DK3021883T3 - Biomimetisk kollagen-hydroxyapatit kompositmateriale - Google Patents
Biomimetisk kollagen-hydroxyapatit kompositmateriale Download PDFInfo
- Publication number
- DK3021883T3 DK3021883T3 DK14741205.0T DK14741205T DK3021883T3 DK 3021883 T3 DK3021883 T3 DK 3021883T3 DK 14741205 T DK14741205 T DK 14741205T DK 3021883 T3 DK3021883 T3 DK 3021883T3
- Authority
- DK
- Denmark
- Prior art keywords
- collagen
- hydroxyapatite
- bone
- biomimetic
- composite material
- Prior art date
Links
- 108010035532 Collagen Proteins 0.000 title claims description 153
- 102000008186 Collagen Human genes 0.000 title claims description 153
- 229920001436 collagen Polymers 0.000 title claims description 153
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims description 122
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims description 94
- 239000002131 composite material Substances 0.000 title claims description 41
- 230000003592 biomimetic effect Effects 0.000 title claims description 33
- 210000000988 bone and bone Anatomy 0.000 claims description 62
- 239000013078 crystal Substances 0.000 claims description 51
- 239000000835 fiber Substances 0.000 claims description 39
- 239000000243 solution Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 21
- 239000011707 mineral Substances 0.000 claims description 21
- 239000002159 nanocrystal Substances 0.000 claims description 19
- 230000008569 process Effects 0.000 claims description 14
- 239000007943 implant Substances 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 238000000978 circular dichroism spectroscopy Methods 0.000 claims description 10
- 238000001878 scanning electron micrograph Methods 0.000 claims description 10
- 230000010478 bone regeneration Effects 0.000 claims description 9
- 230000011164 ossification Effects 0.000 claims description 7
- 229920006395 saturated elastomer Polymers 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 230000008439 repair process Effects 0.000 claims description 6
- 229910001868 water Inorganic materials 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 230000003848 cartilage regeneration Effects 0.000 claims description 4
- 238000002441 X-ray diffraction Methods 0.000 claims description 3
- 239000000316 bone substitute Substances 0.000 claims description 3
- 239000011343 solid material Substances 0.000 claims description 3
- 238000010191 image analysis Methods 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 23
- 239000008055 phosphate buffer solution Substances 0.000 description 21
- 239000011248 coating agent Substances 0.000 description 18
- 238000000576 coating method Methods 0.000 description 18
- 230000007547 defect Effects 0.000 description 15
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
- 239000012528 membrane Substances 0.000 description 13
- 239000011159 matrix material Substances 0.000 description 12
- 230000012010 growth Effects 0.000 description 11
- 239000010410 layer Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 10
- 238000013019 agitation Methods 0.000 description 9
- 238000004132 cross linking Methods 0.000 description 9
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
- 239000001506 calcium phosphate Substances 0.000 description 8
- 239000000515 collagen sponge Substances 0.000 description 8
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 8
- 235000011010 calcium phosphates Nutrition 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 230000035484 reaction time Effects 0.000 description 7
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 6
- 108010009565 Bio-Gide Proteins 0.000 description 6
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 6
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 6
- 229910000389 calcium phosphate Inorganic materials 0.000 description 6
- 230000006911 nucleation Effects 0.000 description 6
- 238000010899 nucleation Methods 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- 238000004626 scanning electron microscopy Methods 0.000 description 6
- 102000012422 Collagen Type I Human genes 0.000 description 5
- 108010022452 Collagen Type I Proteins 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 4
- 239000004809 Teflon Substances 0.000 description 4
- 229920006362 Teflon® Polymers 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000000429 assembly Methods 0.000 description 4
- 230000000712 assembly Effects 0.000 description 4
- 229910001424 calcium ion Inorganic materials 0.000 description 4
- 229960004132 diethyl ether Drugs 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 102000000503 Collagen Type II Human genes 0.000 description 3
- 108010041390 Collagen Type II Proteins 0.000 description 3
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 239000010419 fine particle Substances 0.000 description 3
- 229960002591 hydroxyproline Drugs 0.000 description 3
- 239000005445 natural material Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 238000003775 Density Functional Theory Methods 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 238000003889 chemical engineering Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000012669 compression test Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 230000035557 fibrillogenesis Effects 0.000 description 2
- 230000009629 growth pathway Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
- 210000004373 mandible Anatomy 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 230000001089 mineralizing effect Effects 0.000 description 2
- 238000000329 molecular dynamics simulation Methods 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 238000010883 osseointegration Methods 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 238000002459 porosimetry Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000004627 transmission electron microscopy Methods 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- MISZALMBODQYFT-URVXVIKDSA-N 125-69-9 Chemical compound Br.C([C@@H]12)CCC[C@]11CCN(C)[C@H]2CC2=CC=C(OC)C=C21 MISZALMBODQYFT-URVXVIKDSA-N 0.000 description 1
- 102000001187 Collagen Type III Human genes 0.000 description 1
- 108010069502 Collagen Type III Proteins 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- -1 beta-TCR TTCP Chemical compound 0.000 description 1
- 239000005312 bioglass Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000003109 clavicle Anatomy 0.000 description 1
- 239000000512 collagen gel Substances 0.000 description 1
- 229940096422 collagen type i Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 210000001847 jaw Anatomy 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- AENLSWLSIQAAPU-UHFFFAOYSA-K octacalcium;phosphate;pentahydrate Chemical compound O.O.O.O.O.[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O AENLSWLSIQAAPU-UHFFFAOYSA-K 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 229910052585 phosphate mineral Inorganic materials 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
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- 238000005245 sintering Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- ZTWTYVWXUKTLCP-UHFFFAOYSA-N vinylphosphonic acid Chemical compound OP(O)(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- OIWCYIUQAVBPGV-DAQGAKHBSA-N {1-O-hexadecanoyl-2-O-[(Z)-octadec-9-enoyl]-sn-glycero-3-phospho}serine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC OIWCYIUQAVBPGV-DAQGAKHBSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
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- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/58—Materials at least partially resorbable by the body
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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Claims (15)
- BIOMIMETISK KOLLAGEN-HYDROXYAPATIT KOMPOSITMATERIALE Patentkrav1. Biomimetisk kollagen-hydroxyapatit kompositmateriale omfattende en mindst delvist fibrøs kollagenstruktur som inkluderer modne native kollagenfibre, som besidder tredobbelt helicitet som vist ved cirkulær dikroisme spektroskopi, hvor disse modne native kollagenfibre er mindst delvist dækket med epitaktisk dyrkede krystaller af nanokrystallinsk hydroxyapatit, hvorved de epitaktisk dyrkede nanokrystaller har den samme morfologi som menneskelig knoglemineral og den samme størrelse som menneskelig knoglemineral, nemlig en længde på 30 til 50 nm og en bredde på 14 til 25 nm og hvor de epitaktisk dyrkede krystaller af nanokrystallinsk hydroxyapatit danner et lag med en tykkelse på mindst 30 ± 15 nm, som bestemt ved røngtendiffraktions-analyse.
- 2. Biomimetisk kollagen-hydroxyapatit kompositmateriale ifølge krav 1, hvor den mindst delvist fibrøse kollagenstruktur omfatter på dens ydre overflade mindst 2 % af modne native kollagenfibre bestemt ved billedanalyse af SEM mikrografer og cirkulær dikroisme spektroskopi.
- 3. Biomimetisk kollagen-hydroxyapatit kompositmateriale ifølge krav 1, hvor den mindst delvist fibrøse kollagenstruktur omfatter på dens ydre overflade mindst 10 % af modne native kollagenfibre bestemt ved billedanalyse af SEM mikrografer og cirkulær dikroisme spektroskopi.
- 4. Biomimetisk kollagen-hydroxyapatit kompositmateriale ifølge et hvilket som helst af kravene 1 til 3, hvor vægt til vægt forholdet af den fibrøse kollagenstruktur til de epitaktisk dyrkede krystaller af nanokrystallinsk hydroxyapatit er mellem 5:95 og 95:5, fortrinvis mellem 10:90 og 90:10.
- 5. Biomimetisk kollagen-hydroxyapatit kompositmateriale ifølge et hvilket som helst af kravene 1 til 4 som er et formet legeme.
- 6. Formet legeme ifølge krav 5 som er et knogleerstatningsmateriale med en struktur der har profil som en ossøs legemsdel.
- 7. Formet legeme ifølge krav 5 eller 6 som har en drejningsmomentmodstand på mindst 30 Nem i tør tilstand.
- 8. Biomimetisk kollagen-hydroxyapatit kompositmateriale ifølge et hvilket som helst af kravene 1 til 5 som er membran-formet.
- 9. Fremgangsmåde til fremstilling af det biomimetiske kollagen-hydroxyapatit kompositmateriale ifølge et hvilket som helst af kravene 1 til 8 omfattende trinnene a) at nedsænke en mindst delvist fibrøs kollagenstruktur, som inkluderer modne native kollagenfibre der besidder tredobbelt helicitet som vist ved cirkulær dikroisme spektroskopi, i en mættet vandig opløsning af mættet Ca2+/ HxP04<3"x), som er en phosphatbuffer opløsning (PBS) omfattende fint dispergeret alpha-TCP, beta-TCP, TTCP, octacalcium phosphat pentahydrat, dicalcium phosphat eller dicalcium phosphat dihydrat, for at udføre en dannelsesproces af komposit-implantatmaterialet hvorved epitaktisk dyrkede hydroxyapatit-nanokrystaller dannes på disse modne native kollagenfibre, hvor disse epitaktisk dyrkede hyroxyapatit-nanokrystaller har samme morfologi og samme størrelse som menneskelig knoglemineral, b) at stoppe dannelsesprocessen af komposit-implantatmaterialet ved at adskille faststof materiale fra den vandige opløsning, rense med vand og tørre, og c) at eventuelt sterilisere det adskilte materiale fra trin b).
- 10. Fremgangsmåde ifølge krav 9 hvor i trin b) pH'en af den vandige opløsning forbliver inden for et område af 5,5 til 9,0.
- 11. Fremgangsmåde ifølge krav 9 hvor i trin b) pH'en af den vandige opløsning forbliver inden for et område af 6,5 til 8,0.
- 12. Fremgangsmåde ifølge krav 9 eller 10 hvor temperaturen i trin b) er mellem 25 og 45 °C.
- 13. Fremgangsmåde ifølge krav 9 eller 10 hvor temperaturen i trin b) er mellem 35°C og 42 °C.
- 14. Biomimetisk kollagen-hydroxyapatit kompositmateriale ifølge et hvilket som helst af kravene 1 til 7 til anvendelse som et implantat eller protese til knogledannelse, knogleregenerering, knoglereparation og/eller knogleerstatning i et defekt område hos et menneske eller et dyr.
- 15. Membran-formet biomimetisk kollagen-hydroxyapatit kompositmateriale ifølge krav 8 til anvendelse som et implantat til kombineret knogle og brusk regenerering.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003647.8A EP2826495A1 (en) | 2013-07-19 | 2013-07-19 | Biomimetic collagen-hydroxyapatite composite material |
| PCT/EP2014/001966 WO2015007393A1 (en) | 2013-07-19 | 2014-07-18 | Biomimetic collagen-hydroxyapatite composite material |
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| Publication Number | Publication Date |
|---|---|
| DK3021883T3 true DK3021883T3 (da) | 2017-01-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| DK14741205.0T DK3021883T3 (da) | 2013-07-19 | 2014-07-18 | Biomimetisk kollagen-hydroxyapatit kompositmateriale |
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| Country | Link |
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| US (1) | US10029028B2 (da) |
| EP (2) | EP2826495A1 (da) |
| JP (1) | JP6478993B2 (da) |
| KR (1) | KR101944163B1 (da) |
| CN (1) | CN105358189B (da) |
| AU (1) | AU2014292503B2 (da) |
| BR (1) | BR112016001093B1 (da) |
| CA (1) | CA2917997C (da) |
| DK (1) | DK3021883T3 (da) |
| ES (1) | ES2611202T3 (da) |
| HK (1) | HK1218083A1 (da) |
| HU (1) | HUE031178T2 (da) |
| PL (1) | PL3021883T3 (da) |
| PT (1) | PT3021883T (da) |
| RU (1) | RU2662326C2 (da) |
| SG (1) | SG11201600364VA (da) |
| WO (1) | WO2015007393A1 (da) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US10238507B2 (en) | 2015-01-12 | 2019-03-26 | Surgentec, Llc | Bone graft delivery system and method for using same |
| DE202016103296U1 (de) | 2016-06-09 | 2017-09-18 | Michael Gahlert | Knochenersatzmaterial aus Zirkondioxidkeramik |
| DE102016110622A1 (de) | 2016-06-09 | 2017-12-14 | Michael Gahlert | Knochenersatzmaterial aus Zirkondioxidkeramik |
| CN111511415B (zh) * | 2017-12-14 | 2021-04-20 | 盖斯特里希医药公司 | 干式植入物组合物和可注射的水性植入物制剂 |
| EP3544642B1 (en) * | 2017-12-14 | 2020-05-13 | Geistlich Pharma AG | Bone substitute material |
| PT3544643T (pt) | 2017-12-14 | 2020-07-27 | Geistlich Pharma Ag | Material de substituição óssea |
| US11116647B2 (en) | 2018-04-13 | 2021-09-14 | Surgentec, Llc | Bone graft delivery system and method for using same |
| US10687828B2 (en) | 2018-04-13 | 2020-06-23 | Surgentec, Llc | Bone graft delivery system and method for using same |
| EP3695856A1 (en) * | 2019-02-13 | 2020-08-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Biomaterials comprising a scaffold containing a mineral compound, and uses thereof as bone substitutes |
| ES2939266T3 (es) * | 2019-06-14 | 2023-04-20 | Geistlich Pharma Ag | Matriz de colágeno o mezcla granulada de material sustituto de hueso |
| WO2020249714A1 (en) * | 2019-06-14 | 2020-12-17 | Geistlich Pharma Ag | Collagen matrix or granulate blend of bone substitute material |
| FR3101773B1 (fr) | 2019-10-10 | 2023-04-21 | Regeska | Procede de mineralisation d’une membrane de biopolymere |
| CN114209880B (zh) * | 2021-11-25 | 2022-11-08 | 浙江大学 | 一种有序矿化多肽的生物复合材料的制备方法及其产品和应用 |
| CN114732957B (zh) * | 2022-03-16 | 2022-12-23 | 武汉理工大学 | 一种具有预应力的矿化肌腱复合材料及其制备方法与应用 |
| CN114890400B (zh) * | 2022-06-15 | 2023-12-01 | 杭州彗搏科技有限公司 | 纳米晶体羟基磷灰石骨修复颗粒、制备方法及应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB8813033D0 (en) | 1988-06-02 | 1988-07-06 | Geistlich Soehne Ag | Chemical compound |
| US5231169A (en) | 1990-10-17 | 1993-07-27 | Norian Corporation | Mineralized collagen |
| US5532217A (en) | 1992-04-24 | 1996-07-02 | Silver; Frederick H. | Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone |
| US6201039B1 (en) * | 1993-09-21 | 2001-03-13 | The Penn State Research Foundation | Bone substitute composition comprising hydroxyapatite and a method of production therefor |
| GB9400163D0 (en) | 1994-01-06 | 1994-03-02 | Geistlich Soehne Ag | Membrane |
| JP2754348B2 (ja) * | 1994-10-20 | 1998-05-20 | バイオマップ有限会社 | アパタイト被覆基材とその製造法 |
| GB9503492D0 (en) | 1995-02-22 | 1995-04-12 | Ed Geistlich S Hne A G F R Che | Chemical product |
| US6395036B1 (en) | 1998-04-06 | 2002-05-28 | Isis Innovation Limited | Composite material and methods of making the same |
| US7514249B2 (en) | 2002-04-18 | 2009-04-07 | The University Of Florida Research Foundation, Inc. | Biomimetic organic/inorganic composites |
| WO2006056391A2 (de) * | 2004-11-23 | 2006-06-01 | Ossacur Ag | Bioresorbierbares und oberflächen-mineralisiertes material zur füllung von knochendefekten |
| ITMI20050343A1 (it) * | 2005-03-04 | 2006-09-05 | Fin Ceramica Faenza S R L | Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego |
| EP1909859B1 (en) * | 2005-07-21 | 2017-09-06 | aap Biomaterials GmbH | Method for producing hydroxyapatite particles, in particular subnanodisperse hydroxyapatite particles in a matrix |
| US8491924B2 (en) * | 2006-04-13 | 2013-07-23 | Case Western Reserve University | Biomaterial implants |
| FR2933303B1 (fr) * | 2008-06-30 | 2010-12-03 | Univ Paris Curie | Substitut osseux,et procede pour sa preparation. |
| KR101558856B1 (ko) * | 2009-06-23 | 2015-10-08 | 가이스틀리히 파마 아게 | 뼈 대체 재료 |
| EP2600911B1 (de) * | 2010-08-04 | 2017-10-11 | Technische Universität Dresden | Wachstumsinhibierter hydroxylapatit, verfahren zu dessen herstellung und verwendung |
| KR101599245B1 (ko) * | 2010-12-22 | 2016-03-03 | 가이스틀리히 파마 아게 | 골 대체 물질 |
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2013
- 2013-07-19 EP EP13003647.8A patent/EP2826495A1/en not_active Withdrawn
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2014
- 2014-07-18 AU AU2014292503A patent/AU2014292503B2/en not_active Ceased
- 2014-07-18 BR BR112016001093-0A patent/BR112016001093B1/pt not_active IP Right Cessation
- 2014-07-18 US US14/903,394 patent/US10029028B2/en active Active
- 2014-07-18 CA CA2917997A patent/CA2917997C/en active Active
- 2014-07-18 PT PT147412050T patent/PT3021883T/pt unknown
- 2014-07-18 DK DK14741205.0T patent/DK3021883T3/da active
- 2014-07-18 PL PL14741205T patent/PL3021883T3/pl unknown
- 2014-07-18 KR KR1020167001407A patent/KR101944163B1/ko active IP Right Grant
- 2014-07-18 CN CN201480039113.0A patent/CN105358189B/zh not_active Expired - Fee Related
- 2014-07-18 WO PCT/EP2014/001966 patent/WO2015007393A1/en active Application Filing
- 2014-07-18 RU RU2016105556A patent/RU2662326C2/ru active
- 2014-07-18 HU HUE14741205A patent/HUE031178T2/en unknown
- 2014-07-18 EP EP14741205.0A patent/EP3021883B1/en active Active
- 2014-07-18 JP JP2016526468A patent/JP6478993B2/ja not_active Expired - Fee Related
- 2014-07-18 ES ES14741205.0T patent/ES2611202T3/es active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015007393A1 (en) | 2015-01-22 |
| CA2917997A1 (en) | 2015-01-22 |
| CN105358189A (zh) | 2016-02-24 |
| PT3021883T (pt) | 2016-12-23 |
| EP3021883A1 (en) | 2016-05-25 |
| EP2826495A1 (en) | 2015-01-21 |
| BR112016001093B1 (pt) | 2020-07-28 |
| AU2014292503A1 (en) | 2016-02-11 |
| KR101944163B1 (ko) | 2019-01-30 |
| US10029028B2 (en) | 2018-07-24 |
| CA2917997C (en) | 2019-08-20 |
| SG11201600364VA (en) | 2016-02-26 |
| CN105358189B (zh) | 2018-03-16 |
| JP6478993B2 (ja) | 2019-03-06 |
| EP3021883B1 (en) | 2016-11-09 |
| RU2016105556A (ru) | 2017-08-24 |
| JP2016524964A (ja) | 2016-08-22 |
| RU2662326C2 (ru) | 2018-07-25 |
| KR20160032116A (ko) | 2016-03-23 |
| AU2014292503B2 (en) | 2017-06-15 |
| PL3021883T3 (pl) | 2017-03-31 |
| HK1218083A1 (zh) | 2017-02-03 |
| HUE031178T2 (en) | 2017-06-28 |
| US20160144071A1 (en) | 2016-05-26 |
| ES2611202T3 (es) | 2017-05-05 |
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