DK2766722T3 - Bevægelsesdetektor i nanoskala - Google Patents

Bevægelsesdetektor i nanoskala Download PDF

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Publication number
DK2766722T3
DK2766722T3 DK12797978.9T DK12797978T DK2766722T3 DK 2766722 T3 DK2766722 T3 DK 2766722T3 DK 12797978 T DK12797978 T DK 12797978T DK 2766722 T3 DK2766722 T3 DK 2766722T3
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Prior art keywords
carrier
motion detector
movement
displacement
article
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DK12797978.9T
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English (en)
Inventor
Giovanni Longo
Giovanni Dietler
Sarduy Livan Bladimir Alonso
Sandor Kasas
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Ecole Polytechnique Fed Lausanne Epfl
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/22—Details, e.g. general constructional or apparatus details
    • G01N29/24—Probes
    • G01N29/2418—Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/44—Processing the detected response signal, e.g. electronic circuits specially adapted therefor
    • G01N29/46—Processing the detected response signal, e.g. electronic circuits specially adapted therefor by spectral analysis, e.g. Fourier analysis or wavelet analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/04—Wave modes and trajectories
    • G01N2291/042—Wave modes
    • G01N2291/0427—Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Signal Processing (AREA)
  • Acoustics & Sound (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Mathematical Physics (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Claims (13)

1. Bevægelsesdetektor omfattende: en fleksibel bærer (1,5), der er indrettet til at holde mindst en genstand (6-9), hvor genstanden er udvalgt fra gruppen bestående af lipider, nukleinsyrer, glu-cider, nanoindretninger, proteiner, DNA, vira, bakterier, enkeltceller eller komplekse flercellede systemer, og hvor genstanden inducerer en bevægelse, som bevirker en forskydning af bæreren, en sensor (4) til måling af forskydningen af bæreren (1) som en funktion af tiden, kendetegnet ved at bevægelsesdetektoren yderligere omfatter behandlingsmidler, der er indrettet til at beregne en afvigelse af forskydningen af bæreren (1) for at skelne en bevægelse af bæreren (1) fra den af genstanden inducerede bevægelse (6-9), hvor en stigning i afvigelsen af forskydningen af bæreren (1) i nærvær af genstanden (6-9) beviser den af genstanden inducerede bevægelse (6-9).
2. Bevægelsesdetektor ifølge krav 1, hvor bæreren omfatter en udligger (1).
3. Bevægelsesdetektor ifølge krav 2, hvor sensoren er fastgjort til eller udgør en del af udliggeren.
4. Bevægelsesdetektor ifølge krav 3, hvor sensoren omfatter et piezoelektrisk materiale.
5. Bevægelsesdetektor ifølge et hvilket som helst af de foregående krav 1 til 3, hvor sensoren (4) er en optisk sensor.
6. Bevægelsesdetektor ifølge krav 5, hvor den optiske sensor er fotodetektor (4).
7. Bevægelsesdetektor ifølge et hvilket som helst af de foregående krav, yderligere omfattende et analysekammer.
8. Bevægelsesdetektor ifølge krav 7, hvor analysekammeret omfatter indgangs- og udgangsmidler, der er indrettet således, at at de tilvejebringer forskellige fluidiske omgivelser til genstanden(genstandene) (6-9) i kammeret.
9. Anvendelse af en bevægelsesdetektor ifølge et hvilket som helst af de foregående krav til analyse af mindst en genstand (6-9), der befinder sig på bæreren (1), hvor genstanden er udvalgt fra gruppen bestående af lipider, nukleinsyrer, glucider, nanoindretninger, proteiner, DNA, vira, bakterier, enkeltceller eller komplekse flercellede systemer.
10. Anvendelse ifølge krav 9 til kvantitativ estimering af MIC og/eller MBC.
11. Fremgangsmåde til analyse af mindst en genstand, der holdes på en fleksibel bærer (1), hvor genstanden er udvalgt fra gruppen bestående af lipider, nukleinsyrer, glucider, nanoindretninger, proteiner, DNA, vira, bakterier, enkeltceller eller komplekse flercellede systemer og inducerer en bevægelse, som bevirker forskydning af bæreren, hvilken fremgangsmåde omfatter trinnene: måling af forskydningen af bæreren (1) som en funktion af af tiden med en sensor (4), kendetegnet ved at fremgangsmåde yderligere omfatter beregning af en afgivelse af forskydningen af bæreren (1) med behandlingsmidler for at skelne en bevægelse af bæreren (1) fra den af genstanden inducerede bevægelse (6-9), hvor en stigning i afvigelsen af forskydningen af bæreren (1) i nærvær af genstanden (6-9) beviser den af genstanden inducerede bevægelse (6-9).
12. Fremgangsmåde ifølge krav 11, hvor bevægelse eller dynamik af den mindst ene genstand (6-9) detekteres.
13. Fremgangsmåde ifølge krav 11 eller 12, hvor en forbehandling anvendes på genstandene (6-9) for at fremme genstandenes vedhæftning (6-9) på bæreren (1, 5).
DK12797978.9T 2011-10-14 2012-10-12 Bevægelsesdetektor i nanoskala DK2766722T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2011054553 2011-10-14
PCT/IB2012/055564 WO2013054311A1 (en) 2011-10-14 2012-10-12 Nanoscale motion detector

Publications (1)

Publication Number Publication Date
DK2766722T3 true DK2766722T3 (da) 2019-03-18

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Application Number Title Priority Date Filing Date
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Country Status (8)

Country Link
US (3) US20140287403A1 (da)
EP (1) EP2766722B1 (da)
JP (2) JP2014528591A (da)
DK (1) DK2766722T3 (da)
ES (1) ES2710191T3 (da)
PL (1) PL2766722T3 (da)
TR (1) TR201901893T4 (da)
WO (1) WO2013054311A1 (da)

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JP2023507294A (ja) 2019-12-23 2023-02-22 レジステル アーゲー 表面への、例えばカンチレバーへの生物学的物体及び非生物学的物体、例えば細菌細胞の付着
NL2031130B1 (en) 2022-03-02 2023-09-11 Univ Delft Tech Clinical sample preparation and handling for activity monitoring of single living micro- and nano-organism
WO2023174728A1 (en) 2022-03-15 2023-09-21 Resistell Ag Method of analysing the motional activity of particles

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Publication number Publication date
JP6782274B2 (ja) 2020-11-11
US20140287403A1 (en) 2014-09-25
PL2766722T3 (pl) 2019-07-31
EP2766722B1 (en) 2018-12-26
US11299762B2 (en) 2022-04-12
US20220195489A1 (en) 2022-06-23
JP2018136332A (ja) 2018-08-30
ES2710191T3 (es) 2019-04-23
TR201901893T4 (tr) 2019-03-21
JP2014528591A (ja) 2014-10-27
US20180312898A1 (en) 2018-11-01
EP2766722A1 (en) 2014-08-20
WO2013054311A1 (en) 2013-04-18

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