DK3313869T3 - Cyklisk rgd-cellebindende motiv og anvendelser deraf - Google Patents

Cyklisk rgd-cellebindende motiv og anvendelser deraf Download PDF

Info

Publication number
DK3313869T3
DK3313869T3 DK16731887.2T DK16731887T DK3313869T3 DK 3313869 T3 DK3313869 T3 DK 3313869T3 DK 16731887 T DK16731887 T DK 16731887T DK 3313869 T3 DK3313869 T3 DK 3313869T3
Authority
DK
Denmark
Prior art keywords
cell binding
cyclic rgd
rgd cell
binding design
design
Prior art date
Application number
DK16731887.2T
Other languages
English (en)
Inventor
My Hedhammar
Original Assignee
Spiber Tech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spiber Tech Ab filed Critical Spiber Tech Ab
Application granted granted Critical
Publication of DK3313869T3 publication Critical patent/DK3313869T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK16731887.2T 2015-06-26 2016-06-23 Cyklisk rgd-cellebindende motiv og anvendelser deraf DK3313869T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15174072 2015-06-26
PCT/EP2016/064543 WO2016207281A1 (en) 2015-06-26 2016-06-23 Cyclic rgd cell-binding motif and uses thereof

Publications (1)

Publication Number Publication Date
DK3313869T3 true DK3313869T3 (da) 2021-05-10

Family

ID=53513980

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16731887.2T DK3313869T3 (da) 2015-06-26 2016-06-23 Cyklisk rgd-cellebindende motiv og anvendelser deraf

Country Status (8)

Country Link
US (2) US10316069B2 (da)
EP (1) EP3313869B1 (da)
JP (1) JP6863976B2 (da)
KR (1) KR20180022873A (da)
CN (1) CN108026152B (da)
CA (1) CA2990523C (da)
DK (1) DK3313869T3 (da)
WO (1) WO2016207281A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3263593A1 (en) * 2016-07-01 2018-01-03 Anna Rising Engineered spider silk proteins and uses thereof
JP7029748B2 (ja) * 2018-01-26 2022-03-04 小島プレス工業株式会社 植毛品及びその製造方法
JP7220782B2 (ja) * 2019-06-11 2023-02-10 富士フイルム株式会社 環状ペプチド、細胞足場材、細胞分離材、及び培地
US20240207325A1 (en) 2021-04-12 2024-06-27 Biocrine Ab Pancreatic Islets as Protein Factories
WO2024033299A1 (en) 2022-08-08 2024-02-15 Spiber Technologies Ab In vitro derivation of pancreatic islets from human pluripotent stem cells
WO2024128081A1 (ja) * 2022-12-16 2024-06-20 東亞合成株式会社 合成ペプチド及び構築物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1465591A (zh) * 2002-06-24 2004-01-07 三九生物科技股份有限公司 氨基酸序列精氨酸-甘氨酸-天冬氨酸/纤维素亲和力功能区细胞贴附因子及其制造方法
CN100436477C (zh) * 2005-03-25 2008-11-26 复旦大学附属中山医院 含精-甘-天冬氨酸序列环肽及其主动靶向脂质体
DK1976868T3 (da) * 2005-12-30 2015-04-20 Spiber Technologies Ab Edderkoppesilke-proteiner og fremgangsmåde til fremstilling af edderkoppesilke-proteiner
CN101817873A (zh) * 2010-03-11 2010-09-01 复旦大学 一种促进细胞黏附的多肽及其制备方法
US9157070B2 (en) * 2010-04-12 2015-10-13 Spiber Technologies Ab Methods and combination comprising eukaryotic cells and recombinant spider silk protein
IN2015MN00027A (da) 2012-06-07 2015-10-16 Dcb Usa Llc
DE202013011693U1 (de) 2012-08-17 2014-02-26 Amsilk Gmbh Verwendung selbst-assemblierender Polypeptide als Gewebekleber
WO2015036619A1 (en) 2013-09-16 2015-03-19 Spiber Technologies Ab A method and a cell scaffold material for cell culture

Also Published As

Publication number Publication date
CA2990523C (en) 2023-01-24
EP3313869A1 (en) 2018-05-02
CN108026152B (zh) 2022-03-01
US20190322710A1 (en) 2019-10-24
JP6863976B2 (ja) 2021-04-21
US10316069B2 (en) 2019-06-11
WO2016207281A1 (en) 2016-12-29
EP3313869B1 (en) 2021-02-17
US20180170977A1 (en) 2018-06-21
JP2018527404A (ja) 2018-09-20
CN108026152A (zh) 2018-05-11
KR20180022873A (ko) 2018-03-06
CA2990523A1 (en) 2016-12-29
US10662230B2 (en) 2020-05-26

Similar Documents

Publication Publication Date Title
DK3368534T3 (da) Valbenazin-ditosylat og polymorfer deraf
DK3434762T3 (da) Modificerede, naturlige dræberceller og naturlige dræbercellelinjer med øget cytotoksicitet
DK3303379T3 (da) Tigit-bindende midler og anvendelser deraf
DK3597742T3 (da) Car-udtrykkende vektor og car-udtrykkende t-celler
DK3143134T3 (da) Modificerede, naturlige dræberceller og anvendelser deraf
DK3043784T3 (da) Arylethere og anvendelser deraf
DK3204022T3 (da) Placenta-afledte adhærente celle-exosomer og anvendelser deraf
DK3157552T3 (da) Syntac-polypeptider og anvendelser deraf
DK3154594T3 (da) Fap-aktiverede, terapeutiske midler og anvendelser i forbindelser dermed
DK3218358T3 (da) Ifluorometyl-aminopyridiner og difluorometyl-aminopyrimidiner
DK3099172T3 (da) Modificeret biologisk bekæmpelsesmiddel og anvendelser deraf
DK3524301T3 (da) Kanyleenhed med kanylehylster og bevægelig kanyleunderstøtning
DK3003039T3 (da) Methyl/fluor-pyridinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser og fluor-pyrimidinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser
DK2962100T3 (da) Tuberkulosebiomarkører og anvendelser deraf
DK3313869T3 (da) Cyklisk rgd-cellebindende motiv og anvendelser deraf
DK3302179T3 (da) Fjeder i lomme
DK3138048T3 (da) Kodede celler og cellearrays
DK3161139T3 (da) Tlr-4-specifikke aptamerer og anvendelser heraf
DK3029038T3 (da) Tetrazolinonforbindelse og anvendelse deraf
DK3128005T3 (da) Sirp-alfa-variantkonstruktioner og anvendelser deraf
DK3384079T3 (da) Fibrøs konstruktion og fremgangsmåder i forbindelse hermed
DK3209773T3 (da) Prolintolerante tripeptidylpeptidaser og anvendelser deraf
DK3131577T3 (da) Modificerede værtsceller og anvendelser deraf
DK3089760T3 (da) Konstrukt og sekvens til forbedret genekspression
DK3231016T3 (da) Fotovoltaikmodul og fotovoltaiksystem