DK3555074T3 - Aminopyrazoler som selektive januskinasehæmmere - Google Patents
Aminopyrazoler som selektive januskinasehæmmere Download PDFInfo
- Publication number
- DK3555074T3 DK3555074T3 DK17821530.7T DK17821530T DK3555074T3 DK 3555074 T3 DK3555074 T3 DK 3555074T3 DK 17821530 T DK17821530 T DK 17821530T DK 3555074 T3 DK3555074 T3 DK 3555074T3
- Authority
- DK
- Denmark
- Prior art keywords
- aminopyrazoles
- kinase inhibitors
- janus kinase
- selective janus
- selective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662434154P | 2016-12-14 | 2016-12-14 | |
| PCT/EP2017/082529 WO2018108969A1 (en) | 2016-12-14 | 2017-12-13 | Aminopyrazoles as selective janus kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3555074T3 true DK3555074T3 (da) | 2022-10-03 |
Family
ID=60812050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17821530.7T DK3555074T3 (da) | 2016-12-14 | 2017-12-13 | Aminopyrazoler som selektive januskinasehæmmere |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10875847B2 (da) |
| EP (2) | EP3555074B1 (da) |
| JP (1) | JP7116063B2 (da) |
| CN (2) | CN110062754B (da) |
| AU (1) | AU2017376398B2 (da) |
| BR (1) | BR112019011835A2 (da) |
| CA (1) | CA3045951A1 (da) |
| DK (1) | DK3555074T3 (da) |
| ES (1) | ES2926545T3 (da) |
| PL (1) | PL3555074T3 (da) |
| RU (1) | RU2757218C2 (da) |
| WO (1) | WO2018108969A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113195476A (zh) * | 2018-12-13 | 2021-07-30 | 英特维特国际股份有限公司 | 1-[(3r,4s)-4-氰基四氢吡喃-3-基]-3-[(2-氟-6-甲氧基-4-吡啶基)氨基]吡唑-4-甲酰胺的结晶形式 |
| EP3894403A1 (en) | 2018-12-13 | 2021-10-20 | Intervet International B.V. | Process for preparing 1-[(3r,4s)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl)amino]p yrazole-4-carboxamide |
| WO2020118597A1 (en) * | 2018-12-13 | 2020-06-18 | Intervet International B.V. | Process for making 1- [ (3r, 4s) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide |
| AU2020265788A1 (en) | 2019-05-02 | 2021-11-04 | Intervet International B.V. | Process for the production of ethyl 3-amino-1-((3R,4S)-4-cyanotetrahydropyran-3-yl)pyrazole-4-carboxylate through chiral separation of a racemic mixture |
| FI4076404T3 (fi) * | 2019-12-20 | 2024-01-31 | Intervet Int Bv | Farmaseuttinen pyratsolikoostumus |
| WO2021123094A1 (en) | 2019-12-20 | 2021-06-24 | Intervet International B.V. | Bispecific caninized antibodies and bispecific binding partners for treating atopic dermatitis |
| ES2963626T3 (es) * | 2019-12-20 | 2024-04-01 | Intervet Int Bv | Una composición farmacéutica de un compuesto de pirazol dispersado en una matriz polimérica |
| MX2023004438A (es) | 2020-10-15 | 2023-05-08 | Intervet Int Bv | Anticuerpos de rata caninizados para el receptor alfa de interleucina-31 canino. |
| AU2021401834A1 (en) | 2020-12-18 | 2023-07-06 | Boehringer Ingelheim Animal Health USA Inc. | Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof |
| WO2023021170A2 (en) | 2021-08-20 | 2023-02-23 | Intervet International B.V. | Fusion proteins for treating atopic dermatitis |
| MX2024007090A (es) | 2021-12-16 | 2024-08-22 | Intervet Int B V | Anticuerpos caninizados para el receptor alfa ii de interleucina-31 canino. |
| CN118541364A (zh) | 2021-12-24 | 2024-08-23 | 英特维特国际股份有限公司 | 氨基吡唑化合物的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| JP4666762B2 (ja) | 1998-06-19 | 2011-04-06 | ファイザー・プロダクツ・インク | ピロロ［２．３−ｄ］ピリミジン化合物 |
| ES2533241T3 (es) * | 2005-11-03 | 2015-04-08 | Vertex Pharmaceuticals Incorporated | Aminopirimidinas útiles como inhibidores de cinasas |
| BRPI0917459B1 (pt) | 2008-08-20 | 2017-09-12 | Zoetis Services Llc | N-methyl-1- [trans-4- [methyl (7h-pyrrol [2,3-d] pyridol [2,3-d] pyrimidine compounds, use of these in therapy and crystalline a form of n-methyl- pyrimidin-4-yl) amino] cyclohexyl} methanosulphonamide |
| AU2012312303B2 (en) * | 2011-09-22 | 2016-09-15 | Merck Sharp & Dohme Corp. | Cyanomethylpyrazole carboxamides as janus kinase inhibitors |
| WO2014146246A1 (en) | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
| WO2016170009A1 (en) * | 2015-04-21 | 2016-10-27 | Almirall, S.A. | Amino-substituted heterocyclic derivatives as sodium channel inhibitors |
-
2017
- 2017-12-13 BR BR112019011835A patent/BR112019011835A2/pt not_active Application Discontinuation
- 2017-12-13 AU AU2017376398A patent/AU2017376398B2/en active Active
- 2017-12-13 RU RU2019121667A patent/RU2757218C2/ru active
- 2017-12-13 US US16/468,548 patent/US10875847B2/en active Active
- 2017-12-13 JP JP2019531369A patent/JP7116063B2/ja active Active
- 2017-12-13 DK DK17821530.7T patent/DK3555074T3/da active
- 2017-12-13 CN CN201780077566.6A patent/CN110062754B/zh active Active
- 2017-12-13 PL PL17821530.7T patent/PL3555074T3/pl unknown
- 2017-12-13 EP EP17821530.7A patent/EP3555074B1/en active Active
- 2017-12-13 CA CA3045951A patent/CA3045951A1/en active Pending
- 2017-12-13 WO PCT/EP2017/082529 patent/WO2018108969A1/en unknown
- 2017-12-13 CN CN202311769143.4A patent/CN117756789A/zh active Pending
- 2017-12-13 ES ES17821530T patent/ES2926545T3/es active Active
- 2017-12-13 EP EP22178697.3A patent/EP4095135A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP3555074A1 (en) | 2019-10-23 |
| ES2926545T3 (es) | 2022-10-26 |
| US10875847B2 (en) | 2020-12-29 |
| RU2757218C2 (ru) | 2021-10-12 |
| PL3555074T3 (pl) | 2022-11-07 |
| RU2019121667A3 (da) | 2021-02-25 |
| CN117756789A (zh) | 2024-03-26 |
| AU2017376398A1 (en) | 2019-05-30 |
| EP3555074B1 (en) | 2022-07-27 |
| JP7116063B2 (ja) | 2022-08-09 |
| AU2017376398B2 (en) | 2021-07-15 |
| CA3045951A1 (en) | 2018-06-21 |
| BR112019011835A2 (pt) | 2019-10-22 |
| CN110062754A (zh) | 2019-07-26 |
| CN110062754B (zh) | 2024-01-02 |
| WO2018108969A1 (en) | 2018-06-21 |
| JP2020503288A (ja) | 2020-01-30 |
| EP4095135A1 (en) | 2022-11-30 |
| RU2019121667A (ru) | 2021-01-15 |
| US20200115367A1 (en) | 2020-04-16 |
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