PT3704108T - Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancro - Google Patents
Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancroInfo
- Publication number
- PT3704108T PT3704108T PT188737787T PT18873778T PT3704108T PT 3704108 T PT3704108 T PT 3704108T PT 188737787 T PT188737787 T PT 188737787T PT 18873778 T PT18873778 T PT 18873778T PT 3704108 T PT3704108 T PT 3704108T
- Authority
- PT
- Portugal
- Prior art keywords
- compositions
- compounds
- hematological disorders
- treating hematological
- treating
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 208000014951 hematologic disease Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762579502P | 2017-10-31 | 2017-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT3704108T true PT3704108T (pt) | 2024-06-11 |
Family
ID=66328095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT188737787T PT3704108T (pt) | 2017-10-31 | 2018-10-30 | Inibidor de irak4 em combinação com um inibidor de bcl-2 para utilização no tratamento de cancro |
Country Status (22)
Country | Link |
---|---|
US (3) | US10758518B2 (pt) |
EP (2) | EP4410377A2 (pt) |
JP (3) | JP7241747B2 (pt) |
KR (2) | KR102697663B1 (pt) |
CN (2) | CN117064897A (pt) |
AU (2) | AU2018359248B2 (pt) |
BR (1) | BR112020008214A2 (pt) |
CA (1) | CA3079628A1 (pt) |
DK (1) | DK3704108T3 (pt) |
EA (1) | EA202090497A1 (pt) |
FI (1) | FI3704108T3 (pt) |
HR (1) | HRP20240700T1 (pt) |
IL (2) | IL308364A (pt) |
LT (1) | LT3704108T (pt) |
MX (2) | MX2020003666A (pt) |
PH (1) | PH12020550457A1 (pt) |
PL (1) | PL3704108T3 (pt) |
PT (1) | PT3704108T (pt) |
RS (1) | RS65572B1 (pt) |
SG (1) | SG11202002386WA (pt) |
SI (1) | SI3704108T1 (pt) |
WO (1) | WO2019089580A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102392684B1 (ko) | 2014-01-13 | 2022-04-29 | 오리진 디스커버리 테크놀로지스 리미티드 | Irak4 억제제로서의 바이시클릭 헤테로시클릴 유도체 |
IL293783B2 (en) | 2017-03-31 | 2024-01-01 | Aurigene Oncology Ltd | Compounds and preparations for the treatment of hematological disorders |
CA3152167C (en) * | 2019-09-24 | 2023-12-19 | Guozhong YE | Irak inhibitor and preparation method therefor and use thereof |
AU2021251341A1 (en) | 2020-04-07 | 2022-11-03 | Bayer Aktiengesellschaft | Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances |
MX2023001296A (es) * | 2020-08-03 | 2023-02-22 | Curis Inc | Composiciones y metodos para tratar enfermedades y trastornos. |
US20230414582A1 (en) * | 2020-11-18 | 2023-12-28 | Curis, Inc. | Methods of treating diseases and disorders |
JP2024500247A (ja) * | 2020-12-25 | 2024-01-05 | メッドシャイン ディスカバリー インコーポレイテッド | アミドオキサゾール系化合物 |
CN117120054A (zh) * | 2021-04-08 | 2023-11-24 | 柯里斯公司 | 治疗癌症的组合疗法 |
CN113402499B (zh) | 2021-06-21 | 2022-05-13 | 上海勋和医药科技有限公司 | 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途 |
TW202328151A (zh) | 2021-09-07 | 2023-07-16 | 德商拜耳廠股份有限公司 | 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途 |
TW202328150A (zh) | 2021-09-07 | 2023-07-16 | 德商拜耳廠股份有限公司 | 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途 |
EP4434981A1 (en) * | 2021-12-23 | 2024-09-25 | Hangzhou Polymed Biopharmaceuticals, Inc. | Five- and six-membered compound, and preparation method therefor and pharmaceutical composition and use thereof |
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KR102392684B1 (ko) | 2014-01-13 | 2022-04-29 | 오리진 디스커버리 테크놀로지스 리미티드 | Irak4 억제제로서의 바이시클릭 헤테로시클릴 유도체 |
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2018
- 2018-10-30 PL PL18873778.7T patent/PL3704108T3/pl unknown
- 2018-10-30 AU AU2018359248A patent/AU2018359248B2/en active Active
- 2018-10-30 EP EP24168755.7A patent/EP4410377A2/en active Pending
- 2018-10-30 SG SG11202002386WA patent/SG11202002386WA/en unknown
- 2018-10-30 RS RS20240586A patent/RS65572B1/sr unknown
- 2018-10-30 HR HRP20240700TT patent/HRP20240700T1/hr unknown
- 2018-10-30 EA EA202090497A patent/EA202090497A1/ru unknown
- 2018-10-30 IL IL308364A patent/IL308364A/en unknown
- 2018-10-30 CN CN202311020285.0A patent/CN117064897A/zh active Pending
- 2018-10-30 KR KR1020207013352A patent/KR102697663B1/ko active IP Right Grant
- 2018-10-30 FI FIEP18873778.7T patent/FI3704108T3/fi active
- 2018-10-30 JP JP2020523028A patent/JP7241747B2/ja active Active
- 2018-10-30 CN CN201880066904.0A patent/CN111225911B/zh active Active
- 2018-10-30 LT LTEPPCT/US2018/058194T patent/LT3704108T/lt unknown
- 2018-10-30 WO PCT/US2018/058194 patent/WO2019089580A1/en active Application Filing
- 2018-10-30 PT PT188737787T patent/PT3704108T/pt unknown
- 2018-10-30 EP EP18873778.7A patent/EP3704108B1/en active Active
- 2018-10-30 BR BR112020008214-7A patent/BR112020008214A2/pt unknown
- 2018-10-30 MX MX2020003666A patent/MX2020003666A/es unknown
- 2018-10-30 CA CA3079628A patent/CA3079628A1/en active Pending
- 2018-10-30 SI SI201831106T patent/SI3704108T1/sl unknown
- 2018-10-30 DK DK18873778.7T patent/DK3704108T3/da active
- 2018-10-30 KR KR1020247027492A patent/KR20240130818A/ko active Application Filing
- 2018-10-30 IL IL274248A patent/IL274248B2/en unknown
- 2018-10-31 US US16/176,940 patent/US10758518B2/en active Active
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2020
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- 2020-07-21 US US16/934,724 patent/US20200345704A1/en not_active Abandoned
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2021
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2023
- 2023-03-07 JP JP2023034551A patent/JP7476380B2/ja active Active
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2024
- 2024-04-17 JP JP2024066487A patent/JP2024096919A/ja active Pending
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