DK4155409T3 - Fremgangsmåde til at øge replikationen af et cirkulært dna-molekyle - Google Patents

Fremgangsmåde til at øge replikationen af et cirkulært dna-molekyle Download PDF

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Publication number
DK4155409T3
DK4155409T3 DK22195354.0T DK22195354T DK4155409T3 DK 4155409 T3 DK4155409 T3 DK 4155409T3 DK 22195354 T DK22195354 T DK 22195354T DK 4155409 T3 DK4155409 T3 DK 4155409T3
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replication
increasing
dna molecule
circular dna
circular
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DK22195354.0T
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DK4155409T5 (da
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Jim Williams
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Curevac Mfg Gmbh
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    • CCHEMISTRY; METALLURGY
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2800/00Nucleic acids vectors
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    • C12N2800/101Plasmid DNA for bacteria
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    • C12N2800/00Nucleic acids vectors
    • C12N2800/20Pseudochromosomes, minichrosomosomes
    • C12N2800/202Pseudochromosomes, minichrosomosomes of bacteriophage origin
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    • C12N2800/00Nucleic acids vectors
    • C12N2800/20Pseudochromosomes, minichrosomosomes
    • C12N2800/204Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
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    • C12N2820/00Vectors comprising a special origin of replication system
    • C12N2820/55Vectors comprising a special origin of replication system from bacteria
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    • C12N2820/00Vectors comprising a special origin of replication system
    • C12N2820/60Vectors comprising a special origin of replication system from viruses
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/50Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185Escherichia
    • C12R2001/19Escherichia coli

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  • Genetics & Genomics (AREA)
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  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DK22195354.0T 2015-08-10 2016-08-04 Fremgangsmåde til at øge replikationen af et cirkulært dna-molekyle DK4155409T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2015068398 2015-08-10
EP20201524.4A EP3825407A1 (en) 2015-08-10 2016-08-04 Method of increasing the replication of a circular dna molecule

Publications (2)

Publication Number Publication Date
DK4155409T3 true DK4155409T3 (da) 2024-02-26
DK4155409T5 DK4155409T5 (da) 2024-07-22

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ID=53887104

Family Applications (2)

Application Number Title Priority Date Filing Date
DK16750759.9T DK3334828T3 (en) 2015-08-10 2016-08-04 Fremgangsmåde til at øge replikationen af et cirkulært dna-molekyle
DK22195354.0T DK4155409T5 (da) 2015-08-10 2016-08-04 Fremgangsmåde til at øge replikationen af et cirkulært dna-molekyle

Family Applications Before (1)

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DK16750759.9T DK3334828T3 (en) 2015-08-10 2016-08-04 Fremgangsmåde til at øge replikationen af et cirkulært dna-molekyle

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Country Link
US (2) US20230167456A2 (da)
EP (3) EP3825407A1 (da)
CN (2) CN108138187B (da)
DE (1) DE22195354T1 (da)
DK (2) DK3334828T3 (da)
ES (2) ES2974612T3 (da)
PL (1) PL4155409T3 (da)
PT (2) PT3334828T (da)
WO (1) WO2017025447A1 (da)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012019630A1 (en) 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
WO2012116714A1 (en) 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in elderly patients
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
SG10201710473VA (en) 2013-02-22 2018-02-27 Curevac Ag Combination of vaccination and inhibition of the pd-1 pathway
KR20160044566A (ko) 2013-08-21 2016-04-25 큐어백 아게 호흡기 세포융합 바이러스
BR112016001192A2 (pt) 2013-08-21 2017-08-29 Curevac Ag Vacina contra a raiva
EP3230458B1 (en) 2014-12-12 2020-02-19 CureVac AG Artificial nucleic acid molecules for improved protein expression
US10653768B2 (en) 2015-04-13 2020-05-19 Curevac Real Estate Gmbh Method for producing RNA compositions
WO2016165831A1 (en) 2015-04-17 2016-10-20 Curevac Ag Lyophilization of rna
EP3289101B1 (en) 2015-04-30 2021-06-23 CureVac AG Immobilized poly(n)polymerase
DK3294885T3 (da) 2015-05-08 2020-08-10 Curevac Real Estate Gmbh Fremgangsmåde til at fremstille rna
SG11201708652YA (en) 2015-05-15 2017-11-29 Curevac Ag Prime-boost regimens involving administration of at least one mrna construct
EP3916091A3 (en) 2015-05-20 2022-03-30 CureVac AG Dry powder composition comprising long-chain rna
SG11201708541QA (en) 2015-05-20 2017-12-28 Curevac Ag Dry powder composition comprising long-chain rna
PT3303583T (pt) 2015-05-29 2020-07-07 Curevac Ag Um método para produção e purificação de rna, compreendendendo pelo menos um passo de filtração por fluxo tangencial
US11608513B2 (en) 2015-05-29 2023-03-21 CureVac SE Method for adding cap structures to RNA using immobilized enzymes
US10501768B2 (en) 2015-07-13 2019-12-10 Curevac Ag Method of producing RNA from circular DNA and corresponding template DNA
PL4155409T3 (pl) 2015-08-10 2024-06-17 CureVac Manufacturing GmbH Sposób zwiększania replikacji kolistej cząsteczki dna
WO2017064146A1 (en) 2015-10-12 2017-04-20 Curevac Ag Automated method for isolation, selection and/or detection of microorganisms or cells comprised in a solution
WO2017081110A1 (en) 2015-11-09 2017-05-18 Curevac Ag Rotavirus vaccines
AU2016375021B2 (en) 2015-12-22 2022-02-03 CureVac SE Method for producing RNA molecule compositions
WO2017109161A1 (en) 2015-12-23 2017-06-29 Curevac Ag Method of rna in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof
WO2017140905A1 (en) 2016-02-17 2017-08-24 Curevac Ag Zika virus vaccine
EP3423595A1 (en) 2016-03-03 2019-01-09 CureVac AG Rna analysis by total hydrolysis
EP3448427A1 (en) 2016-04-29 2019-03-06 CureVac AG Rna encoding an antibody
WO2017191264A1 (en) 2016-05-04 2017-11-09 Curevac Ag Nucleic acid molecules and uses thereof
WO2017191274A2 (en) 2016-05-04 2017-11-09 Curevac Ag Rna encoding a therapeutic protein
AU2017277731B2 (en) 2016-06-09 2021-02-18 CureVac SE Hybrid carriers for nucleic acid cargo
WO2018096179A1 (en) 2016-11-28 2018-05-31 Curevac Ag Method for purifying rna
EP3808380A1 (en) 2016-12-08 2021-04-21 CureVac AG Rna for treatment or prophylaxis of a liver disease
WO2018104540A1 (en) 2016-12-08 2018-06-14 Curevac Ag Rnas for wound healing
WO2018115507A2 (en) 2016-12-23 2018-06-28 Curevac Ag Henipavirus vaccine
EP3558354A1 (en) 2016-12-23 2019-10-30 CureVac AG Lassa virus vaccine
US11141476B2 (en) 2016-12-23 2021-10-12 Curevac Ag MERS coronavirus vaccine
BR112019015244A2 (pt) 2017-03-24 2020-04-14 Curevac Ag ácidos nucleicos codificando proteínas associadas a crispr e usos dos mesmos
US11357856B2 (en) 2017-04-13 2022-06-14 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
RU2020103379A (ru) 2017-07-04 2021-08-04 Куревак Аг Новые молекулы нуклеиновых кислот
US11602557B2 (en) 2017-08-22 2023-03-14 Cure Vac SE Bunyavirales vaccine
CN107875375A (zh) * 2017-10-10 2018-04-06 郑州大学 rMBP‑NAP调控巨噬细胞及直接抗肿瘤的用途
US11692002B2 (en) 2017-11-08 2023-07-04 CureVac SE RNA sequence adaptation
WO2019115635A1 (en) 2017-12-13 2019-06-20 Curevac Ag Flavivirus vaccine
US11525158B2 (en) 2017-12-21 2022-12-13 CureVac SE Linear double stranded DNA coupled to a single support or a tag and methods for producing said linear double stranded DNA
BR112020020933A2 (pt) 2018-04-17 2021-04-06 Curevac Ag Moléculas de rna de rsv inovadoras e composições para vacinação
CN108611310A (zh) * 2018-04-28 2018-10-02 中国药科大学 一种重组Hsp65与STEAP1186-193融合蛋白的基因工程菌的构建
US20220042038A1 (en) * 2018-12-20 2022-02-10 Poseida Therapeutics, Inc. Nanotransposon compositions and methods of use
RU2730661C2 (ru) * 2018-12-27 2020-08-24 Селл энд Джин Терапи Лтд Генотерапевтический ДНК-вектор на основе генотерапевтического ДНК-вектора VTvaf17, несущий целевой ген, выбранный из группы генов COL1A1, COL1A2, P4HA1, P4HA2, COL7A1, CLCA2, ELN, PLOD1 для повышения уровня экспрессии этих целевых генов, способ его получения и применения, штамм Escherichia coli SCS110-AF/VTvaf17-COL1A1, или Escherichia coli SCS110-AF/VTvaf17-COL1A2, или Escherichia coli SCS110-AF/VTvaf17-P4HA1, или Escherichia coli SCS110-AF/VTvaf17-P4HA2, или Escherichia coli SCS110-AF/VTvaf17-COL7A1, или Escherichia coli SCS110-AF/VTvaf17-CLCA2, или Escherichia coli SCS110-AF/VTvaf17-ELN, или Escherichia coli SCS110-AF/VTvaf17- PLOD1, несущий генотерапевтический ДНК-вектор, способ его получения, способ производства в промышленных масштабах генотерапевтического ДНК-вектора
WO2020201022A1 (en) * 2019-03-29 2020-10-08 Danmarks Tekniske Universitet Automation-ready dna cloning by bacterial natural transformation
CN113122622A (zh) * 2019-12-31 2021-07-16 南京优智源医药科技有限公司 一种通过piR-31925对弱精症诊断试剂盒及应用
US11241493B2 (en) 2020-02-04 2022-02-08 Curevac Ag Coronavirus vaccine
US20240277830A1 (en) 2020-02-04 2024-08-22 CureVac SE Coronavirus vaccine
CA3174215A1 (en) 2020-04-22 2021-10-28 Ugur Sahin Coronavirus vaccine
KR20230164648A (ko) 2020-12-22 2023-12-04 큐어백 에스이 SARS-CoV-2 변이체에 대한 RNA 백신
US20240102065A1 (en) 2021-01-27 2024-03-28 CureVac SE Method of reducing the immunostimulatory properties of in vitro transcribed rna
US11878055B1 (en) 2022-06-26 2024-01-23 BioNTech SE Coronavirus vaccine

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0180192B1 (en) * 1984-10-29 1992-02-05 Research Association For Utilization Of Light Oil Novel plasmids
KR20070053765A (ko) 2004-08-19 2007-05-25 네이쳐 테크놀로지 코포레이션 플라스미드 디엔에이 발효 공정
DE102005046490A1 (de) * 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
US9045759B2 (en) 2009-01-21 2015-06-02 James Arthur Williams DNA plasmids with improved copy number
WO2012019630A1 (en) 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
EP3492109B1 (en) 2011-10-03 2020-03-04 ModernaTX, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
BR112014023800A2 (pt) * 2012-03-27 2017-07-18 Curevac Gmbh moléculas de ácidos nucleicos artificiais
WO2014035457A1 (en) * 2012-08-29 2014-03-06 Nature Technology Corporation Dna plasmids with improved expression
US9365641B2 (en) 2012-10-01 2016-06-14 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting stromal cells for the treatment of cancer
WO2014152027A1 (en) * 2013-03-15 2014-09-25 Moderna Therapeutics, Inc. Manufacturing methods for production of rna transcripts
CN104278055B (zh) * 2013-07-04 2019-01-25 中国科学院上海巴斯德研究所 制备hbv持续感染动物模型的试剂和方法
CA2915724C (en) * 2013-08-21 2023-09-26 Patrick Baumhof Method for increasing expression of rna-encoded proteins
NO3068888T3 (da) * 2013-11-12 2018-06-30
US20150167017A1 (en) 2013-12-13 2015-06-18 Moderna Therapeutics, Inc. Alternative nucleic acid molecules and uses thereof
BR102014014502B1 (pt) * 2014-06-13 2020-09-15 Ouro Fino Saúde Animal Ltda Vetor de expressão
PL4155409T3 (pl) 2015-08-10 2024-06-17 CureVac Manufacturing GmbH Sposób zwiększania replikacji kolistej cząsteczki dna

Also Published As

Publication number Publication date
EP3334828B1 (en) 2020-10-28
EP3334828A1 (en) 2018-06-20
EP3825407A1 (en) 2021-05-26
CN108138187B (zh) 2022-07-19
US20190225971A1 (en) 2019-07-25
DK4155409T5 (da) 2024-07-22
PT3334828T (pt) 2020-12-18
PL4155409T3 (pl) 2024-06-17
EP4155409A1 (en) 2023-03-29
US20230027681A1 (en) 2023-01-26
WO2017025447A1 (en) 2017-02-16
DE22195354T1 (de) 2023-05-25
DK3334828T3 (en) 2020-12-14
PT4155409T (pt) 2024-02-26
US20230167456A2 (en) 2023-06-01
CN108138187A (zh) 2018-06-08
CN116064623A (zh) 2023-05-05
ES2974612T3 (es) 2024-06-28
EP4155409B1 (en) 2023-12-27
ES2837100T3 (es) 2021-06-29

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