DK3334826T5 - Valmue med højt indhold af thebain og fremgangsmåder til fremstilling heraf - Google Patents
Valmue med højt indhold af thebain og fremgangsmåder til fremstilling heraf Download PDFInfo
- Publication number
- DK3334826T5 DK3334826T5 DK17838267.7T DK17838267T DK3334826T5 DK 3334826 T5 DK3334826 T5 DK 3334826T5 DK 17838267 T DK17838267 T DK 17838267T DK 3334826 T5 DK3334826 T5 DK 3334826T5
- Authority
- DK
- Denmark
- Prior art keywords
- poppy
- preparation
- methods
- thebaine content
- high thebaine
- Prior art date
Links
- 235000008753 Papaver somniferum Nutrition 0.000 title 1
- 240000001090 Papaver somniferum Species 0.000 title 1
- FQXXSQDCDRQNQE-UHFFFAOYSA-N markiertes Thebain Natural products COC1=CC=C2C(N(CC3)C)CC4=CC=C(OC)C5=C4C23C1O5 FQXXSQDCDRQNQE-UHFFFAOYSA-N 0.000 title 1
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical compound C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 title 1
- 229930003945 thebaine Natural products 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
- C12Y114/11031—Thebaine 6-O-demethylase (1.14.11.31)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
- C12Y114/11032—Codeine 3-O-demethylase (1.14.11.32)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374682P | 2016-08-12 | 2016-08-12 | |
| CA2941315A CA2941315C (en) | 2016-08-12 | 2016-09-07 | High thebaine poppy and methods of producing the same |
| PCT/CA2017/050951 WO2018027324A1 (en) | 2016-08-12 | 2017-08-11 | High thebaine poppy and methods of producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3334826T3 DK3334826T3 (da) | 2024-01-15 |
| DK3334826T5 true DK3334826T5 (da) | 2024-10-07 |
Family
ID=57243364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17838267.7T DK3334826T5 (da) | 2016-08-12 | 2017-08-11 | Valmue med højt indhold af thebain og fremgangsmåder til fremstilling heraf |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10808258B2 (https=) |
| EP (1) | EP3334826B1 (https=) |
| JP (2) | JP6906812B2 (https=) |
| CN (1) | CN110088284A (https=) |
| AU (3) | AU2017310339B2 (https=) |
| CA (1) | CA2941315C (https=) |
| DK (1) | DK3334826T5 (https=) |
| ES (1) | ES2970324T3 (https=) |
| HU (1) | HUE065349T2 (https=) |
| PT (1) | PT3334826T (https=) |
| WO (1) | WO2018027324A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3553177T3 (da) | 2013-03-15 | 2021-02-15 | Univ Leland Stanford Junior | Benzylisoquinolinalkaloider (bia) som producerer mikrober, og fremgangsmåder til fremstilling og anvendelse deraf |
| CN112410379B (zh) | 2013-11-04 | 2024-12-31 | 小利兰·斯坦福大学托管委员会 | 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法 |
| EP3292203A4 (en) | 2015-05-04 | 2019-10-09 | The Board of Trustees of the Leland Stanford Junior University | BENZYL ISOCHINOLIN ALKALOID (BIA) Precursor Producing Microbicides and Method for the Preparation and Use Thereof |
| JP7266966B2 (ja) | 2015-05-08 | 2023-05-01 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法 |
| WO2018075670A1 (en) | 2016-10-18 | 2018-04-26 | Antheia, Inc. | Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids |
| AU2018203033B2 (en) * | 2017-05-02 | 2021-07-01 | Sun Pharmaceutical Industries Australia Pty Limited | Modified plant |
| WO2019028390A1 (en) | 2017-08-03 | 2019-02-07 | Antheia, Inc. | ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS |
| EP3758728A4 (en) * | 2018-03-02 | 2021-12-22 | Tasmanian Alkaloids Pty. Ltd. | PAPAVER SOMNIFERUM PLANT WITH AN MODIFIED ALKALOID PROFILE |
| CN120399912A (zh) | 2019-03-08 | 2025-08-01 | 小利兰·斯坦福大学托管委员会 | 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法 |
| JP7555091B2 (ja) * | 2020-02-29 | 2024-09-24 | 国立大学法人千葉大学 | 代謝物センサ及び酵素活性のスクリーニング方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6067749A (en) * | 1996-07-11 | 2000-05-30 | Tasmanian Alkaloids Pty. Ltd. | Papaver somniferum strain with high concentration of thebaine and oripavine |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| CA2317508A1 (en) | 1998-01-08 | 1999-07-15 | Commonwealth Scientific And Industrial Research Organisation | Methods for plant transformation and regeneration |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6730838B1 (en) | 1999-02-12 | 2004-05-04 | Council Of Scientific And Industrial Research | Opiumless and alkaloid-free non-narcotic opium poppy (Papaver somniferum) variety “Sujata” |
| AUPP946399A0 (en) | 1999-03-26 | 1999-04-22 | Johnson & Johnson Research Pty. Limited | Codeinone reductase from alkaloid poppy |
| EP1270727A1 (en) | 2001-06-11 | 2003-01-02 | Institut für Pflanzenbiochemie | Salutaridinol 7-O-acetyltransferase and derivatives thereof |
| CH695417A5 (de) * | 2001-11-15 | 2006-05-15 | Ddr Wassyl Nowicky Dipl Ing | Verfahren zur Umsetzung von Alkaloiden. |
| US6790959B1 (en) | 2003-06-05 | 2004-09-14 | Halsey Drug Company, Inc. | Process for manufacturing thebaine |
| US6864370B1 (en) | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
| EP1512748A1 (en) | 2003-09-03 | 2005-03-09 | Johnson & Johnson Research Pty Limited | O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in papaver somniferum |
| EP1632565A1 (en) | 2004-08-12 | 2006-03-08 | Johnson & Johnson Research Pty Limited | Modulation of alkaloid biosynthesis in plants and plants having altered alkaloid biosynthesis |
| DE102005005449A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| AU2006216715A1 (en) | 2005-02-22 | 2006-08-31 | Ceres Inc. | Modulating plant alkaloids |
| WO2006115575A1 (en) | 2005-04-20 | 2006-11-02 | Ceres Inc. | Regulatory regions from papaveraceae |
| US9131649B2 (en) * | 2008-03-07 | 2015-09-15 | Tasmanian Alkaloids Pty. Ltd | Papaver somniferum strain with high concentration of thebaine |
| US8541647B2 (en) | 2008-05-29 | 2013-09-24 | Tasmania Alkaloids Pty, Ltd. | Papaver somniferum with high concentration of codeine |
| US8586526B2 (en) | 2010-05-17 | 2013-11-19 | Sangamo Biosciences, Inc. | DNA-binding proteins and uses thereof |
| WO2011058446A2 (en) * | 2009-11-12 | 2011-05-19 | Uti Limited Partnership | Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum |
| CA2872079A1 (en) * | 2012-04-30 | 2013-11-07 | Tpi Enterprises Ltd | Papaver bracteatum with modified alkaloid content |
-
2016
- 2016-09-07 CA CA2941315A patent/CA2941315C/en active Active
-
2017
- 2017-08-11 EP EP17838267.7A patent/EP3334826B1/en active Active
- 2017-08-11 DK DK17838267.7T patent/DK3334826T5/da active
- 2017-08-11 CN CN201780063464.9A patent/CN110088284A/zh active Pending
- 2017-08-11 US US15/762,090 patent/US10808258B2/en active Active
- 2017-08-11 HU HUE17838267A patent/HUE065349T2/hu unknown
- 2017-08-11 AU AU2017310339A patent/AU2017310339B2/en active Active
- 2017-08-11 ES ES17838267T patent/ES2970324T3/es active Active
- 2017-08-11 WO PCT/CA2017/050951 patent/WO2018027324A1/en not_active Ceased
- 2017-08-11 PT PT178382677T patent/PT3334826T/pt unknown
- 2017-08-11 JP JP2019521398A patent/JP6906812B2/ja active Active
-
2019
- 2019-03-14 AU AU2019201771A patent/AU2019201771A1/en not_active Abandoned
-
2020
- 2020-08-21 JP JP2020140406A patent/JP2021000097A/ja active Pending
- 2020-09-17 US US17/023,569 patent/US20210246460A1/en not_active Abandoned
-
2021
- 2021-09-16 AU AU2021232757A patent/AU2021232757A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2970324T3 (es) | 2024-05-28 |
| PT3334826T (pt) | 2024-02-07 |
| CN110088284A (zh) | 2019-08-02 |
| HUE065349T2 (hu) | 2024-05-28 |
| AU2017310339A1 (en) | 2018-04-12 |
| JP2021000097A (ja) | 2021-01-07 |
| US20190169625A1 (en) | 2019-06-06 |
| CA2941315A1 (en) | 2016-11-08 |
| EP3334826A1 (en) | 2018-06-20 |
| AU2019201771A1 (en) | 2019-04-04 |
| US10808258B2 (en) | 2020-10-20 |
| JP6906812B2 (ja) | 2021-07-21 |
| DK3334826T3 (da) | 2024-01-15 |
| JP2019528084A (ja) | 2019-10-10 |
| US20210246460A1 (en) | 2021-08-12 |
| WO2018027324A9 (en) | 2019-07-18 |
| CA2941315C (en) | 2018-03-06 |
| EP3334826A4 (en) | 2018-08-08 |
| EP3334826B1 (en) | 2023-10-11 |
| WO2018027324A1 (en) | 2018-02-15 |
| AU2017310339B2 (en) | 2019-01-17 |
| AU2021232757A1 (en) | 2021-10-21 |
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