DK3233493T3 - Cellulosenanofibrillær bioink til 3D-bioprintning til celledyrkning, vævsteknologi og applikationer i regenerativ medicin - Google Patents

Cellulosenanofibrillær bioink til 3D-bioprintning til celledyrkning, vævsteknologi og applikationer i regenerativ medicin Download PDF

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Publication number
DK3233493T3
DK3233493T3 DK15871191.1T DK15871191T DK3233493T3 DK 3233493 T3 DK3233493 T3 DK 3233493T3 DK 15871191 T DK15871191 T DK 15871191T DK 3233493 T3 DK3233493 T3 DK 3233493T3
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bioink
bioprinting
cell culture
regenerative medicine
medicine applications
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DK15871191.1T
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English (en)
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Paul Gatenholm
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Cellink Ab
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3882—Hollow organs, e.g. bladder, esophagus, urether, uterus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y40/00—Auxiliary operations or equipment, e.g. for material handling
    • B33Y40/10—Pre-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/08—Fractionation of cellulose, e.g. separation of cellulose crystallites
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D101/00—Coating compositions based on cellulose, modified cellulose, or cellulose derivatives
    • C09D101/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/04—Printing inks based on proteins
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/14—Printing inks based on carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0081—Prosthesis for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/112—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2001/00—Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2089/00—Use of proteins, e.g. casein, gelatine or derivatives thereof, as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7532—Artificial members, protheses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing & Machinery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Polymers & Plastics (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
DK15871191.1T 2014-12-18 2015-12-18 Cellulosenanofibrillær bioink til 3D-bioprintning til celledyrkning, vævsteknologi og applikationer i regenerativ medicin DK3233493T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462093881P 2014-12-18 2014-12-18
PCT/US2015/066755 WO2016100856A1 (en) 2014-12-18 2015-12-18 Cellulose nanofibrillar bionik for 3d bioprinting for cell culturing, tissue engineering and regenerative medicine applications

Publications (1)

Publication Number Publication Date
DK3233493T3 true DK3233493T3 (da) 2021-09-06

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Country Status (7)

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US (4) US10675379B2 (da)
EP (2) EP3233493B1 (da)
DK (1) DK3233493T3 (da)
ES (1) ES2886127T3 (da)
PL (1) PL3233493T3 (da)
PT (1) PT3233493T (da)
WO (1) WO2016100856A1 (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016100856A1 (en) 2014-12-18 2016-06-23 Advanced Polymer Technology Ab Cellulose nanofibrillar bionik for 3d bioprinting for cell culturing, tissue engineering and regenerative medicine applications
FI129934B (en) 2015-02-13 2022-11-15 Upm Kymmene Corp Sewing thread, method of making sewing thread and its use
EP3469004A4 (en) * 2016-06-09 2020-05-06 Cellink AB PRODUCTION OF MODIFIED CELLULOSE ANOFIBRILLS WITH EXTRACELLULAR MATRIX COMPONENTS AS BIOTINKS FOR 3D BIODINTING
EP3532117B1 (en) 2016-10-28 2023-08-02 CELLINK Bioprinting AB Preparation and applications of 3d bioprinting bioinks for repair of bone defects, based on cellulose nanofibrils hydrogels with natural or synthetic calcium phosphate particles
WO2018078130A1 (en) * 2016-10-28 2018-05-03 Paul Gatenholm Preparation and applications of 3d bioprinting bioinks for repair of bone defects, based on cellulose nanofibrils hydrogels with natural or synthetic calcium phosphate particles
WO2018100580A1 (en) 2016-12-01 2018-06-07 Regenesis Biomedical Ltd. Method and system for 3d printing
FI128467B (en) * 2016-12-30 2020-05-29 Teknologian Tutkimuskeskus Vtt Oy Three-dimensional printing with biomaterials
US10774227B2 (en) * 2017-04-25 2020-09-15 Cellheal As Preparation and applications of biocompatible conductive inks based on cellulose nanofibrils for 3D printing of conductive biomedical devices and for use as models for study of neurodegenerative disorders and connection between brain/neurons and communication or other electronic devices
US10066028B1 (en) 2017-05-11 2018-09-04 King Saud University Method of fabricating biocompatible cellulose nanofibrils
CN107369206B (zh) * 2017-06-08 2020-09-22 北京农业信息技术研究中心 一种玉米群体三维模型构建方法及系统
EP3427949B1 (en) * 2017-07-12 2024-10-09 MAPTECH Holdings UG Mechanically tunable bioinks for bioprinting
CA3079065A1 (en) * 2017-10-17 2019-04-25 Cellutech Ab Biocomposite material comprising cnf and an anionic gelling polysaccharide
WO2019122351A1 (en) 2017-12-22 2019-06-27 Cellink Ab Tissue-specific human bioinks for the physiological 3d-bioprinting of human tissues for in vitro culture and transplantation
US11814524B2 (en) * 2018-01-07 2023-11-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Wood paste and objects made therefrom
WO2019145795A2 (en) 2018-01-26 2019-08-01 Cellink Ab Systems and methods for optical assessments of bioink printability
CN112533652A (zh) * 2018-03-07 2021-03-19 格兰生物科技知识产权控股有限责任公司 用于3d生物打印的含纳米纤维素的生物墨水、其制造和使用方法、以及由此获得的3d生物结构
SE1850409A1 (en) 2018-04-11 2019-10-12 Cellink Ab Use of a microfluidic device for patterning cellular material in a 3D extracellular environment
SE543226C2 (en) * 2018-06-13 2020-10-27 Stora Enso Oyj A method for 3D printing using cross-linkable phosphorylated microfibrillated cellulose
WO2020035734A1 (en) 2018-08-17 2020-02-20 Cellheal As Method of producing three dimensional autologous fat graft using human lipoaspirate-derived adipose tissue with multipotent stem cells and biocompatible cellulose nanofibrils
US20210252189A1 (en) * 2018-08-20 2021-08-19 Alliance For Sustainable Energy, Llc Cellulose nanofiber biomaterial
US11186736B2 (en) 2018-10-10 2021-11-30 Cellink Ab Double network bioinks
EP3799571A4 (en) * 2018-10-25 2022-03-09 Cellink AB BIOGUM AND BOTANICAL GUM HYDROGEL BIO INKS FOR PHYSIOLOGICAL 3D BIOPRINTING OF TISSUE CONSTRUCTS FOR IN VITRO GROWING AND TRANSPLANTATION
TWI771563B (zh) * 2019-02-01 2022-07-21 嬌朋生技股份有限公司 生物纖維組成物
US20220145259A1 (en) 2019-03-13 2022-05-12 Cellink Ab Liver Tissue Model Constructs and Methods for Providing the Same
CN110039050A (zh) * 2019-04-16 2019-07-23 南京医科大学附属逸夫医院 一种特定形态与结构的组织工程支架的制备装置及其制备方法
SE543785C2 (en) * 2019-06-05 2021-07-20 Kristiina Oksman Composition for 3D printing comprising alginate and cellulose nanofibers originating from brown seaweed, a method for the production and the use thereof
SE1950711A1 (en) * 2019-06-13 2020-12-14 Cellink Ab 3d bioprinted skin tissue model
EP3771471A1 (en) 2019-07-31 2021-02-03 Freie Universität Berlin Photocurable composition
WO2021041962A1 (en) * 2019-08-28 2021-03-04 The Regents Of The University Of California Structure and method for promoting microalgae growth
US11826951B2 (en) 2019-09-06 2023-11-28 Cellink Ab Temperature-controlled multi-material overprinting
CN112754944B (zh) * 2019-11-05 2023-03-24 钟春燕 一种生物纤维素基皮肤清洁产品及其制备方法和应用
CN110787320B (zh) * 2019-12-02 2021-10-29 南方医科大学 一种直写成型3d打印生物墨水的制备及其3d打印方法
US20220354993A1 (en) * 2019-12-19 2022-11-10 Paul Gatenholm Biomimetic three-dimensional device for delivery of therapeutic cells and method of making device
JP2023537323A (ja) 2020-07-31 2023-08-31 オーシャン ツニセル エーエス バイオ適合性の注射用及びインサイチューゲル化用ハイドロゲル並びに組織及び器官修復のための、セルロースナノフィブリルに基づくバイオ適合性の注射用及びインサイチューゲル化用ハイドロゲルの調製及び適用
CN112500151B (zh) * 2020-11-30 2022-02-15 华南理工大学 生物活性陶瓷支架与柔性可调的三维生坯及其制备方法
WO2024003287A1 (en) 2022-06-30 2024-01-04 Danmarks Tekniske Universitet 3d printing transparent bioink formulation
EP4393590A1 (en) * 2022-12-30 2024-07-03 Tecnalia Research and Innovation Cellulose and nanocellulose based bioinks

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2716887B1 (fr) 1994-03-01 1996-04-26 Atochem Elf Sa Polymères renforcés de microfibrilles de cellulose, latex, poudres, films, joncs correspondants, et leurs applications.
US8153157B2 (en) * 2005-04-22 2012-04-10 Asahi Kasei Chemicals Corporation Porous cellulose aggregate and molding composition thereof
DE102007016852A1 (de) * 2007-04-10 2008-10-16 Bioregeneration Gmbh Verfahren zur Herstellung einer kristalline Cellulose umfassenden Struktur
US8691974B2 (en) 2009-09-28 2014-04-08 Virginia Tech Intellectual Properties, Inc. Three-dimensional bioprinting of biosynthetic cellulose (BC) implants and scaffolds for tissue engineering
FI123988B (fi) 2010-10-27 2014-01-31 Upm Kymmene Corp Soluviljelymateriaali
US20140038275A1 (en) * 2010-11-24 2014-02-06 Paul Gatenholm Pharmacology Bioassays for Drug Discovery, Toxicity Evaluation and in vitro Cancer Research Using a 3D Nanocellulose Scaffold and Living Tissue
WO2012106707A2 (en) 2011-02-04 2012-08-09 Bc Genesis Llc Biosynthetic functional cellulose (bc) fibers as surgical sutures and reinforcement of implants and growing tissue
JP5545775B2 (ja) 2012-03-05 2014-07-09 第一工業製薬株式会社 水性インク組成物およびそれを用いた筆記具
FI125965B (en) 2012-09-25 2016-04-29 Upm Kymmene Corp Three-dimensional cell culture
ES2523397B1 (es) 2013-05-24 2015-09-10 Fundació Cetemmsa Composición de tinta para impresión por inyección
US11903612B2 (en) 2013-11-04 2024-02-20 University Of Iowa Research Foundation Bioprinter and methods of using same
CN103893825B (zh) 2014-02-24 2015-06-10 钟春燕 含胶原蛋白的细菌纤维素复合羊膜细胞外基质材料制备方法
US9764515B2 (en) 2014-05-01 2017-09-19 Musc Foundation For Research Development Multidispensor cartesian robotic printer
CN106659148A (zh) 2014-05-12 2017-05-10 鲁斯特生物股份有限公司 即用打印细胞和集成装置
HRPK20140564B3 (hr) 2014-06-13 2017-05-19 Milan Majetić 3d pla bioprinter
HUE050420T2 (hu) 2014-12-11 2020-12-28 Eth Zuerich Graft szerkezet porc javításához és eljárás annak elõállítására
JP2018507004A (ja) 2014-12-12 2018-03-15 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ（ウペエフエル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ ｄｅ Ｌａｕｓａｎｎｅ （ＥＰＦＬ） 生細胞を含有する構造体を構築する方法
WO2016100856A1 (en) 2014-12-18 2016-06-23 Advanced Polymer Technology Ab Cellulose nanofibrillar bionik for 3d bioprinting for cell culturing, tissue engineering and regenerative medicine applications
TWI741980B (zh) 2015-04-07 2021-10-11 大陸商四川藍光英諾生物科技股份有限公司 一種生物磚及其用途
WO2017059171A1 (en) 2015-10-02 2017-04-06 Wake Forest University Health Sciences Spontaneously beating cardiac organoid constructs and integrated body-on-chip apparatus containing the same
FR3046420A1 (fr) 2015-12-30 2017-07-07 Lab Skin Creations Procede de fabrication de substituts cutanes par depot additif
JP7177045B2 (ja) 2016-06-03 2022-11-22 ビコ グループ アー・ベー 化粧品の試験及び移植のためのモデルとして使用するための、新規のプリンティングヘッドを用いたヒト皮膚の３ｄバイオプリンティングのための、フィブリン含有又は非含有のｒｇｄ接合多糖類バイオインクの調製及び適用
EP3469004A4 (en) 2016-06-09 2020-05-06 Cellink AB PRODUCTION OF MODIFIED CELLULOSE ANOFIBRILLS WITH EXTRACELLULAR MATRIX COMPONENTS AS BIOTINKS FOR 3D BIODINTING
WO2018119989A1 (zh) 2016-12-30 2018-07-05 苏州聚复高分子材料有限公司 生物墨水
WO2018169965A1 (en) 2017-03-13 2018-09-20 The Texas A&M University System Nanocomposite ionic-covalent entanglement reinforcement mechanism and hydrogel

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EP3233493B1 (en) 2021-06-16
US10675379B2 (en) 2020-06-09
EP3233493A1 (en) 2017-10-25
US20200206385A1 (en) 2020-07-02
EP3912652C0 (en) 2023-11-15
WO2016100856A1 (en) 2016-06-23
EP3233493A4 (en) 2018-10-17
US20230398259A1 (en) 2023-12-14
PT3233493T (pt) 2021-09-07
ES2886127T3 (es) 2021-12-16
EP3912652B1 (en) 2023-11-15
US20170368225A1 (en) 2017-12-28
PL3233493T3 (pl) 2021-12-13
US20200164103A1 (en) 2020-05-28
EP3912652A1 (en) 2021-11-24

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