DK3389701T3 - Nucleotidesekvens, der udtrykker et exosomforankrende, protein til anvendelse som vaccine - Google Patents

Nucleotidesekvens, der udtrykker et exosomforankrende, protein til anvendelse som vaccine Download PDF

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Publication number
DK3389701T3
DK3389701T3 DK17826320.8T DK17826320T DK3389701T3 DK 3389701 T3 DK3389701 T3 DK 3389701T3 DK 17826320 T DK17826320 T DK 17826320T DK 3389701 T3 DK3389701 T3 DK 3389701T3
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Prior art keywords
exosome
vaccine
nucleotide sequence
anchoring protein
sequence expressing
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DK17826320.8T
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Danish (da)
English (en)
Inventor
Maurizio Paolo Maria Federico
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Inst Superiore Di Sanita'
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4205—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A61K40/4272—Melan-A/MART
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK17826320.8T 2016-10-11 2017-10-11 Nucleotidesekvens, der udtrykker et exosomforankrende, protein til anvendelse som vaccine DK3389701T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102016000101794A IT201600101794A1 (it) 2016-10-11 2016-10-11 Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.
PCT/IT2017/000223 WO2018069947A1 (en) 2016-10-11 2017-10-11 Nucleotide sequence expressing an exosome-anchoring protein for use as vaccine

Publications (1)

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DK3389701T3 true DK3389701T3 (da) 2020-08-03

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DK17826320.8T DK3389701T3 (da) 2016-10-11 2017-10-11 Nucleotidesekvens, der udtrykker et exosomforankrende, protein til anvendelse som vaccine

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US (2) US11559571B2 (cg-RX-API-DMAC10.html)
EP (1) EP3389701B1 (cg-RX-API-DMAC10.html)
JP (2) JP2019536473A (cg-RX-API-DMAC10.html)
KR (1) KR102620487B1 (cg-RX-API-DMAC10.html)
CN (2) CN117210480A (cg-RX-API-DMAC10.html)
AU (1) AU2017343893B2 (cg-RX-API-DMAC10.html)
BR (1) BR112019007343A2 (cg-RX-API-DMAC10.html)
DK (1) DK3389701T3 (cg-RX-API-DMAC10.html)
ES (1) ES2809212T3 (cg-RX-API-DMAC10.html)
HU (1) HUE050492T2 (cg-RX-API-DMAC10.html)
IL (1) IL265942B2 (cg-RX-API-DMAC10.html)
IT (1) IT201600101794A1 (cg-RX-API-DMAC10.html)
MX (1) MX2019004183A (cg-RX-API-DMAC10.html)
RU (1) RU2761642C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201903235XA (cg-RX-API-DMAC10.html)
WO (1) WO2018069947A1 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600101794A1 (it) 2016-10-11 2018-04-11 St Superiore Di Sanita Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.
IT202000009688A1 (it) * 2020-05-04 2021-11-04 Biovelocita S R L Proteine di fusione di ancoraggio a esosomi
WO2021224429A1 (en) 2020-05-06 2021-11-11 Biovelocita S.R.L Exosome-anchoring coronavirus fusion proteins and vaccines
IT202000030740A1 (it) 2020-12-14 2022-06-14 St Superiore Di Sanita SEQUENZA NUCLEOTIDICA ESPRIMENTE UNA PROTEINA ANCORANTE VESCICOLE EXTRACELLULARI FUSA AD ANTIGENI DI SARS-CoV-2 E RELATIVA PROTEINA DI FUSIONE PER L’USO COME VACCINO

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534285B1 (en) * 1984-12-24 2003-03-18 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
GB0118532D0 (en) 2001-07-30 2001-09-19 Isis Innovation Materials and methods relating to improved vaccination strategies
FR2928926B1 (fr) 2008-03-18 2015-08-21 Centre Nat Rech Scient Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes
US10238734B2 (en) 2010-03-23 2019-03-26 The Regents Of The University Of California Compositions and methods for self-adjuvanting vaccines against microbes and tumors
WO2011159814A2 (en) 2010-06-15 2011-12-22 The Regents Of The University Of California Novel live recombinant booster vaccine against tuberculosis
WO2015161853A1 (en) 2014-04-24 2015-10-29 Statens Serum Institut New m.tuberculosis vaccines
IT201600101794A1 (it) 2016-10-11 2018-04-11 St Superiore Di Sanita Sequenza nucleotidica esprimente una proteina ancorante esosomi per uso come vaccino.
IT201600131935A1 (it) 2016-12-29 2018-06-29 Enea Agenzia Naz Per Le Nuove Tecnologie Lenergia E Lo Sviluppo Economico Sostenibile Sequenza segnale di proteina vegetale come coadiuvante in vaccini a DNA.
US11130787B2 (en) 2020-06-11 2021-09-28 MBF Therapeutics, Inc. Alphaherpesvirus glycoprotein d-encoding nucleic acid constructs and methods
CN112409496B (zh) 2020-11-26 2021-07-13 焦顺昌 一种跨膜表达新型冠状病毒抗原s2的融合蛋白、重组载体、重组树突状细胞及其应用

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Publication number Publication date
CN110049775A (zh) 2019-07-23
IL265942B2 (en) 2023-11-01
HUE050492T2 (hu) 2020-12-28
CA3040035A1 (en) 2018-04-19
JP7340639B2 (ja) 2023-09-07
SG11201903235XA (en) 2019-05-30
US11559571B2 (en) 2023-01-24
NZ753370A (en) 2024-01-26
AU2017343893B2 (en) 2024-06-13
WO2018069947A1 (en) 2018-04-19
US20230364211A1 (en) 2023-11-16
WO2018069947A8 (en) 2019-07-04
US20200206329A1 (en) 2020-07-02
BR112019007343A2 (pt) 2019-10-01
ES2809212T3 (es) 2021-03-03
EP3389701A1 (en) 2018-10-24
KR102620487B1 (ko) 2024-01-03
IT201600101794A1 (it) 2018-04-11
EP3389701B1 (en) 2020-04-29
AU2017343893A1 (en) 2019-05-30
JP2019536473A (ja) 2019-12-19
KR20190079628A (ko) 2019-07-05
CN117210480A (zh) 2023-12-12
RU2019114370A3 (cg-RX-API-DMAC10.html) 2021-03-01
MX2019004183A (es) 2020-09-03
IL265942A (en) 2019-05-30
RU2019114370A (ru) 2020-11-13
IL265942B1 (en) 2023-07-01
RU2761642C2 (ru) 2021-12-13
JP2022071130A (ja) 2022-05-13

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