DK3436434T3 - Indolin-analoger og anvendelser deraf - Google Patents
Indolin-analoger og anvendelser deraf Download PDFInfo
- Publication number
- DK3436434T3 DK3436434T3 DK17776297.8T DK17776297T DK3436434T3 DK 3436434 T3 DK3436434 T3 DK 3436434T3 DK 17776297 T DK17776297 T DK 17776297T DK 3436434 T3 DK3436434 T3 DK 3436434T3
- Authority
- DK
- Denmark
- Prior art keywords
- indolin
- analogs
- indolin analogs
- Prior art date
Links
- LPAGFVYQRIESJQ-UHFFFAOYSA-N indoline Chemical class C1=CC=C2NCCC2=C1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662316156P | 2016-03-31 | 2016-03-31 | |
| US201662417621P | 2016-11-04 | 2016-11-04 | |
| PCT/US2017/022682 WO2017172368A1 (en) | 2016-03-31 | 2017-03-16 | Indoline analogs and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3436434T3 true DK3436434T3 (da) | 2020-09-21 |
Family
ID=59960688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17776297.8T DK3436434T3 (da) | 2016-03-31 | 2017-03-16 | Indolin-analoger og anvendelser deraf |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9822122B2 (https=) |
| EP (2) | EP3795563B1 (https=) |
| JP (2) | JP6864379B2 (https=) |
| KR (2) | KR102375929B1 (https=) |
| CN (1) | CN109219594B (https=) |
| AR (1) | AR108010A1 (https=) |
| DK (1) | DK3436434T3 (https=) |
| ES (1) | ES2823190T3 (https=) |
| TW (2) | TWI793070B (https=) |
| WO (1) | WO2017172368A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3204376B1 (en) | 2014-10-09 | 2023-04-19 | Oncternal Therapeutics, Inc. | Indolinone compounds and uses thereof |
| EP3795563B1 (en) | 2016-03-31 | 2024-07-17 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| CA3029851A1 (en) | 2016-07-29 | 2018-02-01 | Oncternal Therapeutics, Inc. | Uses of indoline compounds such as tk216 for the treatment of cancer |
| TR202002324A2 (tr) * | 2020-02-17 | 2021-08-23 | Bahcesehir Ueniversitesi | Yeni̇ mouse double minute 2 (mdm2) i̇nhi̇bi̇törü olarak kullanmak i̇çi̇n drg-mdm2-3 |
| CN111518086B (zh) * | 2020-05-22 | 2021-08-06 | 广州医科大学 | 氧化吲哚-萘并呋喃衍生物及其制备方法、用途以及包含其的药物组合物、制剂 |
| WO2023178040A2 (en) * | 2022-03-13 | 2023-09-21 | University Of Virginia Patent Foundation | Inhibitors of ews-fli1 |
| CN115850151A (zh) * | 2022-11-25 | 2023-03-28 | 成都普康生物科技有限公司 | 一种席夫碱类似化合物及其合成方法、pi3k激酶抑制剂及其应用 |
| CN115993455A (zh) * | 2022-12-29 | 2023-04-21 | 南京医科大学康达学院 | Rna结合蛋白nova2作为非小细胞肺癌转移标志物的应用 |
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| EP3204376B1 (en) | 2014-10-09 | 2023-04-19 | Oncternal Therapeutics, Inc. | Indolinone compounds and uses thereof |
| EP3795563B1 (en) * | 2016-03-31 | 2024-07-17 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| CA3029851A1 (en) | 2016-07-29 | 2018-02-01 | Oncternal Therapeutics, Inc. | Uses of indoline compounds such as tk216 for the treatment of cancer |
-
2017
- 2017-03-16 EP EP20184572.4A patent/EP3795563B1/en active Active
- 2017-03-16 EP EP17776297.8A patent/EP3436434B1/en active Active
- 2017-03-16 KR KR1020187031059A patent/KR102375929B1/ko active Active
- 2017-03-16 DK DK17776297.8T patent/DK3436434T3/da active
- 2017-03-16 US US15/461,327 patent/US9822122B2/en active Active
- 2017-03-16 KR KR1020227008510A patent/KR102514814B1/ko active Active
- 2017-03-16 WO PCT/US2017/022682 patent/WO2017172368A1/en not_active Ceased
- 2017-03-16 JP JP2018551785A patent/JP6864379B2/ja active Active
- 2017-03-16 CN CN201780034085.7A patent/CN109219594B/zh active Active
- 2017-03-16 ES ES17776297T patent/ES2823190T3/es active Active
- 2017-03-30 TW TW106110666A patent/TWI793070B/zh active
- 2017-03-30 TW TW110125866A patent/TWI786723B/zh active
- 2017-03-30 AR ARP170100787A patent/AR108010A1/es unknown
- 2017-08-18 US US15/680,905 patent/US10351569B2/en active Active
-
2019
- 2019-06-03 US US16/430,234 patent/US10711008B2/en active Active
-
2021
- 2021-03-26 JP JP2021053887A patent/JP7269668B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2823190T3 (es) | 2021-05-06 |
| EP3436434A1 (en) | 2019-02-06 |
| US10351569B2 (en) | 2019-07-16 |
| JP7269668B2 (ja) | 2023-05-09 |
| KR102514814B1 (ko) | 2023-03-27 |
| TWI786723B (zh) | 2022-12-11 |
| JP2019510069A (ja) | 2019-04-11 |
| US20170283420A1 (en) | 2017-10-05 |
| KR20180123569A (ko) | 2018-11-16 |
| TW202140492A (zh) | 2021-11-01 |
| EP3795563B1 (en) | 2024-07-17 |
| JP2021102643A (ja) | 2021-07-15 |
| TWI793070B (zh) | 2023-02-21 |
| KR20220038529A (ko) | 2022-03-28 |
| US20170349600A1 (en) | 2017-12-07 |
| WO2017172368A1 (en) | 2017-10-05 |
| EP3436434A4 (en) | 2019-08-28 |
| CN109219594B (zh) | 2022-10-11 |
| EP3436434B1 (en) | 2020-07-08 |
| US20190337951A1 (en) | 2019-11-07 |
| JP6864379B2 (ja) | 2021-04-28 |
| CN109219594A (zh) | 2019-01-15 |
| KR102375929B1 (ko) | 2022-03-16 |
| AR108010A1 (es) | 2018-07-04 |
| US10711008B2 (en) | 2020-07-14 |
| TW201738209A (zh) | 2017-11-01 |
| EP3795563A1 (en) | 2021-03-24 |
| US9822122B2 (en) | 2017-11-21 |
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