DK2890810T3 - Sensor for nadp (h) og udvikling af alkoholdehydrogenaser - Google Patents
Sensor for nadp (h) og udvikling af alkoholdehydrogenaserInfo
- Publication number
- DK2890810T3 DK2890810T3 DK13752832.9T DK13752832T DK2890810T3 DK 2890810 T3 DK2890810 T3 DK 2890810T3 DK 13752832 T DK13752832 T DK 13752832T DK 2890810 T3 DK2890810 T3 DK 2890810T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogenas
- nadp
- alcohol
- development
- sensor
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N3/00—Computing arrangements based on biological models
- G06N3/004—Artificial life, i.e. computing arrangements simulating life
- G06N3/006—Artificial life, i.e. computing arrangements simulating life based on simulated virtual individual or collective life forms, e.g. social simulations or particle swarm optimisation [PSO]
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06N5/00—Computing arrangements using knowledge-based models
- G06N5/04—Inference or reasoning models
- G06N5/045—Explanation of inference; Explainable artificial intelligence [XAI]; Interpretable artificial intelligence
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q10/00—Administration; Management
- G06Q10/04—Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q10/00—Administration; Management
- G06Q10/06—Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
- G06Q10/063—Operations research, analysis or management
- G06Q10/0639—Performance analysis of employees; Performance analysis of enterprise or organisation operations
- G06Q10/06395—Quality analysis or management
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04M—TELEPHONIC COMMUNICATION
- H04M1/00—Substation equipment, e.g. for use by subscribers
- H04M1/72—Mobile telephones; Cordless telephones, i.e. devices for establishing wireless links to base stations without route selection
- H04M1/725—Cordless telephones
- H04M1/737—Characterised by transmission of electromagnetic waves other than radio waves, e.g. infrared waves
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Business, Economics & Management (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Human Resources & Organizations (AREA)
- Theoretical Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Economics (AREA)
- Strategic Management (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Entrepreneurship & Innovation (AREA)
- Development Economics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Data Mining & Analysis (AREA)
- Tourism & Hospitality (AREA)
- Game Theory and Decision Science (AREA)
- Educational Administration (AREA)
- General Business, Economics & Management (AREA)
- Quality & Reliability (AREA)
- Operations Research (AREA)
- Marketing (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Artificial Intelligence (AREA)
- Computational Linguistics (AREA)
- Evolutionary Computation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012017026.2A DE102012017026A1 (de) | 2012-08-28 | 2012-08-28 | Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen |
| PCT/EP2013/002481 WO2014032777A1 (de) | 2012-08-28 | 2013-08-16 | Sensor für nadp(h) und entwicklung von alkoholdehydrogenasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2890810T3 true DK2890810T3 (da) | 2017-11-13 |
Family
ID=49034040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13752832.9T DK2890810T3 (da) | 2012-08-28 | 2013-08-16 | Sensor for nadp (h) og udvikling af alkoholdehydrogenaser |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10385349B2 (da) |
| EP (1) | EP2890810B1 (da) |
| JP (1) | JP6228982B2 (da) |
| CN (1) | CN104781419B (da) |
| DE (1) | DE102012017026A1 (da) |
| DK (1) | DK2890810T3 (da) |
| ES (1) | ES2645467T3 (da) |
| HU (1) | HUE034622T2 (da) |
| WO (1) | WO2014032777A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012017026A1 (de) * | 2012-08-28 | 2014-03-06 | Forschungszentrum Jülich GmbH | Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen |
| DE102012024435A1 (de) | 2012-12-14 | 2014-07-10 | Forschungszentrum Jülich GmbH | Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren |
| US20170226503A1 (en) * | 2014-02-06 | 2017-08-10 | MetaMixis Biologics, Inc. | Methods for Sequential Screening with Co-Culture Based Detection of Metagenomic Elements Conferring Heterologous Metabolite Secretion |
| CN106047826B (zh) * | 2016-07-06 | 2019-08-20 | 华东理工大学 | 醛脱氢酶、其重组表达转化体及在他汀前体合成中的应用 |
| KR101997841B1 (ko) * | 2016-11-04 | 2019-07-08 | 한국과학기술원 | SoxRS 변이체를 함유하는 유전자 회로 및 이의 초고속 탐색방법 |
| CN108132318B (zh) * | 2016-12-01 | 2021-03-09 | 山东蓝康药业股份有限公司 | 一种nadph的分离纯化方法 |
| WO2018106932A2 (en) * | 2016-12-07 | 2018-06-14 | University Of Maryland, College Park | Compositions and methods for electronic control of gene expression |
| CN110229828B (zh) * | 2019-05-31 | 2022-03-15 | 天津大学 | 大肠杆菌全局调控因子的突变基因soxR及应用 |
| CN110982832B (zh) * | 2019-11-12 | 2021-09-24 | 北京理工大学 | 一种辐射生物剂量计、制备方法及应用 |
Family Cites Families (37)
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| JPS57163341A (en) | 1981-03-30 | 1982-10-07 | Sumitomo Chem Co Ltd | Preparation of racemized cyclopropanecarboxylic acid derivative |
| JP3155107B2 (ja) | 1993-01-12 | 2001-04-09 | ダイセル化学工業株式会社 | 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法 |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| US5891685A (en) | 1996-06-03 | 1999-04-06 | Mitsubishi Chemical Corporation | Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid |
| DE19857302C2 (de) | 1998-12-14 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester |
| CA2360376C (en) | 1999-12-03 | 2005-04-26 | Noriyuki Kizaki | Novel carbonyl reductase, gene thereof and method of using the same |
| US7202070B2 (en) | 2000-10-31 | 2007-04-10 | Biocatalytics, Inc. | Method for reductive amination of a ketone using a mutated enzyme |
| MXPA03008437A (es) | 2001-03-22 | 2004-01-29 | Bristol Myers Squibb Co | Reduccion estereoselectiva de acetofenona substituida. |
| DE10152113C1 (de) | 2001-10-23 | 2003-03-06 | Viatris Gmbh | Verfahren zur Herstellung von (R)- und (S)-8-Chlor-6-hydroxy-octansäurealkylestern durch enzymatische Reduktion |
| GB0204232D0 (en) | 2002-02-22 | 2002-04-10 | Isis Innovation | Assay |
| GB0311902D0 (en) | 2003-05-22 | 2003-06-25 | Cambridge Life Sciences | Assay method and apparatus |
| DE10327454A1 (de) | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
| CN1215327C (zh) | 2003-09-17 | 2005-08-17 | 中国科学院长春应用化学研究所 | 脱氧核糖核酸电化学纳米传感器的制备方法 |
| US7790374B2 (en) | 2003-10-02 | 2010-09-07 | Basf Aktiengesellschaft | Process for sequence saturation mutagenesis (SeSaM) |
| JP4394647B2 (ja) | 2003-12-02 | 2010-01-06 | メルシャン株式会社 | 光学活性テトラヒドロチオフェン誘導体の製造方法、および、光学活性テトラヒドロチオフェン−３−オールの晶析方法 |
| AT413541B (de) | 2004-05-10 | 2006-03-15 | Iep Gmbh | Verfahren zur herstellung von 2-butanol |
| DE102005010804A1 (de) | 2005-03-07 | 2006-09-14 | Basf Ag | Verfahren zur Herstellung optisch aktiver Alkohole |
| US7550277B2 (en) | 2005-03-28 | 2009-06-23 | Codexis, Inc. | D-amino acid dehydrogenase and method of making D-amino acids |
| US7393667B2 (en) | 2005-05-31 | 2008-07-01 | Bristol-Myers Squibb Company | Stereoselective reduction process for the preparation of pyrrolotriazine compounds |
| BRPI0611821A2 (pt) | 2005-06-10 | 2011-12-20 | Gilupi Gmbh | nanossensor para diagnóstico, método para produzir o mesmo, uso do mesmo, método de detecção |
| DE102005028312B4 (de) | 2005-06-18 | 2008-05-08 | Archimica Gmbh | Verfahren zur Herstellung von enantiomerenreinen Epoxiden durch ADH-Reduktion von α-Abgangsgruppen-substituierten Ketonen und Cyclisierung |
| DE102006023083A1 (de) | 2006-05-16 | 2007-11-22 | Jacobs University Bremen Ggmbh | Bestimmung von Konzentrationsänderungen |
| EP1894999A1 (de) | 2006-09-01 | 2008-03-05 | Basf Se | Verfahren zur enzymatischen Reduktion von Alkinderivaten |
| GB0619240D0 (en) | 2006-09-29 | 2006-11-08 | Almac Sciences Ltd | Reduction of alpha-halo ketones |
| AT504542B1 (de) | 2006-12-07 | 2008-09-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten |
| US7820421B2 (en) | 2007-02-08 | 2010-10-26 | Codexis, Inc. | Ketoreductases and uses thereof |
| CN101386828B (zh) | 2008-07-09 | 2010-10-06 | 温州医学院 | 一种对氧化还原循环反应剂敏感的报告菌株及其制备方法 |
| CA2760410A1 (en) | 2009-04-16 | 2010-10-21 | Isis Innovation Limited | Process for the preparation of (3r)-hydr0xybutyl (3r) -hydroxybutyrate by enzymatic enantioselective reduction employing lactobacillus brevis alcohol dehydrogenase |
| DE102010019059A1 (de) | 2010-05-03 | 2011-11-03 | Forschungszentrum Jülich GmbH | Sensoren zur intrazellulären Metabolit-Detektion |
| EA201300325A1 (ru) | 2010-09-10 | 2013-08-30 | ДСМ АйПи АССЕТС Б.В. | Получение 6-аминокапроновой кислоты из альфа-кетопимелиновой кислоты |
| EP2441771A1 (de) | 2010-10-13 | 2012-04-18 | PharmaZell GmbH | Neue 12alpha-Hydroxysteroid- dehydrogenase-Mutanten, deren Herstellung deren Verwendung |
| EP2643467A1 (de) | 2010-11-24 | 2013-10-02 | Basf Se | Verfahren zur herstellung n-heterozyklischer optisch aktiver alkohole |
| CN102517378A (zh) | 2011-11-16 | 2012-06-27 | 浙江工业大学 | 一种基于nad(p)h荧光的醇脱氢酶的筛选鉴定方法 |
| DE102012017026A1 (de) * | 2012-08-28 | 2014-03-06 | Forschungszentrum Jülich GmbH | Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen |
| US9044530B2 (en) | 2012-12-19 | 2015-06-02 | Southwest Research Institute | Fabrication of bone regeneration scaffolds and bone filler material using a perfusion flow system |
| CA2897855A1 (en) | 2013-03-07 | 2014-09-12 | Allosource | Consistent calcium content bone allograft systems and methods |
| WO2015031809A1 (en) | 2013-09-02 | 2015-03-05 | Muffin Incorporated | Cell-seeded compositions and methods useful for treating bone regions |
-
2012
- 2012-08-28 DE DE102012017026.2A patent/DE102012017026A1/de not_active Withdrawn
-
2013
- 2013-08-16 ES ES13752832.9T patent/ES2645467T3/es active Active
- 2013-08-16 EP EP13752832.9A patent/EP2890810B1/de active Active
- 2013-08-16 JP JP2015528903A patent/JP6228982B2/ja active Active
- 2013-08-16 HU HUE13752832A patent/HUE034622T2/en unknown
- 2013-08-16 CN CN201380055705.7A patent/CN104781419B/zh active Active
- 2013-08-16 US US14/424,559 patent/US10385349B2/en active Active
- 2013-08-16 DK DK13752832.9T patent/DK2890810T3/da active
- 2013-08-16 WO PCT/EP2013/002481 patent/WO2014032777A1/de active Application Filing
-
2019
- 2019-07-22 US US16/518,544 patent/US11875298B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20150299715A1 (en) | 2015-10-22 |
| HUE034622T2 (en) | 2018-02-28 |
| EP2890810B1 (de) | 2017-08-02 |
| JP2015528287A (ja) | 2015-09-28 |
| EP2890810A1 (de) | 2015-07-08 |
| US10385349B2 (en) | 2019-08-20 |
| CN104781419A (zh) | 2015-07-15 |
| CN104781419B (zh) | 2018-09-11 |
| DE102012017026A1 (de) | 2014-03-06 |
| ES2645467T3 (es) | 2017-12-05 |
| WO2014032777A1 (de) | 2014-03-06 |
| US11875298B2 (en) | 2024-01-16 |
| US20200027049A1 (en) | 2020-01-23 |
| JP6228982B2 (ja) | 2017-11-08 |
| US20230297924A9 (en) | 2023-09-21 |
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