DK3220891T3 - Sublingual formulering af riluzol - Google Patents

Sublingual formulering af riluzol Download PDF

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Publication number
DK3220891T3
DK3220891T3 DK15823415T DK15823415T DK3220891T3 DK 3220891 T3 DK3220891 T3 DK 3220891T3 DK 15823415 T DK15823415 T DK 15823415T DK 15823415 T DK15823415 T DK 15823415T DK 3220891 T3 DK3220891 T3 DK 3220891T3
Authority
DK
Denmark
Prior art keywords
riluzol
sublingual formulation
sublingual
formulation
Prior art date
Application number
DK15823415T
Other languages
Danish (da)
English (en)
Inventor
Vladimir Coric
Robert M Berman
Ronald Samuel Vladyka
Amgad Saleh
Danny Yu
Original Assignee
Biohaven Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biohaven Therapeutics Ltd filed Critical Biohaven Therapeutics Ltd
Application granted granted Critical
Publication of DK3220891T3 publication Critical patent/DK3220891T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK15823415T 2014-11-21 2015-11-17 Sublingual formulering af riluzol DK3220891T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462083094P 2014-11-21 2014-11-21
PCT/US2015/061114 WO2016081472A1 (en) 2014-11-21 2015-11-17 Sublingual formulation of riluzole

Publications (1)

Publication Number Publication Date
DK3220891T3 true DK3220891T3 (da) 2019-11-04

Family

ID=55085882

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15823415T DK3220891T3 (da) 2014-11-21 2015-11-17 Sublingual formulering af riluzol

Country Status (24)

Country Link
US (1) US11660267B2 (el)
EP (3) EP3220891B1 (el)
JP (3) JP6753860B2 (el)
KR (2) KR20230135183A (el)
CN (1) CN107249567B (el)
AU (2) AU2015350148B2 (el)
BR (1) BR112017010423B1 (el)
CA (1) CA2967662A1 (el)
CY (1) CY1122469T1 (el)
DK (1) DK3220891T3 (el)
EA (1) EA038518B1 (el)
ES (2) ES2751300T3 (el)
HR (1) HRP20191892T8 (el)
HU (1) HUE046869T2 (el)
IL (2) IL252285B (el)
LT (1) LT3220891T (el)
MX (1) MX368838B (el)
PH (1) PH12017500934A1 (el)
PL (1) PL3220891T3 (el)
PT (1) PT3220891T (el)
RS (1) RS59490B1 (el)
SG (1) SG11201703896QA (el)
SI (1) SI3220891T1 (el)
WO (1) WO2016081472A1 (el)

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WO2018071606A1 (en) 2016-10-11 2018-04-19 Arvinas, Inc. Compounds and methods for the targeted degradation of androgen receptor
AU2019223014B2 (en) * 2018-02-21 2024-10-17 AI Therapeutics, Inc. Combination therapy with apilimod and glutamatergic agents
AU2019277080A1 (en) * 2018-05-27 2021-01-07 Biohaven Pharmaceutical Holding Company Ltd. Use of riluzole oral disintigrating tablets for treating diseases
CA3109769A1 (en) * 2018-08-16 2020-02-20 Biohaven Therapeutics Ltd. Use of riluzole oral disintigrating tablets for treating diseases
CA3158411A1 (en) * 2019-10-22 2021-04-29 Arvinas Operations, Inc. Methods of treating prostate cancer
WO2021231174A1 (en) 2020-05-09 2021-11-18 Arvinas Operations, Inc. Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
WO2022076321A1 (en) * 2020-10-05 2022-04-14 Icahn School Of Medicine At Mount Sinai Riluzole for the treatment of alzheimer's disease
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans
CN113876735B (zh) * 2021-10-20 2023-05-12 陇南市第一人民医院 一种利鲁唑微球制剂及其制备方法
KR102625977B1 (ko) 2021-11-24 2024-01-17 부산대학교 산학협력단 리루졸을 유효성분으로 포함하는 염증성 장질환 예방 또는 치료용 조성물

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Also Published As

Publication number Publication date
IL252285A0 (en) 2017-07-31
AU2015350148A1 (en) 2017-06-15
KR20230135183A (ko) 2023-09-22
EP3616686B1 (en) 2021-05-19
US20210038499A1 (en) 2021-02-11
ES2882783T3 (es) 2021-12-02
EP3220891A1 (en) 2017-09-27
AU2021201034B2 (en) 2023-07-06
JP6753860B2 (ja) 2020-09-09
ES2751300T3 (es) 2020-03-31
EP3616686B8 (en) 2021-06-23
AU2015350148B2 (en) 2020-11-26
CA2967662A1 (en) 2016-05-26
JP2023065398A (ja) 2023-05-12
KR102580378B1 (ko) 2023-09-19
IL252285B (en) 2020-10-29
EA038518B1 (ru) 2021-09-09
AU2021201034A1 (en) 2021-03-11
SI3220891T1 (sl) 2020-02-28
EA201790958A1 (ru) 2018-01-31
RS59490B1 (sr) 2019-12-31
PL3220891T3 (pl) 2020-08-24
EP4039247A3 (en) 2022-11-16
SG11201703896QA (en) 2017-06-29
BR112017010423A2 (pt) 2017-12-26
JP2017535613A (ja) 2017-11-30
PH12017500934A1 (en) 2017-11-20
CY1122469T1 (el) 2021-01-27
EP3220891B1 (en) 2019-07-24
IL278188A (en) 2020-11-30
PT3220891T (pt) 2019-10-31
WO2016081472A1 (en) 2016-05-26
BR112017010423B1 (pt) 2023-09-26
US20180153794A1 (en) 2018-06-07
HRP20191892T8 (hr) 2020-09-18
MX368838B (es) 2019-10-18
CN107249567A (zh) 2017-10-13
US11660267B2 (en) 2023-05-30
JP2021001173A (ja) 2021-01-07
MX2017006446A (es) 2018-02-12
LT3220891T (lt) 2019-11-11
HRP20191892T1 (hr) 2020-01-10
KR20170137032A (ko) 2017-12-12
EP3616686A1 (en) 2020-03-04
HUE046869T2 (hu) 2020-04-28
CN107249567B (zh) 2021-08-03
EP4039247A2 (en) 2022-08-10

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