DK3288596T3 - Fremgangsmåde til kontinuerlig virusinaktivering i en mikroreaktor - Google Patents

Fremgangsmåde til kontinuerlig virusinaktivering i en mikroreaktor Download PDF

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Publication number
DK3288596T3
DK3288596T3 DK16718357.3T DK16718357T DK3288596T3 DK 3288596 T3 DK3288596 T3 DK 3288596T3 DK 16718357 T DK16718357 T DK 16718357T DK 3288596 T3 DK3288596 T3 DK 3288596T3
Authority
DK
Denmark
Prior art keywords
microre
actor
procedure
virus inactivation
continuous virus
Prior art date
Application number
DK16718357.3T
Other languages
Danish (da)
English (en)
Inventor
Peter Schwan
Andrea Vester
Martin Lobedann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK3288596T3 publication Critical patent/DK3288596T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0094—Gaseous substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK16718357.3T 2015-04-28 2016-04-25 Fremgangsmåde til kontinuerlig virusinaktivering i en mikroreaktor DK3288596T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15165505.7A EP3088006A1 (de) 2015-04-28 2015-04-28 Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor
PCT/EP2016/059169 WO2016173982A1 (de) 2015-04-28 2016-04-25 Verfahren zur kontinuierlichen virusinaktivierung in einem mikroreaktor

Publications (1)

Publication Number Publication Date
DK3288596T3 true DK3288596T3 (da) 2019-05-06

Family

ID=53016520

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16718357.3T DK3288596T3 (da) 2015-04-28 2016-04-25 Fremgangsmåde til kontinuerlig virusinaktivering i en mikroreaktor

Country Status (20)

Country Link
US (1) US10434201B2 (OSRAM)
EP (2) EP3088006A1 (OSRAM)
JP (1) JP6851981B2 (OSRAM)
KR (1) KR20170140219A (OSRAM)
CN (1) CN107624073B (OSRAM)
AR (1) AR104440A1 (OSRAM)
AU (1) AU2016254582C1 (OSRAM)
BR (1) BR112017023246B1 (OSRAM)
CA (1) CA2983884A1 (OSRAM)
DK (1) DK3288596T3 (OSRAM)
ES (1) ES2720034T3 (OSRAM)
IL (1) IL255137B (OSRAM)
MX (1) MX380149B (OSRAM)
RU (1) RU2719363C2 (OSRAM)
SA (1) SA517390240B1 (OSRAM)
SG (1) SG11201708749WA (OSRAM)
TR (1) TR201904906T4 (OSRAM)
TW (1) TWI695070B (OSRAM)
WO (1) WO2016173982A1 (OSRAM)
ZA (1) ZA201708043B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102286411B1 (ko) * 2017-05-11 2021-08-05 이엠디 밀리포어 코포레이션 연속 유동 시스템에서 좁은 체류 시간 분포를 유지하기 위한 방법
US11732003B2 (en) 2017-05-11 2023-08-22 Emd Millipore Corporation Mechanical method of maintaining narrow residence time distributions in continuous flow systems
WO2019011900A1 (en) 2017-07-10 2019-01-17 Baxalta Incorporated METHOD FOR LIQUID INCUBATION AND VIRUS INACTIVATION
KR20210073554A (ko) * 2018-10-08 2021-06-18 베링거 인겔하임 인터내셔날 게엠베하 저 pH 바이러스 비활성화를 위한 새로운 연속 유동 반응기
DE102018009597A1 (de) 2018-12-07 2020-06-10 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur mehrfachen Änderung der Zusammensetzung eines Fluids
CN114247395B (zh) * 2020-09-23 2023-04-25 中国科学院大连化学物理研究所 一种中空纤维膜式微通道反应器及应用
GB2631765A (en) 2023-07-13 2025-01-15 Univ Cranfield Viral inactivation reactor and method
CN117298304B (zh) * 2023-09-18 2025-08-22 浙江大学 一种组装式连续病毒灭活装置及其设计方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0629135B1 (en) * 1992-03-02 2000-07-26 Bioeng, Inc. Viral inactivation method
DE69707288T2 (de) 1996-07-15 2002-07-18 Calcitech Ltd., Hamilton Herstellung von pulvern
GB2359765B (en) * 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
DE10056096A1 (de) 2000-11-13 2002-06-13 Bayer Ag Vorrichtung zur Bestrahlung von Flüssigkeiten
WO2002038191A2 (en) 2000-11-13 2002-05-16 Bayer Aktiengesellschaft Method of inactivating microorganisms in a fluid using ultraviolet radiation
DE10312765A1 (de) 2003-03-21 2004-09-30 Bayer Technology Services Gmbh Vorrichtung und Verfahren zur Sterilisation flüssiger Medien mittels UV-Bestrahlung und Kurzzeiterhitzung
US7485671B2 (en) * 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
WO2004103539A2 (en) * 2003-05-16 2004-12-02 Velocys Inc. Process for forming an emulsion using microchannel process technology
US7993580B2 (en) * 2004-08-24 2011-08-09 Baxter International Inc. Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors
EP1802395B1 (en) * 2004-09-09 2020-01-22 Institut Curie Microfluidic device using a collinear electric field
CN101084061B (zh) * 2004-10-01 2012-04-25 万罗赛斯公司 使用微通道工艺技术的多相混合方法
CN1786018B (zh) * 2005-12-12 2011-06-22 天津协和生物科技发展有限公司 高纯度血红蛋白的分离纯化与病毒灭活工艺
DE102006019242A1 (de) 2006-04-21 2007-10-25 Bayer Technology Services Gmbh Prozessanalysensystem mit steriler Probenahme von mechanisch empfindlichem Material aus einem Bioreaktor
WO2009022381A1 (ja) * 2007-08-10 2009-02-19 Photoscience Japan Corporation 短波長紫外線放電灯及び紫外線照射処理装置
US8187554B2 (en) * 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
CN104974251A (zh) * 2008-10-20 2015-10-14 Abbvie公司 在抗体纯化过程中的病毒灭活
US8956566B2 (en) * 2012-03-12 2015-02-17 Pure Biosolutions, Llc System and method for virus inactivation
EP2918294A1 (de) * 2014-03-11 2015-09-16 Bayer Technology Services GmbH Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung

Also Published As

Publication number Publication date
CN107624073A (zh) 2018-01-23
US10434201B2 (en) 2019-10-08
IL255137B (en) 2020-10-29
MX2017013893A (es) 2018-03-15
JP6851981B2 (ja) 2021-03-31
JP2018517455A (ja) 2018-07-05
WO2016173982A1 (de) 2016-11-03
AR104440A1 (es) 2017-07-19
EP3288596A1 (de) 2018-03-07
AU2016254582C1 (en) 2020-04-30
AU2016254582A1 (en) 2017-11-09
US20190117803A1 (en) 2019-04-25
ZA201708043B (en) 2020-01-29
IL255137A0 (en) 2017-12-31
SG11201708749WA (en) 2017-11-29
ES2720034T3 (es) 2019-07-17
SA517390240B1 (ar) 2021-03-01
TR201904906T4 (tr) 2019-05-21
EP3288596B1 (de) 2019-03-20
RU2017141168A (ru) 2019-05-28
MX380149B (es) 2025-03-12
RU2719363C2 (ru) 2020-04-17
HK1249867A1 (zh) 2018-11-16
KR20170140219A (ko) 2017-12-20
BR112017023246A2 (pt) 2020-05-19
TW201702377A (zh) 2017-01-16
BR112017023246B1 (pt) 2021-09-08
AU2016254582B2 (en) 2020-01-30
EP3088006A1 (de) 2016-11-02
TWI695070B (zh) 2020-06-01
RU2017141168A3 (OSRAM) 2019-11-14
CA2983884A1 (en) 2016-11-03
CN107624073B (zh) 2020-05-22

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