DK2951754T3 - Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter - Google Patents

Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter Download PDF

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DK2951754T3
DK2951754T3 DK14746677.5T DK14746677T DK2951754T3 DK 2951754 T3 DK2951754 T3 DK 2951754T3 DK 14746677 T DK14746677 T DK 14746677T DK 2951754 T3 DK2951754 T3 DK 2951754T3
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biomolecules
identification
software
systems
methods
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DK14746677.5T
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Gregory Allan Cope
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Codexis Inc
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16B35/10—Design of libraries
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    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/20—Screening of libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry

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DK14746677.5T 2013-01-31 2014-01-29 Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter DK2951754T3 (da)

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US201361759276P 2013-01-31 2013-01-31
US201361799377P 2013-03-15 2013-03-15
PCT/US2014/013666 WO2014120819A1 (en) 2013-01-31 2014-01-29 Methods, systems, and software for identifying bio-molecules with interacting components

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DK14746677.5T DK2951754T3 (da) 2013-01-31 2014-01-29 Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter

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US (4) US9684771B2 (da)
EP (3) EP2951579B1 (da)
JP (4) JP6377078B2 (da)
KR (3) KR102215219B1 (da)
CN (3) CN109360608B (da)
AU (2) AU2014212430B2 (da)
BR (2) BR112015018454B1 (da)
CA (2) CA2899859C (da)
DK (2) DK2951579T3 (da)
FI (2) FI2951754T3 (da)
IL (2) IL240056A0 (da)
LT (2) LT2951754T (da)
NZ (2) NZ710299A (da)
RU (2) RU2664695C2 (da)
SG (2) SG11201505969XA (da)
WO (2) WO2014120819A1 (da)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6377078B2 (ja) * 2013-01-31 2018-08-22 コデクシス， インコーポレイテッド 相互作用する構成要素を有する生体分子を同定するための方法、システム、およびソフトウェア
WO2014171898A2 (en) 2013-04-17 2014-10-23 Agency For Science, Technology And Research Method for generating extended sequence reads
EP2911075A1 (de) * 2014-02-25 2015-08-26 LTS LOHMANN Therapie-Systeme AG System zur Bestimmung einer Eignung eines Wirkstoffs für die transdermale oder transmukosale Applikation sowie entsprechendes Verfahren
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US20170372005A1 (en) * 2014-12-22 2017-12-28 Board Of Regents Of The University Of Texas System Systems and methods for processing sequence data for variant detection and analysis
BR112017013300A2 (pt) 2014-12-22 2018-02-27 Codexis Inc alfa galactosidase a recombinante e/ou fragmento de alfa galactosidase a recombinante biologicamente ativo, composição, sequência de polinucleotídeos recombinantes, vetor de expressão, célula hospedeira, métodos para produzir uma variante de alfa galactosidase a e para tratar e/ou prevenir os sintomas da doença de fabry, composição farmacêutica, e, uso das composições.
EP3298524A4 (en) 2015-05-22 2019-03-20 CSTS Health Care Inc. THERMODYNAMIC MEASUREMENTS RELATING TO PROTEIN-PROTEIN INTERACTION NETWORKS FOR THE TREATMENT OF CANCER
FR3047013A1 (fr) * 2016-01-22 2017-07-28 Univ Montpellier Procede de classification d'un echantillon biologique.
EP3452940A4 (en) 2016-05-04 2020-01-01 Deep Genomics Incorporated METHODS AND SYSTEMS FOR THE PRODUCTION OF AN EXTENDED EXERCISE DATA SET FOR MACHINE LEARNING WITH BIOLOGICAL SEQUENCES
CN109715817B (zh) 2016-06-09 2022-12-09 科德克希思公司 用于化合物的羟基化的生物催化剂和方法
SG11201810998WA (en) 2016-06-15 2019-01-30 Codexis Inc Engineered beta-glucosidases and glucosylation methods
US11046936B2 (en) 2016-08-26 2021-06-29 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US10118610B2 (en) * 2016-08-31 2018-11-06 Ford Global Technologies, Llc Autonomous vehicle using path prediction
MX2019009615A (es) 2017-02-13 2019-10-14 Codexis Inc Polipeptidos dise?ados de fenilalanina amonio liasa.
CN108693787A (zh) * 2017-03-29 2018-10-23 株式会社东芝 模型构建系统以及模型构建方法
EP3645711A4 (en) 2017-06-30 2021-04-21 Codexis, Inc. T7 RNA POLYMERASE VARIANTS
JP2020530267A (ja) 2017-06-30 2020-10-22 コデクシス， インコーポレイテッド Ｔ７ ｒｎａポリメラーゼバリアント
CN107677997B (zh) * 2017-09-28 2021-06-29 杭州电子科技大学 基于GLMB滤波和Gibbs采样的扩展目标跟踪方法
CN111164701A (zh) * 2017-10-06 2020-05-15 格瑞尔公司 针对靶标定序的定点噪声模型
WO2019079464A1 (en) 2017-10-17 2019-04-25 Jungla Inc. PLATFORM OF MOLECULAR EVIDENCE FOR CONTINUOUS AND VERIFY OPTIMIZATION OF INTERPRETATION OF VARIANTS IN TESTS AND GENETIC ANALYZES
SG11202004185PA (en) 2017-12-13 2020-06-29 Codexis Inc Carboxyesterase polypeptides for amide coupling
CN108281192B (zh) * 2017-12-29 2022-03-22 一诺仪器（中国）有限公司 基于集成学习算法的人体成分预测方法及系统
US11760981B2 (en) 2018-07-30 2023-09-19 Codexis, Inc. Engineered glycosyltransferases and steviol glycoside glucosylation methods
JP2022512637A (ja) * 2018-10-11 2022-02-07 バークレー ライツ，インコーポレイテッド 最適化タンパク質生成の同定のためのシステム及び方法並びにそのためのキット
US11398297B2 (en) * 2018-10-11 2022-07-26 Chun-Chieh Chang Systems and methods for using machine learning and DNA sequencing to extract latent information for DNA, RNA and protein sequences
EP3874033A4 (en) 2018-10-29 2022-08-03 Codexis, Inc. MANIPULATED VARIANTS OF DNA POLYMERASE
AU2019397401A1 (en) 2018-12-14 2021-06-17 Codexis, Inc. Engineered tyrosine ammonia lyase
BR112021011750A2 (pt) 2018-12-20 2021-08-31 Codexis, Inc. Alfa-galactosidase a recombinante e/ou fragmento de alfa-galactosidase a recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, célula hospedeira, métodos para produzir uma variante de alfa-galactosidase a e para tratar e/ou prevenir os sintomas da doença de fabry, composição farmacêutica, e, uso das composições
GB2595106B (en) * 2019-01-22 2022-10-12 Emulate Inc High-content imaging of microfluidic devices
WO2020168286A1 (en) * 2019-02-14 2020-08-20 University Of Washington Systems and methods for improved nanopore-based analysis of nucleic acids
CN109902389B (zh) * 2019-03-01 2021-01-01 厦门大学 基于改进通用似然估计的不确定性有限元模型修正方法
CN109979539B (zh) * 2019-04-10 2020-10-02 电子科技大学 基因序列优化方法、装置及数据处理终端
JP7387760B2 (ja) 2019-05-02 2023-11-28 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 合成タンパク質の安定性を高めるためのシステムおよび方法
JP7298284B2 (ja) * 2019-05-09 2023-06-27 富士通株式会社 演算処理装置、演算処理プログラム、及び演算処理方法
JP2022542751A (ja) * 2019-06-07 2022-10-07 ライカ マイクロシステムズ シーエムエス ゲゼルシャフト ミット ベシュレンクテル ハフツング 生物学関連のデータを処理するためのシステムおよび方法、顕微鏡を制御するためのシステムおよび方法ならびに顕微鏡
AU2020290510A1 (en) * 2019-06-12 2022-02-03 Quantum-Si Incorporated Techniques for protein identification using machine learning and related systems and methods
MX2022002473A (es) 2019-08-30 2022-08-02 Codexis Inc Variantes de lipasa modificadas geneticamente.
JP7438693B2 (ja) 2019-09-02 2024-02-27 キヤノンメディカルシステムズ株式会社 診療支援装置
US20210174909A1 (en) * 2019-12-10 2021-06-10 Homodeus, Inc. Generative machine learning models for predicting functional protein sequences
JP2023507575A (ja) 2019-12-20 2023-02-24 コデクシス， インコーポレイテッド 操作された酸性アルファ－グルコシダーゼバリアント
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
CN116897205A (zh) 2020-08-28 2023-10-17 科德克希思公司 工程化淀粉酶变体
AU2021334371A1 (en) 2020-08-28 2023-03-09 Codexis, Inc. Engineered protease variants
US11361194B2 (en) 2020-10-27 2022-06-14 Illumina, Inc. Systems and methods for per-cluster intensity correction and base calling
EP4262804A2 (en) 2020-12-18 2023-10-25 Codexis, Inc. Engineered uridine phosphorylase variant enzymes
US11439159B2 (en) 2021-03-22 2022-09-13 Shiru, Inc. System for identifying and developing individual naturally-occurring proteins as food ingredients by machine learning and database mining combined with empirical testing for a target food function
EP4314262A1 (en) 2021-04-02 2024-02-07 Codexis, Inc. Engineered guanylate kinase variant enzymes
WO2022212835A1 (en) 2021-04-02 2022-10-06 Codexis, Inc. Engineered acetate kinase variant enzymes
US20220325285A1 (en) 2021-04-02 2022-10-13 Codexis, Inc. ENGINEERED CYCLIC GMP-AMP SYNTHASE (cGAS) VARIANT ENZYMES
IL305919A (en) 2021-04-02 2023-11-01 Codexis Inc A transgenic enzyme variant of adenylate kinase
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
CN114913939B (zh) * 2022-07-19 2022-11-15 北京科技大学 高通量平台和机器学习优化的药物组合设计方法及装置
CN116884503B (zh) * 2023-09-06 2023-12-26 北京齐碳科技有限公司 序列和后验矩阵的处理方法、装置和计算设备
CN117935934B (zh) * 2024-03-25 2024-07-02 中国科学院天津工业生物技术研究所 一种基于机器学习预测磷酸酶最佳催化温度的方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6171820B1 (en) * 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6153410A (en) 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
IL136574A0 (en) 1997-12-08 2001-06-14 California Inst Of Techn A method for forming a polynucleotide of desired properties
US20020048772A1 (en) 2000-02-10 2002-04-25 Dahiyat Bassil I. Protein design automation for protein libraries
US7315786B2 (en) 1998-10-16 2008-01-01 Xencor Protein design automation for protein libraries
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
EP1072010B1 (en) 1999-01-19 2010-04-21 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20070065838A1 (en) 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
WO2001039098A2 (en) * 1999-11-22 2001-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem System and method for searching a combinatorial space
US20010051855A1 (en) * 2000-02-17 2001-12-13 California Institute Of Technology Computationally targeted evolutionary design
AU2001241939A1 (en) 2000-02-28 2001-09-12 Maxygen, Inc. Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
AU4964101A (en) 2000-03-30 2001-10-15 Maxygen Inc In silico cross-over site selection
US20030032059A1 (en) 2000-05-23 2003-02-13 Zhen-Gang Wang Gene recombination and hybrid protein development
EP1283877A2 (en) 2000-05-23 2003-02-19 California Institute Of Technology Gene recombination and hybrid protein development
US20020155460A1 (en) 2000-10-10 2002-10-24 Genencor International Inc. Information rich libraries
CA2487039A1 (en) * 2001-06-11 2002-12-19 Transition Therapeutics Inc. Combination therapies using vitamin b12 and interferon for treatment of viral, proliferative and inflammatory diseases
US7747391B2 (en) 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US7783428B2 (en) 2002-03-01 2010-08-24 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
AU2003220998A1 (en) 2002-04-04 2003-10-20 Ishihara Sangyo Kaisha, Ltd. Apparatus and method for analyzing data
SG135053A1 (en) * 2002-05-20 2007-09-28 Abmaxis Inc Generation and selection of protein library in silico
JP4042492B2 (ja) * 2002-08-07 2008-02-06 トヨタ自動車株式会社 エンジン制御パラメータの適合方法及び適合システム
JP2004355174A (ja) * 2003-05-28 2004-12-16 Ishihara Sangyo Kaisha Ltd データ解析方法及びそのシステム
KR20070007253A (ko) * 2003-10-08 2007-01-15 이바이오사이언스 천연 면역글로불린 결합 물질 및 이의 제조 방법 및 사용방법
US7529714B2 (en) * 2004-12-14 2009-05-05 International Business Machines Corporation Cost management of software application portfolio
CN1763227A (zh) * 2005-09-01 2006-04-26 南京工业大学 一种提高蛋白质生物学功能的方法
US8691730B2 (en) * 2007-09-14 2014-04-08 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
CA2701726A1 (en) 2007-10-04 2009-04-09 Halcyon Molecular Sequencing nucleic acid polymers with electron microscopy
US8383346B2 (en) 2008-06-13 2013-02-26 Codexis, Inc. Combined automated parallel synthesis of polynucleotide variants
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
CN101353372A (zh) * 2008-08-04 2009-01-28 林峻 一种新型蛋白质分子定向进化方法
US9175341B2 (en) * 2008-12-11 2015-11-03 Pacific Biosciences Of California, Inc. Methods for identifying nucleic acid modifications
US8551096B2 (en) * 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
CN101792934A (zh) * 2009-08-26 2010-08-04 青岛科技大学 一种基于组合原理和pcr建立超大容量基因文库的新方法
JP5649424B2 (ja) * 2010-02-03 2015-01-07 大和ハウス工業株式会社 防水シート診断方法および診断装置
US20120115734A1 (en) * 2010-11-04 2012-05-10 Laura Potter In silico prediction of high expression gene combinations and other combinations of biological components
JP4839416B1 (ja) * 2011-01-06 2011-12-21 アクアエンタープライズ株式会社 移動過程予測システム、移動過程予測方法、移動過程予測装置及びコンピュータプログラム
US20120231447A1 (en) * 2011-02-15 2012-09-13 Howard Hughes Medical Institute Surface Passivation Methods for Single Molecule Imaging of Biochemical Reactions
CN102206625A (zh) * 2011-03-04 2011-10-05 东华大学 易错pcr/卡那霉素筛选系统定向进化蛋白质内含子
US20130017540A1 (en) * 2011-06-07 2013-01-17 Yun Yen Identification of mutation types associated with acquired resistance and methods for using same
JP6377078B2 (ja) 2013-01-31 2018-08-22 コデクシス， インコーポレイテッド 相互作用する構成要素を有する生体分子を同定するための方法、システム、およびソフトウェア

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