DK3152232T3 - Bestemmelse af antigen-genkendelse ved stregkodning af MHC-multimerer - Google Patents

Bestemmelse af antigen-genkendelse ved stregkodning af MHC-multimerer Download PDF

Info

Publication number
DK3152232T3
DK3152232T3 DK15739508.8T DK15739508T DK3152232T3 DK 3152232 T3 DK3152232 T3 DK 3152232T3 DK 15739508 T DK15739508 T DK 15739508T DK 3152232 T3 DK3152232 T3 DK 3152232T3
Authority
DK
Denmark
Prior art keywords
determination
antigen recognition
bar coding
mhc multimers
multimers
Prior art date
Application number
DK15739508.8T
Other languages
Danish (da)
English (en)
Inventor
Hadrup Sine Reker
Henrik Pedersen
Amalie Kai Bentzen
Søren Jakobsen
Original Assignee
Immudex Aps
Herlev Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59272565&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3152232(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immudex Aps, Herlev Hospital filed Critical Immudex Aps
Application granted granted Critical
Publication of DK3152232T3 publication Critical patent/DK3152232T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70539MHC-molecules, e.g. HLA-molecules
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1065Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804Nucleic acid analysis using immunogens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539MHC-molecules, e.g. HLA-molecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK15739508.8T 2014-06-06 2015-06-08 Bestemmelse af antigen-genkendelse ved stregkodning af MHC-multimerer DK3152232T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201470340 2014-06-06
PCT/DK2015/050150 WO2015185067A1 (en) 2014-06-06 2015-06-08 Determining antigen recognition through barcoding of mhc multimers

Publications (1)

Publication Number Publication Date
DK3152232T3 true DK3152232T3 (da) 2020-02-24

Family

ID=59272565

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15739508.8T DK3152232T3 (da) 2014-06-06 2015-06-08 Bestemmelse af antigen-genkendelse ved stregkodning af MHC-multimerer

Country Status (10)

Country Link
US (1) US20170343545A1 (enExample)
EP (3) EP4484450A3 (enExample)
JP (4) JP6956632B2 (enExample)
AU (3) AU2015271324B2 (enExample)
CA (2) CA2951325C (enExample)
DK (1) DK3152232T3 (enExample)
ES (1) ES2770634T3 (enExample)
PT (1) PT3152232T (enExample)
SG (2) SG11201610177UA (enExample)
WO (1) WO2015185067A1 (enExample)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011237729B2 (en) 2010-04-05 2014-04-03 Prognosys Biosciences, Inc. Spatially encoded biological assays
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
WO2016069124A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
DE112012002570B4 (de) 2011-06-23 2023-11-23 Board Of Regents, The University Of Texas System Identifizieren von Peptiden auf der Einzelmolekülebene
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
JP6367196B2 (ja) 2012-08-14 2018-08-01 テンエックス・ジェノミクス・インコーポレイテッド マイクロカプセル組成物および方法
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR102190198B1 (ko) 2013-02-08 2020-12-14 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
DK3013983T3 (da) 2013-06-25 2023-03-06 Prognosys Biosciences Inc Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning
CA2943624A1 (en) 2014-04-10 2015-10-15 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
CA2951325C (en) * 2014-06-06 2023-09-12 Herlev Hospital Determining antigen recognition through barcoding of mhc multimers
WO2015188839A2 (en) 2014-06-13 2015-12-17 Immudex Aps General detection and isolation of specific cells by binding of labeled molecules
WO2015200869A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
EP4574974A3 (en) 2014-06-26 2025-10-08 10x Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
CN107427808B (zh) 2015-01-12 2020-10-23 10X基因组学有限公司 用于制备核酸测序文库的方法和系统以及用其制备的文库
EP3262407B1 (en) 2015-02-24 2023-08-30 10X Genomics, Inc. Partition processing methods and systems
CN120425026A (zh) 2015-04-10 2025-08-05 十程基因技术瑞典公司 生物样本的空间区别、多重核酸分析
US10539564B2 (en) 2015-07-22 2020-01-21 Roche Sequencing Solutions, Inc. Identification of antigen epitopes and immune sequences recognizing the antigens
WO2017013170A1 (en) 2015-07-22 2017-01-26 F. Hoffmann-La Roche Ag Identification of antigen epitopes and immune sequences recognizing the antigens
CN108291257B (zh) 2015-09-24 2023-12-29 阿布维特罗有限责任公司 亲和-寡核苷酸缀合物及其用途
SG10202108763UA (en) 2015-12-04 2021-09-29 10X Genomics Inc Methods and compositions for nucleic acid analysis
BR112019005748A2 (pt) * 2016-09-24 2019-06-18 Abvitro Llc afinidade-conjugados de oligonucleotídeo e usos destes
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4310183B1 (en) 2017-01-30 2025-07-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN111051523B (zh) 2017-11-15 2024-03-19 10X基因组学有限公司 功能化凝胶珠
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
WO2019195166A1 (en) 2018-04-06 2019-10-10 10X Genomics, Inc. Systems and methods for quality control in single cell processing
US20210139985A1 (en) * 2018-04-10 2021-05-13 Board Of Regents, The University Of Texas System Dna-barcoded antigen multimers and methods of use thereof
DK3773689T5 (da) * 2018-04-11 2024-08-19 Enterome S A Antigene peptider til forebyggelse og behandling af kræft
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
US11603565B2 (en) 2018-06-15 2023-03-14 Roche Sequencing Solutions, Inc. System for identification of antigens recognized by T cell receptors expressed on tumor infiltrating lymphocytes
CA3110800A1 (en) 2018-07-12 2020-01-16 Board Of Regents, The University Of Texas System Molecular neighborhood detection by oligonucleotides
CN112739708A (zh) * 2018-08-14 2021-04-30 德克萨斯大学系统董事会 对与主要组织相容性复合体结合的肽进行单分子测序
EP4603594A3 (en) 2018-08-28 2025-11-12 10X Genomics, Inc. Increasing spatial array resolution
EP3844308A1 (en) 2018-08-28 2021-07-07 10X Genomics, Inc. Resolving spatial arrays
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
CN110687298A (zh) * 2018-09-06 2020-01-14 天津美瑞特医疗科技有限公司 一种以Chitosan多糖为骨架制备MHC抗原肽多聚体检测试剂的新方法
WO2020056173A1 (en) * 2018-09-13 2020-03-19 Pact Pharma, Inc. Antigen specific tcr identification using single-cell sorting
KR20210063379A (ko) * 2018-09-24 2021-06-01 브리스톨-마이어스 스큅 컴퍼니 바코딩된 펩티드-mhc 복합체 및 그의 용도
CA3117476A1 (en) 2018-10-05 2020-04-09 Board Of Regents, The University Of Texas System Solid-phase n-terminal peptide capture and release
WO2020107496A1 (zh) * 2018-12-01 2020-06-04 铭道创新(北京)医疗技术有限公司 一种免疫细胞中淋巴细胞的流式细胞仪检测方法
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
US20220290217A1 (en) 2018-12-10 2022-09-15 10X Genomics, Inc. Resolving spatial arrays using deconvolution
WO2020127222A2 (en) 2018-12-17 2020-06-25 Immudex Aps Panel comprising borrelia mhc multimers
US20220042008A1 (en) * 2018-12-18 2022-02-10 Mbl International Corp. COMPOSITIONS OF STREPTAVIDIN-OLIGO CONJUGATES OF pMHC OCCUPANCY
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
CN114174531A (zh) 2019-02-28 2022-03-11 10X基因组学有限公司 用空间条码化寡核苷酸阵列对生物分析物进行概况分析
CN114127309A (zh) 2019-03-15 2022-03-01 10X基因组学有限公司 使用空间阵列进行单细胞测序的方法
WO2020198071A1 (en) 2019-03-22 2020-10-01 10X Genomics, Inc. Three-dimensional spatial analysis
EP3976820A1 (en) 2019-05-30 2022-04-06 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
GB201909509D0 (en) * 2019-07-02 2019-08-14 Immunocore Ltd Peptide-MHC complexes
KR102406463B1 (ko) * 2019-09-03 2022-06-10 재단법인 오송첨단의료산업진흥재단 단백질 생산성 향상을 위한 개별 바코딩 시스템 도입한 시그널 펩타이드 초고속 선별방법
JP7711049B2 (ja) * 2019-10-03 2025-07-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 初代ヒト細胞における、同族t細胞及びエピトープ反応性をスクリーニングするハイスループット法
EP4055185A1 (en) 2019-11-08 2022-09-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
ES3024383T3 (en) 2019-11-13 2025-06-04 10X Genomics Inc Generating capture probes for spatial analysis
EP4081777B1 (en) 2019-12-23 2026-02-18 10X Genomics, Inc. Reversible fixing reagents and methods of use thereof
EP4081656A1 (en) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
JP7107535B2 (ja) * 2020-01-10 2022-07-27 シンクサイト株式会社 新規細胞表現型スクリーニング方法
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
CN115776987A (zh) * 2020-03-31 2023-03-10 瑞佩尔托利免疫医药股份有限公司 可条码化可交换肽-mhc多聚体文库
WO2021216787A1 (en) * 2020-04-21 2021-10-28 Regeneron Pharmaceuticals, Inc. Methods and systems for analysis of receptor interaction
EP4414459B1 (en) 2020-05-22 2025-09-03 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
US12265079B1 (en) 2020-06-02 2025-04-01 10X Genomics, Inc. Systems and methods for detecting analytes from captured single biological particles
WO2022109339A1 (en) 2020-11-20 2022-05-27 Becton, Dickinson And Company Use of dextramer in single cell analysis
US20240271120A1 (en) * 2021-01-28 2024-08-15 Gigavax Aps Pmhc multiplexers for detection of antigen-specific cells
US20240158781A1 (en) * 2021-01-28 2024-05-16 FWD Holdings APS Pmhc multiplexers by addition of mhc2 and rolling circle peptide multimer display
EP4212653A1 (en) * 2022-01-18 2023-07-19 Universität Potsdam Molecular tagging using position-oriented nucleic acid encryption
EP4519674A1 (en) 2022-05-06 2025-03-12 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
WO2023225294A1 (en) * 2022-05-20 2023-11-23 10X Genomics, Inc. Improved major histocompatibility complex molecules
EP4709743A1 (en) 2023-05-11 2026-03-18 Immudex ApS Mhc class i molecules
WO2025109111A1 (en) 2023-11-22 2025-05-30 Immudex Aps Immune cell activating multimers
WO2025125477A1 (en) 2023-12-12 2025-06-19 Immudex Aps Mhc class i molecule matched negative control reagents
WO2025144972A1 (en) * 2023-12-29 2025-07-03 Illumina, Inc. Materials and methods for preparation of a spatial transcriptomics library
WO2026087501A1 (en) 2024-10-22 2026-04-30 Immudex Aps Antigen multimers for detection of antigen-specific chimeric antigen receptor (car) t cells

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001158800A (ja) * 1999-12-03 2001-06-12 Jsr Corp アビジン粒子
AU783689B2 (en) * 2000-01-24 2005-11-24 Adnexus Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
US7902121B2 (en) * 2001-07-02 2011-03-08 The Board Of Trustees Of The Leland Stanford Junior University MHC-antigen arrays for detection and characterization of immune responses
AU2002360272A1 (en) 2001-10-10 2003-04-22 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
JP2007525970A (ja) * 2003-06-27 2007-09-13 ナノスフェアー インコーポレイテッド バイオバーコードに基づく標的分析物の検出
GB2422834B8 (en) * 2005-02-04 2007-01-04 Proimmune Ltd MHC oligomer and method of making the same
EP2167537A2 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Compiled methods for analysing and sorting samples
WO2009077173A2 (en) 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
JP2011518553A (ja) * 2008-04-09 2011-06-30 カリフォルニア インスティチュート オブ テクノロジー 標的を検出及び/又は分類する捕捉剤および関連する方法およびシステム
WO2010037397A1 (en) * 2008-10-01 2010-04-08 Dako Denmark A/S Mhc multimers in cmv immune monitoring
US20110318380A1 (en) * 2008-10-01 2011-12-29 Dako Denmark A/S MHC Multimers in Cancer Vaccines and Immune Monitoring
JP5690272B2 (ja) 2008-11-03 2015-03-25 ステフティン サンクイン ブルードフォルツィーニング サンプル中の抗原応答性細胞の検出
US8735327B2 (en) * 2010-01-07 2014-05-27 Jeansee, Llc Combinatorial DNA taggants and methods of preparation and use thereof
US10023657B2 (en) * 2010-10-01 2018-07-17 Ludwig Institute For Cancer Research Ltd. Reversible protein multimers, methods for their production and use
WO2013137737A1 (en) * 2012-03-16 2013-09-19 Flexgen B.V. Methods of creating and screening of dna encoded combinatorial libraries of chemical antibodies
CA2951325C (en) 2014-06-06 2023-09-12 Herlev Hospital Determining antigen recognition through barcoding of mhc multimers
WO2015188839A2 (en) * 2014-06-13 2015-12-17 Immudex Aps General detection and isolation of specific cells by binding of labeled molecules
US9789974B2 (en) 2015-10-19 2017-10-17 Goodrich Corporation Brake monitoring system

Also Published As

Publication number Publication date
AU2021204496A1 (en) 2021-07-29
EP3628684B1 (en) 2024-09-18
CA3205428A1 (en) 2015-12-10
AU2015271324A1 (en) 2017-01-12
EP3628684C0 (en) 2024-09-18
JP2025128229A (ja) 2025-09-02
EP4484450A3 (en) 2025-03-26
EP3628684A1 (en) 2020-04-01
EP3152232A1 (en) 2017-04-12
WO2015185067A9 (en) 2019-06-13
ES2770634T3 (es) 2020-07-02
SG10202005892SA (en) 2020-07-29
EP4484450A2 (en) 2025-01-01
AU2015271324B2 (en) 2019-09-12
JP6956632B2 (ja) 2021-11-02
US20170343545A1 (en) 2017-11-30
WO2015185067A1 (en) 2015-12-10
JP7271465B2 (ja) 2023-05-11
CA2951325A1 (en) 2015-12-10
JP2017518375A (ja) 2017-07-06
PT3152232T (pt) 2020-02-19
AU2019264685A1 (en) 2019-12-05
CA2951325C (en) 2023-09-12
JP2020109114A (ja) 2020-07-16
SG11201610177UA (en) 2017-01-27
EP3152232B1 (en) 2019-11-13
AU2019264685B2 (en) 2021-04-01
AU2021204496B2 (en) 2023-07-06
JP2023100746A (ja) 2023-07-19

Similar Documents

Publication Publication Date Title
IL285403A (en) Mhc class i epitope delivering polypeptides
SI3256853T1 (sl) Napovedovanje za cepljenje uporabnih epitopov T-celic
EP3628684C0 (en) DETERMINATION OF ANTIGEN RECOGNITION BY MEANS OF BARCODE LABELING OF MHC MULTIMERS
IL251963A0 (en) Anti-pd-1 antibodies
DK3122403T3 (da) Mekanisme til aftrækning af hylster
DK3556775T3 (da) Anti-lag-3 antistoffer til behandling af hæmatologiske maligniteter
DK3137169T3 (da) Hæmmere af lysin-specifik demethylase-1
DK3186376T3 (da) Fremgangsmåder til forbedring af cas9-medieret manipulationseffektivitet
DK3116891T3 (da) Immunglobulinrensning ved hjælp af forrensningstrin
LT3218504T (lt) Trijų segmentų arenavirusai kaip vakcinos vektoriai
DK3234128T3 (da) Sekventeringskontroller
CL2016001742A1 (es) Anticuerpos anti-baff novedosos
DK3180331T3 (da) Polymorfer af selinexor
DK3157559T3 (da) Anti-axl-antistoffer
DK3236881T3 (da) System til vaccination af fjerkræ
EP3194180C0 (en) SECURE LENS LAYER
DK3130392T3 (da) Virusfjernelsesmembran
IL235565A0 (en) Location based optical character recognition (ocr)
PL3215530T3 (pl) Ulepszone przeciwciała anty-il-6
EP3500351C0 (en) HYDROCARBON FLUID-WATER SEPARATION
DK3137449T3 (da) Fremgangsmåder til fremstilling af substituerede cycloseriner
LT3178931T (lt) Anti-orai1 antikūnas
EP3160502B1 (en) BI-SPECIFIC ANTIBODIES ANTI-IL4-IL13
LT3126391T (lt) Hpa-1a antikūnai
DK3855181T3 (da) Forbindelser til behandling af lipofuscinrelaterede sygdomme