DK2861741T3 - CHO expression system - Google Patents

Info

Publication number

DK2861741T3

DK2861741T3 DK13732112.1T DK13732112T DK2861741T3 DK 2861741 T3 DK2861741 T3 DK 2861741T3 DK 13732112 T DK13732112 T DK 13732112T DK 2861741 T3 DK2861741 T3 DK 2861741T3

Authority

DK

Denmark

Prior art keywords

gly

cell line

ala

glu

sequence

Prior art date

2012-06-14

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• 230000014509 gene expression Effects 0.000 title claims description 65
• 239000013598 vector Substances 0.000 claims description 148
• 102000005396 glutamine synthetase Human genes 0.000 claims description 139
• 108020002326 glutamine synthetase Proteins 0.000 claims description 139
• 210000004027 cell Anatomy 0.000 claims description 122
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 87
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 87
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 57
• 108020004414 DNA Proteins 0.000 claims description 52
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• 238000004519 manufacturing process Methods 0.000 claims description 28
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 26
• 238000000034 method Methods 0.000 claims description 25
• 101000888841 Homo sapiens Glutamine synthetase Proteins 0.000 claims description 23
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• XUVTWGPERWIERB-IHRRRGAJSA-N Asp-Pro-Phe Chemical compound N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O XUVTWGPERWIERB-IHRRRGAJSA-N 0.000 description 7
• BKMOHWJHXQLFEX-IRIUXVKKSA-N Glu-Tyr-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCC(=O)O)N)O BKMOHWJHXQLFEX-IRIUXVKKSA-N 0.000 description 7
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• UXUSHQYYQCZWET-WDSKDSINSA-N Cys-Glu-Gly Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(O)=O UXUSHQYYQCZWET-WDSKDSINSA-N 0.000 description 5
• JXVFJOMFOLFPMP-KKUMJFAQSA-N Cys-Leu-Tyr Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O JXVFJOMFOLFPMP-KKUMJFAQSA-N 0.000 description 5
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