DK3461825T3 - Nye heterocykliske derivater samt deres anvendelser - Google Patents

Nye heterocykliske derivater samt deres anvendelser Download PDF

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Publication number
DK3461825T3
DK3461825T3 DK18180710.8T DK18180710T DK3461825T3 DK 3461825 T3 DK3461825 T3 DK 3461825T3 DK 18180710 T DK18180710 T DK 18180710T DK 3461825 T3 DK3461825 T3 DK 3461825T3
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heterocyclic derivatives
new heterocyclic
new
derivatives
heterocyclic
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DK18180710.8T
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English (en)
Inventor
Pil Su Ho
Dong Oh Yoon
Sun Young Han
Won Il Lee
Jung Sook Kim
Woul Seong Park
Sung Oh Ahn
Hye Jung Kim
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C&C Res Lab
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
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    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
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    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
DK18180710.8T 2011-09-30 2012-09-28 Nye heterocykliske derivater samt deres anvendelser DK3461825T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20110100369 2011-09-30
KR20120033444 2012-03-30
EP12834688.9A EP2760865B1 (en) 2011-09-30 2012-09-28 Novel heterocyclic derivatives and their uses

Publications (1)

Publication Number Publication Date
DK3461825T3 true DK3461825T3 (da) 2023-08-14

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DK18180710.8T DK3461825T3 (da) 2011-09-30 2012-09-28 Nye heterocykliske derivater samt deres anvendelser
DK12834688.9T DK2760865T3 (da) 2011-09-30 2012-09-28 Nye heterocykliske derivater og anvendelser deraf

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US (1) US9586959B2 (da)
EP (2) EP3461825B1 (da)
JP (1) JP6031107B2 (da)
KR (1) KR101800749B1 (da)
CN (1) CN103889986B (da)
AR (1) AR088085A1 (da)
AU (1) AU2012316912B9 (da)
BR (1) BR112014007645A2 (da)
CA (1) CA2848154C (da)
CY (1) CY1121292T1 (da)
DK (2) DK3461825T3 (da)
ES (2) ES2687693T3 (da)
FI (1) FI3461825T3 (da)
HR (2) HRP20230893T1 (da)
HU (2) HUE040374T2 (da)
LT (2) LT2760865T (da)
MX (1) MX355795B (da)
PL (2) PL3461825T3 (da)
PT (2) PT2760865T (da)
RS (2) RS57854B1 (da)
RU (1) RU2628074C2 (da)
SG (1) SG11201400484RA (da)
SI (2) SI2760865T1 (da)
TR (1) TR201814710T4 (da)
TW (1) TWI551600B (da)
WO (1) WO2013048214A2 (da)

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CN104016911A (zh) * 2014-04-03 2014-09-03 定陶县友帮化工有限公司 一种2-氨基-3,5-二溴吡啶的合成方法
CN112010772A (zh) * 2016-01-26 2020-12-01 赵鸣 5-氨基酮戊酸及其衍生物的盐化合物和应用
JP2019520379A (ja) 2016-07-01 2019-07-18 ジー1 セラピューティクス, インコーポレイテッド ピリミジン系の抗増殖剤
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TW202317568A (zh) * 2021-06-22 2023-05-01 丹麥商理奧藥品公司 1-(8-溴化吡啶并[2,3-e][1,2,4]三唑并[4,3-a]吡嗪-4-基)-n-甲基吖丁啶-3-胺半琥珀酸鹽之新穎結晶形式
WO2024068851A1 (en) * 2022-09-29 2024-04-04 Jw Pharmaceutical Corporation A process for the manufacture of salts and crystalline forms of 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-n-methylazetidin-3-amine and novel crystalline forms
WO2024069577A1 (en) * 2022-09-29 2024-04-04 Jw Pharmaceutical Corporation Novel crystalline form of 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-n-methylazetidin-3-amine
WO2024069576A1 (en) * 2022-09-30 2024-04-04 Jw Pharmaceutical Corporation Novel crystalline form of 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-n-methylazetidin-3-amine mono succinate

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Also Published As

Publication number Publication date
FI3461825T3 (fi) 2023-08-17
CN103889986A (zh) 2014-06-25
ES2954303T3 (es) 2023-11-21
WO2013048214A3 (en) 2013-05-23
SG11201400484RA (en) 2014-10-30
PL2760865T3 (pl) 2018-12-31
RU2014115478A (ru) 2015-11-10
DK2760865T3 (da) 2018-10-08
AR088085A1 (es) 2014-05-07
EP3461825A1 (en) 2019-04-03
SI2760865T1 (sl) 2018-10-30
HUE040374T2 (hu) 2019-03-28
PL3461825T3 (pl) 2023-10-30
EP2760865A4 (en) 2015-03-18
HRP20181310T1 (hr) 2018-10-19
AU2012316912A1 (en) 2014-03-20
WO2013048214A2 (en) 2013-04-04
AU2012316912B9 (en) 2017-04-27
EP2760865B1 (en) 2018-07-11
KR101800749B1 (ko) 2017-11-24
BR112014007645A2 (pt) 2017-04-18
US9586959B2 (en) 2017-03-07
JP6031107B2 (ja) 2016-11-24
EP3461825B1 (en) 2023-06-07
HRP20230893T1 (hr) 2023-11-24
MX2014003042A (es) 2014-05-28
RS57854B1 (sr) 2018-12-31
CA2848154C (en) 2020-04-28
PT2760865T (pt) 2018-11-05
LT2760865T (lt) 2018-09-25
TWI551600B (zh) 2016-10-01
SI3461825T1 (sl) 2023-11-30
MX355795B (es) 2018-04-30
KR20140090984A (ko) 2014-07-18
LT3461825T (lt) 2023-08-25
AU2012316912B2 (en) 2017-04-20
TR201814710T4 (tr) 2019-01-21
TW201321381A (zh) 2013-06-01
CN103889986B (zh) 2017-07-21
US20140315888A1 (en) 2014-10-23
RU2628074C2 (ru) 2017-08-14
JP2014531458A (ja) 2014-11-27
AU2012316912A8 (en) 2014-04-10
ES2687693T3 (es) 2018-10-26
HUE062842T2 (hu) 2023-12-28
CA2848154A1 (en) 2013-04-04
PT3461825T (pt) 2023-09-11
EP2760865A2 (en) 2014-08-06
RS64575B1 (sr) 2023-10-31
CY1121292T1 (el) 2020-05-29

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