DK3548492T5 - Cell impermeable coelenterazine analogues - Google Patents

Cell impermeable coelenterazine analogues Download PDF

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Publication number
DK3548492T5
DK3548492T5 DK17829356.9T DK17829356T DK3548492T5 DK 3548492 T5 DK3548492 T5 DK 3548492T5 DK 17829356 T DK17829356 T DK 17829356T DK 3548492 T5 DK3548492 T5 DK 3548492T5
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DK
Denmark
Prior art keywords
cell impermeable
coelenterazine analogues
coelenterazine
analogues
impermeable
Prior art date
Application number
DK17829356.9T
Other languages
Danish (da)
English (en)
Other versions
DK3548492T3 (en
Inventor
Rachel Friedman Ohana
Mary Hall
Thomas Kirkland
Poncho Meisenheimer
Anton Shakhmin
Joel R Walker
Wenhui Zhou
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Publication of DK3548492T3 publication Critical patent/DK3548492T3/da
Application granted granted Critical
Publication of DK3548492T5 publication Critical patent/DK3548492T5/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90241—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK17829356.9T 2016-12-01 2017-12-01 Cell impermeable coelenterazine analogues DK3548492T5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662428997P 2016-12-01 2016-12-01
US201762477512P 2017-03-28 2017-03-28
PCT/US2017/064229 WO2018102693A1 (en) 2016-12-01 2017-12-01 Cell impermeable coelenterazine analogues

Publications (2)

Publication Number Publication Date
DK3548492T3 DK3548492T3 (en) 2023-08-07
DK3548492T5 true DK3548492T5 (en) 2024-08-05

Family

ID=60972321

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17829356.9T DK3548492T5 (en) 2016-12-01 2017-12-01 Cell impermeable coelenterazine analogues

Country Status (5)

Country Link
US (2) US10577370B2 (enExample)
EP (2) EP3548492B1 (enExample)
JP (1) JP7139330B2 (enExample)
DK (1) DK3548492T5 (enExample)
WO (1) WO2018102693A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3548492B1 (en) * 2016-12-01 2023-07-05 Promega Corporation Cell impermeable coelenterazine analogues
JP7036343B2 (ja) * 2017-03-28 2022-03-15 国立大学法人電気通信大学 新規セレンテラジン誘導体
EP3788048A1 (en) * 2018-05-01 2021-03-10 Promega Corporation Coelenterazine compounds as nanoluc suicide substrates
JP7653351B2 (ja) * 2018-08-23 2025-03-28 プロメガ コーポレイション セレンテラジン類似体
IL318819A (en) 2018-10-03 2025-04-01 Promega Corp Compounds and methods for stabilizing cholinetyrazine and its derivatives
CN111116594B (zh) * 2019-12-03 2021-05-28 山东大学 一种C-6位改造NanoLuc类型类似物及其制备方法与应用
KR102940072B1 (ko) * 2022-01-10 2026-03-17 주식회사 엘지화학 환상 술폰산에스테르 유도체 화합물의 제조방법
CN116082185B (zh) * 2023-04-06 2023-07-21 佛山职业技术学院 虫酰肼类半抗原、抗原、抗体、检测装置及其制备与应用
WO2026128753A2 (en) 2024-12-12 2026-06-18 Juno Therapeutics, Inc. Methods for assessing cell proliferation of cell compositions

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268229B2 (en) 2001-11-02 2007-09-11 Promega Corporation Compounds to co-localize luminophores with luminescent proteins
US8883486B2 (en) 2004-05-04 2014-11-11 Universite De Montreal Arrestin biosensor
US20080248511A1 (en) 2007-03-26 2008-10-09 Promega Corporation Methods to quench light from optical reactions
ES2795287T3 (es) 2009-05-01 2020-11-23 Promega Corp Luciferasas de Oplophorus sintéticas con mayor emisión de luz
CA2815381C (en) 2010-11-02 2019-03-19 Promega Corporation Coelenterazine derivatives and methods of using same
CN103443121B (zh) * 2010-11-02 2016-04-20 普罗梅加公司 新型腔肠素底物及其使用方法
US9273343B2 (en) 2011-09-02 2016-03-01 Promega Corporation Compounds and methods for assaying redox state of metabolically active cells and methods for measuring NAD(P)/NAD(P)H
WO2013078244A1 (en) 2011-11-21 2013-05-30 Promega Corporation Carboxy x rhodamine analogs
CN104395306B (zh) * 2012-03-02 2019-04-23 皮尔斯生物科技有限公司 作为生物分子的标记染料的吲哚衍生物
US9790537B2 (en) 2014-01-29 2017-10-17 Promega Corporation Quinone-masked probes as labeling reagents for cell uptake measurements
EP3099691B1 (en) 2014-01-29 2019-11-20 Promega Corporation Pro-substrates for live cell applications
EP3313846B1 (en) 2015-06-25 2020-05-06 Promega Corporation Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases
JP7092677B2 (ja) 2016-02-15 2022-06-28 プロメガ コーポレイション セレンテラジン類似体
CN105968114B (zh) * 2016-05-27 2018-11-09 山东大学 一种腔肠素类似物及其制备方法与应用
JP7212612B2 (ja) * 2016-07-28 2023-01-25 プロメガ コーポレイション セレンテラジン類縁体
JP7200102B2 (ja) * 2016-11-01 2023-01-06 プロメガ コーポレイション エネルギー受容体に係留されたセレンテラジン類縁体
EP3548492B1 (en) * 2016-12-01 2023-07-05 Promega Corporation Cell impermeable coelenterazine analogues

Also Published As

Publication number Publication date
US11192894B2 (en) 2021-12-07
US20200239475A1 (en) 2020-07-30
JP2020510617A (ja) 2020-04-09
DK3548492T3 (en) 2023-08-07
US10577370B2 (en) 2020-03-03
EP3548492A1 (en) 2019-10-09
US20180155350A1 (en) 2018-06-07
EP4279490A3 (en) 2024-04-10
WO2018102693A1 (en) 2018-06-07
EP3548492B1 (en) 2023-07-05
EP4279490A2 (en) 2023-11-22
JP7139330B2 (ja) 2022-09-20

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