MA44019A - Modulateurs de cftr modifiés par deutérium - Google Patents

Modulateurs de cftr modifiés par deutérium

Info

Publication number
MA44019A
MA44019A MA044019A MA44019A MA44019A MA 44019 A MA44019 A MA 44019A MA 044019 A MA044019 A MA 044019A MA 44019 A MA44019 A MA 44019A MA 44019 A MA44019 A MA 44019A
Authority
MA
Morocco
Prior art keywords
deuterium modified
cftr modulators
modified cftr
modulators
deuterium
Prior art date
Application number
MA044019A
Other languages
English (en)
Inventor
I Robert Silverman
Original Assignee
Vertex Pharmaceuticals Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Europe Ltd filed Critical Vertex Pharmaceuticals Europe Ltd
Publication of MA44019A publication Critical patent/MA44019A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA044019A 2016-02-12 2017-02-10 Modulateurs de cftr modifiés par deutérium MA44019A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662294543P 2016-02-12 2016-02-12

Publications (1)

Publication Number Publication Date
MA44019A true MA44019A (fr) 2018-12-19

Family

ID=59563573

Family Applications (1)

Application Number Title Priority Date Filing Date
MA044019A MA44019A (fr) 2016-02-12 2017-02-10 Modulateurs de cftr modifiés par deutérium

Country Status (6)

Country Link
US (1) US20190048020A1 (fr)
EP (1) EP3414235A4 (fr)
AU (1) AU2017217806A1 (fr)
CA (1) CA3014275A1 (fr)
MA (1) MA44019A (fr)
WO (1) WO2017139569A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10196384B2 (en) 2015-03-31 2019-02-05 Vertex Pharmaceuticals (Europe) Limited Deuterated CFTR modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9453027B2 (en) * 2009-07-27 2016-09-27 Daljit Singh Dhanoa Deuterium-enriched pyridinonecarboxamides and derivatives
US20150197525A1 (en) * 2012-06-15 2015-07-16 Concert Pharmaceuticals, Inc. Deuterated derivatives of ruxolitinib
MY176814A (en) * 2013-08-08 2020-08-21 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis

Also Published As

Publication number Publication date
EP3414235A4 (fr) 2019-01-02
EP3414235A1 (fr) 2018-12-19
US20190048020A1 (en) 2019-02-14
CA3014275A1 (fr) 2017-08-17
AU2017217806A1 (en) 2018-08-16
WO2017139569A1 (fr) 2017-08-17

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