DK3533875T3 - Corynebacterium til fremstilling af l-lysin ved fermentering - Google Patents

Corynebacterium til fremstilling af l-lysin ved fermentering Download PDF

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Publication number
DK3533875T3
DK3533875T3 DK17844780.1T DK17844780T DK3533875T3 DK 3533875 T3 DK3533875 T3 DK 3533875T3 DK 17844780 T DK17844780 T DK 17844780T DK 3533875 T3 DK3533875 T3 DK 3533875T3
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DK
Denmark
Prior art keywords
corynebacterium
lysine
fermentation
production
Prior art date
Application number
DK17844780.1T
Other languages
English (en)
Inventor
Fengyong Ma
Huiping Jia
Jiyin Ma
Gang Meng
Aiying Wei
Original Assignee
Ningxia Eppen Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201610800567.6A external-priority patent/CN106318964B/zh
Priority claimed from CN201610800601.XA external-priority patent/CN106367432B/zh
Application filed by Ningxia Eppen Biotech Co Ltd filed Critical Ningxia Eppen Biotech Co Ltd
Application granted granted Critical
Publication of DK3533875T3 publication Critical patent/DK3533875T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/08Lysine; Diaminopimelic acid; Threonine; Valine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15Corynebacterium

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK17844780.1T 2016-09-01 2017-01-09 Corynebacterium til fremstilling af l-lysin ved fermentering DK3533875T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610800567.6A CN106318964B (zh) 2016-09-01 2016-09-01 棒杆菌发酵生产l‑赖氨酸的方法及其启动子改造
CN201610800601.XA CN106367432B (zh) 2016-09-01 2016-09-01 发酵生产l‑赖氨酸的方法及改造的棒杆菌
PCT/CN2017/070629 WO2018040469A1 (zh) 2016-09-01 2017-01-09 发酵生产l-赖氨酸的棒杆菌

Publications (1)

Publication Number Publication Date
DK3533875T3 true DK3533875T3 (da) 2023-04-03

Family

ID=61299966

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17844780.1T DK3533875T3 (da) 2016-09-01 2017-01-09 Corynebacterium til fremstilling af l-lysin ved fermentering

Country Status (8)

Country Link
US (2) US11242545B2 (da)
EP (1) EP3533875B1 (da)
JP (1) JP6739651B2 (da)
CA (1) CA3035466C (da)
DK (1) DK3533875T3 (da)
ES (1) ES2939979T3 (da)
PL (1) PL3533875T3 (da)
WO (1) WO2018040469A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3533875B1 (en) * 2016-09-01 2023-02-15 Ningxia Eppen Biotech Co. Ltd Corynebacterium for producing l-lysine by fermentation

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0655149B2 (ja) 1985-03-12 1994-07-27 協和醗酵工業株式会社 L―リジンの製造法
MY113040A (en) 1994-02-24 2001-11-30 Ajinomoto Kk Novel gene derived from coryneform bacteria and use thereof
US5977331A (en) 1994-06-14 1999-11-02 Ajinomoto Co., Inc. α-Ketoglutarate dehydrogenase gene
JP4075087B2 (ja) 1996-12-05 2008-04-16 味の素株式会社 L−リジンの製造法
BR0014059B1 (pt) 1999-09-30 2013-02-05 processo para produzir transglutaminase.
AU2002242986A1 (en) 2001-03-30 2002-10-21 Ajinomoto Co., Inc. Method for the sectetion and production of protein
JP2003088380A (ja) 2001-09-18 2003-03-25 Railway Technical Res Inst ビフェニル又はその誘導体の分解法、及びそれに用いられる微生物
CA2547860A1 (en) 2003-12-18 2005-06-30 Basf Aktiengesellschaft Methods for the preparation of lysine by fermentation of corynebacterium glutamicum
JP4595506B2 (ja) 2004-11-25 2010-12-08 味の素株式会社 L−アミノ酸生産菌及びl−アミノ酸の製造方法
DE102005032426A1 (de) 2004-12-18 2006-06-22 Degussa Ag Allele des gnd-Gens aus coryneformen Bakterien
CN101578361A (zh) 2005-06-17 2009-11-11 米克罗比亚精密工程股份有限公司 改进的氨基酸和代谢物生物合成
EP3170889A1 (en) 2006-09-15 2017-05-24 CJ Cheiljedang Corporation A corynebacteria having enhanced l-lysine productivity and a method of producing l-lysine using the same
KR100838038B1 (ko) 2006-12-29 2008-06-12 씨제이제일제당 (주) L-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용한 l-라이신 생산 방법
JP2010110217A (ja) 2007-02-22 2010-05-20 Ajinomoto Co Inc L−アミノ酸生産菌及びl−アミノ酸の製造法
CN101855357A (zh) 2007-09-26 2010-10-06 阿彻-丹尼尔斯-米德兰公司 在谷氨酸棒状杆菌中从蔗糖生产氨基酸的方法
KR100930203B1 (ko) 2008-01-28 2009-12-07 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 l-라이신의 생산 방법
KR101226384B1 (ko) 2010-03-05 2013-01-25 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 l-라이신의 생산 방법
WO2013105802A2 (ko) 2012-01-10 2013-07-18 씨제이제일제당 (주) 자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 l-라이신의 생산방법
DK2824186T3 (da) 2013-02-08 2018-07-23 Ningxia Eppen Biotech Co Ltd L-lysingenereringsfremgangsmåde ved hjælp af fermenteringsbakterier med modificeret aconitasegen og/eller regulatorisk element
BR112016008830B1 (pt) 2013-10-23 2023-02-23 Ajinomoto Co., Inc Método para produzir uma substância alvo
EP3533875B1 (en) * 2016-09-01 2023-02-15 Ningxia Eppen Biotech Co. Ltd Corynebacterium for producing l-lysine by fermentation
CN106367432B (zh) * 2016-09-01 2017-07-18 宁夏伊品生物科技股份有限公司 发酵生产l‑赖氨酸的方法及改造的棒杆菌

Also Published As

Publication number Publication date
JP2019526283A (ja) 2019-09-19
EP3533875A4 (en) 2020-01-22
US20190241918A1 (en) 2019-08-08
WO2018040469A1 (zh) 2018-03-08
EP3533875A1 (en) 2019-09-04
PL3533875T3 (pl) 2023-06-12
CA3035466C (en) 2023-08-29
US11242545B2 (en) 2022-02-08
ES2939979T3 (es) 2023-04-28
US11905540B2 (en) 2024-02-20
CA3035466A1 (en) 2018-03-08
EP3533875B1 (en) 2023-02-15
US20220112529A1 (en) 2022-04-14
JP6739651B2 (ja) 2020-08-12

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