DK367987A - 1,2,3,3a,8,8a-hexahydro-3a,8(og 1,3a,8)-di(og tri)methylpyrrolooe2,3-baaindoler, deres fremstilling og anvendelse som laegemidler - Google Patents

1,2,3,3a,8,8a-hexahydro-3a,8(og 1,3a,8)-di(og tri)methylpyrrolooe2,3-baaindoler, deres fremstilling og anvendelse som laegemidler

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Publication number
DK367987A
DK367987A DK367987A DK367987A DK367987A DK 367987 A DK367987 A DK 367987A DK 367987 A DK367987 A DK 367987A DK 367987 A DK367987 A DK 367987A DK 367987 A DK367987 A DK 367987A
Authority
DK
Denmark
Prior art keywords
loweralkyl
methyl
hydrogen
arylloweralkyl
baa
Prior art date
Application number
DK367987A
Other languages
Danish (da)
English (en)
Other versions
DK367987D0 (da
Inventor
Russell Richard Lee Hamer
Grover Cleveland Helsley
Edward J Glamkowski
Yulin Chiang
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK367987D0 publication Critical patent/DK367987D0/da
Publication of DK367987A publication Critical patent/DK367987A/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK367987A 1986-07-16 1987-07-15 1,2,3,3a,8,8a-hexahydro-3a,8(og 1,3a,8)-di(og tri)methylpyrrolooe2,3-baaindoler, deres fremstilling og anvendelse som laegemidler DK367987A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88599186A 1986-07-16 1986-07-16
US07/049,894 US4791107A (en) 1986-07-16 1987-05-15 Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use

Publications (2)

Publication Number Publication Date
DK367987D0 DK367987D0 (da) 1987-07-15
DK367987A true DK367987A (da) 1988-01-17

Family

ID=26727666

Family Applications (1)

Application Number Title Priority Date Filing Date
DK367987A DK367987A (da) 1986-07-16 1987-07-15 1,2,3,3a,8,8a-hexahydro-3a,8(og 1,3a,8)-di(og tri)methylpyrrolooe2,3-baaindoler, deres fremstilling og anvendelse som laegemidler

Country Status (15)

Country Link
US (9) US4791107A (de)
EP (1) EP0253372B1 (de)
JP (1) JP2716099B2 (de)
KR (1) KR960003614B1 (de)
AT (1) ATE112278T1 (de)
AU (1) AU612583B2 (de)
CA (1) CA1307788C (de)
DE (1) DE3750596T2 (de)
DK (1) DK367987A (de)
ES (1) ES2060585T3 (de)
HU (1) HU206717B (de)
IE (1) IE64429B1 (de)
IL (1) IL83190A0 (de)
NZ (1) NZ221060A (de)
PT (1) PT85334B (de)

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US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof
US5177101A (en) * 1989-11-30 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
US5077289A (en) * 1989-11-30 1991-12-31 Hoechst Roussel Pharmaceuticals Inc. Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine
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US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
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FI933264A (fi) * 1992-07-21 1994-01-22 Hoechst Roussel Pharma Foerfarande foer framstaellning av fysostigminkarbamatderivat fraon fysostigmin
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US5409948A (en) * 1992-11-23 1995-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating cognitive disorders with phenserine
US5571929A (en) * 1994-12-07 1996-11-05 The United States Of America As Represented By The Department Of Health And Human Services Resolution and reduction of physostigmine intermediates and derivatives
US5665880A (en) * 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
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JP2010518010A (ja) * 2007-02-02 2010-05-27 コルシド・ファーマシューティカルズ・インコーポレイテッド コリンエステラーゼを阻害する化合物
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Also Published As

Publication number Publication date
HU206717B (en) 1992-12-28
ATE112278T1 (de) 1994-10-15
JPS6323881A (ja) 1988-02-01
PT85334B (pt) 1990-04-30
DE3750596D1 (de) 1994-11-03
CA1307788C (en) 1992-09-22
HUT47275A (en) 1989-02-28
US5550254A (en) 1996-08-27
US5621114A (en) 1997-04-15
JP2716099B2 (ja) 1998-02-18
PT85334A (en) 1987-08-01
US5639892A (en) 1997-06-17
EP0253372A3 (en) 1989-11-08
DK367987D0 (da) 1987-07-15
IE64429B1 (en) 1995-08-09
DE3750596T2 (de) 1995-03-23
NZ221060A (en) 1990-11-27
KR880001656A (ko) 1988-04-25
EP0253372A2 (de) 1988-01-20
US4791107A (en) 1988-12-13
US5663190A (en) 1997-09-02
US5547977A (en) 1996-08-20
ES2060585T3 (es) 1994-12-01
IL83190A0 (en) 1987-12-31
US5550253A (en) 1996-08-27
KR960003614B1 (ko) 1996-03-20
US5541216A (en) 1996-07-30
AU7566887A (en) 1988-01-21
IE871911L (en) 1988-01-16
EP0253372B1 (de) 1994-09-28
AU612583B2 (en) 1991-07-18
US5541340A (en) 1996-07-30

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