DK3555313T3 - Molekylær detektering ved hjælp af ligeringsamplifikation - Google Patents

Molekylær detektering ved hjælp af ligeringsamplifikation Download PDF

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Publication number
DK3555313T3
DK3555313T3 DK17881278.0T DK17881278T DK3555313T3 DK 3555313 T3 DK3555313 T3 DK 3555313T3 DK 17881278 T DK17881278 T DK 17881278T DK 3555313 T3 DK3555313 T3 DK 3555313T3
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Prior art keywords
ligeration
amplification
molecular detection
molecular
detection
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DK17881278.0T
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Danish (da)
English (en)
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Jay Trautman
Gordon Wang
David Lenzi
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Aratome Llc
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
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    • C12Y—ENZYMES
    • C12Y605/00—Ligases forming phosphoric ester bonds (6.5)
    • C12Y605/01—Ligases forming phosphoric ester bonds (6.5) forming phosphoric ester bonds (6.5.1)
    • C12Y605/01001—DNA ligase (ATP) (6.5.1.1)

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Enzymes And Modification Thereof (AREA)
DK17881278.0T 2016-12-16 2017-12-15 Molekylær detektering ved hjælp af ligeringsamplifikation DK3555313T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662435424P 2016-12-16 2016-12-16
US201762480107P 2017-03-31 2017-03-31
US201762509995P 2017-05-23 2017-05-23
PCT/US2017/066841 WO2018112422A1 (en) 2016-12-16 2017-12-15 Molecular detection using ligation amplification

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DK3555313T3 true DK3555313T3 (da) 2021-08-09

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DK17881278.0T DK3555313T3 (da) 2016-12-16 2017-12-15 Molekylær detektering ved hjælp af ligeringsamplifikation
DK21177377.5T DK3929304T3 (da) 2016-12-16 2017-12-15 Molekylær detektering ved ligeringsforstærkning

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US (2) US10781477B2 (enExample)
EP (3) EP3555313B1 (enExample)
JP (2) JP7093355B2 (enExample)
CN (2) CN110300806B (enExample)
CA (1) CA3047127A1 (enExample)
DK (2) DK3555313T3 (enExample)
FI (1) FI3929304T3 (enExample)
WO (1) WO2018112422A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7093355B2 (ja) * 2016-12-16 2022-06-29 アラトム， エルエルシー ライゲーション増幅を使用する分子検出
CN114555825A (zh) * 2019-02-15 2022-05-27 领先细胞医疗诊断有限公司 用于通过原位杂交进行核酸的多路复用检测的方法
US11076219B2 (en) * 2019-04-12 2021-07-27 Bose Corporation Automated control of noise reduction or noise masking
WO2024102736A1 (en) * 2022-11-08 2024-05-16 10X Genomics, Inc. Immobilization methods and compositions for in situ detection
EP4653542A1 (en) * 2024-05-21 2025-11-26 Leica Microsystems CMS GmbH Label, marker and method for analysing a biological sample
WO2026096993A1 (en) * 2024-11-01 2026-05-07 The Regents Of The University Of Colorado, A Body Corporate Configurations and methods for detecting insulin autoantibodies by enzyme-linked immunosorbent assay
EP4768596A1 (en) * 2024-12-30 2026-07-01 Leica Microsystems CMS GmbH LABEL, MARKER AND METHOD FOR ANALYZING BIOLOGICAL SAMPLES

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US317077A (en) * 1885-05-05 belcher
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US6011020A (en) * 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US5386020A (en) * 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
US5902724A (en) * 1996-07-12 1999-05-11 Tm Technologies, Inc. Signal amplification method
US6261771B1 (en) * 1998-02-18 2001-07-17 The United States Of America As Represented By The Secretary Of The Army Method and apparatus for detection of multiple nucleic acid sequences and multiple antigens
US6403309B1 (en) * 1999-03-19 2002-06-11 Valigen (Us), Inc. Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays
JP2001013139A (ja) 1999-06-28 2001-01-19 Toyobo Co Ltd 免疫学的測定法
US6686461B1 (en) * 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7033758B2 (en) * 2000-06-02 2006-04-25 Bayer Corporation Highly sensitive gene detection and localization using in situ branched-DNA hybridization
US6531283B1 (en) 2000-06-20 2003-03-11 Molecular Staging, Inc. Protein expression profiling
DE10201886B4 (de) * 2001-01-19 2014-01-23 Honda Giken Kogyo K.K. Polymerelektrolytmembran sowie Verfahren zur Herstellung dieser und Festpolymerelektrolytbrennstoffzelle, welche diese verwendet
WO2002068695A2 (en) 2001-02-22 2002-09-06 Arcturus Engineering, Inc. Quantitative immunohistochemistry (qihc)
US20030082584A1 (en) * 2001-06-29 2003-05-01 Liang Shi Enzymatic ligation-based identification of transcript expression
US20030148335A1 (en) 2001-10-10 2003-08-07 Li Shen Detecting targets by unique identifier nucleotide tags
CA2363703A1 (en) * 2001-11-23 2003-05-23 Royce Technologies Llc, A Nevada Corporation Method for amplification of molecular bio-assay signals
US20050079520A1 (en) 2003-07-21 2005-04-14 Jie Wu Multiplexed analyte detection
US7727721B2 (en) * 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US8241874B2 (en) * 2005-05-04 2012-08-14 Wayne State University Rolling circle amplification
US20070048759A1 (en) * 2005-06-10 2007-03-01 Dan Luo Detection of target molecules with labeled nucleic acid detection molecules
EP3042963A1 (en) 2005-06-20 2016-07-13 Advanced Cell Diagnostics, Inc. Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
EP1920072A2 (en) 2005-07-01 2008-05-14 Dako Denmark A/S In situ hybridization detection method
WO2007076129A2 (en) * 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
US9315536B2 (en) * 2006-08-29 2016-04-19 Creatrone, Inc. Self-assembling oligonucleotides and methods
EP3276349B1 (en) * 2006-11-01 2019-08-07 Ventana Medical Systems, Inc. Haptens, hapten conjugates, compositions thereof and method for their preparation and use
US8309306B2 (en) * 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
DK2189539T4 (en) * 2008-11-21 2018-09-17 Chimera Biotec Gmbh Conjugate complexes for analyte detection
DK2539355T3 (da) * 2010-02-26 2017-01-02 Ventana Med Syst Inc IN-SITU-hybridisering med polytag-prober
US9512471B2 (en) * 2010-06-30 2016-12-06 Diacarta Inc Methods and kits for detecting human papillomavirus
ES2562821T3 (es) 2010-10-21 2016-03-08 Advanced Cell Diagnostics, Inc. Método ultrasensible para la detección in situ de ácidos nucleicos
BR112013012450B1 (pt) * 2010-11-19 2020-10-13 Speedx Pty Ltd métodos de detecção de alvos
US9556473B2 (en) * 2011-02-15 2017-01-31 Leica Biosystems Newcastle Ltd Methods for identifying nucleic acid sequences
US8946389B2 (en) 2011-04-25 2015-02-03 University Of Washington Compositions and methods for multiplex biomarker profiling
GB201108678D0 (en) * 2011-05-24 2011-07-06 Olink Ab Multiplexed proximity ligation assay
US9651549B2 (en) * 2012-07-13 2017-05-16 Genisphere, Llc Lateral flow assays using DNA dendrimers
GB201218909D0 (en) 2012-10-22 2012-12-05 Univ Singapore Assay for the parallel detection of biological material based on PCR
WO2014145620A2 (en) * 2013-03-15 2014-09-18 The Broad Institute, Inc. Novel hybridization probes and uses thereof
US20160161472A1 (en) * 2013-07-30 2016-06-09 President And Fellows Of Harvard College Quantitative dna-based imaging and super-resolution imaging
DE102014001685A1 (de) * 2014-02-07 2015-08-13 Kiekert Aktiengesellschaft Kraftfahrzeugschloss mit integrierter Zuziehhilfe
US9909167B2 (en) 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
EP3204768A4 (en) 2014-10-08 2018-03-21 Aratome LLC High resolution imaging of tissue proteins
EP3913068B1 (en) 2015-10-12 2023-08-02 Advanced Cell Diagnostics, Inc. In situ detection of nucleotide variants in high noise samples, and compositions and methods related thereto
CN105353131B (zh) * 2015-10-23 2017-04-19 山东大学 基于双编码和单分子计数的细胞因子多重检测方法
KR102516168B1 (ko) * 2016-05-02 2023-03-30 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
ES2908919T3 (es) * 2016-07-05 2022-05-04 California Inst Of Techn Reacción en cadena de hibridación de iniciador fraccionario
IL265478B2 (en) * 2016-09-26 2024-10-01 Becton Dickinson Co Measurement of protein expression using reagents with barcoded oligonucleotide sequences
JP7093355B2 (ja) * 2016-12-16 2022-06-29 アラトム， エルエルシー ライゲーション増幅を使用する分子検出

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CA3047127A1 (en) 2018-06-21
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