DK2868206T3 - Microparticles for encapsulating probiotics, manufacture and applications. - Google Patents

Microparticles for encapsulating probiotics, manufacture and applications. Download PDF

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Publication number
DK2868206T3
DK2868206T3 DK13760072.2T DK13760072T DK2868206T3 DK 2868206 T3 DK2868206 T3 DK 2868206T3 DK 13760072 T DK13760072 T DK 13760072T DK 2868206 T3 DK2868206 T3 DK 2868206T3
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Denmark
Prior art keywords
microparticles
composition
chitosan
casein
bacteria
Prior art date
Application number
DK13760072.2T
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Danish (da)
English (en)
Inventor
BAZO Maite AGÜEROS
De La Rasilla Carlos Gamazo
Garreta Juan Manuel Irache
Catalã�N Irene Esparza
Ferrero Carolina Gonzã�Lez
Navarro Carlos Javier Gonzã�Lez
Sobrã¿N Rebeca Peã`Alba
Hualde Ana Romo
Resano Raquel Virto
Original Assignee
Centro Nac De Tecnología Y Seguridad Alimentaria Laboratorio Del Ebro
Univ Navarra
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Publication of DK2868206T3 publication Critical patent/DK2868206T3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/22—Compounds of alkali metals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/26—Compounds containing phosphorus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK13760072.2T 2012-07-05 2013-07-05 Microparticles for encapsulating probiotics, manufacture and applications. DK2868206T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201231058 2012-07-05
PCT/ES2013/070477 WO2014006261A2 (es) 2012-07-05 2013-07-05 Micropartículas para encapsulación de probióticos, su obtención y usos

Publications (1)

Publication Number Publication Date
DK2868206T3 true DK2868206T3 (en) 2017-01-09

Family

ID=49162167

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13760072.2T DK2868206T3 (en) 2012-07-05 2013-07-05 Microparticles for encapsulating probiotics, manufacture and applications.

Country Status (15)

Country Link
US (1) US10111835B2 (https=)
EP (1) EP2868206B1 (https=)
JP (1) JP6442401B2 (https=)
KR (1) KR102203837B1 (https=)
CN (1) CN104602545B (https=)
AU (1) AU2013285330B2 (https=)
BR (1) BR112015000041B1 (https=)
CA (1) CA2878026C (https=)
DK (1) DK2868206T3 (https=)
ES (1) ES2606679T3 (https=)
MX (1) MX366411B (https=)
PL (1) PL2868206T3 (https=)
PT (1) PT2868206T (https=)
RU (1) RU2015103826A (https=)
WO (1) WO2014006261A2 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3217992A4 (en) * 2014-11-10 2018-07-18 National Institutes Of Health Probiotic therapeutic applications
GB201507760D0 (en) 2015-05-06 2015-06-17 Anabio Technologies Ltd Gelated microparticle suitable for oral delivery of therapeutic peptides to the lower intestine
GB201508745D0 (en) * 2015-05-21 2015-07-01 Anabio Technologies Ltd A method of producing microparticles of the type having a crosslinked, aggregated protein matrix by spray drying
FR3039990B1 (fr) 2015-08-10 2018-07-06 Rhodia Operations Procede d'encapsulation
WO2017087234A1 (en) * 2015-11-18 2017-05-26 Empire Technology Development Llc Methods and compositions for treating and preventing dag formation
ES3059594T3 (en) 2015-12-17 2026-03-23 Univ Navarra Microparticles for encapsulating probiotics, obtaining said microparticles and uses thereof
CN105535580A (zh) * 2015-12-21 2016-05-04 上海善力健生物科技有限公司 一种用于改善人体肠道菌群的生物制剂及其制备方法
CN105496971B (zh) * 2015-12-28 2018-04-03 河北科技大学 复配型生物交联剂交联壳聚糖的缓控释微球及其制备方法
US12318475B2 (en) 2016-03-14 2025-06-03 The University Of Chicago Injectable pastes based on oppositely charged polymer/calcium phosphate nanoparticles
CN106418547A (zh) * 2016-10-09 2017-02-22 西安创客村电子商务有限责任公司 一种益生菌微胶囊及其制备方法
CN116676222A (zh) * 2017-01-31 2023-09-01 庆熙大学校产学协力团 新型乳酸菌及其用途
EP3578637A4 (en) * 2017-01-31 2020-12-16 University - Industry Cooperation Group of Kyung Hee University NEW LACTIC BACTERIA AND THEIR USE
CN106937737B (zh) * 2017-02-07 2019-12-03 中国农业大学 一种酪蛋白凝胶颗粒乳化剂及其制备方法和用途
EP3651743B1 (en) * 2017-07-14 2023-10-04 The University of Chicago Freeze-dried formulations including nanoparticles and methods of freeze-drying
US11147845B2 (en) 2018-07-16 2021-10-19 ProBiora Health, LLC Foods containing beneficial oral bacteria
MX2021006708A (es) * 2018-12-07 2021-09-21 Pivot Bio Inc Composiciones polimericas con mayor estabilidad para productos microbianos fijadores de nitrogeno.
WO2020176697A1 (en) * 2019-02-27 2020-09-03 Accuro Agriservices, Inc. Insect repelling compositions and methods of manufacture thereof
WO2020203667A1 (ja) * 2019-03-29 2020-10-08 三菱商事ライフサイエンス株式会社 有用微生物の菌体の保護方法
WO2020209909A1 (en) * 2019-04-12 2020-10-15 International Flavors & Fragrances Inc. Sustainable core-shell microcapsules prepared with combinations of cross-linkers
US11219612B2 (en) 2019-06-11 2022-01-11 Dremcubed, Llc Nutraceutical formulation for unblocking receptors
KR102149102B1 (ko) * 2019-07-05 2020-08-27 에스케이바이오랜드 주식회사 피부보습 및 피부재생 기능이 있는 더모바이오틱스 블록 조성물의 제조방법
TW202126317A (zh) 2019-09-24 2021-07-16 美商普拉塔生技公司 用於治療發炎和免疫疾病之組成物和方法
CN111544322A (zh) * 2020-06-04 2020-08-18 广群化妆品科学技术研究院(广州)有限公司 一种干酪乳杆菌核壳体化妆品原料及其制备方法
US11426353B2 (en) 2020-06-24 2022-08-30 13400719 Canada Inc. Composite coating for an active agent
US20230323332A1 (en) * 2020-08-28 2023-10-12 Chr. Hansen A/S Microencapsulation of microbial culture using octenyl succinic anhydride starch-chitosan complex coacervate
CN112826836A (zh) * 2021-01-08 2021-05-25 深圳未知君生物科技有限公司 一种粪菌口服制剂及其制备方法
KR102334386B1 (ko) * 2021-01-22 2021-12-01 김향숙 유산균이 함유된 배설물 악취 방지용 기능성 사료의 제조방법
KR102682973B1 (ko) * 2021-05-17 2024-07-09 가천대학교 산학협력단 프탈레이트 환경 호르몬 제거를 위한 유산균-키토산 복합체 및 이의 제조방법
AU2022361451A1 (en) * 2021-10-05 2024-04-18 Massachusetts Institute Of Technology Protection of next-generation probiotics during processing
CN114794484A (zh) * 2022-03-21 2022-07-29 宁波大学 一种乳酪蛋白微胶囊、制备方法及应用
CN115088732B (zh) * 2022-06-24 2024-12-06 大连益丰农生物科技有限公司 一种含有植物根际促生菌微胶囊的种衣剂及其制备方法
CN115399461A (zh) * 2022-08-30 2022-11-29 常熟理工学院 一种益生菌缓释果冻及其制备方法和应用
CN117481312A (zh) * 2023-11-08 2024-02-02 河南尚品食品有限公司 一种低温肉制品中添加益生菌的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9004950D0 (en) * 1990-03-06 1990-05-02 Kelco Int Ltd Controlled release formulation
US6159504A (en) 1999-01-11 2000-12-12 Kitii Corporation, Ltd. Core substance-containing calcium microparticles and methods for producing the same
EP1395246A1 (en) * 2001-05-23 2004-03-10 Institut National de la Recherche Scientifique Biocompatible compositions as carriers or excipients for pharmaceutical and nutraceutical formulations and for food protection
US8871266B2 (en) 2003-10-01 2014-10-28 Commonwealth Scientific & Industrial Research Organisation Probiotic storage and delivery
CN1319637C (zh) 2003-10-15 2007-06-06 中国科学院过程工程研究所 一种尺寸均一的壳聚糖微球和微囊及其制备方法
US7935334B2 (en) 2005-07-07 2011-05-03 Imagilin Technologies, LLC Probiotics as alternative medicines against infectious diseases
CN101172118A (zh) * 2006-07-26 2008-05-07 美国医迈科技有限公司 作为抗传染病替代药物的益生微生物
US8460726B2 (en) 2006-12-18 2013-06-11 Advanced Bionutrition Corporation Dry food product containing live probiotic
US8834951B2 (en) 2010-01-28 2014-09-16 Advanced Bionutrition Corporation Dry glassy composition comprising a bioactive material
WO2012021783A2 (en) 2010-08-13 2012-02-16 Advanced Bionutrition Corporation Dry storage stabilizing composition for biological materials

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Publication number Publication date
BR112015000041B1 (pt) 2020-11-03
MX366411B (es) 2019-07-05
CN104602545A (zh) 2015-05-06
JP6442401B2 (ja) 2018-12-26
EP2868206B1 (en) 2016-09-14
CN104602545B (zh) 2017-11-17
CA2878026C (en) 2021-11-09
JP2015527308A (ja) 2015-09-17
KR20150034243A (ko) 2015-04-02
EP2868206A2 (en) 2015-05-06
AU2013285330A1 (en) 2015-02-26
WO2014006261A2 (es) 2014-01-09
RU2015103826A (ru) 2016-08-27
KR102203837B1 (ko) 2021-01-15
US10111835B2 (en) 2018-10-30
CA2878026A1 (en) 2014-01-09
PL2868206T3 (pl) 2017-03-31
ES2606679T3 (es) 2017-03-27
AU2013285330B2 (en) 2016-04-21
US20150335577A1 (en) 2015-11-26
PT2868206T (pt) 2016-12-16
BR112015000041A2 (pt) 2018-05-15
MX2015000218A (es) 2015-08-14
WO2014006261A3 (es) 2014-03-20

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