DK3392584T3 - Nukleation - Google Patents

Nukleation Download PDF

Info

Publication number
DK3392584T3
DK3392584T3 DK17167643.0T DK17167643T DK3392584T3 DK 3392584 T3 DK3392584 T3 DK 3392584T3 DK 17167643 T DK17167643 T DK 17167643T DK 3392584 T3 DK3392584 T3 DK 3392584T3
Authority
DK
Denmark
Prior art keywords
nucleation
Prior art date
Application number
DK17167643.0T
Other languages
English (en)
Inventor
Thomas Heinrich Ludwig Beutler
Marion Böckem
Alexey Bauer
Carolin Wolf
Original Assignee
Gea Lyophil Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Lyophil Gmbh filed Critical Gea Lyophil Gmbh
Application granted granted Critical
Publication of DK3392584T3 publication Critical patent/DK3392584T3/da

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/003—Supply-air or gas filters
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/06—Controlling, e.g. regulating, parameters of gas supply
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/14—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects using gases or vapours other than air or steam, e.g. inert gases
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/044—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum for drying materials in a batch operation in an enclosure having a plurality of shelves which may be heated
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B9/00—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards
    • F26B9/06—Machines or apparatus for drying solid materials or objects at rest or with only local agitation; Domestic airing cupboards in stationary drums or chambers

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Drying Of Solid Materials (AREA)
DK17167643.0T 2017-04-21 2017-04-21 Nukleation DK3392584T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17167643.0A EP3392584B1 (en) 2017-04-21 2017-04-21 A freeze dryer and a method for inducing nucleation in products

Publications (1)

Publication Number Publication Date
DK3392584T3 true DK3392584T3 (da) 2020-03-02

Family

ID=58644851

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17167643.0T DK3392584T3 (da) 2017-04-21 2017-04-21 Nukleation

Country Status (9)

Country Link
US (1) US11047620B2 (da)
EP (1) EP3392584B1 (da)
JP (1) JP7186718B2 (da)
KR (1) KR102575015B1 (da)
CN (1) CN110945305B (da)
DK (1) DK3392584T3 (da)
ES (1) ES2774058T3 (da)
SI (1) SI3392584T1 (da)
WO (1) WO2018193100A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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US10113797B2 (en) * 2016-09-09 2018-10-30 Sp Industries, Inc. Energy recovery in a freeze-drying system
US11268759B2 (en) * 2017-03-24 2022-03-08 Azbil Corporation Housing device
SI3392584T1 (sl) * 2017-04-21 2020-09-30 Gea Lyophil Gmbh Zamrzovalni sušilnik in postopek za induciranje nukleacije v proizvodih
US11340014B2 (en) * 2017-05-02 2022-05-24 Massachusetts Institute Of Technology Freeze-drying methods and related products
JP7144291B2 (ja) * 2018-11-26 2022-09-29 株式会社アーステクニカ 減圧乾燥方法
US11885563B2 (en) * 2018-12-28 2024-01-30 Utilization Technology Development, Nfp Method and system of thermo-vacuum drying and processing
US11231212B2 (en) * 2019-04-05 2022-01-25 Johnson Controls Technology Company Refrigerant discharge heat exchange system and method
CA3168873A1 (en) 2020-02-04 2021-08-12 Regeneron Pharmaceuticals, Inc. Target residual moisture content for lyophilized drug product
EP4158263A1 (en) * 2020-06-01 2023-04-05 IMA Life North America Inc. Freeze drying with combined freezing chamber and condenser
EP4204751A1 (en) * 2020-08-31 2023-07-05 Massachusetts Institute of Technology Lyophilization systems and methods
WO2022175999A1 (ja) 2021-02-16 2022-08-25 株式会社アルバック 凍結乾燥装置、および凍結乾燥方法
CN113340065A (zh) * 2021-06-10 2021-09-03 上海臻臣化妆品有限公司 一种低温低气压干燥工艺
US20230079635A1 (en) * 2021-09-16 2023-03-16 Benjamin BRITTON Extraction freeze drying system with removable condenser

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US3648379A (en) * 1970-03-16 1972-03-14 Horton John T Continuous freeze drying system
US4016657A (en) * 1971-07-14 1977-04-12 Passey Now By Change Of Name C Heat pump freeze drying system
US3740860A (en) * 1972-07-31 1973-06-26 Smitherm Industries Freeze drying method and apparatus
US4177577A (en) * 1978-05-16 1979-12-11 The Virtis Company, Inc. Shelf arrangement for freeze drying apparatus
EP0350515A1 (de) * 1988-07-11 1990-01-17 FINN-AQUA SANTASALO-SOHLBERG GmbH Verfahren zum Betrieb einer industriellen Anlage mit mindestens einer Vakuumkammer und Anlage zur Durchführung dieses Verfahrens
CA2064803A1 (en) * 1989-08-07 1991-02-08 George John Morris Cooling process and apparatus
FR2685065B1 (fr) * 1991-12-12 1994-03-04 Guy Beurel Procede de regulation de lyophilisation.
WO1996022496A1 (en) * 1995-01-20 1996-07-25 Freezedry Specialties, Inc. Freeze dryer
DE19719398A1 (de) * 1997-05-07 1998-11-12 Amsco Finn Aqua Gmbh Verfahren zur Steuerung eines Gefriertrocknungsprozesses
JPH11264659A (ja) * 1998-03-09 1999-09-28 Hal Co Division Of Sp Ind Inc 凍結乾燥方法および装置
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US6199297B1 (en) * 1999-02-01 2001-03-13 Integrated Biosystems, Inc. Lyophilization apparatus and methods
DE10136498A1 (de) * 2001-07-27 2003-02-06 Steris Gmbh Kammer für eine Gefriertrocknungseinrichtung
TWI252297B (en) * 2001-12-27 2006-04-01 Jeng-Ming Jou Multi-functional closed type cleaning and vacuum drying method
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DE10307571A1 (de) * 2003-02-22 2004-09-02 Steris Gmbh Einrichtung mit einer Stellfläche
US6935049B2 (en) * 2003-12-24 2005-08-30 Edward K. Alstat Method and apparatus for reclaiming effluent from a freeze-drying process, and uses for effluent
DE102004007526A1 (de) * 2004-02-17 2005-09-01 Oetjen, Georg-Wilhelm, Dr. Verfahren und Einrichtung zur Gefriertrocknung von Produkten
FR2880105B1 (fr) * 2004-12-23 2007-04-20 Cie Financiere Alcatel Sa Dispositif et procede de pilotage de l'operation de deshydratation durant un traitement de lyophilisation
CN101379356B (zh) * 2006-02-10 2013-07-17 普莱克斯技术有限公司 诱导材料成核的方法
KR20080003598A (ko) * 2006-07-03 2008-01-08 김상인 냉온풍기를 이용한 음식물 처리기
US8015841B2 (en) * 2006-09-08 2011-09-13 Praxair Technology, Inc. Cryogenic refrigeration system for lyophilization
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US8240065B2 (en) * 2007-02-05 2012-08-14 Praxair Technology, Inc. Freeze-dryer and method of controlling the same
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EP2509873B1 (en) * 2009-12-11 2019-03-20 Wyssmont Company Inc. Apparatus and method for continuous lyophilization
FR2955927B1 (fr) * 2010-02-01 2012-04-06 Alcatel Lucent Dispositif et procede de pilotage d'une operation de deshydratation durant un traitement de lyophilisation
US8966782B2 (en) * 2010-09-28 2015-03-03 Baxter International Inc. Optimization of nucleation and crystallization for lyophilization using gap freezing
US8689460B2 (en) * 2010-09-28 2014-04-08 Baxter International Inc. Optimization of nucleation and crystallization for lyophilization using gap freezing
CN102091046B (zh) * 2011-02-12 2012-07-18 海南锦瑞制药股份有限公司 一种磷酸氟达拉滨冻干粉针剂及其制备方法
US8839528B2 (en) * 2011-04-29 2014-09-23 Millrock Technology, Inc. Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice fog distribution
US9435586B2 (en) 2012-08-13 2016-09-06 Millrock Technology, Inc. Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost
US8875413B2 (en) 2012-08-13 2014-11-04 Millrock Technology, Inc. Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost
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US9470453B2 (en) 2013-08-06 2016-10-18 Millrock Technology, Inc. Controlled nucleation during freezing step of freeze drying cycle using pressure differential water vapor CO2 ice crystals
DE102013225047A1 (de) * 2013-12-05 2015-06-11 Gea Lyophil Gmbh Entladevorrichtung mit Vakuumansaugung
JP6389270B2 (ja) 2014-03-12 2018-09-12 ミルロック テクノロジー, インコーポレイテッドMillrock Technology, Inc. 凝縮した霜から発生させた氷晶の、圧力差による分布を用いた凍結乾燥サイクルの凍結ステップにおける制御された核形成
JP5847919B1 (ja) * 2014-12-26 2016-01-27 共和真空技術株式会社 凍結乾燥装置の凍結乾燥方法
US9739532B2 (en) * 2015-02-04 2017-08-22 Steven F. Baugh Botanical freeze drying system and method
EP3093597B1 (de) 2015-05-11 2017-12-27 Martin Christ Gefriertrocknungsanlagen GmbH Gefriertrocknungsanlage
SG11201900479QA (en) * 2016-08-16 2019-02-27 Univ Gent Method and apparatus and container for freeze-drying
US10113797B2 (en) * 2016-09-09 2018-10-30 Sp Industries, Inc. Energy recovery in a freeze-drying system
SI3392584T1 (sl) * 2017-04-21 2020-09-30 Gea Lyophil Gmbh Zamrzovalni sušilnik in postopek za induciranje nukleacije v proizvodih
EP3502649B1 (en) * 2017-12-22 2021-01-27 safematic GmbH Method for dehydration and critical point drying
US10451346B1 (en) * 2019-03-31 2019-10-22 Vinamit Usa Llc Convection current freeze drying apparatus and method of operating the same

Also Published As

Publication number Publication date
EP3392584B1 (en) 2019-12-18
JP7186718B2 (ja) 2022-12-09
KR20200029380A (ko) 2020-03-18
US11047620B2 (en) 2021-06-29
ES2774058T3 (es) 2020-07-16
JP2020517884A (ja) 2020-06-18
US20200248963A1 (en) 2020-08-06
SI3392584T1 (sl) 2020-09-30
CN110945305B (zh) 2021-07-16
WO2018193100A1 (en) 2018-10-25
KR102575015B1 (ko) 2023-09-05
CN110945305A (zh) 2020-03-31
EP3392584A1 (en) 2018-10-24

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