DK297284A - Krystallinsk 7-(r)-amino-3-(1-pyridiniummethyl)-ceph-3-em-4-carboxylat-monohydrat og fremgangsmaade til fremstilling heraf - Google Patents

Krystallinsk 7-(r)-amino-3-(1-pyridiniummethyl)-ceph-3-em-4-carboxylat-monohydrat og fremgangsmaade til fremstilling heraf Download PDF

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Publication number
DK297284A
DK297284A DK297284A DK297284A DK297284A DK 297284 A DK297284 A DK 297284A DK 297284 A DK297284 A DK 297284A DK 297284 A DK297284 A DK 297284A DK 297284 A DK297284 A DK 297284A
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DK
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Prior art keywords
ceph
crystalline
amino
preparing
procedure
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DK297284A
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English (en)
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DK297284D0 (da
DK166388C (da
DK166388B (da
Inventor
Preston Charles Conrad
Alvydas Alfonsas Jarmas
Original Assignee
Lilly Co Eli
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Publication of DK297284D0 publication Critical patent/DK297284D0/da
Publication of DK297284A publication Critical patent/DK297284A/da
Publication of DK166388B publication Critical patent/DK166388B/da
Application granted granted Critical
Publication of DK166388C publication Critical patent/DK166388C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
DK297284A 1983-06-20 1984-06-18 Krystallinsk 7-(r)-amino-3-(1-pyridiniummethyl)-ceph-3-em-4-carboxylat-monohydrochlorid-monohydrat og fremgangsmaade til fremstilling heraf DK166388C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50566283 1983-06-20
US06/505,662 US4540779A (en) 1983-06-20 1983-06-20 Crystalline 7-(R)-amino-3-(1'pyridiniummethyl)-ceph-3-em-4-carboxylate monohydrochloride monohydrate compound

Publications (4)

Publication Number Publication Date
DK297284D0 DK297284D0 (da) 1984-06-18
DK297284A true DK297284A (da) 1984-12-21
DK166388B DK166388B (da) 1993-05-10
DK166388C DK166388C (da) 1993-09-27

Family

ID=24011278

Family Applications (1)

Application Number Title Priority Date Filing Date
DK297284A DK166388C (da) 1983-06-20 1984-06-18 Krystallinsk 7-(r)-amino-3-(1-pyridiniummethyl)-ceph-3-em-4-carboxylat-monohydrochlorid-monohydrat og fremgangsmaade til fremstilling heraf

Country Status (12)

Country Link
US (1) US4540779A (da)
EP (1) EP0135258B1 (da)
JP (1) JPS6013793A (da)
KR (1) KR870000327B1 (da)
CA (1) CA1216577A (da)
DE (1) DE3479659D1 (da)
DK (1) DK166388C (da)
GB (1) GB2141715B (da)
GR (1) GR82375B (da)
HU (1) HU192558B (da)
IE (1) IE57622B1 (da)
IL (1) IL72103A (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
US4959469A (en) * 1984-12-27 1990-09-25 Banyu Pharmaceutical Company, Ltd. Crystalline cephalosporin compounds
JPH0649707B2 (ja) * 1985-03-01 1994-06-29 第一製薬株式会社 ３−ピリジニウムメチルセフエム誘導体
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
US4692518A (en) * 1985-11-06 1987-09-08 Eli Lilly And Company Crystalline (7R)-7-amino-3-(1'-pyridiniummethyl)-3-cephem-4-carboxylate monohydrate compound
DE10155242A1 (de) * 2001-11-09 2003-05-22 Bayer Ag Herstellung von Polyamid
CN109134499A (zh) * 2018-10-10 2019-01-04 河北鸿旭翔药业有限公司 7-氨基-3-（1-吡啶甲基）头孢烯酸氯化物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB953695A (en) * 1959-08-04 1964-03-25 Nat Res Dev Derivatives of cephalosporin c
AR228726A1 (es) * 1978-05-26 1983-04-15 Glaxo Group Ltd Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato
FR2457295A1 (fr) * 1979-05-25 1980-12-19 Glaxo Group Ltd Composes intermediaires pour la preparation de cephalosporines

Also Published As

Publication number Publication date
DK297284D0 (da) 1984-06-18
CA1216577A (en) 1987-01-13
HU192558B (en) 1987-06-29
GB2141715B (en) 1986-12-10
IL72103A0 (en) 1984-10-31
JPS6013793A (ja) 1985-01-24
GB2141715A (en) 1985-01-03
GB8415508D0 (en) 1984-07-25
KR850000459A (ko) 1985-02-27
GR82375B (da) 1984-12-13
DK166388C (da) 1993-09-27
EP0135258B1 (en) 1989-09-06
HUT34756A (en) 1985-04-28
IE57622B1 (en) 1993-02-10
IE841505L (en) 1984-12-20
EP0135258A2 (en) 1985-03-27
DK166388B (da) 1993-05-10
IL72103A (en) 1987-12-20
EP0135258A3 (en) 1985-12-18
US4540779A (en) 1985-09-10
DE3479659D1 (en) 1989-10-12
KR870000327B1 (ko) 1987-02-27

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