DK2788339T3 - Hydantoinderivater, anvendelige som kv3-inhibitorer - Google Patents
Hydantoinderivater, anvendelige som kv3-inhibitorer Download PDFInfo
- Publication number
- DK2788339T3 DK2788339T3 DK12806092.8T DK12806092T DK2788339T3 DK 2788339 T3 DK2788339 T3 DK 2788339T3 DK 12806092 T DK12806092 T DK 12806092T DK 2788339 T3 DK2788339 T3 DK 2788339T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzofuran
- disorder
- compound
- mmol
- ethyl acetate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (18)
1. Forbindelseifølge formel (I):
(O hvor: W er CRaRb eller O; når W er CRaRb, så er Z CH2; når W er O, så er Z CF2; Ra og Rb er CFI3 eller sammen danner en C3-spiro-cycloalkyl; hvor, når W er CRaRb, Z er CH2 og Ra og Rb er CFI3, så er rina A:
og ring B er:
eller så er rina A:
og ring B er:
hvor, når W er CRaRb, Z er CH2 og Ra og Rb sammen danner en C3-spiro-cycloalkyl: så er ring A: eller '
* ' og ring B er:
og hvor, når W er O og Z er CF2: så er ring A:
og ring B er:
eller et farmaceutisk acceptabelt salt og/eller solvat deraf.
2. Forbindelse ifølge krav 1, som er: (5R)-5-ethyl-5-methyl-3-[2-(7-methylspiro[2H-benzofuran-3,l'-cyclopropan]-4- yl)oxypyrimidin-5-yl]imidazolidin-2,4-dion
3. Forbindelse ifølge krav 1, som er: (5R)-5-ethyl-5-methyl-3-{2-[(3,3,7-trimethyl-2,3-dihydro-l-benzofuran-4-yl)oxy]- 5-pyrimidinyl}-2,4-imidazolidindion
4. Forbindelse ifølge krav 1, som er: (5R)-3-{2-[(2,2-difluor-7-methyl-l,3-benzodioxol-4-yl)oxy]-5-pyrimidinyl>-5-ethyl- 5-methyl-2,4-imidazolidindion
5. Forbindelse ifølge krav 1, som er: 5,5-dimethyl-3-[2-(7-methylspiro[2H-benzofuran-3,l'-cyclopropan]-4- yl)oxypyrimidin-5-yl]imidazolidin-2,4-dion
6. Forbindelse ifølge krav 1, som er: (5R)-5-ethyl-3-[2-(7-methylspiro[2H-benzofuran-3,l'-cyclopropan]-4- yl)oxypyrimidin-5-yl]imidazolidin-2,4-dion
7. Forbindelse ifølge krav 1, som er: (5R)-5-ethyl-3-[6-(7-methylspiro[2H-benzofuran-3,l'-cyclopropan]-4-yl)oxy-3- pyridyl]imidazolidin-2,4-dion
8. Forbindelse ifølge krav 1, som er: (5R)-5-ethyl-3-{6-[(3,3,7-trimethyl-2,3-dihydro-l-benzofuran-4-yl)oxy]-3- pyridinyl}-2,4-imidazolidindion
9. Forbindelse ifølge krav 1, som er: (5R)-5-ethyl-3-{2-[(3,3,7-trimethyl-2,3-dihydro-l-benzofuran-4-yl)oxy]-5- pyrimidinyl>-2,4-imidazolidindion
10. Forbindelse ifølge krav 1, som er: (5R)-5-ethyl-5-methyl-3-[6-(7-methylspiro[2H-benzofuran-3,l'-cyclopropan]-4- yl)oxy-3-pyridyl]imidazolidin-2,4-dion 4
11. Forbindelse ifølge krav 1, som er: 5,5-dimethyl-3-[6-(7-methylspiro[2H-benzofuran-3,l'-cyclopropan]-4-yl)oxy-3- pyridyl]imidazolidin-2,4-dion
12. Forbindelse ifølge et hvilket som helst af krav 1 til 11, til anvendelse som et lægemiddel.
13. Forbindelse til anvendelse ifølge krav 12, til forebyggelse eller behandling af hørelseslidelser.
14. Forbindelse til anvendelse ifølge krav 13, hvor hørelseslidelsen er hørelsestab hos voksne over 60 (presbyacusis) eller tinnitus.
15. Forbindelse til anvendelse ifølge krav 12, til forebyggelse eller behandling af skizofreni.
16. Forbindelse til anvendelse ifølge krav 12, til forebyggelse eller behandling af fragilt X-syndrom.
17. Forbindelse valgt blandt: 7-methylspiro[2FI-benzofuran-3,r-cydopropan]-4-ol (mellemprodukt 13)
og 3,3,7-trimethyl-2,3-dihydro-l-benzofuran-4-ol (mellemprodukt 27)
og 2,2-difluor-7-methyl-l,3-benzodioxol-4-ol (mellemprodukt 37)
eller et salt deraf.
18. Forbindelse valgt blandt: 6-(7-methylspiro[2H-benzofuran-3,l'-cyclopropan]-4-yl)oxypyridin-3-annin (mellemprodukt 15)
og 2-(7-methylspiro[2H-benzofuran-3,l,-cyclopropan]-4-yl)oxypyrimidin-5-amin (mellemprodukt 19)
og 6-[(3,3,7-trimethyl-2,3-dihydro-l-benzofuran-4-yl)oxy]-3-pyridinamin (mellemprodukt 29)
og 2-[(3,3,7-trimethyl-2,3-dihydro-l-benzofuran-4-yl)oxy]-5-pyrimidinamin (mellemprodukt 33)
eller et salt deraf.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2011/052414 WO2012076877A1 (en) | 2010-12-06 | 2011-12-06 | Hydantoin derivatives useful as kv3 inhibitors |
PCT/GB2012/053045 WO2013083994A1 (en) | 2011-12-06 | 2012-12-06 | Hydantoin derivatives useful as kv3 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2788339T3 true DK2788339T3 (da) | 2016-05-23 |
Family
ID=47429936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12806092.8T DK2788339T3 (da) | 2011-12-06 | 2012-12-06 | Hydantoinderivater, anvendelige som kv3-inhibitorer |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP2788339B1 (da) |
JP (1) | JP5985651B2 (da) |
KR (1) | KR20140098850A (da) |
CN (1) | CN103974944B (da) |
AU (1) | AU2012349847B2 (da) |
CA (1) | CA2856654C (da) |
DK (1) | DK2788339T3 (da) |
ES (1) | ES2576628T3 (da) |
HK (1) | HK1203072A1 (da) |
IL (2) | IL232612B (da) |
IN (1) | IN2014CN04014A (da) |
MX (1) | MX356813B (da) |
PL (1) | PL2788339T3 (da) |
WO (1) | WO2013083994A1 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103596943B (zh) | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
US9422252B2 (en) | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
US9669030B2 (en) | 2012-05-22 | 2017-06-06 | Autifony Therapeutics Limited | Hydantoin derivatives as Kv3 inhibitors |
WO2013182851A1 (en) * | 2012-06-06 | 2013-12-12 | Autifony Therapeutics Limited | Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required |
GB201521751D0 (en) * | 2015-12-10 | 2016-01-27 | Autifony Therapeutics Ltd | Novel uses |
GB201613163D0 (en) | 2016-07-29 | 2016-09-14 | Autifony Therapeutics Ltd | Novel compounds |
WO2018220762A1 (ja) | 2017-05-31 | 2018-12-06 | 大塚製薬株式会社 | ピリミジン化合物 |
US12090146B2 (en) | 2018-09-21 | 2024-09-17 | Bionomics Limited | Substituted-pyridinyl compounds and uses thereof |
AU2019360017A1 (en) | 2018-10-16 | 2021-04-01 | Autifony Therapeutics Limited | Novel compounds |
KR20220139923A (ko) | 2020-02-06 | 2022-10-17 | 오티포니 세라피틱스 리미티드 | Kv3 조절제 |
AU2022327657A1 (en) | 2021-08-10 | 2024-02-01 | Autifony Therapeutics Limited | Potassium channel modulators |
WO2024121552A1 (en) | 2022-12-06 | 2024-06-13 | Autifony Therapeutics Limited | Compounds for the treatment of centra nervous system disorders |
CN117448440A (zh) * | 2023-10-23 | 2024-01-26 | 中国人民解放军空军军医大学 | Kv3在制备诊断或治疗创伤后应激障碍异常恐惧记忆消退产品中的应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
DK123493D0 (da) * | 1993-11-01 | 1993-11-01 | Lundbeck & Co As H | Compounds |
WO2010072598A1 (en) * | 2008-12-22 | 2010-07-01 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
BR112012015868A2 (pt) * | 2009-12-11 | 2017-06-20 | Autifony Therapeutics Ltd | derivados de imidazolidinadiona |
JP2013513584A (ja) * | 2009-12-14 | 2013-04-22 | エフ.ホフマン−ラ ロシュ アーゲー | 複素環式抗ウイルス化合物 |
KR101862375B1 (ko) * | 2010-12-06 | 2018-05-29 | 오티포니 세라피틱스 리미티드 | Kv3 억제제로서 유용한 하이단토인 유도체 |
CN103596943B (zh) * | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
-
2012
- 2012-12-06 KR KR1020147018643A patent/KR20140098850A/ko not_active Application Discontinuation
- 2012-12-06 IN IN4014CHN2014 patent/IN2014CN04014A/en unknown
- 2012-12-06 DK DK12806092.8T patent/DK2788339T3/da active
- 2012-12-06 AU AU2012349847A patent/AU2012349847B2/en active Active
- 2012-12-06 JP JP2014545355A patent/JP5985651B2/ja active Active
- 2012-12-06 CA CA2856654A patent/CA2856654C/en active Active
- 2012-12-06 PL PL12806092.8T patent/PL2788339T3/pl unknown
- 2012-12-06 CN CN201280059633.9A patent/CN103974944B/zh active Active
- 2012-12-06 EP EP12806092.8A patent/EP2788339B1/en active Active
- 2012-12-06 ES ES12806092.8T patent/ES2576628T3/es active Active
- 2012-12-06 WO PCT/GB2012/053045 patent/WO2013083994A1/en active Application Filing
- 2012-12-06 MX MX2014006753A patent/MX356813B/es active IP Right Grant
-
2014
- 2014-05-14 IL IL232612A patent/IL232612B/en active IP Right Grant
-
2015
- 2015-04-13 HK HK15103579.6A patent/HK1203072A1/zh unknown
-
2018
- 2018-04-15 IL IL258704A patent/IL258704B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP2788339A1 (en) | 2014-10-15 |
AU2012349847B2 (en) | 2017-02-16 |
ES2576628T3 (es) | 2016-07-08 |
HK1203072A1 (zh) | 2015-10-16 |
IL258704A (en) | 2018-06-28 |
JP5985651B2 (ja) | 2016-09-06 |
MX356813B (es) | 2018-06-13 |
CA2856654A1 (en) | 2013-06-13 |
JP2015502951A (ja) | 2015-01-29 |
MX2014006753A (es) | 2014-10-15 |
PL2788339T3 (pl) | 2016-09-30 |
IN2014CN04014A (da) | 2015-07-10 |
IL232612A0 (en) | 2014-06-30 |
AU2012349847A1 (en) | 2014-06-26 |
EP2788339B1 (en) | 2016-03-09 |
CA2856654C (en) | 2020-03-31 |
CN103974944B (zh) | 2016-11-02 |
IL232612B (en) | 2018-07-31 |
KR20140098850A (ko) | 2014-08-08 |
CN103974944A (zh) | 2014-08-06 |
WO2013083994A1 (en) | 2013-06-13 |
IL258704B (en) | 2019-05-30 |
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