DK2970225T3 - DIPEPTIDE AND TRIPEPTIDE AS EPOXY-KETONE PROTEASE INHIBITORS - Google Patents

DIPEPTIDE AND TRIPEPTIDE AS EPOXY-KETONE PROTEASE INHIBITORS Download PDF

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Publication number
DK2970225T3
DK2970225T3 DK14723553.5T DK14723553T DK2970225T3 DK 2970225 T3 DK2970225 T3 DK 2970225T3 DK 14723553 T DK14723553 T DK 14723553T DK 2970225 T3 DK2970225 T3 DK 2970225T3
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oxopropan
amino
mmol
methoxyphenyl
methyloxiran
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DK14723553.5T
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Danish (da)
English (en)
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Dustin Mcminn
Henry Johnson
David C Moebius
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Onyx Therapeutics Inc
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
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DK14723553.5T 2013-03-14 2014-03-14 DIPEPTIDE AND TRIPEPTIDE AS EPOXY-KETONE PROTEASE INHIBITORS DK2970225T3 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361786086P 2013-03-14 2013-03-14
US201361785608P 2013-03-14 2013-03-14
US201361847780P 2013-07-18 2013-07-18
US201361856847P 2013-07-22 2013-07-22
US201361883843P 2013-09-27 2013-09-27
US201361883798P 2013-09-27 2013-09-27
US201461941798P 2014-02-19 2014-02-19
PCT/US2014/026980 WO2014152127A1 (en) 2013-03-14 2014-03-14 Dipeptide and tripeptide epoxy ketone protease inhibitors

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DK2970225T3 true DK2970225T3 (en) 2018-09-24

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US (1) US9657057B2 (ru)
EP (1) EP2970225B1 (ru)
JP (2) JP2016515127A (ru)
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