DK3055315T3 - Thiazolopyrimidinoner som modulatorer af NMDA-receptoraktivitet - Google Patents

Thiazolopyrimidinoner som modulatorer af NMDA-receptoraktivitet Download PDF

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DK3055315T3
DK3055315T3 DK14781878.5T DK14781878T DK3055315T3 DK 3055315 T3 DK3055315 T3 DK 3055315T3 DK 14781878 T DK14781878 T DK 14781878T DK 3055315 T3 DK3055315 T3 DK 3055315T3
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methyl
thiazolo
pyrimidin
trifluoromethyl
oxo
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Jiang Yu
Guosheng Wu
Po-Wai Yuen
Elisia Villemure
Jacob Schwarz
Cuong Ly
Benjamin Sellers
Matthew Volgraf
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Hoffmann La Roche
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Claims (39)

1. Forbindelse med formlen (II):
hvor Ra er Ci-6alkyl eller Cb-ealkcnyl, hver eventuelt substitueret med en eller flere Rb-substituenter; C2-6alkynyl; halogen; -C(O)RC; -NRdRe; -C(O)NRdRe; -C(S)NRdRe; -C(=N-OH)-Ci-4alkyl; -OCi_4alkyl; -OCi-4halogenalkyl; -SCi-4alkyl; -SC>2Ci-4alkyl; cyano; C3-6cycloalkyl, eventuelt substitueret med en eller flere Rf-substituenter; eller en phenyl, monocyklisk heteroaryl eller heterocycloalkylring, hver ring eventuelt substitueret med en eller flere R8-substituenter; hvor hver Rb-substituent er uafhængigt valgt fra gruppen bestående af -OH, -Ci-4alkoxy, -NRdRe, -C(O)NRdRe, -SCi^alkyl, -SO2Ci-4alkyl, cyano, halogen, C3-6cycloalkyl og monocyklisk heteroaryl; Rc er Ci-4alkyl, -Ci-4halogenalkyl, C3-6cycloalkyl eller en monocyklisk carbonbundet heterocycloalkyl; Rd er H eller Ci-4alkyl; Re er H; Ci-4alkyl, eventuelt substitueret med -CN, -CF3, -OH, eller en monocyklisk heterocycloalkyl; C3-6cycloalkyl; -OH; eller -OCi-4alkoxy; eller Rd og Re, taget sammen med det nitrogenatom, de er bundet til, danner en heterocycloalkyl, eventuelt substitueret med Ci-4alkyl eller -OH; hver Rf-substituent er uafhængigt valgt fra gruppen bestående af: Ci-4alkyl, eventuelt substitueret med -OH, cyano eller Ci-4alkoxy; -OH; halogen; Ci-4haloalkyl; -CONH2; og cyano; og hver Rg-substituent er uafhængigt valgt fra gruppen bestående af Ci-4alkyl, -CF3, halogen, -nh2, -OCH3, cyano og -OH; R1 er valgt ffa gruppen bestående af H, Ci-6alkyl, CMhalogcnalkyl, C3-6cycloalkyl, halogen, -OCi-4alkyl, -OCi-4halogenalkyl, cyano og -C(O)Ci-4alkyl; eller Ra og R1, taget sammen
med de carbonatomer, de er bundet til, danner en 5- til 7-leddet ring, der eventuelt indeholder et O eller en NH, og eventuelt substitueret med en eller flere Rh-substituenter; hvor hver Rh-substituent uafhængigt er -C(O)NR'R', cyano, eller er Ci-4alkyl, eventuelt substitueret med -OH, -OCH3, cyano eller -QOjNR'R’; eller to Rh-grupper, der er bundet til samme carbonatom og, taget sammen med det carbonatom, de er bundet til, danner en carbonyl eller en C3-6cycloalkyl; hvor R1 og R' hver uafhængigt er H eller Ci-4alkyl; R2 er -Rm, -ORm eller -NRmRn; hvor Rm er phenyl, naphthyl, pyridyl, pyrazinyl, pyridazinyl, pyrrolyl, pyrazolyl, triazolyl, imidazolyl, furanyl, oxazolyl, isoxazolyl, thiophenyl, thiazolyl, isothiazolyl, indolyl, indazolyl, quinolinyl eller isoquinolinyl, hver eventuelt substitueret med en eller flere Rs-substituenter; hvor hver Rs-substituent er uafhængigt valgt fra gruppen bestående af Ci-4alkyl, C2-4alkenyl (eventuelt substitueret med halogen), C2-4alkynyl, Ci-4haloalkyl, Ci-4alkoxy, Ci-4alkyl-OH, Ci-4halogenalkoxy, halogen, cyano, C3-6cycloalkyl (eventuelt substitueret med -OH eller halogen), monocyklisk heteroaryl, -NH2, -NO2, -NHSO2Ci-4alkyl og -SO2Ci-4alkyl; Rn er H, Ci-4halogenalkyl eller Cwalkyl, eventuelt substitueret med -OH eller Ci-4alkoxy; eller Rm og Rn, taget sammen med det nitrogenatom, de er bundet til, danner en pyrrolidin-eller piperidinring, eventuelt substitueret med Ci-4alkyl og eventuelt kondenseret til phenyl, hvilken phenyl eventuelt er substitueret med halogen; R3 er H eller methyl; og R4 er H eller fluor; eller et farmaceutisk acceptabelt salt deraf.
2. Forbindelse ifølge krav 1, hvor Ra er methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl eller isopentyl, hver eventuelt substitueret med en eller flere Rh-substituenter.
3. Forbindelse ifølge et hvilket som helst af kravene 1-2, hvor hver Rb uafhængigt er -OH, methoxy, ethoxy, -NRdRe, -C(O)NRdRe, thiomethyl, thioethyl, methansulfonyl, ethansulfonyl, cyano, fluor, chlor, brom, pyrrolyl, pyrazolyl, imidazolyl, furanyl, thiophenyl, triazolyl, tetrazolyl, oxazolyl eller thiazolyl.
4. Forbindelse ifølge et hvilket som helst af kravene 1-3, hvor hver Rb uafhængigt er -OH, -C(O)NHCH3, -CF3, methoxy, ethoxy, fluor, -C(O)NH2, -C(O)N(CH3)2, -N(CH3)2, methansulfonyl, thiomethyl, cyano, pyrazolyl, 6-oxa-l-azaspiro[3.3]heptan-l-yl, azetidinyl, 3-hydroxyazetidinyl, pyrrolidinyl eller hydroxyethylamino.
5. Forbindelse ifølge krav 1, hvor Ra er ethenyl, isopropenyl eller propynyl.
6. Forbindelse ifølge krav 1, hvor Ra er halogen.
7. Forbindelse ifølge krav 1, hvor Rc er methyl, ethyl, propyl, isopropyl, butyl, fluormethyl, difluormethyl, trifluormethyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, oxetanyl, tetrahydrofuranyl eller tetrahydropyranyl.
8. Forbindelse ifølge krav 1, hvor Rd er H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl eller tert-butyl.
9. Forbindelse ifølge kravene 1 eller 7-8, hvor Re er H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, cyanomethyl, trifluorethyl, hydroxy ethyl, 2-hydroxy-l-methylethyl, hydroxypropyl, cyclopropyl, hydroxy, methoxy eller oxetanylmethyl.
10. Forbindelse ifølge krav 1 eller 7, hvor Rd og Re, taget sammen med det nitrogenatom, de er bundet til, danner azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl eller 6-oxa-l-azaspiro[3.3]heptan-l-yl, hver eventuelt substitueret med Ci-4alkyl eller -OH.
11. Forbindelse ifølge krav 1, hvor Ra er cyano.
12. Forbindelse ifølge krav 1, hvor Ra er cyclopropyl, cyclobutyl, cyclopentyl eller cyclohexyl, hver eventuelt substitueret med en eller flere Rf-substituenter.
13. Forbindelse ifølge krav 1, hvor hver Rf uafhængigt er hydroxymethyl, methyl, cyano, trifluormethyl, cyanomethyl, methoxymethyl, fluormethyl, hydroxymethyl, 1-hydroxy-1-methylethyl eller -CONH2.
14. Forbindelse ifølge krav 1, hvor Ra er en phenyl, pyrrolyl, furanyl, thiophenyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl eller pyrimidinyl, hver eventuelt substitueret med en eller flere Rg-substituenter.
15. Forbindelse ifølge krav 1 eller 14, hvor hver Rg uafhængigt er methyl, ethyl, propyl, isopropyl, -CF3, fluor, chlor, -NH2, -OCH3, cyano eller -OH.
16. Forbindelse ifølge krav 1, hvor Ra og R1, taget sammen med de carbonatomer, de er bundet til, danner cyclopentenyl, cyclohexenyl, dihydrofuranyl, dihydropyranyl, dihydropyrrolyl eller tetrahydropyridin, hver eventuelt substitueret med en eller flere Rh-substituenter.
17. Forbindelse ifølge krav 1, hvor hver Rh uafhængigt er hydroxypropyl, hydroxy ethyl, hydroxymethyl, methyl, cyano, methoxymethyl, -Ο(Ο)ΝΗ2 eller -CH2C(O)N(CH3)2.
18. Forbindelse ifølge krav 1 eller 16, hvor to Rh-grupper, der er bundet til det samme carbonatom, tages sammen med det carbonatom, de er bundet til, for at danne cyclopentyl eller en carbonyl.
19. Forbindelse ifølge et hvilket som helst af kravene 1-18, hvor R1 er H, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, fluormethyl, fluormethyl, trifluormethyl, fluorethyl, trifluorethyl, cyclopropyl, cyclobutyl, cyclopentyl eller cyclohexyl.
20. Forbindelse ifølge et hvilket som helst af kravene 1-19, hvor Rm er phenyl, naphthyl, pyridyl, indazolyl, isoquinolinyl eller pyrazolyl, hver eventuelt substitueret med en eller flere Rs-substituenter.
21. Forbindelse ifølge et hvilket som helst afkravene 1-20, hvor hver Rs uafhængigt er methyl, ethyl, propyl, isopropyl, butyl, fluormethyl, difluormethyl, trifluormethyl, fluorethyl, trifluorethyl, methoxy, ethoxy, isopropoxy, hydroxymethyl, hydroxyethyl, trifluormethoxy, fluor, chlor, brom, iod, cyano, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, -NHSO2Ci-2alkyl eller -SO2Ci-2alkyl.
22. Forbindelse ifølge et hvilket som helst afkravene 1-19, hvor R2 er Rm, og Rm er
hvor mindst en af X1, X2 og X3 er N, og de andre to uafhængigt er N, NRr, O, S eller C-Rr; Rp og Rr hver uafhængigt er H; Ci-4halogenalkyl; Ci-4alkyl, eventuelt substitueret med -OH; halogen; cyano; eller C3-6cycloalkyl; og Rq er H eller fluor; eller Rq og Rr, taget sammen med de carbonatomer, de er bundet til, danner phenyl, eventuelt substitueret med halogen.
23. Forbindelse ifølge krav 22, hvor X1, X2 og X3 hver er N.
24. Forbindelse ifølge krav 22, hvor Rp og Rr hver uafhængigt er H, fluormethyl, difluormethyl, trifluormethyl, fluorethyl, trifluorethyl, methyl, ethyl, hydroxymethyl, hydroxyethyl, chlor, cyano, cyclopropyl, cyclobutyl eller cyclopentyl.
25. Forbindelse ifølge krav 22-24, hvor Rq er H eller fluor.
26. Forbindelse ifølge krav 22, hvor Rq og Rr, taget sammen med de carbonatomer, de er bundet til, danner phenyl, eventuelt substitueret med fluor.
27. Forbindelse ifølge et hvilket som helst afkravene 1-21, hvor Rn er H, fluormethyl, difluormethyl, trifluormethyl, fluorethyl, difluorethyl eller trifluorethyl, eller er methyl eller ethyl, eventuelt substitueret med -OH, methoxy eller ethoxy.
28. Forbindelse ifølge et hvilket som helst af kravene 1-20, hvor Rm og Rn, taget sammen med det nitrogenatom, de er bundet til, danner dihydroindol, eventuelt substitueret med methyl eller fluor.
29. Forbindelse ifølge et hvilket som helst af kravene 1-28, hvor R3 er H eller methyl.
30. Forbindelse ifølge et hvilket som helst af kravene 1-29, hvor R4 er H eller fluor.
31. Forbindelse ifølge et hvilket som helst af kravene 1-30, der er valgt fra gruppen bestående af N-(cyanomethyl)-7-((4-fluorphenoxy)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(4-fluorphenoxymethyl)-N,2-dimethyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3-carboxamid; 3-[(azetidin-l-yl)carbonyl]-7-(4-fluorphenoxymethyl)-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on; N-ethyl-7-(4-fluorphenoxymethyl)-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(4-fluorphenoxymethyl)-2-methyl-5-oxo-N-(2,2,2-trifluorethyl)-5H-[l,3]thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-(3,4-difluorphenoxymethyl)-N,2-dimethyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-(4-fluorphenoxymethyl)-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-((4-fluorphenoxy)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-((4-fluorphenoxy)methyl)-N-hydroxy-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(4-fluorphenoxymethyl)-2-methyl-5-oxo-N-(propan-2-yl)-5H-[l,3]thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-(4-fluorphenoxymethyl)-N-(2-hydroxyethyl)-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-(4-fluorphenoxymethyl)-N-(l-hydroxypropan-2-yl)-2-methyl-5-oxo-5H- [l,3]thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-((4-fluorphenoxy)methyl)-2-methyl-N-(oxetan-3-ylmethyl)-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-((4-fluorphenoxy)methyl)-N-(3-hydroxypropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-cyclopropyl-7-((4-fluorphenoxy)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-((4-fluorphenoxy)methyl)-N-methoxy-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(4-fluorphenoxymethyl)-N,2-dimethyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3-carbothioamid; 7-((4-fluorphenoxy)methyl)-2-methyl-3-propionyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((4-fluorphenoxy)methyl)-3-(l-hydroxypropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin- 5-on; 7-(4-fluorphenoxymethyl)-3-(l-hydroxyethyl)-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-(4-fluorphenoxymethyl)-3-(2-hydroxypropan-2-yl)-2-methyl-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-on; 3-acetyl-7-((4-fluorphenoxy)methyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 2- (7-((4-fluorphenoxy)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-yl)-N-methylacetamid; 3- cyclopropancarbonyl-7-(4-fluorphenoxymethyl)-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-(4-fluorphenoxymethyl)-3-[l-(hydroxyimino)ethyl]-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-((4-fluorphenoxy)methyl)-2-methyl-3-(oxetan-3-carbonyl)-5H-thiazolo[3,2- a]pyrimidin-5-on; 7-((4-fluorphenoxy)methyl)-2-methyl-3-(2,2,2-trifluor-l-hydroxyethyl)-5H-thiazolo[3,2- a]pyrimidin-5-on; 7-(4-fluorphenoxymethyl)-2-methyl-3 -(trifluo racety 1)-5H- [ 1,3 jthiazolo [3,2-a]pyrimidin- 5-on; 2-cyclopropyl-N-ethyl-7-((4-fluorphenoxy)methyl)-5-oxo-5H-thiazolo[3,2-a]pyrimidin- 3-carboxamid; 7-(4-fluorphenoxymethyl)-N-methyl-5-oxo-2-(trifluormethyl)-5H-[l,3]thiazolo[3,2- a]pyrimidin-3-carboxamid; 2-cyclopropyl-7-(4-fluorphenoxymethyl)-N-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-(4-fluorphenoxymethyl)-5-oxo-2-(trifluormethyl)-5H-[l,3]thiazolo[3,2- a]pyrimidin-3 -carboxamid; 7-((4-fluorphenoxy)methyl)-N-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-[[(5-fluorpyridin-2-yl)oxy]methyl]-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-(4-fluorphenoxymethyl)-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-(4-fluorphenoxymethyl)-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-((3-fluorphenoxy)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-((4-fluorphenoxy)methyl)-2-methyl-3 -(pyrimidin-5 -y 1)-5 H-thiazolo [3,2 -a]pyrimidin-5 -on; 7-(2,4-difluorphenoxymethyl)-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-(3,4-difluorphenoxymethyl)-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-(4-chlorphenoxymethyl)-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-[[(5-fluorpyridin-2-yl)oxy]methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on; 3 -(trans -2 -(hydroxymethyl) cyclopropyl) -2 -methyl- 7-((4-(trifluormethyl)phenoxy)methyl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((4-fluorphenoxy)methyl)-2-methyl-3-(oxazol-2-yl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((2-fluorphenoxy)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 4-((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methoxy)benzonitril; 7-((4-fluorphenoxy)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((4-fluorphenoxy)methyl)-2-methyl-3-(lH-pyrazol-5-yl)-5H-thiazolo[3,2-a]pyrimidin- 5-on; 7-((4-fluorphenoxy)methyl)-2-methyl-3-(4H-l,2,4-triazol-3-yl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 3-cyclopropyl-7-[(4-fluorphenoxy)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; cis-2-[7-(4-fluorphenoxymethyl)-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3-yl]cyclopropan-l -carbonitril; trans-2-[7-(4-fluorphenoxymethyl)-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3-yl] eye lopropan-1 -carbonitril; cis-2-[7-(4-fluorphenoxymethyl)-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3- yl] eye lopropan-1 -carbonitril; trans-2-[7-(4-fluorphenoxymethyl)-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin-3-yl] eye lopropan-1 -carbonitril; 7-(4-fluorphenoxymethyl)-3-[cis-2-(hydroxymethyl)cyclopropyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; trans-7-(4-fluorphenoxymethyl)-2-methyl-3-[2-(trifluormethyl)cyclopropyl]-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-(4-fluorphenoxymethyl)-2-methyl-3 -(2-methylcyclopropyl)-5H- [ 1,3 ] thi azolo [3,2-a]pyrimidin-5-on; trans-2-[2-[7-(4-fluorphenoxymethyl)-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidin- 3 -yl] eye lopropyl] acetonitr il; 7-(4-fluorphenoxymethyl)-3-[2-(methoxymethyl)cyclopropyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 3-(2-(fluormethyl)cyclopropyl)-7-((4-fluorphenoxy)methyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 6- fluor-7-((4-fluorphenoxy)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 7- (4-fluorphenoxymethyl)-3-(3-hydroxypropyl)-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-(4-fluorphenoxymethyl)-3-(methoxymethyl)-2-methyl-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-on; 7-((4-fluorphenoxy)methyl)-3-(3-hydroxyoxetan-3-yl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-(4-fluorphenoxymethyl)-3-(4-hydroxybutan-2-yl)-2-methyl-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-on; 7-(4-fluorphenoxymethyl)-3-[2-(2-hydro xypropan-2-yl)cyclopropyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7 - [(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3 -pyrimidin-5 -yl-thiazolo [3,2 -ajpyrimidin- 5-on; 7-(((4-fluorphenyl)(methyl)amino)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-(((4-fluorphenyl)(2,2,2-trifluorethyl)amino)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-(((3,4-difluorphenyl)(ethyl)amino)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H- thiazolo [3,2-a]pyrimidin-5-on; 7-((ethyl(3-fluorphenyl)amino)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-(((2,2-difluorethyl)(4-fluorphenyl)amino)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-((ethyl(pyridin-2-yl)amino)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-(thiazol-2-yl)-5H-thiazolo[3,2- a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-(thiophen-2-yl)-5H-thiazolo[3,2- a]pyrimidin-5-on; 3-(ethyl((2-methyl-5-oxo-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)amino)benzonitril; 3-(2-aminopyridin-3-yl)-7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-5H- thiazolo [3,2-a]pyrimidin-5-on; 7-((ethyl(pyridin-2-yl)amino)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((4-fluorphenylamino)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo[3,2- a]pyrimidin-5-on; 3 -butyl-7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-5 H-thiazolo [3,2 -a]pyrimidin-5 - on; 2-cyclopropyl-7 - [(N-ethyl-4-fluor-anilino)methyl] -3 -pyrimidin-5 -yl-thiazolo [3,2-a]pyrimidin-5-on; 2-ethyl-7-((ethyl(4-fluorphenyl)amino)methyl)-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-thiazol-4-yl-thiazolo[3,2-a]pyrimidin-5- on; 7 - [(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3 -(3 -pyridyl)thiazolo [3,2-a]pyrimidin-5 -on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-phenyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2,3-dimethyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-(5-fluor-3-pyridyl)-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-(2-fluor-3-pyridyl)-2-methyl-thiazolo[3,2- a]pyrimidin-5-on; 3 -cyclopropyl-7 - [(N-ethyl-4-fluor-anilino)methyl] -2-methyl-thiazolo [3,2-a]pyrimidin-5 - on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-pyrazin-2-yl-thiazolo[3,2-a]pyrimidin-5- on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-isopropenyl-2-methyl-thiazolo[3,2-a]pyrimidin-5- on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-pyridazin-4-yl-thiazolo[3,2-a]pyrimidin- 5-on; 3-(5-chlor-3-pyridyl)-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2- a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-(4-pyridyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-(l-methylpyrazol-4-yl)thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-(lH-pyrazol-4-yl)thiazolo[3,2- a]pyrimidin-5-on; 5-[7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]pyridin-3 -carbonitril; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-[5-(trifluormethyl)-3-pyridyl]thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-oxazol-2-yl-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-(trifluormethyl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(trans-2-(fluormethyl)cyclopropyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 3-ethyl-7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-propyl-5H-thiazolo[3,2-a]pyrimidin- 5-on; 7-[[4-fluor-N-(2-fluorethyl)anilino]methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(furan-3-yl)-2-methyl-5H-thiazolo[3,2- a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(furan-2-yl)-2-methyl-5H-thiazolo[3,2- a]pyrimidin-5-on; 7-((5-fluor-2-methylindolin-l-yl)methyl)-3-(furan-2-yl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-(thiophen-3-yl)-5H-thiazolo[3,2- a]pyrimidin-5-on; 7-((5-fluor-2-methylindolin-l-yl)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo[3,2- a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-(4-methylthiazol-2-yl)-5H- thiazolo [3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-(6-oxo-l,6-dihydropyridin-3-yl)-5H- thiazolo [3,2-a]pyrimidin-5-on; 3-(6-aminopyridin-3-yl)-7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-5H- thiazolo [3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-(prop-l-ynyl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-vinyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 3-brom-2-cyclopropyl-7-[(N-ethyl-4-fluor-anilino)methyl]thiazolo[3,2-a]pyrimidin-5-on; 3-(3,5-difluorphenyl)-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-(l-methylpyrazol-3-yl)thiazolo[3,2- a]pyrimidin-5-on; 3-(2-amino-4-pyridyl)-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-(5-methoxy-3-pyridyl)-2-methyl-thiazolo[3,2- a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-morpholino-5H-thiazolo[3,2- a]pyrimidin-5-on; 3-(dimethylamino)-7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-(pyrrolidin-l-yl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-(((3,4-difluorphenyl)(ethyl)amino)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carbonitril; 7-((ethyl(3-fluorphenyl)amino)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carbonitril; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carbonitril; 7-[(N-ethyl-4-fluor-anilino)methyl]-5-oxo -thiazolo [3,2-a]pyrimidin-3-carbonitril; 7-((5-fluor-2-methylindolin-l-yl)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carbonitril; 7-(((3-cyanophenyl)(ethyl)amino)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin- 3- carbonitril; 7-((ethyl(pyridin-2-yl)amino)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carbonitril; 2-methyl-7-((2-methylindolin-l-yl)methyl)-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carbonitril; 7-(((3,5-difluorphenyl)(ethyl)amino)methyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carbonitril; 6-[(N-ethyl-4-fluor-anilino)methyl]-2,3-dihydro-lH-cyclopenta[3,4]thiazolo[l,4-a]pyrimidin-8-on; 2-[(N-ethyl-4-fluor-anilino)methyl]-6,7,8,9-tetrahydropyrimido[2,l-b][l,3]benzothiazol- 4- on; 6-[(N-ethyl-4-fluor-anilino)methyl]-1 -(hydroxymethyl)-2,3-dihydro-l H-cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-8-on; 6-[(N-ethyl-4-fluor-anilino)methyl]-1 -(hydroxymethyl)-2,3-dihydro-l H-cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-8-on; 6-[(N-ethyl-4-fluor-anilino)methyl]spiro[2,3-dihydrocyclopenta[3,4]thiazolo[l,4-a]pyrimidin-l ,1 '-cyclopentan]-8-on; 6-[(N-ethyl-4-fluor-anilino)methyl]-2,3-dihydrocyclopenta[3,4]thiazolo[l,4-a]pyrimidin- 1,8-dion; 6-[(N-ethyl-4-fluor-anilino)methyl]-l,l-dimethyl-2,3-dihydrocyclopenta[3,4]thiazolo[l,4-a]pyrimidin-8-on; 2-[(N-ethyl-4-fluor-anilino)methyl]-8,9-dihydro-6H-pyrano[3,4]thiazolo[l,4-a]pyrimidin- 4-on; 2-[(N-ethyl-4-fluor-anilino)methyl]-7-methyl-8,9-dihydro-6H-pyrido[3,4]thiazolo[l,4-a]pyrimidin-4-on; 6-[(N-ethyl-4-fluor-anilino)methyl]-8-oxo-2,3-dihydro-l H-cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-l -carboxamid; 6-[(N-ethyl-4-fluor-anilino)methyl]-8-oxo-2,3-dihydro-l H-cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-l -carbonitril; 2-[6-[(N-ethyl-4-fluor-anilino)methyl]-8-oxo-2,3-dihydro-lH- cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-l -yljacetonitril; 6- [(N-ethyl-4-fluor-anilino)methyl]-1 -(2-hydroxyethyl)-2,3-dihydro-l H-cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-8-on; 2-((ethyl(4-fluorphenyl)amino)methyl)-6-(methoxymethyl)-7,8-dihydrocyclopenta[4,5]thiazolo[3,2-a]pyrimidin-4(6H)-on; 2- [6-[(N-ethyl-4-fluor-anilino)methyl]-8-oxo-2,3-dihydro-lH- cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-l -yljacetamid; 3- cyclohexyl-7-[[ethyl(4-fluorphenyl)amino]methyl]-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on; 7- [(N-ethyl-4-fluor-anilino)methyl]-3-isopropyl-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 3-cyclopentyl-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5- on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-tetrahydropyran-4-yl-thiazolo[3,2-a]pyrimidin-5-on; 3 -cyclobutyl-7 - [(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo [3,2 -a]pyrimidin-5 - on; 3-tert-butyl-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 3-acetyl-7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5- on; 7-[(N-ethyl-4-fluor-anilino)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-(l-hydroxy-l-methyl-ethyl)-2-methyl-thiazolo[3,2- a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-(l-hydroxyethyl)-2-methyl-thiazolo[3,2- a]pyrimidin-5-on; 3-[(dimethylamino)methyl]-7-[[ethyl(4-fluorphenyl)amino]methyl]-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 3-(azetidin-l-ylmethyl)-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-(pyrrolidin-l-ylmethyl)thiazolo[3,2- a]pyrimidin-5-on; 7 - [(N-ethyl-4-fluor-anilino)methyl]-3 - [(3 -hydroxyazetidin-1 -yl)methyl] -2 -methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-(2,2,2-trifluor-l-hydroxy-ethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(hydroxymethyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-[[ethyl(4-fluorphenyl)amino]methyl]-3-(methoxymethyl)-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-[[ethyl(4-fluorphenyl)amino]methyl]-2-methyl-3-(lH-pyrazol-l-ylmethyl)-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-(methylsulfonylmethyl)thiazolo[3,2-a]pyrimidin-5-on; 3-(ethoxymethyl)-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin- 5-on; 2- [7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yljacetonitril; 3- tert-butyl-7-[(N-ethyl-4-fluor-anilino)methyl]thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-(l-hydroxy-l-methyl-ethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-(l-hydroxyethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-(6-oxa-l -azaspiro[3,3]heptan-l -ylmethyl)thiazolo [3,2-a]pyrimidin-5 -on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-[(2-hydroxyethylamino)methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 3-(ethyl((3-(hydroxymethyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)amino)benzonitril; 3-[ethyl-[[3-(methoxymethyl)-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl]methyl]amino]benzonitril; 7-((ethyl(4-fluorphenyl)amino)methyl)-2-methyl-3-((methylthio)methyl)-5H- thiazolo [3,2-a]pyrimidin-5-on; 3-chlor-7-[[ethyl(4-fluorphenyl)amino]methyl]-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-fluor-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-iodo-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 3-chlor-7-[(N-ethyl-4-fluor-anilino)methyl]thiazolo[3,2-a]pyrimidin-5-on; 7 - [(N-ethylanilino)methyl] -2 -methyl-thiazolo [3,2 -a]pyrimidin-5 -on; 3-(l,3-dihydroxypropyl)-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-3-(l-fluor-3-hydroxy-propyl)-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 3-(l,3-dihydroxypropyl)-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 3-(l,2-dihydroxyethyl)-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7 - [(N-ethyl-4-fluor-anilino)methyl]-3 -(3 -hydroxypropyl)-2 -methyl-thiazolo [3,2 - a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(3-methoxypropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(4-hydroxybutyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((ethyl(4-fluorphenyl)amino)methyl)-3-(2-hydroxyethyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-[[ethyl(4-fluorphenyl)amino]methyl]-3-(2-metho xyethyl)-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 3-(7-[[ethyl(4-fluorphenyl)amino]methyl]-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2- a]pyrimidin-3 -yl)propanamid; 3-[7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yljpropannitril; 3-[7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]- N,N-dimethyl-propanamid; 7-[[ethyl(4-fluorphenyl)amino]methyl]-3-(3-hydroxy-3-methylbutyl)-2-methyl-5H- [l,3]thiazolo[3,2-a]pyrimidin-5-on; 2- (7-[[ethyl(4-fluorphenyl)amino]methyl]-2-methyl-5-oxo-5H-[l,3]thiazolo[3,2- a]pyrimidin-3-yl)cyclopropan-l -carbonitril; 7-((5-ethyl-3-(trifluormethyl)-lH-pyrazol-l-yl)methyl)-3-(2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((3,5-bis(trifluormethyl)-lH-pyrazol-l-yl)methyl)-3-(trans-2- (hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((3-chlor-5-methyl-lH-pyrazol-l-yl)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((5-chlor-3-methyl-lH-pyrazol-l-yl)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 3- (trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-7-((3-(trifluormethyl)-lH-pyrazol-l-yl)methyl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((1 H-indazol-1 -yl)methyl)-3 -(trans-2-(hydroxymethyl)cyclopropyl)-2 -methyl-5 H-thiazolo [3,2-a]pyrimidin-5-on; 7-((5-(2-hydroxyethyl)-3-(trifluormethyl)-lH-pyrazol-l-yl)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((3-(2-hydroxyethyl)-5-(trifluormethyl)-lH-pyrazol-l-yl)methyl)-3-(trans-2- (hydro xymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((3-cyclopropyl-4-fluor-5-(trifluormethyl)-l H-pyrazol-1 -yl)methyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((5-cyclopropyl-4-fluor-3-(trifluormethyl)-lH-pyrazol-l-yl)methyl)-3-(trans-2- (hydro xymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((5-cyclopropyl-3-(trifluormethyl)-l H-pyrazol-1-yl)methyl)-3-(trans-2- (hydro xymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-((3-cyclopropyl-5-(trifluormethyl)-l H-pyrazol-1-yl)methyl)-3-(trans-2- (hydro xymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-[(5-cyclopropyl-3-methyl-pyrazol-l-yl)methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(3-cyclopropyl-5-methyl-pyrazol-l-yl)methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(3,5-dicyclopropylpyrazol-l-yl)methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-((3,5-dimethyl-l H-pyrazol-1-yl)methyl)-6-fluor-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; l-((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)-3-(trifluormethyl)-lH-pyrazol-5-carbonitril; 7-((5 -cyclopropyl-3 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-6-fluor-3 -(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; l-[[3-[trans-2-(hydro xymethyl)cyclopropyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl]methyl]-5-methyl-pyrazol-3-carbonitril; 7-[[3-(difluormethyl)-5-methyl-pyrazol-l-yl]methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(6-fluorindazol-l-yl)methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7 - [ [5 -cy clopropy 1-3 -(tr ifluormethyl)pyrazo 1-1 -y 1] methyl] -3 - [2 -(hydroxymethyl)cyclopropyl]-2-isopropyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[(3,5-dimethylpyrazol-l-yl)methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[(5-fluorindazol-l-yl)methyl]-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 5 -ethy 1-3 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-2 -methyl-3 -(pyrimidin-5 -yl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-((3-cyclopropyl-5-(trifluormethyl)-l H-pyrazol-1-yl)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo [3,2 -a]pyrimidin-5 -on; 7-((5-cyclopropyl-3-(trifluormethyl)-lH-pyrazol-l-yl)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo [3,2 -a]pyrimidin-5 -on; 7-((3,5-bis(trifluormethyl)-l H-pyrazol-1-yl)methyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 2-methyl-3-(pyrimidin-5-yl)-7-((5-(trifluormethyl)-l H-pyrazol-1 -yl)methyl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 2-methyl-7-((5 -methyl-3 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-3 -(pyrimidin-5 -yl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-((3,5-bis(trifluormethyl)-l H-pyrazol-1 -yl)methyl)-2-methyl-5H-thiazo lo[3,2-a]pyrimidin-5-on; 7-((1 H-indazol-1 -yl)methyl)-2 -methyl-3 -(pyrimidin-5 -yl)-5H-thiazolo [3,2-a]pyrimidin-5 -on; 7-((5 -cyclopropyl-3 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-N,2 -dimethyl-5 -oxo -5 H-thiazolo [3,2-a]pyrimidin-3-carboxamid; 7-((3 -cyclopropyl-5 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-N,2 -dimethyl-5 -oxo -5 H-thiazolo [3,2-a]pyrimidin-3-carboxamid; 7-((5-cyclopropyl-3-(trifluormethyl)-l H-pyrazol-1-yl)methyl)-N-ethyl-5-oxo-2-(trifluormethyl)-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-((3-cyclopropyl-5-(trifluormethyl)-l H-pyrazol-1-yl)methyl)-N-ethyl-5-oxo-2-(trifluormethyl)-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-((5-cyclopropyl-3-(trifluormethyl)-l H-pyrazol-1-yl)methyl)-N-ethyl-5-oxo-5H-thiazolo [3,2-a]pyrimidin-3-carboxamid; 2-cyclopropyl-7-((5 -cyclopropyl-3 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-N-ethyl-5 -oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 2-cyclopropyl-7-((3 -cyclopropyl-5 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-N-ethyl-5 -oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 2- methyl-5-oxo-7-((3-(trifluormethyl)-1 H-pyrazol- l-yl)methyl)-5H-thiazolo[3,2-a]pyrimidin-3 -carbonitril; 7-((5-cyclopropyl-3-(trifluormethyl)-l H-pyrazol-1 -yl)methyl)-2-methyl-5-oxo-5H-thiazolo [3,2-a]pyrimidin-3 -carbonitril; 7-((3-cyclopropyl-5-(trifluormethyl)-l H-pyrazol-1 -yl)methyl)-2-methyl-5-oxo-5H-thiazolo [3,2-a]pyrimidin-3 -carbonitril; 3- (1 -hydro xyethyl)-2 -methyl-7-((3-(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 3-acetyl-7-((5 -cyclopropyl-3 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 3-acetyl-7-((3 -cyclopropyl-5 -(trifluormethyl)-1 H-pyrazol-1 -yl)methyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 3-(2-hydro xypropan-2-yl)-2-methyl-7-((3-(trifluormethyl)-l H-pyrazol-1 -yl)methyl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-((5-fluor-3-methyl-lH-indazol-l-yl)methyl)-3-(l-hydroxyethyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-(l-(5-cyclopropyl-3-(trifluormethyl)-l H-pyrazol-l-yl)ethyl)-3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-(1 -(5-cyclopropyl-3-(trifluormethyl)-1 H-pyrazol- l-yl)ethyl)-3-(2-(hydroxymethyl)-l-methylcyclopropyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on; 3-((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 3-((6-fluor-3-(2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 2- fluor-3-((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 3- (trans-2-(hydro xymethyl)cyclopropyl)-7-(isoquinolin -4-ylmethyl)-2 -methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 3-(trans-2-(hydro xymethyl)cyclopropyl)-2-methyl-7-(3-(trifluormethyl)benzyl)-5H-thiazolo [3,2-a]pyrimidin-5-on; 3- ((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)-4-methylbenzonitril; 4- fluor-3-((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 3-fluor-5-((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 2- fluor-5-((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 3- [[3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl]methyl]-4-methoxy-benzonitril; 3- (2-(hydroxymethyl)cyclopropyl)-2-methyl-7-(4-(trifluormethyl)benzyl)-5H- thiazolo [3,2-a]pyrimidin-5-on; 4- ((3-(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)picolinonitril; 4-cyclopropyl-3 -((3 -(trans-2-(hydroxymethyl)cyclopropyl)-2-methyl-5 -oxo -5 H-thiazolo [3,2-a]pyrimidin-7 -yl)methyl)benzonitril; 7-(3-cyanobenzyl)-N,2-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyano-2-fluorbenzyl)-N,2-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-chlor-2-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-methyl-7-(2-fluor-3-(trifluormethyl)benzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-(2-fluor-3-methylbenzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(2-chlor-5-cyanobenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-2-methyl-5-oxo-7-(3-(trifluormethyl)benzyl)-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyanobenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyano-2-fluorbenzyl)-2-cyclopropyl-N-ethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyano-5-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-(2-fluor-3-(trifluormethyl)benzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyano-2-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-chlor-2-fluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; N,2-dimethyl-5-oxo-7-[[3-(trifluormethyl)phenyl]methyl]thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-chlorphenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[2-cyclopropyl-5-(trifluormethyl)phenyl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-2-methyl-5-oxo-7-((6-(trifluormethyl)pyridin-2-yl)methyl)-5H-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-(2-ethyl-4,5-difluorbenzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[3-(difluormethyl)-2-fluor-phenyl]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-((6-cyanopyridin-2-yl)methyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[3-(difluormethyl)-2-fluor-phenyl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[2-fluor-3-(hydroxymethyl)phenyl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2- a]pyrimidin-3-carboxamid; 7-(3-cyclopropyl-2-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyano-2-fluorbenzyl)-N-ethyl-6-fluor-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3- carboxamid; 7-(3-cyano-2-fluorbenzyl)-6-fluor-N,N-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyano-2-fluorbenzyl)-N-ethyl-6-fluor-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin- 3-carboxamid; 6- fluor-7-(2-fluor-3-(trifluormethyl)benzyl)-N,2-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7- (5-cyano-2-methylbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(5-cyano-2-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(2-chlor-5-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyano-2-fluorbenzyl)-N-ethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-(5-fluor-2-(trifluormethyl)benzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-2-methyl-7-(naphthalen-l-ylmethyl)-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-(5-fluor-2-methylbenzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(3-cyano-4-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-2-methyl-7-((1-methyl-lH-indazol-4-yl)methyl)-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-2-methyl-7 -(3 -(methylsulfonamido)benzyl)-5 -oxo -5 H-thiazolo [3,2-a]pyrimidin- 3-carboxamid; 7-(5-cyano-2-(trifluormethyl)benzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2- a]pyrimidin-3-carboxamid; 7-(4-chlor-2-methylbenzyl)-N,2-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(2,5-difluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo [3,2-a]pyrimidin-3- carboxamid; 7-(3-cyanobenzyl)-2-cyclopropyl-N-ethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-(2-fluorbenzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(2,3-difluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo [3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-(3-fluorbenzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-chlor-4-fluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(2,5-dichlorphenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3- carboxamid; N,2-dimethyl-5-oxo-7-[[3-(tri fluormetho xy)phenyl]methyl]thiazolo[3,2-a]pyrimidin-3- carboxamid; 7-[(5-cyano-2-fluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-chlor-5-cyano-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-cyclopropylphenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3- carboxamid; 7-[(2,5-difluorphenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3- carboxamid; 7-[(3,4-difluorphenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(2,3-difluorphenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3- carboxamid; 7-[(4-chlor-2-fluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3- carboxamid; 7-[(2,4-dichlorphenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3- carboxamid; 7-[(3-fluor-4-methyl-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[4-fluor-2-(trifluormethyl)phenyl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(2-cyclopropyl-4-fluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3-carboxamid; 7-(5-cyano-2-(2-fluorethyl)benzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-(2-chlor-3-cyanobenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-(6-ethyl-2,3-difluorbenzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(5-cyano-2-ethylbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-(2-cyclopropyl-5-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3- carboxamid; 7-(5-cyano-2-cyclopropylbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin- 3-carboxamid; N-ethyl-7-(5-fluor-2-propylbenzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[2-fluor-3-(fluormethyl)phenyl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3-carboxamid; N-ethyl-7-(l-(2-fluor-3-(trifluormethyl)phenyl)ethyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-(2-fluor-3-(trifluormethyl)benzyl)-N,2-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 3-((3-(2-cyanocyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7- yl)methyl)benzonitril; 3-((3-(2-cyanocyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)-2-fluorbenzonitril; 6- ((3-(2-cyanocyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)picolinonitril; 3-((3-(2-cyanocyclopropyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)-4-methoxybenzonitril; 2-methy 1-3 -(pyrimidin-5 -yl)-7-(3 -(trifluormethyl)benzyl)-5H-thiazo lo [3,2 -a]pyrimidin-5 -on; 7- (2-fluor-3-(trifluormethyl)benzyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 2- fluor-3-((2-methyl-5-oxo-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 3- ((3-cyclopropyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)-2-fluorbenzonitril; 7-(isoquinolin-4-ylmethyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-5- on; 3-((2-methyl-5-oxo-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 7-(5-fluor-2-methoxybenzyl)-2-methyl-3-(pyrimidin-5-yl)-5H-thiazolo[3,2-a]pyrimidin- 5-on; 2-fluor-3-((3-(furan-2-yl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 3 -brom-2-methyl-7 -(3 -(methylsulfonyl)benzyl)-5 H-thiazolo [3,2-a]pyrimidin-5 -on; 7-(3-cyano-2-fluorbenzyl)-2-methyl-5-oxo-N-(2,2,2-trifluorethyl)-5H-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-(cyanomethyl)-7-(2-fluor-3-(trifluormethyl)benzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-(3-cyanobenzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carbonitril; 7-(2-fluor-3-(trifluormethyl)benzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carbonitril; 10-(4-fluorphenoxymethyl)-3-(hydroxymethyl)-7 -thia-1,9-diazatricyclo[6.4.0.0A[2,6]]dodeca-2(6),8,10-trien-12-on; 10-(4-fluorphenoxymethyl)-3-(2-hydro xyethyl)-7 -thia-1,9- diazatricyclo[6.4.0.0A[2,6]]dodeca-2(6),8,10-trien-12-on; 7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-3-methylsulfonyl-thiazolo[3,2-a]pyrimidin- 5-on; 3-(hydroxymethyl)-10-[[3-(trifluormethyl)-1 H-pyrazol-1 -yl]methyl]-7 -thia-1,9-diazatricyclo[6.4.0.0A[2,6]]dodeca-2(6),8,10-trien-12-on; 10- {[5 -cyclopropyl-3 -(trifluormethyl)-1 H-pyrazol-1 -yljmethyl} -7 -thia-1,9- diazatricyclo[6.4.0.0A{2,6}]dodeca-2(6),8,10-trien-12-on; 10- {[3 -cyclopropyl-5 -(trifluormethyl)-1 H-pyrazol-1 -yljmethyl} -7 -thia-1,9- diazatricyclo[6.4.0.0A{2,6}]dodeca-2(6),8,10-trien-12-on; 10- {[5 -cyclopropyl-3 -(trifluormethyl)-1 H-pyrazol-1 -yljmethyl} -3,3 -dimethyl-7-thia-1,9- diazatricyclo[6.4.0.0A{2,6}]dodeca-2(6),8,10-trien-12-on; 10- {[3 -cyclopropyl-5 -(trifluormethyl)-1 H-pyrazol-1 -yljmethyl} -3,3 -dimethyl-7-thia-1,9- diazatricyclo[6.4.0.0A{2,6}]dodeca-2(6),8,10-trien-12-on; 10- {[3,5-bis(trifluormethyl)-1 H-pyrazol-1 -yljmethyl} -3,3-dimethyl-7-thia-1,9- diazatricyclo[6.4.0.0A{2,6}]dodeca-2(6),8,10-trien-12-on; 3-((3-acetyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)-2-fluorbenzonitril; 7-(2-fluor-3 -(trifluormethyl)benzyl)-3 -(1 -hydroxyethyl)-2-methyl-5H-thiazolo[3,2- a]pyrimidin-5-on; 3-((3-acetyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-7-yl)methyl)benzonitril; 7-(2-fluor-3 -(trifluormethyl)benzyl)-3 -(hydro xymethyl)-2-methyl-5H-thiazolo [3,2-a]pyrimidin-5-on; 7-(2-fluor-3-(trifluormethyl)benzyl)-2-methyl-3-((methylamino)methyl)-5H-thiazolo[3,2-a]pyrimidin-5-on; 7-[(3-cyclopropyl-2-fluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3-carboxamid; N-ethyl-2-methyl-5-oxo-7-[(2,3,6-trifluorphenyl)methyl]thiazolo[3,2-a]pyrimidin-3-carboxamid; 2-fluor-3-[(2-methyl-3-oxazol-2-yl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl)methyl]benzonitril; 7 - [(5 -cyano -3 -cyclopropyl-2 -fluor-phenyl)methyl] -N-ethyl-2-methyl-5 -oxo -thiazolo [3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-[(2-fluor-3-methoxy-phenyl)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3-carboxamid; 7-[(3-cyclopropyl-2-fluor-phenyl)methyl]-6-fluor-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 2-[7-[(3-chlor-2-fluor-phenyl)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; 7-[(3-chlor-2-fluor-phenyl)methyl]-N-ethyl-6-fluor-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(4,5-difluor-2-methoxy-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3-carboxamid; 2-fluor-3-[[2-methyl-3-(2-methylcyclopropyl)-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl]methyl]benzonitril; 2-[7-[(3-cyclopropyl-2-fluor-phenyl)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; N-ethyl-6-fluor-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo- thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[2-chlor-5-(trifluormethyl)phenyl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(3-cyano-2-fluor-phenyl)methyl]-6-fluor-2-methyl-5-oxo-N-(2,2,2-trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 7-[(2-chlor-4,5-difluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[4,5-difluor-2-(2-fluorethyl)phenyl]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 2-[7-[[5-cyclopropyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo- thiazo lo [3,2 -a]pyrimidin-3 -yl] -N-methyl-acetamid; 2- [7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; 7-[(5-chlor-3-methyl-pyrazol-l-yl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(3-chlor-5-methyl-pyrazol-l-yl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(3-chlor-5-cyclopropyl-pyrazol-l-yl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(5-chlor-3-cyclopropyl-pyrazol-l-yl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 3- [2-(hydroxymethyl)cyclopropyl]-2-methyl-7-[[4-(trifluormethyl)thiazol-2-yl]methyl]thiazolo[3,2-a]pyrimidin-5-on; 2-[7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; N-ethyl-2-methyl-7-[[5-methyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; N-ethyl-2-methyl-7-[[3-methyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo- thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[3-(difluormethyl)-2-fluor-phenyl]methyl]-6-fluor-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[3-(difluormethyl)-2-fluor-phenyl]methyl]-N-ethyl-6-fluor-2-methyl-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-(4-bicyclo[4.2.0]octa-l,3,5-trienylmethyl)-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-[[2-fluor-3-(l -hydro xycyclopropyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-[[2-fluor-3-(l-fluorcyclopropyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-[[2-fluor-3-[l-(fluormethyl)vinyl]phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(2-ethynyl-4,5-difluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3-carboxamid; 2- fluor-3-[[2-methyl-5-oxo-3-[2-(trifluormethyl)cyclopropyl]thiazolo[3,2-a]pyrimidin-7-yl]methyl]benzonitril; 3- [[3-(2,2-difluorcyclopropyl)-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl]methyl]-2-fluor-benzonitril; N-ethyl-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-cyano-2-fluor-phenyl)methyl]-N-ethyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[3-(difluormethyl)-2-fluor-phenyl]methyl]-N-ethyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-[[5-methyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-[[3-methyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-3-(lH-imidazol-2-yl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[(3-cyano -2-fluor-5 -methyl-phenyl)methyl]-N-ethyl-2-methyl-5-oxo-thiazo lo [3,2 -a]pyrimidin-3 -carboxamid; 7-[(3-chlor-2-fluor-phenyl)methyl]-N-ethyl-5-oxo-2-(trifluormethyl)thiazolo[3,2- a]pyrimidin-3-carboxamid; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-N-(2,2,2-trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 2-methyl-7-[[5-methyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-N-(2,2,2-trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 7-[[5-cyclopropyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-methyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[3-cyclopropyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-methyl-5-oxo-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-methyl-5-oxo-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-methyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[5-cyclopropyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-N-(2,2,2-trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 7-[[3-cyclopropyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-N-(2,2,2-trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 2-chlor-N-ethyl-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-methyl-7-[[5-methyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; N-methyl-7-[[3-methyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-N-methyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-chlor-2-fluor-phenyl)methyl]-N-methyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-N-(2,2,2-trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-N-(2,2,2- trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 2-methyl-7-[[3-methyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-N-(2,2,2- trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 2- chlor-7-[(3-cyano-2-fluor-phenyl)methyl]-N-ethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-cyano-2-fluor-phenyl)methyl]-N-methyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-2-[7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -yl] acetamid; N,2-dimethyl-5-oxo-7-[[4-(trifluormethyl)pyrazol-l-yl]methyl]thiazolo[3,2-a]pyrimidin- 3-carboxamid; 3- [[2-chlor-5-oxo-3-[2-(trifluormethyl)cyclopropyl]thiazolo[3,2-a]pyrimidin-7- yl] methyl] -2 - fluo r-benzonitr il; 2-[7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; 7-[[5-cyclopropyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo [3,2-a]pyrimidin-3-carboxamid; 2-[7-[[5-cyclopropyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; 2-[7-[[3-cyclopropyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-3-(methylsulfonylmethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-3-(lH-imidazol-2-ylmethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; N-ethyl-7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-[(N-ethyl-4-fluor-anilino)methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 2- fluor-3-[[3-(2-methylcyclopropyl)-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-7-yl]methyl]benzonitril; 3- [[2-chlor-3-(2-methylcyclopropyl)-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl]methyl]-2-fluor-benzonitril; N-ethyl-7-[ [2-fluor-3 -(trifluormethyl)phenyl] methyl] -2 -isopropyl-5 -oxo -thiazolo [3,2 -a]pyrimidin-3 -carboxamid; 2-fluor-3-[[5-oxo-2-(trifluormethyl)-3-[2-(trifluormethyl)cyclopropyl]thiazolo[3,2-a]pyrimidin-7-yl]methyl]benzonitril; 6-[[5-chlor-3-(trifluormethyl)pyrazol-1-yl]methyl]-2,3-dihydro-1H-cyclopenta[3,4]thiazolo[l,4-a]pyrimidin-8-on; 6-[[3-chlor-5-(trifluormethyl)pyrazol-1-yl]methyl]-2,3-dihydro-1H-cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-8-on; N-ethyl-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methoxy-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 6-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-1 -(hydro xymethyl)-2,3 -dihydro- 1H-cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-8-on; 2-ethyl-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-N-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 2-[7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 6- [[5 -cyclopropyl-3 -(trifluormethyl)pyrazol-1 -yljmethyl] -1 -(hydroxymethyl)-2,3 -dihydro-lH-cyclopenta[3,4]thiazolo[l,4-a]pyrimidin-8-on; 7- [[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; 2-[7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-3-(2-hydroxycyclopropyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-[2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-[2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 2- cyano-N-ethyl-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-N-isopropyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(l-hydroxy-l-methyl-ethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-(l-hydroxy-l-methyl-ethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(l-hydroxyethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-(l-hydroxyethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-N-sec-butyl-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 3- [[3-(azetidin-l-yl)-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl]methyl]-2-fluor-benzonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carbonitril; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carbonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-cyclopropyl-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-cyclopropyl-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(2-methylcyclopropyl)thiazolo[3,2-a]pyrimidin-5-on; 3-acetyl-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 3-acetyl-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 2-chlor-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-3-(2-methylcyclopropyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-pyrimidin-5-yl- thiazolo [3,2-a]pyrimidin-5-on; 7-[[3-cyclopropyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[(5-chlor-2-pyridyl)-methyl-amino]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methoxy-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methoxy-5-oxo- thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[5-cyclopropyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methoxy-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[3-cyclopropyl-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methoxy-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 2-[7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(lH-pyrazol-5-yl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(lH-pyrazol-5- yl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(3-pyridyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-isopropenyl-2-methyl-thiazolo[3,2- a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(5-fluor-3-pyridyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-(5-fluor-3-pyridyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-propanoyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-propanoyl-thiazolo[3,2- a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-thiazol-2-yl-thiazolo[3,2-a]pyrimidin-5-on; N-ethyl-7-[[(5-fluor-2-pyridyl)-methyl-amino]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 2- [7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; N-ethyl-7-[[ethyl-(5-fluor-2-pyridyl)amino]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-[[ethyl(2-pyridyl)amino]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 3- (5-chlor-3-pyridyl)-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 3-(5-chlor-3-pyridyl)-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-thiazol-4-yl-thiazolo[3,2- a]pyrimidin-5-on; 7-[[(5-chlor-2-pyridyl)-ethyl-amino]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(5-cyclopropyltriazol-l-yl)methyl]-3-[2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-[2-methylcyclopropyl]thiazolo[3,2-a]pyrimidin-5-on; 2- ethoxy-N-ethyl-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(2-fluor-3-pyridyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-oxazol-2-yl-thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-oxazol-2-yl-thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[(5-chlor-2-pyridyl)-methyl-amino]methyl]-3-[2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7 - [(3,5 -dichlorpyrazol-1 -yl)methyl] -N-ethyl-2-methyl-5 -oxo -thiazolo [3,2 -a]pyrimidin-3 -carboxamid; N-ethyl-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-5-oxo-2-(2,2,2-trifluorethoxy)thiazolo[3,2-a]pyrimidin-3-carboxamid; 3- acetyl-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 3-acetyl-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 3 - [(4-chlorpyrazol-1 -yl)methyl] -7- [ [5 -chlor-3 -(trifluormethyl)pyrazol-1 -yljmethyl] -2 -methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-isopropenyl-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(lH-imidazol-2-yl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-pyrimidin-5-yl-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-pyrimidin-5-yl-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-(3-pyridyl)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-5-oxo-2-(2,2,2-trifluoretho xy)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-ethoxy-N-ethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-ethoxy-N-ethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(2-methylpropanoyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(2-methylpropanoyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-N-[(lR)-l-methylpropyl]-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-N-[(lS)-l-methylpropyl]-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[(4-chlor-2-pyridyl)-ethyl-amino]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[(5-fluor-2-pyridyl)-methyl-amino]methyl]-3-[2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(methoxymethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-cyclopropyl-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(methylsulfonylmethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(pyrazol-l-ylmethyl)thiazolo [3,2-a]pyrimidin-5 -on; 2-[7-[[2-chlor-5-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-cyclobutyl-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-cyclobutyl-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 2- [7-[[(5-chlor-2-pyridyl)-methyl-amino]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 7-[[ethyl-(5-fluor-2-pyridyl)amino]methyl]-3-[2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 3- chlor-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 3-chlor-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 2-[7-[(4,5-difluor-2 -metho xy-phenyl)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3 -yl] cyclopropancarbonitril; 2-[7-[[ethyl-(5-fluor-2-pyridyl)amino]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3 -yl] cyclopropancarbonitril; 7-[[(5-chlor-2-pyridyl)-ethyl-amino]methyl]-3-[2-(hydroxymethyl)cyclopropyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 5-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]pyridin-3-carbonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(2,2,2-trifluoracetyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(2-methylcyclopropyl)-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-(2-methylcyclopropyl)-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-pyrimidin-5-yl- thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-ethyl-3-(3-pyridyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlo r-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-3-(2,2,2-trifluor-l-hydroxy-ethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[(5-brom-2-pyridyl)-ethyl-amino]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2- a]pyrimidin-3 -carboxamid; N-ethyl-7-[[ethyl-(5-fluor-2-pyridyl)amino]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2- a]pyrimidin-3 -carboxamid; 3 -(azetidin-1 -yl)-7 - [ [5 -chlor-3 -(trifluormethyl)pyrazol-1 -yljmethyl] -2 -(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 2-[7-[[5-methoxy-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 2- [7-[[3-methoxy-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2- a]pyrimidin-3-yl]cyclopropancarbonitril; 3- acetyl-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-ethyl-thiazolo[3,2-a]pyrimidin-5-on; 3-acetyl-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-ethyl-thiazolo[3,2-a]pyrimidin-5-on; 2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-ethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 2- [7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-ethyl-5-oxo-thiazolo[3,2- a]pyrimidin-3-yl]cyclopropancarbonitril; 3- brom-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 3-brom-7-[[3-chlor-5-(trifluormethyl)pyrazol-l -yl]methyl]-2 -methyl-thiazolo [3,2-a]pyrimidin-5-on; 3-chlor-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methoxy-thiazolo[3,2-a]pyrimidin-5-on; 3-chlor-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methoxy-thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-methylsulfanyl-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 2- [7-[(N-ethyl-4-fluor-anilino)methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-l-(hydroxymethyl)cyclopropancarbonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(cyclopropylmethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol- l-yl]methyl]-3-(2 -hydro xy-1 -methyl-ethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-[[3-chlor-5-(trifluormethyl)pyrazol- l-yl]methyl]-3-(2 -hydro xy-1 -methyl-ethyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(cyclopropancarbonyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 3- brom-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]thiazolo[3,2-a]pyrimidin-5-on; 3-brom-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]thiazolo[3,2-a]pyrimidin-5-on; 7-[(3-amino-5-chlor-pyrazol-l-yl)methyl]-3-brom-2-methyl-thiazolo[3,2-a]pyrimidin-5- on; 7-[(5-amino-3-chlor-pyrazol-l-yl)methyl]-3-brom-2-methyl-thiazolo[3,2-a]pyrimidin-5- on; 2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]acetonitril; N-ethyl-7-[[(5-fluor-2-pyridyl)-methyl-amino]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(3,3-difluorazetidin-l-yl)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methoxy-3-(3-pyridyl)thiazolo[3,2-a]pyrimidin-5-on; 2- [7-[[5-brom-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 3- chlor-7-[[5-chlor-3-(trifluomiethyl)pyrazol-l-yl]methyl]thiazolo[3,2-a]pyrimidin-5-on; 3-chlor-7-[[3-chlor-5-(trifluomiethyl)pyrazol-l-yl]methyl]thiazolo[3,2-a]pyrimidin-5-on; 2-acetyl-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 2-acetyl-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(trifluormethyl)thiazolo[3,2- a]pyrimidin-5-on; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-3-(lH-l,2,4-triazol-5-yl)thiazolo[3,2-a]pyrimidin-5-on; 2- [7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl] cyclopropancarbonitril; 3- acetyl-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]thiazolo[3,2-a]pyrimidin-5- on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(2,2,2-trifluorethoxy)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 3-acetyl-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methoxy-thiazolo[3,2-a]pyrimidin-5-on; 3-acetyl-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methoxy-thiazolo[3,2- a]pyrimidin-5-on; 3 -brom-7 - [(5 -chlor-3 -nitro -pyrazol-1 -yl)methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5 -on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(lH-pyrazol-5-yl)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-thiazol-4-yl-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(5-fluor-3-pyridyl)-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-propanoyl-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 2-[7-[(3,5-dichlorpyrazol-l-yl)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3- yl] cyclopropancarbonitril; 2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -yljpropannitril; 2-[7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -yljpropannitril; 2- fluor-3-[[3-[2-methylcyclopropyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-7-yljmethyljbenzonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(3-fluorazetidin-l-yl)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 3- (5-chlor-3-pyridyl)-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[(3,5-dichlorpyrazol-l-yl)methyl]-N-ethyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3 -carboxamid; 3-[[3-acetyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-7-yl]methyl]-2-fluor-benzonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-(difluormethyl)-N-ethyl-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-(difluormethyl)-N-ethyl-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; (Z)-3-[7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]prop-2-ennitril; (E)-3-[7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]prop-2-enamid; (E)-3-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]prop-2-ennitril; (Z)-3-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]prop-2-ennitril; (E)-3-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]prop-2-enamid; N-ethyl-7-[[5-isobutyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-5-oxo- thiazolo [3,2-a]pyrimidin-3 -carboxamid; 2-[2-chlor-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 2-[2-chlor-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-[2-(hydroxymethyl)cyclopropyl]-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 2-[7-[(4-chlor-l-methyl-pyrazol-3-yl)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3 -yl] cyclopropancarbonitril; 2-[2-methyl-5-oxo-7-[[3-(trifluormethyl)pyrazol-l-yl]methyl]thiazolo[3,2-a]pyrimidin-3-yl] cyclopropancarbonitril; 2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-6-fluor-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; 2-[2-methyl-7-[[l-methyl-4-(trifluormethyl)imidazol-2-yl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]cyclopropancarbonitril; (E)-3-[7-[(N-ethyl-4-fluor-anilino)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]prop-2-ennitril; 7-[(4-fluorphenoxy)methyl]-3-[[2-hydroxyethyl(methyl)amino]methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[(4-fluorphenoxy)methyl]-3-[(2-hydroxyethylamino)methyl]-2-methyl-thiazolo[3,2-a]pyrimidin-5-on; 2-[7-[(4-fluorphenoxy)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N,N-dimethyl-acetamid; 7-[(2-cyano-4,5-difluor-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(2-cyclopropyl-4,5-difluor-phenyl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 3-[2-(azetidin-l-yl)-2-oxo-ethyl]-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[(4-fluorphenoxy)methyl]-2-methyl-3-(4H-l,2,4-triazol-3-ylmethyl)thiazolo[3,2-a]pyrimidin-5-on; 2- [7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-propanamid; 3- [7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-propanamid; 7-[[5-chlor-2-(trifluormethyl)phenyl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(5-ethyl-l,3-benzoxazol-6-yl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(3-chlorpyrazol-l-yl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(5-chlorpyrazol-l-yl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 2-[7-[(3-cyano-2-fluor-phenyl)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; N-ethyl-7-[[2-fluor-3-(l-hydroxypropyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[(4,5-difluor-2-oxazol-2-yl-phenyl)methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 2-fluor-3 - [(2-methyl-5 -oxo -3 -propanoyl-thiazolo [3,2 -a]pyrimidin-7 -yl)methyl]benzonitril; 7-[[4,5-difluor-2-(trifluormethyl)phenyl]methyl]-N,2-dimethyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[2-chlor-5-(trifluormethyl)phenyl]methyl]-N-ethyl-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[2-chlor-5-(trifluormethyl)phenyl]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[2-chlor-5-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-N-(2,2,2- trifluorethyl)thiazolo [3,2-a]pyrimidin-3-carboxamid; 3 - [(2-chlor-3 -cyclopropyl-5 -oxo -thiazolo [3,2-a]pyrimidin-7 -yl)methyl] -2-fluor-benzonitril; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-3-(pyrazol-l-ylmethyl)thiazolo [3,2-a]pyrimidin-5 -on; N,2-dimethyl-7-[[3-methyl-4-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; N,2-dimethyl-7-[[5-methyl-4-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 2-fluor-3 - [(8-oxo -2,3 -dihydro-1 H-cyclopenta[3,4]thiazolo [ 1,4-a]pyrimidin-6-yl)methyl]benzonitril; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-3-[hydroxy(thiazol-2-yl)methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 2-fluor-3-[(3-methyl-8-oxo-2,3-dihydro-lH-cyclopenta[3,4]thiazolo[l,4-a]pyrimidin-6-yl)methyl]benzonitril; 2-[7-[(4-fluorphenoxy)methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]-N-methyl-acetamid; 2- fluor-3-[[l-(hydro xymethyl)-8-oxo-2,3-dihydro-l H-cyclopenta[3,4]thiazolo[ 1,4-a]pyrimidin-6-yl]methyl]benzonitril; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-N-(2-hydroxy-l-methyl-ethyl)-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 3- [[3-(2,3-dimethylcyclopropyl)-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-7-yl]methyl]-2-fluor-benzonitril; 6- [[3 -cyclopropyl-5 -(trifluormethyl)pyrazol-1 -yl] methyl] -1 -(hydroxymethyl)-2,3 -dihydro-lH-cyclopenta[3,4]thiazolo[l,4-a]pyrimidin-8-on; 7- [[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)thiazolo[3,2-a]pyrimidin-5-on; N-ethyl-6-fluor-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(4-fluorphenoxy)methyl]-5-oxo-N-(2,2,2-trifluorethyl)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3 -carboxamid; N-cyclopentyl-7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7 - [(4,5 -dichlorpyrazol-1 -yl)methyl] -N-ethyl-2-methyl-5 -oxo -thiazolo [3,2 -a]pyrimidin-3 -carboxamid; 7- [(3,4-dichlorpyrazol-1 -yl)methyl] -N-ethyl-2-methyl-5 -oxo -thiazolo [3,2 -a]pyrimidin-3 -carboxamid; N-ethyl-2-methyl-7-[[methyl(thiazol-2-yl)amino]methyl]-5-oxo-thiazolo[3,2- a]pyrimidin-3 -carboxamid; 7-[(4-chlorpyrazol-l-yl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-2-methyl-7-[[methyl-(l-methylpyrazol-4-yl)amino]methyl]-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[(4-fluorphenoxy)rnethyl]-2-(trifluormethyl)-3-[2-(trifluormethyl)cyclopropyl]thiazolo[3,2-a]pyrimidin-5-on; 7-[[(3-ethoxy-2-pyridyl)-methyl-amino]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 7-[[(3,5-dimethylisoxazol-4-yl)-methyl-amino]methyl]-N-ethyl-2-methyl-5-oxo-thiazolo [3,2-a]pyrimidin-3 -carboxamid; 3-cyclopropyl-7-[(4-fluorphenoxy)methyl]-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5- on; 7-[(4-fluorphenoxy)methyl]-3-pyrimidin-5-yl-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin- 5-on; 7 - [(4- fluorphenoxy)methyl] -3 - [2 -(hydroxymethyl) cyclopropyl] -2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-3-(4-methyl-l,2,4-triazol-3-yl)thiazolo[3,2-a]pyrimidin-5-on; N-ethyl-7-[[ethyl(4-pyridyl)amino]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; N-ethyl-7-[[ethyl(3-pyridyl)amino]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(2-methoxy-3-pyridyl)-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-isopropenyl-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 3-(5 -chlor-3 -pyridyl)-7 -[ [(5 -chlor-2-pyridyl)-methyl-amino]methyl] -2 -methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(3-pyridyl)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-5-oxo-2-(2,2,2-trifluoretho xy)thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[3-chlor-6-(trifluormethyl)-2-pyridyl]methyl]-2-methyl-3-(2-methylcyclopropyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[(5-chlor-2-pyridyl)oxymethyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-carboxamid; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-ethyl-3-(3-pyridyl)thiazolo[3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-1 -yl]methyl]-3-pyrro lidin-1 -yl-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; N-ethyl-7-[[(5-methoxy-2-pyridyl)-methyl-amino]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3 -carboxamid; 3-(2-chlor-3-pyridyl)-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 3-(2-chlor-3-pyridyl)-7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-2-methyl-thiazolo [3,2-a]pyrimidin-5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(3-pyridyl)thiazolo[3,2-a]pyrimidin- 5-on; 7-[[3-chlor-5-(trifluormethyl)pyrazol-l-yl]methyl]-3-(3-pyridyl)thiazolo[3,2-a]pyrimidin- 5-on; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(3-methoxyazetidin-l-yl)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 5-[7-[[2-fluor-3-(trifluormethyl)phenyl]methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin-3-yl]pyridin-3 -carbonitril; 7-[(3,5-diisopropylpyrazol-l-yl)methyl]-N-ethyl-2-methyl-5-oxo-thiazolo[3,2- a]pyrimidin-3 -carboxamid; 2-[7-[(4-chlor-2-methyl-pyrazol-3-yl)methyl]-2-methyl-5-oxo-thiazolo[3,2-a]pyrimidin- 3 -yl] cyclopropancarbonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-(2-methylazetidin-l-yl)-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 2- [7-[(3,5-dichlorpyrazol-l-yl)methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin- 3 -yl] cyclopropancarbonitril; 7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-3-[2-(2-hydroxyethyl)cyclopropyl]-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 3- chlor-7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-5-on; 5-chlor-l-[[3-[2-methylcyclopropyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-7-yl]methyl]pyrazol-3-carbonitril; 5-chlor-2-[[3-[(2-methylcyclopropyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin- 7-yl]methyl]pyrazol-3-carbonitril; 7-[[5-ethoxy-3-(trifluormethyl)pyrazol-l-yl]methyl]-N-ethyl-2-methyl-5-oxo- thiazolo [3,2-a]pyrimidin-3 -carboxamid; N-ethyl-7-[[5-isobutyl-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2- (trifluormethyl)thiazolo[3,2-a]pyrimidin-3-carboxamid; og 2-[2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-l-yl]methyl]-5-oxo-2-(trifluormethyl)thiazolo[3,2-a]pyrimidin-3-yl]cyclopropyl]acetonitril; og farmaceutisk acceptable salte deraf.
32. Forbindelse ifølge et hvilket som helst af kravene 1-30, der er 2-[7-[[5-chlor-3-(trifluormethyl)pyrazol-1 -yl] methyl] -5 -oxo-2 -(trifluormethyl)thiazolo [3,2 -a]pyrimidin-3 -yl] cyclopropancarbonitril eller et farmaceutisk acceptabelt salt deraf.
33. Forbindelse ifølge et hvilket som helst af kravene 1-30, der er 7-(4-fluorphenoxymethyl)-3-[trans-2-(hydroxymethyl)cyclopropyl]-2-methyl-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-on eller et farmaceutisk acceptabelt salt deraf.
34. Forbindelse ifølge et hvilket som helst af kravene 1-30, der er 3-acetyl-7-((ethyl(4-fhiorphenyl)amino)methyl)-2-methyl-5H-thiazolo[3,2-a]pyrimidin-5-on eller et farmaceutisk acceptabelt salt deraf.
35. Forbindelse ifølge et hvilket som helst af kravene 1-30, der er 7-(3-cyano-2-fluorbenzyl)-N-ethyl-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid eller et farmaceutisk acceptabelt salt deraf.
36. Forbindelse ifølge et hvilket som helst af kravene 1-30, der er N-ethyl-7-(2-fluor-3-(trifluormethyl)benzyl)-2-methyl-5-oxo-5H-thiazolo[3,2-a]pyrimidin-3-carboxamid eller et farmaceutisk acceptabelt salt deraf.
37. Farmaceutisk sammensætning, der omfatter: (a) en effektiv mængde af mindst én forbindelse ifølge et hvilket som helst af kravene 1-36 og (b) en farmaceutisk acceptabel bærer.
38. Forbindelse ifølge et hvilket somhelst afkravene 1-37 til anvendelse som medikament.
39. Forbindelse ifølge et hvilket som helst afkravene 1-37 til anvendelse ved behandling af smerte, neuropatisk smerte, inflammatorisk smerte, perifer neuropati, slagtilfælde, epilepsi, neurodegeneration, skizofreni, stofmisbrug, humørforstyrrelser, post-traumatisk stressforstyrrelse, krampeanfald, krampe, aldersrelateret hukommelsestab, depression, slagtilfælde, traumatisk hjerneskade, iskæmi, Alzheimers sygdom, Parkinsons sygdom, Huntingtons sygdom, amyotrofisk lateralsklerose eller Creutzfeldt-Jakobs sygdom.
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