DK3360538T3 - Injicerbar, flydende sammensætning omfattende buprenorphin - Google Patents

Injicerbar, flydende sammensætning omfattende buprenorphin Download PDF

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Publication number
DK3360538T3
DK3360538T3 DK17205986.7T DK17205986T DK3360538T3 DK 3360538 T3 DK3360538 T3 DK 3360538T3 DK 17205986 T DK17205986 T DK 17205986T DK 3360538 T3 DK3360538 T3 DK 3360538T3
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DK
Denmark
Prior art keywords
buprenorphine
liquid composition
injectable liquid
injectable
composition
Prior art date
Application number
DK17205986.7T
Other languages
Danish (da)
English (en)
Inventor
Richard L Norton
Andrew Watkins
Mingxing Zhou
Original Assignee
Indivior Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42471306&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3360538(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Indivior Uk Ltd filed Critical Indivior Uk Ltd
Application granted granted Critical
Publication of DK3360538T3 publication Critical patent/DK3360538T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK17205986.7T 2010-06-08 2011-06-06 Injicerbar, flydende sammensætning omfattende buprenorphin DK3360538T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1009549.5A GB2481018B (en) 2010-06-08 2010-06-08 Injectable flowable composition comprising buprenorphine
EP11728037.0A EP2579874B1 (en) 2010-06-08 2011-06-06 Injectable flowable composition comprising buprenorphine

Publications (1)

Publication Number Publication Date
DK3360538T3 true DK3360538T3 (da) 2023-03-06

Family

ID=42471306

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17205986.7T DK3360538T3 (da) 2010-06-08 2011-06-06 Injicerbar, flydende sammensætning omfattende buprenorphin
DK11728037.0T DK2579874T3 (da) 2010-06-08 2011-06-06 Injicerbar, flydende sammensætning omfattende buprenorphin

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK11728037.0T DK2579874T3 (da) 2010-06-08 2011-06-06 Injicerbar, flydende sammensætning omfattende buprenorphin

Country Status (32)

Country Link
US (1) US8921387B2 (OSRAM)
EP (3) EP4218720A1 (OSRAM)
JP (2) JP5986072B2 (OSRAM)
KR (1) KR101865689B1 (OSRAM)
CN (1) CN103079544B (OSRAM)
AU (1) AU2011263478B2 (OSRAM)
BR (1) BR112012031290A2 (OSRAM)
CA (1) CA2801676C (OSRAM)
CL (1) CL2012003462A1 (OSRAM)
CO (1) CO6670529A2 (OSRAM)
CY (1) CY1120761T1 (OSRAM)
DK (2) DK3360538T3 (OSRAM)
ES (2) ES2939612T3 (OSRAM)
FI (1) FI3360538T3 (OSRAM)
GB (2) GB2513267B (OSRAM)
HR (1) HRP20180118T1 (OSRAM)
HU (1) HUE038275T2 (OSRAM)
IL (2) IL223488A (OSRAM)
LT (1) LT2579874T (OSRAM)
MX (1) MX339209B (OSRAM)
MY (1) MY171625A (OSRAM)
NO (1) NO2579874T3 (OSRAM)
NZ (1) NZ604026A (OSRAM)
PL (1) PL2579874T3 (OSRAM)
PT (1) PT2579874T (OSRAM)
RS (1) RS56820B1 (OSRAM)
RU (1) RU2607498C2 (OSRAM)
SG (1) SG186200A1 (OSRAM)
SI (1) SI2579874T1 (OSRAM)
SM (1) SMT201800038T1 (OSRAM)
WO (1) WO2011154724A2 (OSRAM)
ZA (1) ZA201209233B (OSRAM)

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US8470359B2 (en) * 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2513060B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
GB2513267B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine
WO2013126552A1 (en) 2012-02-21 2013-08-29 Auburn University Buprenorphine nanoparticle composition and methods thereof
DE112013002074T5 (de) 2012-04-17 2015-01-29 Purdue Pharma L.P. Systeme und Methoden zur Behandlung einer Opioid-induzierten unerwünschten pharmakodynamischen Reaktion
PL2877155T3 (pl) * 2012-07-26 2021-05-17 Camurus Ab Formulacje opioidowe
EA034855B1 (ru) 2012-07-26 2020-03-30 Камурус Аб Предшественник депо-препарата, содержащий бупренорфин, и способ лечения путем его введения
US20150320866A1 (en) * 2012-12-13 2015-11-12 Heron Therapeutics, Inc. Pharmaceutical composition comprising antiemetic compounds and polyorthoester
US9636308B2 (en) 2013-03-15 2017-05-02 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
US9393211B2 (en) 2013-03-15 2016-07-19 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
CN111956598A (zh) * 2013-03-15 2020-11-20 赫伦治疗有限公司 聚原酸酯和质子惰性溶剂的组合物
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
JP6723162B2 (ja) * 2014-04-21 2020-07-15 ヘロン セラピューティクス, インコーポレイテッドHeron Therapeutics, Inc. ポリオルトエステルおよび有機酸添加剤の組成物
SI3134068T1 (sl) 2014-04-21 2021-11-30 Heron Therapeutics, Inc. Polimerni dovajalni sistemi z dolgotrajnim delovanjem
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
WO2018048460A1 (en) 2014-04-21 2018-03-15 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
AU2015253417B2 (en) 2014-04-28 2020-02-20 Dimerx, Inc. Pharmaceutically active dimers linked through phenolic hydroxyl groups
GB201419091D0 (en) 2014-10-27 2014-12-10 Camurus Ab Formulations
WO2016071767A1 (en) * 2014-11-07 2016-05-12 Indivior Uk Limited Buprenorphine dosing regimens
US10786515B2 (en) 2015-08-03 2020-09-29 Tolmar International Limited Liquid polymer delivery system for extended administration of drugs
AU2016355236C1 (en) 2015-11-16 2022-09-22 Medincell A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue
HUE060906T2 (hu) 2016-09-13 2023-04-28 Alar Pharmaceuticals Inc Nyújtott felszabadulású buprenorfin-készítmények
AU2018283724B2 (en) 2017-06-16 2021-08-19 Indivior Uk Limited Methods to treat opioid use disorder
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
JP2021511326A (ja) 2018-01-22 2021-05-06 フォアシー ファーマシューティカルズ シーオー.,リミテッド ブプレノルフィンの徐放送達のための薬学的組成物
CA3089256C (en) * 2018-05-11 2023-10-10 Alar Pharmaceuticals Inc. Long-acting injectable formulations and crystalline forms of buprenorphine derivatives
IL319386A (en) 2018-10-11 2025-05-01 Indivior Uk Ltd Buprenorphine for the treatment of respiratory depression
US12403291B2 (en) 2019-08-30 2025-09-02 Intersect Ent, Inc. Submucosal bioresorbable drug eluting platform
CN118831057A (zh) * 2023-04-25 2024-10-25 深圳善康医药科技股份有限公司 丁丙诺啡植入剂及其制备方法

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GB2513267B (en) 2010-06-08 2015-03-18 Rb Pharmaceuticals Ltd Injectable flowable composition comprising buprenorphine

Also Published As

Publication number Publication date
GB2481018A (en) 2011-12-14
JP6251774B2 (ja) 2017-12-20
MX2012014335A (es) 2013-03-05
HRP20180118T1 (hr) 2018-03-09
US20130210853A1 (en) 2013-08-15
EP4218720A1 (en) 2023-08-02
GB201413064D0 (en) 2014-09-03
PL2579874T3 (pl) 2018-05-30
IL223488A (en) 2017-10-31
JP5986072B2 (ja) 2016-09-06
RU2607498C2 (ru) 2017-01-10
FI3360538T3 (fi) 2023-03-22
GB201009549D0 (en) 2010-07-21
WO2011154724A3 (en) 2012-07-12
BR112012031290A2 (pt) 2016-11-01
KR101865689B1 (ko) 2018-06-08
ES2656938T3 (es) 2018-03-01
ES2939612T3 (es) 2023-04-25
ZA201209233B (en) 2014-04-30
GB2513267A (en) 2014-10-22
SMT201800038T1 (it) 2018-03-08
MX339209B (es) 2016-04-15
PT2579874T (pt) 2018-01-29
EP3360538B1 (en) 2023-02-15
RS56820B1 (sr) 2018-04-30
NZ604026A (en) 2015-01-30
DK2579874T3 (da) 2018-01-29
HUE038275T2 (hu) 2018-10-29
JP2016155865A (ja) 2016-09-01
NO2579874T3 (OSRAM) 2018-06-09
GB2481018B (en) 2015-03-18
US8921387B2 (en) 2014-12-30
CN103079544B (zh) 2017-06-09
CL2012003462A1 (es) 2013-04-01
IL254417A0 (en) 2017-11-30
CA2801676A1 (en) 2011-12-15
CN103079544A (zh) 2013-05-01
KR20130135026A (ko) 2013-12-10
GB2513267B (en) 2015-03-18
CO6670529A2 (es) 2013-05-15
JP2013533230A (ja) 2013-08-22
WO2011154724A9 (en) 2012-08-16
EP3360538A1 (en) 2018-08-15
EP2579874A2 (en) 2013-04-17
AU2011263478A1 (en) 2013-01-10
SI2579874T1 (en) 2018-03-30
EP2579874B1 (en) 2018-01-10
CA2801676C (en) 2018-08-07
MY171625A (en) 2019-10-21
RU2012157244A (ru) 2014-07-20
SG186200A1 (en) 2013-01-30
CY1120761T1 (el) 2019-12-11
LT2579874T (lt) 2018-02-12
WO2011154724A2 (en) 2011-12-15
AU2011263478B2 (en) 2015-01-22

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