DK3852748T3 - Farnesoid x-receptor-agonister og deres anvendelse - Google Patents
Farnesoid x-receptor-agonister og deres anvendelseInfo
- Publication number
- DK3852748T3 DK3852748T3 DK19862391.0T DK19862391T DK3852748T3 DK 3852748 T3 DK3852748 T3 DK 3852748T3 DK 19862391 T DK19862391 T DK 19862391T DK 3852748 T3 DK3852748 T3 DK 3852748T3
- Authority
- DK
- Denmark
- Prior art keywords
- farnesoid
- receptor agonists
- agonists
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Virology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862733004P | 2018-09-18 | 2018-09-18 | |
| US201862733006P | 2018-09-18 | 2018-09-18 | |
| US201962881560P | 2019-08-01 | 2019-08-01 | |
| PCT/US2019/051603 WO2020061113A1 (en) | 2018-09-18 | 2019-09-17 | Farnesoid x receptor agonists and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3852748T3 true DK3852748T3 (da) | 2025-10-06 |
Family
ID=69887982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19862391.0T DK3852748T3 (da) | 2018-09-18 | 2019-09-17 | Farnesoid x-receptor-agonister og deres anvendelse |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US11084817B2 (https=) |
| EP (2) | EP4596543A3 (https=) |
| JP (1) | JP7554739B2 (https=) |
| KR (2) | KR102810978B1 (https=) |
| CN (1) | CN113056271B (https=) |
| AU (2) | AU2019344903B2 (https=) |
| BR (1) | BR112021004919A2 (https=) |
| CA (1) | CA3112411A1 (https=) |
| CL (1) | CL2021000632A1 (https=) |
| DK (1) | DK3852748T3 (https=) |
| ES (1) | ES3051007T3 (https=) |
| FI (1) | FI3852748T3 (https=) |
| HR (1) | HRP20251321T1 (https=) |
| IL (1) | IL281475B2 (https=) |
| LT (1) | LT3852748T (https=) |
| MA (1) | MA53665B1 (https=) |
| MD (1) | MD3852748T2 (https=) |
| MX (1) | MX2021003110A (https=) |
| PH (1) | PH12021550605A1 (https=) |
| PL (1) | PL3852748T3 (https=) |
| PT (1) | PT3852748T (https=) |
| RS (1) | RS67371B1 (https=) |
| SG (1) | SG11202102651SA (https=) |
| SI (1) | SI3852748T1 (https=) |
| SM (1) | SMT202600076T1 (https=) |
| TW (1) | TWI833805B (https=) |
| WO (1) | WO2020061113A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7258763B2 (ja) * | 2017-03-15 | 2023-04-17 | メタクリン，インク． | ファルネソイドｘ受容体アゴニストおよびその使用 |
| CA3055990A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| AU2019344903B2 (en) | 2018-09-18 | 2025-02-27 | Eli Lilly And Company | Farnesoid X receptor agonists and uses thereof |
| IL293892A (en) | 2020-01-15 | 2022-08-01 | Inserm Institut National De La Sant? Et De La Rech M?Dicale | Use of fxr agonists for treating an infection by hepatitis d virus |
| CN120732855A (zh) * | 2020-03-18 | 2025-10-03 | 伊莱利利公司 | 用于治疗疾病的法尼醇x受体激动剂 |
| WO2021188695A1 (en) | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
| KR20220155356A (ko) * | 2020-03-18 | 2022-11-22 | 메타크린, 인크. | 파르네소이드 x 수용체 효능제의 결정형 |
| JP2024502673A (ja) | 2021-01-14 | 2024-01-22 | ウエヌイグレックオ・ファーマ | Ｈｂｖ感染の処置のためのｆｘｒアゴニストとｉｆｎの相乗効果 |
| JP2024517181A (ja) | 2021-04-28 | 2024-04-19 | ウエヌイグレックオ・ファーマ | 組合せ治療としてｆｘｒアゴニストを使用するｔｌｒ３アゴニストの効果の強い増強 |
| CN116554121A (zh) * | 2023-05-05 | 2023-08-08 | 济南悟通生物科技有限公司 | 一种2-异丁基噻唑的合成方法 |
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| EP3852749A4 (en) | 2018-09-18 | 2022-08-24 | Metacrine, Inc. | CRYSTALLINE FORMS OF A FARNESOID X RECEPTOR AGONIST |
| CN113056264A (zh) | 2018-09-18 | 2021-06-29 | 梅塔科林公司 | 法尼醇x受体激动剂及其用途 |
| AU2019344903B2 (en) | 2018-09-18 | 2025-02-27 | Eli Lilly And Company | Farnesoid X receptor agonists and uses thereof |
| EA202190661A1 (ru) | 2018-09-18 | 2021-08-13 | Метакрайн, Инк. | Агонисты фарнезоидного х-рецептора для лечения заболевания |
| CN120732855A (zh) | 2020-03-18 | 2025-10-03 | 伊莱利利公司 | 用于治疗疾病的法尼醇x受体激动剂 |
| WO2021188695A1 (en) | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
| KR20220155356A (ko) | 2020-03-18 | 2022-11-22 | 메타크린, 인크. | 파르네소이드 x 수용체 효능제의 결정형 |
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2019
- 2019-09-17 AU AU2019344903A patent/AU2019344903B2/en active Active
- 2019-09-17 CA CA3112411A patent/CA3112411A1/en active Pending
- 2019-09-17 WO PCT/US2019/051603 patent/WO2020061113A1/en not_active Ceased
- 2019-09-17 LT LTEPPCT/US2019/051603T patent/LT3852748T/lt unknown
- 2019-09-17 MA MA53665A patent/MA53665B1/fr unknown
- 2019-09-17 EP EP25178478.1A patent/EP4596543A3/en active Pending
- 2019-09-17 PL PL19862391.0T patent/PL3852748T3/pl unknown
- 2019-09-17 MX MX2021003110A patent/MX2021003110A/es unknown
- 2019-09-17 HR HRP20251321TT patent/HRP20251321T1/hr unknown
- 2019-09-17 TW TW108133441A patent/TWI833805B/zh active
- 2019-09-17 DK DK19862391.0T patent/DK3852748T3/da active
- 2019-09-17 PT PT198623910T patent/PT3852748T/pt unknown
- 2019-09-17 SG SG11202102651SA patent/SG11202102651SA/en unknown
- 2019-09-17 SI SI201930976T patent/SI3852748T1/sl unknown
- 2019-09-17 US US16/573,993 patent/US11084817B2/en active Active
- 2019-09-17 JP JP2021513407A patent/JP7554739B2/ja active Active
- 2019-09-17 BR BR112021004919-3A patent/BR112021004919A2/pt unknown
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- 2019-09-17 SM SM20260076T patent/SMT202600076T1/it unknown
- 2019-09-17 CN CN201980075902.2A patent/CN113056271B/zh active Active
- 2019-09-17 ES ES19862391T patent/ES3051007T3/es active Active
- 2019-09-17 KR KR1020217011359A patent/KR102810978B1/ko active Active
- 2019-09-17 RS RS20251101A patent/RS67371B1/sr unknown
- 2019-09-17 KR KR1020257016139A patent/KR20250073553A/ko active Pending
- 2019-09-17 FI FIEP19862391.0T patent/FI3852748T3/fi active
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2021
- 2021-03-16 CL CL2021000632A patent/CL2021000632A1/es unknown
- 2021-03-17 PH PH12021550605A patent/PH12021550605A1/en unknown
- 2021-06-16 US US17/349,757 patent/US11773094B2/en active Active
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2023
- 2023-07-17 US US18/353,659 patent/US20230382913A1/en not_active Abandoned
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2024
- 2024-10-31 US US18/933,587 patent/US20250289821A1/en active Pending
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2025
- 2025-05-22 AU AU2025203804A patent/AU2025203804A1/en active Pending
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