DK2951579T3 - Fremgangsmåder, systemer og software til identifikation af biomolekyler under anvendelse af modeller i multiplikativ form - Google Patents

Fremgangsmåder, systemer og software til identifikation af biomolekyler under anvendelse af modeller i multiplikativ form Download PDF

Info

Publication number
DK2951579T3
DK2951579T3 DK14746406.9T DK14746406T DK2951579T3 DK 2951579 T3 DK2951579 T3 DK 2951579T3 DK 14746406 T DK14746406 T DK 14746406T DK 2951579 T3 DK2951579 T3 DK 2951579T3
Authority
DK
Denmark
Prior art keywords
biomolecules
models
identification
software
systems
Prior art date
Application number
DK14746406.9T
Other languages
English (en)
Inventor
Gregory Allan Cope
Nicholas John Agard
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Application granted granted Critical
Publication of DK2951579T3 publication Critical patent/DK2951579T3/da

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C10/00Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1058Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B10/00ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50Mutagenesis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/10Design of libraries
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/20Screening of libraries
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20Probabilistic models
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/30Prediction of properties of chemical compounds, compositions or mixtures
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50Molecular design, e.g. of drugs
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60In silico combinatorial chemistry

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Library & Information Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physiology (AREA)
  • Computing Systems (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Probability & Statistics with Applications (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Ecology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
DK14746406.9T 2013-01-31 2014-01-29 Fremgangsmåder, systemer og software til identifikation af biomolekyler under anvendelse af modeller i multiplikativ form DK2951579T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759276P 2013-01-31 2013-01-31
US201361799377P 2013-03-15 2013-03-15
PCT/US2014/013668 WO2014120821A1 (en) 2013-01-31 2014-01-29 Methods, systems, and software for identifying bio-molecules using models of multiplicative form

Publications (1)

Publication Number Publication Date
DK2951579T3 true DK2951579T3 (da) 2024-05-21

Family

ID=51223867

Family Applications (2)

Application Number Title Priority Date Filing Date
DK14746406.9T DK2951579T3 (da) 2013-01-31 2014-01-29 Fremgangsmåder, systemer og software til identifikation af biomolekyler under anvendelse af modeller i multiplikativ form
DK14746677.5T DK2951754T3 (da) 2013-01-31 2014-01-29 Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14746677.5T DK2951754T3 (da) 2013-01-31 2014-01-29 Fremgangsmåder, systemer og software til identifikation af biomolekyler med interagerende komponenter

Country Status (16)

Country Link
US (4) US9665694B2 (da)
EP (2) EP2951754B1 (da)
JP (4) JP6377078B2 (da)
KR (3) KR102490720B1 (da)
CN (3) CN105074463B (da)
AU (2) AU2014212432B2 (da)
BR (2) BR112015018449B1 (da)
CA (2) CA2898777C (da)
DK (2) DK2951579T3 (da)
FI (2) FI2951579T3 (da)
IL (2) IL240056A0 (da)
LT (2) LT2951579T (da)
NZ (2) NZ710323A (da)
RU (2) RU2664695C2 (da)
SG (2) SG11201505977RA (da)
WO (2) WO2014120821A1 (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2951579T (lt) 2013-01-31 2024-05-27 Codexis, Inc. Biomolekulių identifikavimo naudojant multiplikacinės formos modelius būdai, sistemos ir programinė įranga
EP2986741B1 (en) 2013-04-17 2019-07-24 Agency For Science, Technology And Research Method for generating extended sequence reads
EP2911075A1 (de) * 2014-02-25 2015-08-26 LTS LOHMANN Therapie-Systeme AG System zur Bestimmung einer Eignung eines Wirkstoffs für die transdermale oder transmukosale Applikation sowie entsprechendes Verfahren
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
PT3237621T (pt) 2014-12-22 2023-07-20 Codexis Inc Variantes da alfa-galactosidase humana
WO2016105579A1 (en) * 2014-12-22 2016-06-30 Board Of Regents Of The University Of Texas System Systems and methods for processing sequence data for variant detection and analysis
EP3298524A4 (en) 2015-05-22 2019-03-20 CSTS Health Care Inc. THERMODYNAMIC MEASUREMENTS RELATING TO PROTEIN-PROTEIN INTERACTION NETWORKS FOR THE TREATMENT OF CANCER
FR3047013A1 (fr) * 2016-01-22 2017-07-28 Univ Montpellier Procede de classification d'un echantillon biologique.
WO2017190211A1 (en) * 2016-05-04 2017-11-09 Deep Genomics Incorporated Methods and systems for producing an expanded training set for machine learning using biological sequences
CN109715817B (zh) 2016-06-09 2022-12-09 科德克希思公司 用于化合物的羟基化的生物催化剂和方法
EA201990035A1 (ru) 2016-06-15 2019-06-28 Кодексис, Инк. Генно-инженерные бета-глюкозидазы и способы глюкозилирования
WO2018038906A1 (en) 2016-08-26 2018-03-01 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
US10118610B2 (en) * 2016-08-31 2018-11-06 Ford Global Technologies, Llc Autonomous vehicle using path prediction
MY196740A (en) 2017-02-13 2023-05-03 Codexis Inc Engineered phenylalanine ammonia lyase polypeptides
CN108693787A (zh) * 2017-03-29 2018-10-23 株式会社东芝 模型构建系统以及模型构建方法
JP2020530267A (ja) 2017-06-30 2020-10-22 コデクシス, インコーポレイテッド T7 rnaポリメラーゼバリアント
US10793841B2 (en) 2017-06-30 2020-10-06 Codexis, Inc. T7 RNA polymerase variants
CN107677997B (zh) * 2017-09-28 2021-06-29 杭州电子科技大学 基于GLMB滤波和Gibbs采样的扩展目标跟踪方法
WO2019071219A1 (en) * 2017-10-06 2019-04-11 Grail, Inc. SPECIFIC SITE NOISE MODEL FOR TARGETED SEQUENCING
US11462299B2 (en) 2017-10-17 2022-10-04 Invitae Corporation Molecular evidence platform for auditable, continuous optimization of variant interpretation in genetic and genomic testing and analysis
US11015180B2 (en) 2017-12-13 2021-05-25 Codexis, Inc. Carboxyesterase polypeptides for amide coupling
CN108281192B (zh) * 2017-12-29 2022-03-22 一诺仪器(中国)有限公司 基于集成学习算法的人体成分预测方法及系统
EP3830106A4 (en) 2018-07-30 2022-07-06 Codexis, Inc. MANIPULATED GLYCOSYLTRANSFERASES AND METHODS FOR STEVIOL GLYCOSIDE GLUCOSYLATION
JP2022512637A (ja) * 2018-10-11 2022-02-07 バークレー ライツ,インコーポレイテッド 最適化タンパク質生成の同定のためのシステム及び方法並びにそのためのキット
US11398297B2 (en) * 2018-10-11 2022-07-26 Chun-Chieh Chang Systems and methods for using machine learning and DNA sequencing to extract latent information for DNA, RNA and protein sequences
SG11202103639SA (en) 2018-10-29 2021-05-28 Codexis Inc Engineered dna polymerase variants
AU2019397401A1 (en) 2018-12-14 2021-06-17 Codexis, Inc. Engineered tyrosine ammonia lyase
US11427813B2 (en) 2018-12-20 2022-08-30 Codexis, Inc. Human alpha-galactosidase variants
CA3127602A1 (en) * 2019-01-22 2020-07-30 EMULATE, Inc. High-content imaging of microfluidic devices
WO2020168286A1 (en) * 2019-02-14 2020-08-20 University Of Washington Systems and methods for improved nanopore-based analysis of nucleic acids
CN109902389B (zh) * 2019-03-01 2021-01-01 厦门大学 基于改进通用似然估计的不确定性有限元模型修正方法
CN109979539B (zh) * 2019-04-10 2020-10-02 电子科技大学 基因序列优化方法、装置及数据处理终端
CA3138861A1 (en) * 2019-05-02 2020-12-10 Board Of Regents, The University Of Texas System System and method for increasing synthesized protein stability
JP7298284B2 (ja) * 2019-05-09 2023-06-27 富士通株式会社 演算処理装置、演算処理プログラム、及び演算処理方法
JP2022542751A (ja) * 2019-06-07 2022-10-07 ライカ マイクロシステムズ シーエムエス ゲゼルシャフト ミット ベシュレンクテル ハフツング 生物学関連のデータを処理するためのシステムおよび方法、顕微鏡を制御するためのシステムおよび方法ならびに顕微鏡
KR20220019778A (ko) * 2019-06-12 2022-02-17 퀀텀-에스아이 인코포레이티드 머신 학습을 이용한 단백질 식별을 위한 기법들 및 관련된 시스템들 및 방법들
JP2022545718A (ja) 2019-08-30 2022-10-28 コデクシス, インコーポレイテッド 操作されたリパーゼ改変体
JP7438693B2 (ja) 2019-09-02 2024-02-27 キヤノンメディカルシステムズ株式会社 診療支援装置
WO2021119261A1 (en) * 2019-12-10 2021-06-17 Homodeus, Inc. Generative machine learning models for predicting functional protein sequences
CA3165484A1 (en) 2019-12-20 2021-06-24 Codexis, Inc. Engineered acid alpha-glucosidase variants
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
MX2023002421A (es) 2020-08-28 2023-05-18 Codexis Inc Variantes de amilasa modificadas geneticamente.
JP2023539632A (ja) 2020-08-28 2023-09-15 コデクシス, インコーポレイテッド 操作されたプロテアーゼバリアント
US11361194B2 (en) 2020-10-27 2022-06-14 Illumina, Inc. Systems and methods for per-cluster intensity correction and base calling
EP4262804A2 (en) 2020-12-18 2023-10-25 Codexis, Inc. Engineered uridine phosphorylase variant enzymes
US11439159B2 (en) 2021-03-22 2022-09-13 Shiru, Inc. System for identifying and developing individual naturally-occurring proteins as food ingredients by machine learning and database mining combined with empirical testing for a target food function
CN117120600A (zh) 2021-04-02 2023-11-24 科德克希思公司 工程化腺苷酸激酶变体酶
CA3215105A1 (en) 2021-04-02 2022-10-06 Codexis, Inc. Engineered acetate kinase variant enzymes
IL305922A (en) 2021-04-02 2023-11-01 Codexis Inc Transgenic enzymes of variant guanylate kinase
US20220325285A1 (en) 2021-04-02 2022-10-13 Codexis, Inc. ENGINEERED CYCLIC GMP-AMP SYNTHASE (cGAS) VARIANT ENZYMES
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
CN114913939B (zh) * 2022-07-19 2022-11-15 北京科技大学 高通量平台和机器学习优化的药物组合设计方法及装置
CN116884503B (zh) * 2023-09-06 2023-12-26 北京齐碳科技有限公司 序列和后验矩阵的处理方法、装置和计算设备

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6153410A (en) 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
EP1036198B1 (en) 1997-12-08 2012-09-26 California Institute Of Technology Method for creating polynucleotide and polypeptide sequences
US7315786B2 (en) 1998-10-16 2008-01-01 Xencor Protein design automation for protein libraries
US20020048772A1 (en) 2000-02-10 2002-04-25 Dahiyat Bassil I. Protein design automation for protein libraries
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
EP1130093A1 (en) 1999-01-19 2001-09-05 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US20070065838A1 (en) 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
WO2001039098A2 (en) * 1999-11-22 2001-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem System and method for searching a combinatorial space
US20010051855A1 (en) * 2000-02-17 2001-12-13 California Institute Of Technology Computationally targeted evolutionary design
AU2001241939A1 (en) 2000-02-28 2001-09-12 Maxygen, Inc. Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation
EP1272967A2 (en) 2000-03-30 2003-01-08 Maxygen, Inc. In silico cross-over site selection
US20020045175A1 (en) 2000-05-23 2002-04-18 Zhen-Gang Wang Gene recombination and hybrid protein development
US20030032059A1 (en) 2000-05-23 2003-02-13 Zhen-Gang Wang Gene recombination and hybrid protein development
US20020155460A1 (en) 2000-10-10 2002-10-24 Genencor International Inc. Information rich libraries
CN1541105A (zh) * 2001-06-11 2004-10-27 转新疗法公司 用维生素b12和干扰素联合治疗病毒性、增殖性和炎性疾病的方法
US7747391B2 (en) 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
ES2564570T3 (es) * 2002-03-01 2016-03-23 Codexis Mayflower Holdings, Llc Métodos, sistemas y software para la identificación de biomoléculas funcionales
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
JPWO2003085548A1 (ja) 2002-04-04 2005-08-11 石原産業株式会社 データ解析装置および方法
WO2003099999A2 (en) * 2002-05-20 2003-12-04 Abmaxis, Inc. Generation and selection of protein library in silico
JP4042492B2 (ja) 2002-08-07 2008-02-06 トヨタ自動車株式会社 エンジン制御パラメータの適合方法及び適合システム
JP2004355174A (ja) * 2003-05-28 2004-12-16 Ishihara Sangyo Kaisha Ltd データ解析方法及びそのシステム
CA2540165A1 (en) * 2003-10-08 2005-04-21 Ebioscience Native immunoglobulin binding reagents and methods for making and using same
US7529714B2 (en) * 2004-12-14 2009-05-05 International Business Machines Corporation Cost management of software application portfolio
CN1763227A (zh) * 2005-09-01 2006-04-26 南京工业大学 一种提高蛋白质生物学功能的方法
CA2697193C (en) 2007-09-14 2017-06-06 Adimab, Inc. Rationally designed, synthetic antibody libraries and uses therefor
CA2701726A1 (en) 2007-10-04 2009-04-09 Halcyon Molecular Sequencing nucleic acid polymers with electron microscopy
US8383346B2 (en) 2008-06-13 2013-02-26 Codexis, Inc. Combined automated parallel synthesis of polynucleotide variants
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
CN101353372A (zh) * 2008-08-04 2009-01-28 林峻 一种新型蛋白质分子定向进化方法
US9175341B2 (en) * 2008-12-11 2015-11-03 Pacific Biosciences Of California, Inc. Methods for identifying nucleic acid modifications
US8551096B2 (en) * 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
CN101792934A (zh) * 2009-08-26 2010-08-04 青岛科技大学 一种基于组合原理和pcr建立超大容量基因文库的新方法
JP5649424B2 (ja) * 2010-02-03 2015-01-07 大和ハウス工業株式会社 防水シート診断方法および診断装置
US20120115734A1 (en) 2010-11-04 2012-05-10 Laura Potter In silico prediction of high expression gene combinations and other combinations of biological components
JP4839416B1 (ja) 2011-01-06 2011-12-21 アクアエンタープライズ株式会社 移動過程予測システム、移動過程予測方法、移動過程予測装置及びコンピュータプログラム
US20120231447A1 (en) * 2011-02-15 2012-09-13 Howard Hughes Medical Institute Surface Passivation Methods for Single Molecule Imaging of Biochemical Reactions
CN102206625A (zh) * 2011-03-04 2011-10-05 东华大学 易错pcr/卡那霉素筛选系统定向进化蛋白质内含子
US20130017540A1 (en) 2011-06-07 2013-01-17 Yun Yen Identification of mutation types associated with acquired resistance and methods for using same
LT2951579T (lt) 2013-01-31 2024-05-27 Codexis, Inc. Biomolekulių identifikavimo naudojant multiplikacinės formos modelius būdai, sistemos ir programinė įranga

Also Published As

Publication number Publication date
AU2014212430B2 (en) 2019-06-20
AU2014212432B2 (en) 2019-09-19
BR112015018454A2 (pt) 2018-12-04
CA2898777A1 (en) 2014-08-07
CA2898777C (en) 2024-01-02
CN105144190B (zh) 2018-05-01
KR20150113166A (ko) 2015-10-07
EP2951754B1 (en) 2024-03-20
EP2951579A1 (en) 2015-12-09
CN105074463B (zh) 2018-09-25
US9684771B2 (en) 2017-06-20
EP2951754A4 (en) 2016-11-30
RU2015136780A (ru) 2017-03-10
CN109360608A (zh) 2019-02-19
JP2017189176A (ja) 2017-10-19
WO2014120819A1 (en) 2014-08-07
JP6655670B2 (ja) 2020-02-26
LT2951579T (lt) 2024-05-27
FI2951579T3 (fi) 2024-05-29
IL240056A0 (en) 2015-09-24
WO2014120821A1 (en) 2014-08-07
US20140221216A1 (en) 2014-08-07
NZ710323A (en) 2020-02-28
SG11201505977RA (en) 2015-08-28
IL240055A0 (en) 2015-09-24
AU2014212432A1 (en) 2015-08-06
CN105074463A (zh) 2015-11-18
JP2018161148A (ja) 2018-10-18
CA2899859C (en) 2022-08-16
DK2951754T3 (da) 2024-04-15
RU2015136776A (ru) 2017-03-10
US9665694B2 (en) 2017-05-30
AU2014212430A1 (en) 2015-08-06
BR112015018449B1 (pt) 2022-05-31
BR112015018454B1 (pt) 2023-05-09
KR102215219B1 (ko) 2021-02-16
RU2664695C2 (ru) 2018-08-21
LT2951754T (lt) 2024-04-25
EP2951579A4 (en) 2016-09-21
CA2899859A1 (en) 2014-08-07
KR20150113167A (ko) 2015-10-07
JP2016504924A (ja) 2016-02-18
JP6377078B2 (ja) 2018-08-22
KR102490720B1 (ko) 2023-01-27
KR20210005325A (ko) 2021-01-13
JP6433028B2 (ja) 2018-12-05
CN109360608B (zh) 2022-05-24
JP2016511884A (ja) 2016-04-21
RU2695146C2 (ru) 2019-07-22
US20170211206A1 (en) 2017-07-27
BR112015018449A2 (pt) 2019-05-14
US20140214391A1 (en) 2014-07-31
EP2951579B1 (en) 2024-04-24
US20170204405A1 (en) 2017-07-20
CN105144190A (zh) 2015-12-09
EP2951754A1 (en) 2015-12-09
SG11201505969XA (en) 2015-08-28
NZ710299A (en) 2020-01-31
FI2951754T3 (fi) 2024-05-16

Similar Documents

Publication Publication Date Title
DK2951579T3 (da) Fremgangsmåder, systemer og software til identifikation af biomolekyler under anvendelse af modeller i multiplikativ form
DK3052225T3 (da) Nanobobleholdige væskeopløsninger, systemer og metoder
CL2015001924A1 (es) Anticuerpos anti-pdgfr-beta y usos relacionados.
BR112016009958A2 (pt) dispositivo microfluídico, método, sistema e kit
DK3327123T3 (da) Fremgangsmåder til sekvensering af immunrepertoiret
DK2970460T3 (da) Anti-IL-33-antistoffer og anvendelser deraf
DK3052181T3 (da) Mikronåleplastre og systemer
DK3079719T3 (da) ANTI-SIGLEC-8-antistoffer og fremgangsmåder til anvendelse deraf
FI20135275A (fi) Tapahtumien auktorisointimenetelmä ja -järjestelmä
BR112015029662A2 (pt) sistema, e método
DK3080302T3 (da) Metoder og sonder til identifikation af genalleler
DK3068505T3 (da) Spillesystem og -fremgangsmåde
DK3022361T4 (da) Rambuk og fremgangsmåde til anvendelse deraf
DK3453144T3 (da) Fremgangsmåde til integrering af en yderligere busdeltager i et bussystem og bussystem
DK2953957T3 (da) Modificerede glycolipider og fremgangsmåder til fremstilling og brug af disse
DK3380487T3 (da) Additivsystemer til anvendelse i proteinpegylering
DK3198005T3 (da) Fremgangsmåder til in vitro-oocytudvikling
DK2970425T3 (da) Mutante membranproteiner og fremgangsmåder til fremstilling heraf
DK2969086T3 (da) Kinetisk underholdningsindretning, kit og fremgangsmåde til fremstilling af samme
FI20135408A (fi) Autentikointimenetelmä
TH1501002658A (th) ระบบเชื่อมต่ออุปกรณ์, เครื่องปลายทางแบบพกพา, วิธีเชื่อมต่ออุปกรณ์ และโปรแกรมเชื่อมต่ออุปกรณ์
BR302013003493S1 (pt) Configuração aplicada em estojo.
BR302014000252S1 (pt) Configuração aplicada em ralo
TH1501000260A (th) วิธีการและระบบการพิสูจน์ตัวจริง
BR302013002083S1 (pt) Configuração aplicada em ralo