es active IP Right Grant
- 2013-06-14 SM SM20250302T patent/SMT202500302T1/it unknown
- 2013-06-14 EA EA201492287A patent/EA201492287A1/ru unknown
- 2013-06-14 BR BR122023027277-3A patent/BR122023027277A2/pt not_active Application Discontinuation
- 2013-06-14 IN IN10670DEN2014 patent/IN2014DN10670A/en unknown
- 2013-06-14 EP EP21156398.6A patent/EP3882249B1/en active Active
- 2013-06-14 RS RS20250758A patent/RS67061B1/sr unknown
- 2013-06-14 PT PT211563986T patent/PT3882249T/pt unknown
- 2013-06-14 AU AU2013274030A patent/AU2013274030B2/en active Active
- 2013-06-14 LT LTEP21156398.6T patent/LT3882249T/lt unknown
- 2013-06-14 ES ES18188152T patent/ES2867048T3/es active Active
- 2013-06-14 DK DK21156398.6T patent/DK3882249T3/da active
- 2013-06-14 CA CA2876306A patent/CA2876306C/en active Active
- 2013-06-14 DK DK18188152.5T patent/DK3450434T3/da active
- 2013-06-14 MX MX2018013542A patent/MX373123B/es unknown
- 2013-06-14 PL PL21156398.6T patent/PL3882249T3/pl unknown
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2014
- 2014-12-15 US US14/570,954 patent/US20150197525A1/en not_active Abandoned
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2015
- 2015-05-08 US US14/707,912 patent/US9249149B2/en active Active
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2016
- 2016-10-05 AU AU2016238877A patent/AU2016238877B2/en active Active
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2017
- 2017-03-09 US US15/454,844 patent/US20170239254A1/en not_active Abandoned
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2018
- 2018-11-26 AU AU2018271227A patent/AU2018271227B2/en active Active
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2019
- 2019-03-11 US US16/298,795 patent/US20190308976A1/en not_active Abandoned
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2020
- 2020-12-10 US US17/118,050 patent/US20210330674A1/en not_active Abandoned
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2022
- 2022-12-09 US US18/078,571 patent/US20230355629A1/en active Pending
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2024
- 2024-10-03 US US18/905,925 patent/US20250025467A1/en active Pending
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