PT2868206T - Micropartículas para o encapsulamento de probióticos, preparação e usos das mesmas - Google Patents

Micropartículas para o encapsulamento de probióticos, preparação e usos das mesmas

Info

Publication number
PT2868206T
PT2868206T PT137600722T PT13760072T PT2868206T PT 2868206 T PT2868206 T PT 2868206T PT 137600722 T PT137600722 T PT 137600722T PT 13760072 T PT13760072 T PT 13760072T PT 2868206 T PT2868206 T PT 2868206T
Authority
PT
Portugal
Prior art keywords
probiotics
microparticles
encapsulation
preparation
Prior art date
Application number
PT137600722T
Other languages
English (en)
Inventor
Agüeros Bazo Maite
Esparza Catalán Irene
De La Rasilla Carlos Gamazo
González Ferrero Carolina
Javier González Navarro Carlos
Manuel Irache Garreta Juan
Peñalba Sobrón Rebeca
Romo Hualde Ana
Resano Raquel Virto
Original Assignee
Univ Navarra
Centro Nac De Tecnología Y Seguridad Alimentaria Laboratorio Del Ebro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Navarra, Centro Nac De Tecnología Y Seguridad Alimentaria Laboratorio Del Ebro filed Critical Univ Navarra
Publication of PT2868206T publication Critical patent/PT2868206T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/22—Compounds of alkali metals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/26—Compounds containing phosphorus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Physiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
PT137600722T 2012-07-05 2013-07-05 Micropartículas para o encapsulamento de probióticos, preparação e usos das mesmas PT2868206T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201231058 2012-07-05

Publications (1)

Publication Number Publication Date
PT2868206T true PT2868206T (pt) 2016-12-16

Family

ID=49162167

Family Applications (1)

Application Number Title Priority Date Filing Date
PT137600722T PT2868206T (pt) 2012-07-05 2013-07-05 Micropartículas para o encapsulamento de probióticos, preparação e usos das mesmas

Country Status (15)

Country Link
US (1) US10111835B2 (pt)
EP (1) EP2868206B1 (pt)
JP (1) JP6442401B2 (pt)
KR (1) KR102203837B1 (pt)
CN (1) CN104602545B (pt)
AU (1) AU2013285330B2 (pt)
BR (1) BR112015000041B1 (pt)
CA (1) CA2878026C (pt)
DK (1) DK2868206T3 (pt)
ES (1) ES2606679T3 (pt)
MX (1) MX366411B (pt)
PL (1) PL2868206T3 (pt)
PT (1) PT2868206T (pt)
RU (1) RU2015103826A (pt)
WO (1) WO2014006261A2 (pt)

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CA2967039A1 (en) * 2014-11-10 2016-05-19 National Institutes Of Health Probiotic therapeutic applications
GB201507760D0 (en) 2015-05-06 2015-06-17 Anabio Technologies Ltd Gelated microparticle suitable for oral delivery of therapeutic peptides to the lower intestine
GB201508745D0 (en) * 2015-05-21 2015-07-01 Anabio Technologies Ltd A method of producing microparticles of the type having a crosslinked, aggregated protein matrix by spray drying
FR3039990B1 (fr) * 2015-08-10 2018-07-06 Rhodia Operations Procede d'encapsulation
WO2017087234A1 (en) * 2015-11-18 2017-05-26 Empire Technology Development Llc Methods and compositions for treating and preventing dag formation
EP3389399A1 (en) 2015-12-17 2018-10-24 Universidad de Navarra Microparticles for encapsulating probiotics, obtaining said microparticles and uses thereof
CN105535580A (zh) * 2015-12-21 2016-05-04 上海善力健生物科技有限公司 一种用于改善人体肠道菌群的生物制剂及其制备方法
CN105496971B (zh) * 2015-12-28 2018-04-03 河北科技大学 复配型生物交联剂交联壳聚糖的缓控释微球及其制备方法
CN106418547A (zh) * 2016-10-09 2017-02-22 西安创客村电子商务有限责任公司 一种益生菌微胶囊及其制备方法
MX2019009079A (es) 2017-01-31 2019-09-26 Univ Industry Cooperation Group Kyung Hee Univ Nuevas bacterias acido lacticas y usos de las mismas.
EP3578637A4 (en) * 2017-01-31 2020-12-16 University - Industry Cooperation Group of Kyung Hee University NEW LACTIC BACTERIA AND THEIR USE
CN106937737B (zh) * 2017-02-07 2019-12-03 中国农业大学 一种酪蛋白凝胶颗粒乳化剂及其制备方法和用途
US20210145901A1 (en) * 2017-07-14 2021-05-20 University Of Chicago Freeze-dried formulations including nanoparticles and methods of freeze-drying
US11147845B2 (en) 2018-07-16 2021-10-19 ProBiora Health, LLC Foods containing beneficial oral bacteria
CA3120608A1 (en) * 2018-12-07 2020-06-11 Pivot Bio, Inc. Polymer compositions with improved stability for nitrogen fixing microbial products
US20220167631A1 (en) * 2019-02-27 2022-06-02 Accuro Agriservices, Inc. Insect repelling compositions and methods of manufacture thereof
JPWO2020203667A1 (pt) * 2019-03-29 2020-10-08
US11219612B2 (en) 2019-06-11 2022-01-11 Dremcubed, Llc Nutraceutical formulation for unblocking receptors
KR102149102B1 (ko) * 2019-07-05 2020-08-27 에스케이바이오랜드 주식회사 피부보습 및 피부재생 기능이 있는 더모바이오틱스 블록 조성물의 제조방법
WO2021061991A1 (en) * 2019-09-24 2021-04-01 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases
CN111544322A (zh) * 2020-06-04 2020-08-18 广群化妆品科学技术研究院(广州)有限公司 一种干酪乳杆菌核壳体化妆品原料及其制备方法
US11426353B2 (en) 2020-06-24 2022-08-30 13400719 Canada Inc. Composite coating for an active agent
WO2022043223A1 (en) * 2020-08-28 2022-03-03 Chr. Hansen A/S Microencapsulation of microbial culture using octenyl succinic anhydride starch-chitosan complex coacervate
CN112826836A (zh) * 2021-01-08 2021-05-25 深圳未知君生物科技有限公司 一种粪菌口服制剂及其制备方法
KR102334386B1 (ko) * 2021-01-22 2021-12-01 김향숙 유산균이 함유된 배설물 악취 방지용 기능성 사료의 제조방법
AU2022361451A1 (en) * 2021-10-05 2024-04-18 Massachusetts Institute Of Technology Protection of next-generation probiotics during processing
CN114794484A (zh) * 2022-03-21 2022-07-29 宁波大学 一种乳酪蛋白微胶囊、制备方法及应用
CN115399461A (zh) * 2022-08-30 2022-11-29 常熟理工学院 一种益生菌缓释果冻及其制备方法和应用

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US6159504A (en) * 1999-01-11 2000-12-12 Kitii Corporation, Ltd. Core substance-containing calcium microparticles and methods for producing the same
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US8871266B2 (en) 2003-10-01 2014-10-28 Commonwealth Scientific & Industrial Research Organisation Probiotic storage and delivery
CN1319637C (zh) 2003-10-15 2007-06-06 中国科学院过程工程研究所 一种尺寸均一的壳聚糖微球和微囊及其制备方法
US7935334B2 (en) 2005-07-07 2011-05-03 Imagilin Technologies, LLC Probiotics as alternative medicines against infectious diseases
CN101172118A (zh) * 2006-07-26 2008-05-07 美国医迈科技有限公司 作为抗传染病替代药物的益生微生物
US8460726B2 (en) 2006-12-18 2013-06-11 Advanced Bionutrition Corporation Dry food product containing live probiotic
BR112012018839B1 (pt) * 2010-01-28 2020-04-14 Advanced Bionutrition Corp composição vítrea seca compreendendo um material bioativo
CN103140145B (zh) 2010-08-13 2014-08-20 高级生物营养公司 用于生物材料的干的贮存稳定用组合物

Also Published As

Publication number Publication date
EP2868206A2 (en) 2015-05-06
CN104602545B (zh) 2017-11-17
EP2868206B1 (en) 2016-09-14
JP2015527308A (ja) 2015-09-17
AU2013285330A1 (en) 2015-02-26
WO2014006261A3 (es) 2014-03-20
BR112015000041B1 (pt) 2020-11-03
WO2014006261A2 (es) 2014-01-09
DK2868206T3 (en) 2017-01-09
US10111835B2 (en) 2018-10-30
US20150335577A1 (en) 2015-11-26
PL2868206T3 (pl) 2017-03-31
RU2015103826A (ru) 2016-08-27
CN104602545A (zh) 2015-05-06
AU2013285330B2 (en) 2016-04-21
CA2878026A1 (en) 2014-01-09
BR112015000041A2 (pt) 2018-05-15
MX366411B (es) 2019-07-05
KR102203837B1 (ko) 2021-01-15
KR20150034243A (ko) 2015-04-02
CA2878026C (en) 2021-11-09
JP6442401B2 (ja) 2018-12-26
MX2015000218A (es) 2015-08-14
ES2606679T3 (es) 2017-03-27

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