DK3704108T3 - Irak4-hæmmer i kombination med en bcl-2-hæmmer til anvendelse i cancerbehandling - Google Patents

Irak4-hæmmer i kombination med en bcl-2-hæmmer til anvendelse i cancerbehandling Download PDF

Info

Publication number
DK3704108T3
DK3704108T3 DK18873778.7T DK18873778T DK3704108T3 DK 3704108 T3 DK3704108 T3 DK 3704108T3 DK 18873778 T DK18873778 T DK 18873778T DK 3704108 T3 DK3704108 T3 DK 3704108T3
Authority
DK
Denmark
Prior art keywords
inhibitor
bcl
cancer
treatment
combination
Prior art date
Application number
DK18873778.7T
Other languages
Danish (da)
English (en)
Inventor
Robert Booher
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Application granted granted Critical
Publication of DK3704108T3 publication Critical patent/DK3704108T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK18873778.7T 2017-10-31 2018-10-30 Irak4-hæmmer i kombination med en bcl-2-hæmmer til anvendelse i cancerbehandling DK3704108T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762579502P 2017-10-31 2017-10-31
PCT/US2018/058194 WO2019089580A1 (en) 2017-10-31 2018-10-30 Compounds and compositions for treating hematological disorders

Publications (1)

Publication Number Publication Date
DK3704108T3 true DK3704108T3 (da) 2024-06-10

Family

ID=66328095

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18873778.7T DK3704108T3 (da) 2017-10-31 2018-10-30 Irak4-hæmmer i kombination med en bcl-2-hæmmer til anvendelse i cancerbehandling

Country Status (27)

Country Link
US (3) US10758518B2 (enExample)
EP (2) EP3704108B1 (enExample)
JP (3) JP7241747B2 (enExample)
KR (2) KR102697663B1 (enExample)
CN (2) CN117064897A (enExample)
AU (3) AU2018359248B2 (enExample)
BR (1) BR112020008214A2 (enExample)
CA (1) CA3079628A1 (enExample)
DK (1) DK3704108T3 (enExample)
EA (1) EA202090497A1 (enExample)
ES (1) ES2979273T3 (enExample)
FI (1) FI3704108T3 (enExample)
HR (1) HRP20240700T1 (enExample)
HU (1) HUE067356T2 (enExample)
IL (3) IL308364B2 (enExample)
LT (1) LT3704108T (enExample)
MX (2) MX2020003666A (enExample)
MY (1) MY203827A (enExample)
NZ (1) NZ762393A (enExample)
PH (1) PH12020550457A1 (enExample)
PL (1) PL3704108T3 (enExample)
PT (1) PT3704108T (enExample)
RS (1) RS65572B1 (enExample)
SG (1) SG11202002386WA (enExample)
SI (1) SI3704108T1 (enExample)
SM (1) SMT202400216T1 (enExample)
WO (1) WO2019089580A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20181795T1 (hr) 2014-01-13 2019-01-25 Aurigene Discovery Technologies Limited Biciklički heterociklilni derivati kao inhibitori irak4
US11419875B2 (en) 2017-03-31 2022-08-23 Aurigene Discovery Technologies Limited Compounds and compositions for treating hematological disorders
EP3704108B1 (en) * 2017-10-31 2024-04-24 Curis, Inc. Irak4 inhibitor in combination with a bcl-2 inhibitor for use in treating cancer
HRP20240122T8 (hr) * 2019-09-24 2024-05-24 Shanghai Meiyue Biotech Development Co., Ltd. Irak inhibitor i metoda njegove pripreme i upotrebe
US20230151025A1 (en) 2020-04-07 2023-05-18 Bayer Aktiengesellschaft Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances
WO2022031330A1 (en) * 2020-08-03 2022-02-10 Curis, Inc. Compositions and methods for treating diseases and disorders
CN116710776A (zh) * 2020-11-18 2023-09-05 柯里斯公司 治疗疾病和病症的方法
CN116745294A (zh) * 2020-12-25 2023-09-12 南京明德新药研发有限公司 酰胺噁唑类化合物
KR20240004476A (ko) * 2021-04-08 2024-01-11 쿠리스 인코퍼레이션 암 치료를 위한 병용 요법
CN113402499B (zh) 2021-06-21 2022-05-13 上海勋和医药科技有限公司 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途
TW202328151A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途
TW202328150A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途
CN118530221A (zh) 2021-12-23 2024-08-23 杭州多域生物技术有限公司 一种五元并六元化合物、制备方法、药物组合物和应用
WO2025090844A1 (en) * 2023-10-27 2025-05-01 Curis, Inc. Methods of treating cancer associated with reduced interleukin 1 beta expression

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
HU222234B1 (hu) 1990-05-18 2003-05-28 Aventis Pharma Deutschland Gmbh. Eljárás izoxazol-4-karbonsav-amidok és hidroxi-alkilidén-cián-ecetsav-amidok, a vegyületeket tartalmazó gyógyászati készítmények és az ismert vegyületeket tartalmazó rákellenes hatású gyógyszerkészítmények előállítására
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
CN100408100C (zh) 1997-07-29 2008-08-06 阿尔康实验室公司 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物
JP2002501892A (ja) 1998-01-29 2002-01-22 セプラコア インコーポレーテッド 光学的に純粋な（−）−ビュープロピオンの薬学的使用
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
DE10023486C1 (de) 2000-05-09 2002-03-14 Schering Ag Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
BRPI0409949A (pt) 2003-05-01 2006-04-25 Bristol Myers Squibb Co compostos de pirazol amida aril-substituìda úteis como inibidores de cinase
WO2004103954A1 (ja) 2003-05-20 2004-12-02 Ajinomoto Co., Inc. アミド誘導体
JP2006526660A (ja) 2003-06-05 2006-11-24 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｖｒ１レセプターのモジュレーター
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US7338950B2 (en) 2003-10-07 2008-03-04 Renovis, Inc. Amide compounds as ion channel ligands and uses thereof
WO2005107460A1 (en) 2004-04-22 2005-11-17 Bayer Cropscience Lp Method and composition for controlling weeds
EP1655297A1 (en) 2004-11-03 2006-05-10 Schering Aktiengesellschaft Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
US7906533B2 (en) 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
EP1819341A4 (en) 2004-11-10 2011-06-29 Synta Pharmaceuticals Corp IL-12 MODULATORY CONNECTIONS
ATE404555T1 (de) 2004-12-17 2008-08-15 Lilly Co Eli Neue mch-rezeptorantagonisten
JP5072602B2 (ja) 2004-12-17 2012-11-14 イーライ リリー アンド カンパニー Ｍｃｈ受容体アンタゴニストとしてのチアゾロピリジノン誘導体
EP1674467A1 (en) 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
EP2295432A1 (en) 2006-02-10 2011-03-16 TransTech Pharma Inc. Process for the preparation of aminobenzimidazole derivatives
GB0606429D0 (en) 2006-03-30 2006-05-10 Novartis Ag Organic compounds
EP2001480A4 (en) 2006-03-31 2011-06-15 Abbott Lab Indazole CONNECTIONS
US20080293785A1 (en) 2006-04-11 2008-11-27 Connolly Peter J Substituted benzothiazole kinase inhibitors
US20110021513A1 (en) 2006-09-07 2011-01-27 Biogen Idec Ma Inc. Modulators of interleukin-1 receptor-associated kinase
EP2061786A2 (en) 2006-09-07 2009-05-27 Biogen Idec MA Inc. Indazole derivatives as modulators of interleukin-1 receptor-associated kinase
WO2008061109A2 (en) 2006-11-15 2008-05-22 Forest Laboratories Holdings Limited Indazole derivatives useful as melanin concentrating receptor ligands
EP2121621B1 (en) 2006-12-08 2014-05-07 Exelixis Patent Company LLC Lxr and fxr modulators
JP4785881B2 (ja) 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
ES2457418T3 (es) 2007-07-16 2014-04-25 Abbvie Inc. Indazoles, bencisoxazoles y bencisotiazoles como inhibidores de proteína cinasas
WO2009011850A2 (en) 2007-07-16 2009-01-22 Abbott Laboratories Novel therapeutic compounds
BRPI0814975A2 (pt) 2007-08-08 2015-02-03 Merck Serono Sa Derivados de 6-amino-pirimidina-4-carboxamida e compostos relacionados que se ligam ao receptor de 1-fosfato de esfingosina (s1p) para o tratamento de esclerose múltipla
US20090221612A1 (en) 2008-02-13 2009-09-03 Mitchell Scott A Certain substituted amides, method of making, and method of use thereof
US8716312B2 (en) 2008-11-19 2014-05-06 Merck Sharp & Dohme Corporation Inhibitors of diacylglycerol acyltransferase
WO2010071819A1 (en) 2008-12-19 2010-06-24 Schering Corporation Bicyclic heterocyclic derivatives and methods of use thereof
CN102264701A (zh) 2008-12-23 2011-11-30 霍夫曼-拉罗奇有限公司 作为p2x7调节剂的二氢吡啶酮脲
WO2011046954A1 (en) 2009-10-13 2011-04-21 Ligand Pharmaceuticals Inc. Hematopoietic growth factor mimetic small molecule compounds and their uses
JP2013525370A (ja) 2010-04-22 2013-06-20 ヤンセン ファーマシューティカ エヌ．ベー． ケトヘキソキナーゼ阻害剤として有用なインダゾール化合物
US20130053382A1 (en) 2010-04-30 2013-02-28 Sunil Paliwal Inhibitors of Phosphoinositide Dependent Kinase 1 (PDK1)
US9126939B2 (en) 2010-06-24 2015-09-08 Pingchen Fan C5AR antagonists
KR101995013B1 (ko) 2010-07-13 2019-07-02 에프. 호프만-라 로슈 아게 Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체
MX366318B (es) 2010-11-19 2019-07-05 Ligand Pharm Inc Derivados de aminas heterocíclicas que inhiben la transducción de señal mediana por cinasa asociada con el receptor de interleucina-1.
ES2592713T3 (es) 2010-12-20 2016-12-01 Merck Serono S.A. Derivados de indazolil-triazol como inhibidores de IRAK
EP2696873B1 (en) 2011-04-12 2022-08-03 The United States of America, as represented by The Secretary, Department of Health and Human Services Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
WO2013059587A1 (en) 2011-10-20 2013-04-25 Sirtris Pharmaceuticals, Inc. Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
GB201119401D0 (en) 2011-11-10 2011-12-21 Ucb Pharma Sa Therapeutic agents
KR101385603B1 (ko) 2012-05-17 2014-04-21 한국원자력의학원 벤조티아졸 유도체 및 암 치료를 위한 그의 용도
WO2014003483A1 (en) 2012-06-29 2014-01-03 Hanmi Pharm. Co., Ltd. Fused pyrimidine derivatives having inhibitory activity on fms kinases
EP2872144A4 (en) 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
JP6372666B2 (ja) 2012-11-03 2018-08-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害剤
WO2014190163A2 (en) * 2013-05-22 2014-11-27 Children's Hospital Medical Center Combination therapy for mds
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
KR20160115933A (ko) 2014-01-10 2016-10-06 오리진 디스커버리 테크놀로지스 리미티드 Irak4 억제제로서의 인다졸 화합물
HRP20181795T1 (hr) 2014-01-13 2019-01-25 Aurigene Discovery Technologies Limited Biciklički heterociklilni derivati kao inhibitori irak4
KR20160118345A (ko) 2014-02-06 2016-10-11 애브비 인코포레이티드 6-헤테로아릴옥시- 및 6-아릴옥시-퀴놀린-2-카복사미드 및 이의 용도
EP3157521A4 (en) * 2014-06-20 2018-02-14 Aurigene Discovery Technologies Limited Substituted indazole compounds as irak4 inhibitors
EA201890307A1 (ru) 2015-07-15 2018-10-31 Ориджин Дискавери Текнолоджиз Лимитед Индазольные и азаиндазольные соединения как ингибиторы irak-4
EP3322409A4 (en) 2015-07-15 2019-07-24 Aurigene Discovery Technologies Limited SUBSTITUTED AZA COMPOUNDS AS IRAQ-4 INHIBITORS
US10065946B2 (en) * 2015-08-04 2018-09-04 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
US20210292843A1 (en) 2016-10-28 2021-09-23 Children's Hospital Medical Center Treatment of diseases associated with activated irak
EP3704108B1 (en) * 2017-10-31 2024-04-24 Curis, Inc. Irak4 inhibitor in combination with a bcl-2 inhibitor for use in treating cancer

Also Published As

Publication number Publication date
KR20200080254A (ko) 2020-07-06
IL308364B2 (en) 2025-02-01
MX2023010882A (es) 2023-09-27
IL308364A (en) 2024-01-01
IL274248B1 (en) 2024-02-01
CA3079628A1 (en) 2019-05-09
AU2023222890B2 (en) 2025-04-17
ES2979273T3 (es) 2024-09-25
PH12020550457A1 (en) 2021-03-22
JP7241747B2 (ja) 2023-03-17
KR102697663B1 (ko) 2024-08-21
KR20240130818A (ko) 2024-08-29
MX2020003666A (es) 2020-08-03
JP7476380B2 (ja) 2024-04-30
SMT202400216T1 (it) 2024-07-09
JP2021501145A (ja) 2021-01-14
JP2024096919A (ja) 2024-07-17
IL315025A (en) 2024-10-01
EP3704108A4 (en) 2021-08-25
IL308364B1 (en) 2024-10-01
PT3704108T (pt) 2024-06-11
HUE067356T2 (hu) 2024-10-28
MY203827A (en) 2024-07-19
US20200345704A1 (en) 2020-11-05
AU2018359248B2 (en) 2023-06-01
CN111225911B (zh) 2023-09-01
AU2018359248A1 (en) 2020-03-26
SG11202002386WA (en) 2020-04-29
FI3704108T3 (fi) 2024-05-23
EP4410377A2 (en) 2024-08-07
AU2025205341A1 (en) 2025-07-31
IL274248A (en) 2020-06-30
CN117064897A (zh) 2023-11-17
EA202090497A1 (ru) 2020-11-23
US20220370422A1 (en) 2022-11-24
IL274248B2 (en) 2024-06-01
RS65572B1 (sr) 2024-06-28
WO2019089580A1 (en) 2019-05-09
CN111225911A (zh) 2020-06-02
EP4410377A3 (en) 2024-11-13
EP3704108A1 (en) 2020-09-09
AU2023222890A1 (en) 2023-09-14
NZ762393A (en) 2025-07-25
JP2023071915A (ja) 2023-05-23
LT3704108T (lt) 2024-06-25
PL3704108T3 (pl) 2024-07-22
BR112020008214A2 (pt) 2020-10-27
HRP20240700T1 (hr) 2024-08-16
US10758518B2 (en) 2020-09-01
US20190134010A1 (en) 2019-05-09
EP3704108B1 (en) 2024-04-24
SI3704108T1 (sl) 2024-07-31

Similar Documents

Publication Publication Date Title
DK3704108T3 (da) Irak4-hæmmer i kombination med en bcl-2-hæmmer til anvendelse i cancerbehandling
HUS2500039I1 (hu) Elafibranor primer biliáris cirrózis kezelésében történõ alkalmazásra
GB201614522D0 (en) Use of cannabinoids in the treatment of multiple myeloma
HRP20181490T1 (hr) Spojevi 1, 3, 4-tiadiazola i njihova upotreba u liječenju raka
DK3710000T3 (da) Tradipitant til anvendelse til behandling af gastroparese
PL3490560T3 (pl) Niraparyb do stosowania w sposobie leczenia nowotworu prostaty
HUE059990T2 (hu) 2-Oxo-tiazol-származékok A2A inhibitorként és a rákos megbetegedések kezelésében alkalmazható vegyületekként
HUE058314T2 (hu) Pridopidin alkalmazása Rett-szindróma kezelésére
PL3732294T3 (pl) Tymohydrochinon do stosowania w leczeniu hiperglikemii
HUE053927T2 (hu) Farneziltranszferáz inhibitorok rák kezelésében történõ alkalmazásra
DK3463436T3 (da) Vaccine i kombination med en immuncheckpoint-hæmmer til anvendelse i cancerbehandling
PT3773589T (pt) Inibidor de ret para utilização no tratamento de cancro com alteração de ret
PL3236960T3 (pl) Fluralaner do zastosowania w leczeniu demodekozy
HUE054065T2 (hu) Szerek glióma kezelésében történõ alkalmazásra
IL247969B (en) A medicinal component for use in the treatment of infections
IL260373B (en) IL-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
EP3704104A4 (en) IRAK4 INHIBITORS AND THEIR USES
HUE058645T2 (hu) Gyógyszer köszvény kezelésében való felhasználásra
LT3405197T (lt) Delgocitinibo panaudojimas lėtinės rankų egzemos gydymui
HUE046209T2 (hu) Kompozíció porckoronggal összefüggõ fájdalom kezelésében történõ alkalmazásra
ZA202006886B (en) R-fadrozole for use in the treatment of aldostonerism
IL273863B1 (en) Hemorrhoid treatment device
IL269121A (en) Usl-311 for use in the treatment of cancer
PT3402474T (pt) Inibidores de il-8 para utilização no tratamento de neuropatia periférica induzida por quimioterapia