DK3256605T3 - Påvisning af mutationer til cancerscreening og føtal analyse - Google Patents
Påvisning af mutationer til cancerscreening og føtal analyse Download PDFInfo
- Publication number
- DK3256605T3 DK3256605T3 DK16748745.3T DK16748745T DK3256605T3 DK 3256605 T3 DK3256605 T3 DK 3256605T3 DK 16748745 T DK16748745 T DK 16748745T DK 3256605 T3 DK3256605 T3 DK 3256605T3
- Authority
- DK
- Denmark
- Prior art keywords
- mutations
- detection
- cancer screening
- fetal analysis
- fetal
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562114471P | 2015-02-10 | 2015-02-10 | |
| US201562271196P | 2015-12-22 | 2015-12-22 | |
| PCT/CN2016/073753 WO2016127944A1 (en) | 2015-02-10 | 2016-02-14 | Detecting mutations for cancer screening and fetal analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3256605T3 true DK3256605T3 (da) | 2022-03-14 |
Family
ID=56615337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16748745.3T DK3256605T3 (da) | 2015-02-10 | 2016-02-14 | Påvisning af mutationer til cancerscreening og føtal analyse |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10240209B2 (https=) |
| EP (2) | EP3256605B1 (https=) |
| JP (3) | JP6829211B2 (https=) |
| KR (1) | KR20170125044A (https=) |
| CN (2) | CN107771221B (https=) |
| AU (2) | AU2016218631B2 (https=) |
| CA (1) | CA2976303A1 (https=) |
| DK (1) | DK3256605T3 (https=) |
| ES (1) | ES2908347T3 (https=) |
| HU (1) | HUE058263T2 (https=) |
| PT (1) | PT3256605T (https=) |
| SG (1) | SG11201706529TA (https=) |
| TW (3) | TWI740817B (https=) |
| WO (1) | WO2016127944A1 (https=) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| CN104781421B (zh) | 2012-09-04 | 2020-06-05 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| CN111254500B (zh) | 2012-12-10 | 2024-01-23 | 分析生物科学有限公司 | 靶向基因组分析的方法 |
| ES2660989T3 (es) | 2013-12-28 | 2018-03-27 | Guardant Health, Inc. | Métodos y sistemas para detectar variantes genéticas |
| TWI813141B (zh) | 2014-07-18 | 2023-08-21 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
| EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| US10125399B2 (en) | 2014-10-30 | 2018-11-13 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| HUE058263T2 (hu) | 2015-02-10 | 2022-07-28 | Univ Hong Kong Chinese | Mutációk detektálása rákszûrési és magzatelemzési célból |
| IL305462A (en) | 2015-07-23 | 2023-10-01 | Univ Hong Kong Chinese | DNA fragmentation pattern analysis suitable clean |
| WO2017062970A1 (en) | 2015-10-10 | 2017-04-13 | Guardant Health, Inc. | Methods and applications of gene fusion detection in cell-free dna analysis |
| JP6913089B2 (ja) | 2015-11-11 | 2021-08-04 | レゾリューション バイオサイエンス， インコーポレイテッド | Ｄｎａライブラリーの高効率構築 |
| SG11201805119QA (en) | 2015-12-17 | 2018-07-30 | Guardant Health Inc | Methods to determine tumor gene copy number by analysis of cell-free dna |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| EP3427183A1 (en) * | 2016-03-10 | 2019-01-16 | Genomic Vision | Method of curvilinear signal detection and analysis and associated platform |
| US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
| US11566284B2 (en) | 2016-08-10 | 2023-01-31 | Grail, Llc | Methods of preparing dual-indexed DNA libraries for bisulfite conversion sequencing |
| US11319594B2 (en) | 2016-08-25 | 2022-05-03 | Resolution Bioscience, Inc. | Methods for the detection of genomic copy changes in DNA samples |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| EP3461274B1 (en) | 2016-09-30 | 2020-11-04 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| WO2018081130A1 (en) * | 2016-10-24 | 2018-05-03 | The Chinese University Of Hong Kong | Methods and systems for tumor detection |
| KR20260032575A (ko) | 2016-11-30 | 2026-03-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
| ES3022457T3 (en) * | 2016-12-21 | 2025-05-28 | Univ California | Deconvolution and detection of rare dna in plasma |
| SG11201906397UA (en) * | 2017-01-25 | 2019-08-27 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
| EP3366780B1 (en) | 2017-02-23 | 2020-05-06 | Siemens Healthcare GmbH | Single-molecule sequence and high sensitivity methylation analysis for tissue-specific analysis |
| IT201700045353A1 (it) * | 2017-04-26 | 2018-10-26 | Bioscience Services S R L | Metodo per la ricerca e l'individuazione di una condizione genetica prodromica all'insorgenza di tumori solidi |
| CN110914450B (zh) * | 2017-05-16 | 2024-07-02 | 夸登特健康公司 | 无细胞dna的体细胞来源或种系来源的鉴定 |
| US10081829B1 (en) | 2017-06-13 | 2018-09-25 | Genetics Research, Llc | Detection of targeted sequence regions |
| US10636512B2 (en) | 2017-07-14 | 2020-04-28 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| EP3431610A1 (en) * | 2017-07-19 | 2019-01-23 | Noscendo GmbH | Methods and devices for nucleic acid-based real-time determination of disease states |
| CN111051536A (zh) | 2017-07-26 | 2020-04-21 | 香港中文大学 | 利用不含细胞的病毒核酸改善癌症筛选 |
| US20190108311A1 (en) * | 2017-10-06 | 2019-04-11 | Grail, Inc. | Site-specific noise model for targeted sequencing |
| WO2019090156A1 (en) * | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Normalizing tumor mutation burden |
| WO2019109086A1 (en) | 2017-12-01 | 2019-06-06 | Illumina, Inc. | Methods and systems for determining somatic mutation clonality |
| AU2019206599A1 (en) | 2018-01-12 | 2020-07-30 | Grail, Inc. | Methods for analyzing viral nucleic acid |
| DE202019005627U1 (de) | 2018-04-02 | 2021-05-31 | Grail, Inc. | Methylierungsmarker und gezielte Methylierungssondenpanels |
| WO2019200398A1 (en) * | 2018-04-13 | 2019-10-17 | Dana-Farber Cancer Institute, Inc. | Ultra-sensitive detection of cancer by algorithmic analysis |
| WO2019204360A1 (en) * | 2018-04-16 | 2019-10-24 | Grail, Inc. | Systems and methods for determining tumor fraction in cell-free nucleic acid |
| EP3784806A4 (en) * | 2018-04-24 | 2022-01-19 | Grail, LLC | SYSTEMS AND METHODS OF USING A PATHOGENIC NUCLEIC ACID LOAD TO DETERMINE IF A SUBJECT HAS A CANCER CONDITION |
| CN108900319B (zh) * | 2018-05-30 | 2021-05-25 | 北京百度网讯科技有限公司 | 故障检测方法和装置 |
| WO2020023420A2 (en) * | 2018-07-23 | 2020-01-30 | Guardant Health, Inc. | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
| WO2020023671A1 (en) * | 2018-07-24 | 2020-01-30 | Protocol Intelligence, Inc. | Methods and systems for treating cancer and predicting and optimizing treatment outcomes in individual cancer patients |
| AU2019309870A1 (en) | 2018-07-26 | 2021-02-18 | Lexent Bio, Inc. | Multiple sequencing using a single flow cell |
| CN109022619A (zh) * | 2018-08-27 | 2018-12-18 | 郑州安图生物工程股份有限公司 | 一种用于检测人类疱疹病毒4型的试剂盒 |
| JP7535998B2 (ja) | 2018-08-31 | 2024-08-19 | ガーダント ヘルス， インコーポレイテッド | マージされたリードおよびマージされないリードに基づいた遺伝的変異体の検出 |
| WO2020069350A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| JP7499239B2 (ja) * | 2018-11-13 | 2024-06-13 | ミリアド・ジェネティックス・インコーポレイテッド | 体細胞変異のための方法およびシステム、ならびにそれらの使用 |
| CN113366122B (zh) * | 2018-12-19 | 2024-01-12 | 香港中文大学 | 游离dna末端特征 |
| WO2020160414A1 (en) | 2019-01-31 | 2020-08-06 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用 |
| US12497662B2 (en) | 2019-04-16 | 2025-12-16 | Grail, Inc. | Systems and methods for tumor fraction estimation from small variants |
| CN114026646A (zh) * | 2019-05-20 | 2022-02-08 | 基金会医学公司 | 用于评估肿瘤分数的系统和方法 |
| JP7506060B2 (ja) * | 2019-06-03 | 2024-06-25 | イルミナ インコーポレイテッド | 検出限界ベースの品質管理メトリック |
| KR20220064951A (ko) * | 2019-06-21 | 2022-05-19 | 쿠퍼서지컬, 인코퍼레이션. | 인간 배아에서의 복제 수 변이의 확인을 위한 단일 뉴클레오티드 변이의 밀도를 사용하는 시스템 및 방법(systems and methods for using density of single nucleotide variations for the verification of copy number variations in human embryos) |
| US20210065842A1 (en) * | 2019-07-23 | 2021-03-04 | Grail, Inc. | Systems and methods for determining tumor fraction |
| CA3147613A1 (en) * | 2019-08-19 | 2021-02-25 | Chang-Seok Ki | Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments |
| EP4041924A1 (en) * | 2019-10-08 | 2022-08-17 | Illumina, Inc. | Fragment size characterization of cell-free dna mutations from clonal hematopoiesis |
| JP7470787B2 (ja) | 2019-11-05 | 2024-04-18 | パーソナリス，インコーポレイティド | 単一試料からの腫瘍純度の推定 |
| WO2021137770A1 (en) * | 2019-12-30 | 2021-07-08 | Geneton S.R.O. | Method for fetal fraction estimation based on detection and interpretation of single nucleotide variants |
| EP4087942A4 (en) * | 2020-01-08 | 2024-01-24 | The Chinese University Of Hong Kong | Biterminal dna fragment types in cell-free samples and uses thereof |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| EP4259817A4 (en) * | 2020-12-08 | 2024-12-11 | The Chinese University of Hong Kong | Methods using characteristics of urinary and other dna |
| CN113628683B (zh) * | 2021-08-24 | 2024-04-09 | 慧算医疗科技（上海）有限公司 | 一种高通量测序突变检测方法、设备、装置及可读存储介质 |
| WO2023129983A1 (en) * | 2021-12-29 | 2023-07-06 | AiOnco, Inc. | Processing encrypted data for artificial intelligence-based analysis |
| CN114582429B (zh) * | 2022-03-03 | 2023-06-13 | 四川大学 | 基于层次注意力神经网络的结核分枝杆菌耐药性预测方法及装置 |
| WO2023181370A1 (ja) * | 2022-03-25 | 2023-09-28 | 国立大学法人 東京大学 | 情報処理装置、情報処理方法、及び情報処理プログラム |
| KR102491322B1 (ko) * | 2022-03-29 | 2023-01-27 | 주식회사 아이엠비디엑스 | 암 진단을 위한 다중 분석 예측 모델의 제조 방법 |
| US20250316332A1 (en) * | 2022-05-19 | 2025-10-09 | Personalis, Inc. | Methods and system for using methylation data for disease detection and quantification |
| CN115394358B (zh) * | 2022-08-31 | 2023-05-12 | 西安理工大学 | 基于深度学习的单细胞测序基因表达数据插补方法和系统 |
| WO2024051806A1 (zh) * | 2022-09-09 | 2024-03-14 | 南京金斯瑞生物科技有限公司 | 一种设计人源化抗体序列的方法 |
| CN115424666B (zh) * | 2022-09-13 | 2023-07-11 | 江苏先声医学诊断有限公司 | 一种基于全基因组重亚硫酸盐测序数据筛选泛癌早筛分子标志物的方法及系统 |
| JP7736308B2 (ja) * | 2022-11-18 | 2025-09-09 | 株式会社ニューギン | 遊技機 |
| JP7736310B2 (ja) * | 2022-11-18 | 2025-09-09 | 株式会社ニューギン | 遊技機 |
| JP7736307B2 (ja) * | 2022-11-18 | 2025-09-09 | 株式会社ニューギン | 遊技機 |
| JP7736309B2 (ja) * | 2022-11-18 | 2025-09-09 | 株式会社ニューギン | 遊技機 |
| WO2024151667A2 (en) * | 2023-01-09 | 2024-07-18 | Clearnote Health, Inc. | 5-hydroxymethylation analysis of buffy coat gdna in cancer detection |
| WO2025054456A1 (en) * | 2023-09-08 | 2025-03-13 | Ellison Institute, Llc | Methods of determining variability in molecular alterations |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA005140B1 (ru) | 1999-04-02 | 2004-12-30 | Корикса Корпорейшн | Соединения и способы для лечения и диагностики рака легкого |
| US20030219765A1 (en) | 2000-03-23 | 2003-11-27 | Jose Costa | Methods for evaluating cancer risk |
| US20030211522A1 (en) * | 2002-01-18 | 2003-11-13 | Landes Gregory M. | Methods for fetal DNA detection and allele quantitation |
| US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
| EP1599608A4 (en) | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| PL201608B1 (pl) | 2003-06-13 | 2009-04-30 | Cezary Cybulski | Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1 |
| ATE435301T1 (de) | 2003-10-16 | 2009-07-15 | Sequenom Inc | Nicht invasiver nachweis fötaler genetischer merkmale |
| WO2005108621A1 (en) | 2004-04-30 | 2005-11-17 | Yale University | Methods and compositions for cancer diagnosis |
| US20070122823A1 (en) | 2005-09-01 | 2007-05-31 | Bianchi Diana W | Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis |
| EP3591068A1 (en) | 2006-02-02 | 2020-01-08 | The Board of Trustees of the Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
| EP2351858B1 (en) | 2006-02-28 | 2014-12-31 | University of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| WO2008024009A1 (en) | 2006-08-15 | 2008-02-28 | Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) | Transcriptional level of a timp3 gene in the form of a diagnosis marker of a non-small cell carcinoma of lung |
| JP2010527603A (ja) | 2007-05-25 | 2010-08-19 | ディコーデ ジェネテクス イーエイチエフ | 乳癌のリスクアセスメント、診断、予後診断および治療における使用のためのマーカーとしてのＣＨＲ５ｐ１２および１０ｑ２６上の遺伝的変異 |
| PL2557520T3 (pl) | 2007-07-23 | 2021-10-11 | The Chinese University Of Hong Kong | Określanie zaburzenia równowagi sekwencji kwasu nukleinowego |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| CA3069082C (en) | 2008-09-20 | 2022-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
| US20100136560A1 (en) | 2008-12-02 | 2010-06-03 | The Johns Hopkins University | Integrated Analyses of Breast and Colorectal Cancers |
| US20120021428A1 (en) | 2009-03-31 | 2012-01-26 | Marcus Otte | Method for diagnosis of cancer and monitoring of cancer treatments |
| US20120208711A1 (en) | 2009-10-02 | 2012-08-16 | Centre For Addiction And Mental Health | Method for Analysis of DNA Methylation Profiles of Cell-Free Circulating DNA in Bodily Fluids |
| WO2011053790A2 (en) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis |
| EP3783110B1 (en) | 2009-11-05 | 2022-11-23 | The Chinese University Of Hong Kong | Fetal genomic analysis from a maternal biological sample |
| CA2780016C (en) | 2009-11-06 | 2017-09-19 | The Chinese University Of Hong Kong | Size-based genomic analysis |
| GB0922006D0 (en) | 2009-12-17 | 2010-02-03 | Genome Res Ltd | Diagnostic |
| EP2370599B1 (en) | 2010-01-19 | 2015-01-21 | Verinata Health, Inc | Method for determining copy number variations |
| EP2513341B1 (en) | 2010-01-19 | 2017-04-12 | Verinata Health, Inc | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
| WO2011103236A2 (en) | 2010-02-18 | 2011-08-25 | The Johns Hopkins University | Personalized tumor biomarkers |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| CN105243295B (zh) | 2010-11-30 | 2018-08-17 | 香港中文大学 | 与癌症相关的遗传或分子畸变的检测 |
| AU2011373694A1 (en) | 2011-07-26 | 2013-05-02 | Verinata Health, Inc. | Method for determining the presence or absence of different aneuploidies in a sample |
| JP6073902B2 (ja) * | 2011-10-06 | 2017-02-01 | セクエノム， インコーポレイテッド | 遺伝的変異の非侵襲的評価のための方法およびプロセス |
| WO2013086352A1 (en) | 2011-12-07 | 2013-06-13 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| WO2013138510A1 (en) | 2012-03-13 | 2013-09-19 | Patel Abhijit Ajit | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| WO2013179443A1 (ja) | 2012-05-31 | 2013-12-05 | 住友電気工業株式会社 | 酸化物超電導薄膜とその製造方法 |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| CN104781421B (zh) * | 2012-09-04 | 2020-06-05 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| SI4056712T1 (sl) * | 2012-09-20 | 2024-10-30 | The Chinese University Of Hong Kong | Neinvazivno določanje metiloma tumorja iz plazme |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| EP2959016A4 (en) * | 2013-02-21 | 2016-10-12 | Toma Biosciences Inc | METHOD, COMPOSITIONS AND NUCLEIC ACID ANALYSIS KITS |
| WO2014145078A1 (en) | 2013-03-15 | 2014-09-18 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| US10262755B2 (en) * | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
| US20160002717A1 (en) | 2014-07-02 | 2016-01-07 | Boreal Genomics, Inc. | Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease |
| EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| WO2016085876A1 (en) | 2014-11-25 | 2016-06-02 | The Broad Institute Inc. | Clonal haematopoiesis |
| EP3227464B1 (en) | 2014-12-05 | 2022-04-20 | Foundation Medicine, Inc. | Multigene analysis of tumor samples |
| EP3766986B1 (en) | 2014-12-31 | 2022-06-01 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| HUE058263T2 (hu) | 2015-02-10 | 2022-07-28 | Univ Hong Kong Chinese | Mutációk detektálása rákszûrési és magzatelemzési célból |
| WO2016149261A1 (en) | 2015-03-16 | 2016-09-22 | Personal Genome Diagnostics, Inc. | Systems and methods for analyzing nucleic acid |
-
2016
- 2016-02-14 HU HUE16748745A patent/HUE058263T2/hu unknown
- 2016-02-14 JP JP2017559756A patent/JP6829211B2/ja active Active
- 2016-02-14 ES ES16748745T patent/ES2908347T3/es active Active
- 2016-02-14 WO PCT/CN2016/073753 patent/WO2016127944A1/en not_active Ceased
- 2016-02-14 CN CN201680009446.8A patent/CN107771221B/zh active Active
- 2016-02-14 DK DK16748745.3T patent/DK3256605T3/da active
- 2016-02-14 KR KR1020177025432A patent/KR20170125044A/ko active Pending
- 2016-02-14 CN CN202111196156.8A patent/CN113957124A/zh active Pending
- 2016-02-14 AU AU2016218631A patent/AU2016218631B2/en active Active
- 2016-02-14 SG SG11201706529TA patent/SG11201706529TA/en unknown
- 2016-02-14 CA CA2976303A patent/CA2976303A1/en active Pending
- 2016-02-14 PT PT167487453T patent/PT3256605T/pt unknown
- 2016-02-14 EP EP16748745.3A patent/EP3256605B1/en active Active
- 2016-02-14 EP EP21205562.8A patent/EP4012715B1/en active Active
- 2016-02-15 TW TW105104407A patent/TWI740817B/zh active
- 2016-02-15 TW TW112132531A patent/TW202400808A/zh unknown
- 2016-02-15 TW TW110131934A patent/TWI817187B/zh active
- 2016-11-28 US US15/362,631 patent/US10240209B2/en active Active
-
2019
- 2019-01-22 US US16/254,492 patent/US11168370B2/en active Active
-
2021
- 2021-01-21 JP JP2021007944A patent/JP7168247B2/ja active Active
- 2021-10-29 US US17/514,902 patent/US20220127683A1/en active Pending
-
2022
- 2022-05-10 AU AU2022203114A patent/AU2022203114A1/en not_active Abandoned
- 2022-10-17 JP JP2022166050A patent/JP2022185149A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3256605T3 (da) | Påvisning af mutationer til cancerscreening og føtal analyse | |
| DK3227684T3 (da) | Analyse af og screening for cellesekretionsprofiler | |
| DK3171765T3 (da) | Indsamling og analyse af data til diagnostiske formål | |
| DK3792378T3 (da) | Fremgangsmåder og anordninger til analyse af partikler | |
| DK3662407T3 (da) | Systemer og fremgangsmåder til analyse af vævsbilleder | |
| DK3110975T3 (da) | Fremgangsmåder til analyse af somatiske mobile elementer og anvendelser deraf | |
| EP3323070A4 (en) | Neo-antigen-ANALYSIS | |
| DK3178258T3 (da) | Justering af målingsmellemrum og opdagelsessignaler | |
| ZA201706572B (en) | Devices and methods for sample analysis | |
| DK3289362T3 (da) | Detektering og sortering af mikrofluid-smådråber | |
| DK3317824T3 (da) | Undersøgelse og visualisering af laboratorieforsøgsdata | |
| DK3332034T3 (da) | Systemer og fremgangsmåder til genomisk analyse | |
| DK3077943T3 (da) | Fremgangsmåder og systemer til analyse af billeddata | |
| DK3055803T3 (da) | Sporing og analyse af kliniske resultater | |
| DK3182901T3 (da) | System og fremgangsmåde til ikke-invasiv analyse af kropsfluider | |
| MA42847A (fr) | Analyse de micro-moment | |
| DK3267884T3 (da) | Systemer, apparater og fremgangsmåder til måling af føtal aktivitet | |
| IL253666A0 (en) | Hyperspectral testing device for testing different types of samples | |
| DK3357000T3 (da) | Systemer og fremgangsmåder til cancerdetektering | |
| EP3467512A4 (en) | SAMPLE PROCESSING AND MEASUREMENT SYSTEM | |
| DK3156503T3 (da) | Mavecancer-biomarkør og detektionsfremgangsmåde | |
| GB2559921B (en) | Measuring reagent and analysis device for analyzing biopolymer | |
| DK3100523T3 (da) | Opdagelsessignaler og fremgangsmåder | |
| DK3071956T3 (da) | Afstandsdetektering og analyse af genstande | |
| EP3123166C0 (en) | DETECTOR INPUT AND SAMPLING METHOD |