JP2014528591A - ナノスケール運動検出器(MotionDetector) - Google Patents
ナノスケール運動検出器(MotionDetector) Download PDFInfo
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- JP2014528591A JP2014528591A JP2014535222A JP2014535222A JP2014528591A JP 2014528591 A JP2014528591 A JP 2014528591A JP 2014535222 A JP2014535222 A JP 2014535222A JP 2014535222 A JP2014535222 A JP 2014535222A JP 2014528591 A JP2014528591 A JP 2014528591A
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/533—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving isomerase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
- G01N29/022—Fluid sensors based on microsensors, e.g. quartz crystal-microbalance [QCM], surface acoustic wave [SAW] devices, tuning forks, cantilevers, flexural plate wave [FPW] devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
- G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/24—Probes
- G01N29/2418—Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/44—Processing the detected response signal, e.g. electronic circuits specially adapted therefor
- G01N29/46—Processing the detected response signal, e.g. electronic circuits specially adapted therefor by spectral analysis, e.g. Fourier analysis or wavelet analysis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/04—Wave modes and trajectories
- G01N2291/042—Wave modes
- G01N2291/0427—Flexural waves, plate waves, e.g. Lamb waves, tuning fork, cantilever
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- Food Science & Technology (AREA)
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
薬物親和性の検出
これらの実験は、トポイソメラーゼII(TopoII、図3)、および抗がん剤に対するその相互作用に関する。TopoIIは、DNAと相互作用してそのトポロジーを簡略化し、転写を安全に行うことを可能にする必須酵素である。
生化学反応の検出
前述のように、TopoIIは、DNAと相互作用してそのトポロジーを簡略化する。発明者らの方法を用いてこの反応を記録するために、発明者らは、図6に示すように、AFMカンチレバーの両側にTopoII−スーパーコイルDNA複合体を堆積させた。
抗生物質感受性検出
本方法は、細菌の外部ならびに内部の運動を検出するのに十分なほど感度が高く、抗菌剤の作用を評価するために使用することができる。この実験は、秒から分の範囲の非常に高い時間分解能で抗生物質に対する細菌の感度を探る能力を示す。
1 Boisen et al., Rep. Prog. Phys., 74 (2011) 036101
2 Ilic et al., Appl. Phys. Lett., 77 (2000) 450-452
3 Braun et al., Nature Nanotech., 4 (2009) 179-185
4 Lui et al., Sensors 2008 IEEE, 1464-1467
5 特許 US 7148017B1
6 特許出願 US 2009235746A1
7 特許出願 WO 2011021984A1
8 Fritz et al., Science, 288 (2000) 316-318
9 Berger et al., Science, 276 (1997) 2021-2024
10 Godin et al., Nanotech., 21 (2010) 075501
11 特許 EP 1342789A2
12 特許 WO 0058729A2
13 特許 WO 03023363A2
14 Luckulum et al., Anal. Bioanal. Chem., 384 (2006) 667-682
15 Jensen et al., Cancer Res., 51 (1991): 5093-5099
16 Mckendry et al., PNAS, 99 (2002) 9783-9788
17 Gupta et al., J. Vac. Sci. Technol. B, 22 (2004) 2785-2791
18 Campbell et al., J. Bios. Bioel., 21 (2005) 462-473
19 Djuric et al., J. Microel. Eng., 84 (2007) 1639-1642
20 特許出願 US 2006121502A1
21 特許出願 US 2003045019A1
22 特許出願 WO 2004038762A2
23 特許出願 WO 03081204A2
24 特許出願 US 2008136291A1
2 レーザ・ビーム
3 鏡
4 光検出器
5 光ファイバ
6 動いている標本
7 TopoII
8 DNA分子
9 細菌
Claims (17)
- 少なくとも1つの物体(6〜9)を保持するように適合された可撓性支持体(1、5)と、前記支持体(1)の変位を測定するためのセンサ(4)と、前記物体(6〜9)によって誘起される変動から前記支持体(1)の変動を区別するための処理手段とを備える運動検出器。
- 前記処理手段は、前記変位の分散を計算するように適合される、請求項1に記載の運動検出器。
- 前記支持体はカンチレバー(1)を備える、請求項1または2に記載の運動検出器。
- 前記センサは、前記カンチレバーの一部に固定され、または前記カンチレバーの一部を形成する、請求項3に記載の運動検出器。
- センサは圧電材料を備える、請求項4に記載の運動検出器。
- 前記センサ(4)は光センサである、請求項1〜4のいずれか1項に記載の運動検出器。
- 前記光センサは光検出器(4)である、請求項6に記載の運動検出器。
- 分析チャンバをさらに備える、請求項1〜7のいずれか1項に記載の運動検出器。
- 前記分析チャンバは、前記チャンバ内で物体(複数可)(6〜9)に対して異なる流体環境を提供するように適合された入口および出口手段を備える、請求項8に記載の運動検出器。
- 前記支持体(1)上に位置する少なくとも1つの物体(6〜9)を分析するための請求項1〜9のいずれか1項に記載の運動検出器の使用。
- 前記物体(6〜9)は生物学的物体である、請求項10に記載の使用。
- 前記生体は細菌(6、9)である、請求項11に記載の使用。
- MICおよび/またはMBCの定量的な推定のための請求項10〜12のいずれか1項に記載の使用。
- 可撓性支持体(1)上に保持された少なくとも1つの物体を分析する方法であって;前記支持体(1)の変位を測定する工程と、前記物体(6〜9)によって誘起される変動から前記支持体(1)の変動を区別するための処理工程とを含む上記方法。
- 少なくとも1つの物体(6〜9)の動きまたはダイナミクスを検出する、請求項14に記載の方法。
- 前記処理工程は、前記変位の分散を計算する工程を含む、請求項14または15に記載の方法。
- 前記支持体(1、5)に対する前記物体(6〜9)の粘着を容易にするために物体(6〜9)に適用される前処理を含む、請求項14〜16のいずれか1項に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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IB2011054553 | 2011-10-14 | ||
IBPCT/IB2011/054553 | 2011-10-14 | ||
PCT/IB2012/055564 WO2013054311A1 (en) | 2011-10-14 | 2012-10-12 | Nanoscale motion detector |
Related Child Applications (1)
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JP2018073545A Division JP6782274B2 (ja) | 2011-10-14 | 2018-04-06 | ナノスケール運動検出器(Motion Detector) |
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JP2014528591A true JP2014528591A (ja) | 2014-10-27 |
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JP2014535222A Pending JP2014528591A (ja) | 2011-10-14 | 2012-10-12 | ナノスケール運動検出器(MotionDetector) |
JP2018073545A Active JP6782274B2 (ja) | 2011-10-14 | 2018-04-06 | ナノスケール運動検出器(Motion Detector) |
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JP2018073545A Active JP6782274B2 (ja) | 2011-10-14 | 2018-04-06 | ナノスケール運動検出器(Motion Detector) |
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Country | Link |
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US (3) | US20140287403A1 (ja) |
EP (1) | EP2766722B1 (ja) |
JP (2) | JP2014528591A (ja) |
DK (1) | DK2766722T3 (ja) |
ES (1) | ES2710191T3 (ja) |
PL (1) | PL2766722T3 (ja) |
TR (1) | TR201901893T4 (ja) |
WO (1) | WO2013054311A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014145765A1 (en) | 2013-03-15 | 2014-09-18 | Ancera, Inc. | Systems and methods for bead-based assays in ferrofluids |
US11285490B2 (en) | 2015-06-26 | 2022-03-29 | Ancera, Llc | Background defocusing and clearing in ferrofluid-based capture assays |
US10947576B2 (en) | 2017-07-25 | 2021-03-16 | Arizona Board Of Regents On Behalf Of Arizona State University | Rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells |
NL2024356B1 (en) | 2019-12-02 | 2021-08-31 | Univ Delft Tech | 2D material detector for activity monitoring of single living micro-organisms and nano-organisms |
CN114829620A (zh) | 2019-12-23 | 2022-07-29 | 雷希斯特尔股份公司 | 生物物体和非生物物体例如细菌细胞向表面例如悬臂的附着 |
NL2031130B1 (en) | 2022-03-02 | 2023-09-11 | Univ Delft Tech | Clinical sample preparation and handling for activity monitoring of single living micro- and nano-organism |
WO2023174728A1 (en) | 2022-03-15 | 2023-09-21 | Resistell Ag | Method of analysing the motional activity of particles |
Citations (8)
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JPH0835976A (ja) * | 1994-07-21 | 1996-02-06 | Olympus Optical Co Ltd | 集積型spmセンサーおよび変位検出回路 |
JP2001013155A (ja) * | 1999-07-02 | 2001-01-19 | Seiko Instruments Inc | 走査型プローブ顕微鏡の測定方法および装置 |
JP2002543403A (ja) * | 1999-05-03 | 2002-12-17 | カンション アクティーゼルスカブ | 液体中において物質の存在を検出するための方法及びセンサ、並びにセンサの製造方法 |
JP2005348651A (ja) * | 2004-06-10 | 2005-12-22 | Nagasaki Prefecture | 有機・無機系抗菌剤のマイクロプレート殺菌力試験方法 |
US7148017B1 (en) * | 2000-07-12 | 2006-12-12 | Cornell Research Foundation, Inc. | High sensitivity mechanical resonant sensor |
JP2006337249A (ja) * | 2005-06-03 | 2006-12-14 | Canon Inc | カンチレバーセンサを利用するターゲット物質の検出方法及び検出装置 |
JP2008541098A (ja) * | 2005-05-20 | 2008-11-20 | アールエムアイティー ユニバーシティー | 分析装置 |
JP2010535385A (ja) * | 2007-08-22 | 2010-11-18 | ホンダ リサーチ インスティテュート ヨーロッパ ゲーエムベーハー | オプティカルフロー、運動学及び深さ情報を使用して、物体の適切な運動を推定する方法 |
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-
2012
- 2012-10-12 EP EP12797978.9A patent/EP2766722B1/en active Active
- 2012-10-12 PL PL12797978T patent/PL2766722T3/pl unknown
- 2012-10-12 DK DK12797978.9T patent/DK2766722T3/en active
- 2012-10-12 US US14/350,451 patent/US20140287403A1/en not_active Abandoned
- 2012-10-12 WO PCT/IB2012/055564 patent/WO2013054311A1/en active Application Filing
- 2012-10-12 ES ES12797978T patent/ES2710191T3/es active Active
- 2012-10-12 TR TR2019/01893T patent/TR201901893T4/tr unknown
- 2012-10-12 JP JP2014535222A patent/JP2014528591A/ja active Pending
-
2018
- 2018-04-06 JP JP2018073545A patent/JP6782274B2/ja active Active
- 2018-04-19 US US15/957,694 patent/US11299762B2/en active Active
-
2022
- 2022-03-14 US US17/693,682 patent/US20220195489A1/en active Pending
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JPH0835976A (ja) * | 1994-07-21 | 1996-02-06 | Olympus Optical Co Ltd | 集積型spmセンサーおよび変位検出回路 |
JP2002543403A (ja) * | 1999-05-03 | 2002-12-17 | カンション アクティーゼルスカブ | 液体中において物質の存在を検出するための方法及びセンサ、並びにセンサの製造方法 |
JP2001013155A (ja) * | 1999-07-02 | 2001-01-19 | Seiko Instruments Inc | 走査型プローブ顕微鏡の測定方法および装置 |
US7148017B1 (en) * | 2000-07-12 | 2006-12-12 | Cornell Research Foundation, Inc. | High sensitivity mechanical resonant sensor |
JP2005348651A (ja) * | 2004-06-10 | 2005-12-22 | Nagasaki Prefecture | 有機・無機系抗菌剤のマイクロプレート殺菌力試験方法 |
JP2008541098A (ja) * | 2005-05-20 | 2008-11-20 | アールエムアイティー ユニバーシティー | 分析装置 |
JP2006337249A (ja) * | 2005-06-03 | 2006-12-14 | Canon Inc | カンチレバーセンサを利用するターゲット物質の検出方法及び検出装置 |
JP2010535385A (ja) * | 2007-08-22 | 2010-11-18 | ホンダ リサーチ インスティテュート ヨーロッパ ゲーエムベーハー | オプティカルフロー、運動学及び深さ情報を使用して、物体の適切な運動を推定する方法 |
Also Published As
Publication number | Publication date |
---|---|
DK2766722T3 (en) | 2019-03-18 |
US20140287403A1 (en) | 2014-09-25 |
JP6782274B2 (ja) | 2020-11-11 |
JP2018136332A (ja) | 2018-08-30 |
EP2766722B1 (en) | 2018-12-26 |
US20220195489A1 (en) | 2022-06-23 |
US20180312898A1 (en) | 2018-11-01 |
PL2766722T3 (pl) | 2019-07-31 |
US11299762B2 (en) | 2022-04-12 |
WO2013054311A1 (en) | 2013-04-18 |
TR201901893T4 (tr) | 2019-03-21 |
EP2766722A1 (en) | 2014-08-20 |
ES2710191T3 (es) | 2019-04-23 |
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